JP2014533656A5 - - Google Patents

Download PDF

Info

Publication number: JP2014533656A5
Authority: JP; Japan
Prior art keywords: tablet; manufactured; weight; trade name; enteric coating
Prior art date: 2012-11-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP2014525239A

Other languages

English (en)

Japanese (ja)

Other versions

JP2014533656A (ja

JP5925318B2 (ja

Filing date

2012-11-29

Publication date

2016-01-21

2012-11-29 Application filed filed Critical

2012-11-29 Priority to JP2014525239A priority Critical patent/JP5925318B2/ja

2012-11-29 Priority claimed from JP2014525239A external-priority patent/JP5925318B2/ja

2014-12-15 Publication of JP2014533656A publication Critical patent/JP2014533656A/ja

2016-01-21 Publication of JP2014533656A5 publication Critical patent/JP2014533656A5/ja

2016-05-25 Application granted granted Critical

2016-05-25 Publication of JP5925318B2 publication Critical patent/JP5925318B2/ja

Status Active legal-status Critical Current

2032-11-29 Anticipated expiration legal-status Critical

Links

239000003826 tablet Substances 0.000 description 58
239000002702 enteric coating Substances 0.000 description 33
238000009505 enteric coating Methods 0.000 description 33
239000010410 layer Substances 0.000 description 28
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 24
229920001577 copolymer Polymers 0.000 description 23
229920003145 methacrylic acid copolymer Polymers 0.000 description 23
229940117841 methacrylic acid copolymer Drugs 0.000 description 22
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 20
229960001138 acetylsalicylic acid Drugs 0.000 description 20
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 17
239000007787 solid Substances 0.000 description 17
239000000243 solution Substances 0.000 description 15
JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 14
PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 14
229920000642 polymer Polymers 0.000 description 14
229920002678 cellulose Polymers 0.000 description 11
239000001913 cellulose Substances 0.000 description 11
229940075507 glyceryl monostearate Drugs 0.000 description 11
239000001788 mono and diglycerides of fatty acids Substances 0.000 description 11
229940126409 proton pump inhibitor Drugs 0.000 description 11
229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 10
239000011812 mixed powder Substances 0.000 description 9
238000013268 sustained release Methods 0.000 description 9
239000012730 sustained-release form Substances 0.000 description 9
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
239000002253 acid Substances 0.000 description 8
-1 carboxymethyl ethyl Chemical group 0.000 description 8
239000011248 coating agent Substances 0.000 description 8
239000000203 mixture Substances 0.000 description 8
239000004014 plasticizer Substances 0.000 description 8
229920003138 Eudragit® L 30 D-55 Polymers 0.000 description 7
229920003163 Eudragit® NE 30 D Polymers 0.000 description 7
DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 7
229960004543 anhydrous citric acid Drugs 0.000 description 7
238000000576 coating method Methods 0.000 description 7
239000006185 dispersion Substances 0.000 description 7
239000002552 dosage form Substances 0.000 description 7
GDCRSXZBSIRSFR-UHFFFAOYSA-N ethyl prop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.CCOC(=O)C=C GDCRSXZBSIRSFR-UHFFFAOYSA-N 0.000 description 7
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 7
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 7
229940068968 polysorbate 80 Drugs 0.000 description 7
229920000053 polysorbate 80 Polymers 0.000 description 7
239000000612 proton pump inhibitor Substances 0.000 description 7
239000001069 triethyl citrate Substances 0.000 description 7
VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 7
235000013769 triethyl citrate Nutrition 0.000 description 7
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 6
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 6
239000001863 hydroxypropyl cellulose Substances 0.000 description 6
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 6
229920003169 water-soluble polymer Polymers 0.000 description 6
208000007107 Stomach Ulcer Diseases 0.000 description 5
208000000718 duodenal ulcer Diseases 0.000 description 5
MJIHNNLFOKEZEW-UHFFFAOYSA-N lansoprazole Chemical compound CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1 MJIHNNLFOKEZEW-UHFFFAOYSA-N 0.000 description 5
229960003174 lansoprazole Drugs 0.000 description 5
239000000314 lubricant Substances 0.000 description 5
229920000333 poly(propyleneimine) Polymers 0.000 description 5
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 4
239000002662 enteric coated tablet Substances 0.000 description 4
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 4
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 4
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 4
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 4
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 4
239000000843 powder Substances 0.000 description 4
URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 4
OVSKIKFHRZPJSS-UHFFFAOYSA-N 2,4-D Chemical compound OC(=O)COC1=CC=C(Cl)C=C1Cl OVSKIKFHRZPJSS-UHFFFAOYSA-N 0.000 description 3
229920002134 Carboxymethyl cellulose Polymers 0.000 description 3
229920002261 Corn starch Polymers 0.000 description 3
VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 description 3
235000010948 carboxy methyl cellulose Nutrition 0.000 description 3
229950008138 carmellose Drugs 0.000 description 3
239000008120 corn starch Substances 0.000 description 3
230000002496 gastric effect Effects 0.000 description 3
201000005917 gastric ulcer Diseases 0.000 description 3
229910052742 iron Inorganic materials 0.000 description 3
239000003002 pH adjusting agent Substances 0.000 description 3
239000008194 pharmaceutical composition Substances 0.000 description 3
239000004094 surface-active agent Substances 0.000 description 3
229920000623 Cellulose acetate phthalate Polymers 0.000 description 2
239000001856 Ethyl cellulose Substances 0.000 description 2
229920003157 Eudragit® RL 30 D Polymers 0.000 description 2
229920003161 Eudragit® RS 30 D Polymers 0.000 description 2
229920002907 Guar gum Polymers 0.000 description 2
206010061218 Inflammation Diseases 0.000 description 2
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
208000002193 Pain Diseases 0.000 description 2
239000002202 Polyethylene glycol Substances 0.000 description 2
239000004372 Polyvinyl alcohol Substances 0.000 description 2
229920001800 Shellac Polymers 0.000 description 2
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
208000007536 Thrombosis Diseases 0.000 description 2
208000025865 Ulcer Diseases 0.000 description 2
235000010724 Wisteria floribunda Nutrition 0.000 description 2
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
IYKJEILNJZQJPU-UHFFFAOYSA-N acetic acid;butanedioic acid Chemical compound CC(O)=O.OC(=O)CCC(O)=O IYKJEILNJZQJPU-UHFFFAOYSA-N 0.000 description 2
239000004480 active ingredient Substances 0.000 description 2
229920003144 amino alkyl methacrylate copolymer Polymers 0.000 description 2
229920003147 ammonioalkyl methacrylate copolymer Polymers 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
239000004359 castor oil Substances 0.000 description 2
235000019438 castor oil Nutrition 0.000 description 2
229940081734 cellulose acetate phthalate Drugs 0.000 description 2
239000003086 colorant Substances 0.000 description 2
229960000913 crospovidone Drugs 0.000 description 2
229920001249 ethyl cellulose Polymers 0.000 description 2
235000019325 ethyl cellulose Nutrition 0.000 description 2
239000000796 flavoring agent Substances 0.000 description 2
235000013355 food flavoring agent Nutrition 0.000 description 2
210000004051 gastric juice Anatomy 0.000 description 2
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
239000001087 glyceryl triacetate Substances 0.000 description 2
235000013773 glyceryl triacetate Nutrition 0.000 description 2
239000008187 granular material Substances 0.000 description 2
238000005469 granulation Methods 0.000 description 2
230000003179 granulation Effects 0.000 description 2
239000000665 guar gum Substances 0.000 description 2
235000010417 guar gum Nutrition 0.000 description 2
229960002154 guar gum Drugs 0.000 description 2
229920003063 hydroxymethyl cellulose Polymers 0.000 description 2
229940031574 hydroxymethyl cellulose Drugs 0.000 description 2
229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 2
229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 2
230000004054 inflammatory process Effects 0.000 description 2
239000003112 inhibitor Substances 0.000 description 2
230000002401 inhibitory effect Effects 0.000 description 2
235000019359 magnesium stearate Nutrition 0.000 description 2
235000010355 mannitol Nutrition 0.000 description 2
229920000609 methyl cellulose Polymers 0.000 description 2
239000001923 methylcellulose Substances 0.000 description 2
239000002245 particle Substances 0.000 description 2
239000000546 pharmaceutical excipient Substances 0.000 description 2
229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 2
229920001223 polyethylene glycol Polymers 0.000 description 2
229920000136 polysorbate Polymers 0.000 description 2
229950008882 polysorbate Drugs 0.000 description 2
229920002451 polyvinyl alcohol Polymers 0.000 description 2
229940068984 polyvinyl alcohol Drugs 0.000 description 2
235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 2
229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 2
229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
239000001267 polyvinylpyrrolidone Substances 0.000 description 2
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
239000004208 shellac Substances 0.000 description 2
229940113147 shellac Drugs 0.000 description 2
235000013874 shellac Nutrition 0.000 description 2
ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 2
235000019333 sodium laurylsulphate Nutrition 0.000 description 2
NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 2
239000007921 spray Substances 0.000 description 2
239000000126 substance Substances 0.000 description 2
230000001629 suppression Effects 0.000 description 2
229960002622 triacetin Drugs 0.000 description 2
231100000397 ulcer Toxicity 0.000 description 2
LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 description 1
BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 description 1
GNYWBJRDQHPSJL-UHFFFAOYSA-N 6-acetyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid Chemical compound CC(=O)C1(O)C=CC=CC1C(O)=O GNYWBJRDQHPSJL-UHFFFAOYSA-N 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
208000008469 Peptic Ulcer Diseases 0.000 description 1
229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
206010037660 Pyrexia Diseases 0.000 description 1
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
239000000654 additive Substances 0.000 description 1
235000010443 alginic acid Nutrition 0.000 description 1
229920000615 alginic acid Polymers 0.000 description 1
238000013176 antiplatelet therapy Methods 0.000 description 1
150000001556 benzimidazoles Chemical class 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
229960004106 citric acid Drugs 0.000 description 1
230000007012 clinical effect Effects 0.000 description 1
238000004581 coalescence Methods 0.000 description 1
238000005336 cracking Methods 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
229940099371 diacetylated monoglycerides Drugs 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000003814 drug Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
230000010102 embolization Effects 0.000 description 1
230000027119 gastric acid secretion Effects 0.000 description 1
238000000034 method Methods 0.000 description 1
230000008881 mucosal defense Effects 0.000 description 1
229960000381 omeprazole Drugs 0.000 description 1
239000006186 oral dosage form Substances 0.000 description 1
201000008482 osteoarthritis Diseases 0.000 description 1
208000011906 peptic ulcer disease Diseases 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
229940093429 polyethylene glycol 6000 Drugs 0.000 description 1
229920001451 polypropylene glycol Polymers 0.000 description 1
235000019422 polyvinyl alcohol Nutrition 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
206010039073 rheumatoid arthritis Diseases 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1

JP2014525239A 2011-11-30 2012-11-29 有核錠 Active JP5925318B2 (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP2014525239A JP5925318B2 (ja)	2011-11-30	2012-11-29	有核錠

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP2011262679		2011-11-30
JP2011262679		2011-11-30
JP2014525239A JP5925318B2 (ja)	2011-11-30	2012-11-29	有核錠
PCT/JP2012/081583 WO2013081177A1 (en)	2011-11-30	2012-11-29	Dry coated tablet

Publications (3)

Publication Number	Publication Date
JP2014533656A JP2014533656A (ja)	2014-12-15
JP2014533656A5 true JP2014533656A5 (2)	2016-01-21
JP5925318B2 JP5925318B2 (ja)	2016-05-25

Family

ID=47428946

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2014525239A Active JP5925318B2 (ja)	2011-11-30	2012-11-29	有核錠

Country Status (14)

Country	Link
US (2)	US9433632B2 (2)
EP (1)	EP2785331B1 (2)
JP (1)	JP5925318B2 (2)
KR (1)	KR101952478B1 (2)
CN (1)	CN104080446B (2)
AR (1)	AR089032A1 (2)
CA (1)	CA2857457C (2)
ES (1)	ES2561098T3 (2)
MY (1)	MY186477A (2)
PH (1)	PH12014501218A1 (2)
SG (1)	SG11201402400YA (2)
TW (1)	TWI630002B (2)
UY (1)	UY34478A (2)
WO (1)	WO2013081177A1 (2)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9693962B2 (en)	2012-06-05	2017-07-04	Takeda Pharmaceutical Limited	Dry-coated tablet
EP3000470A4 (en)	2013-05-21	2017-01-11	Takeda Pharmaceutical Company Limited	Orally disintegrable tablet
CN107148473B (zh) *	2014-10-08	2021-08-06	合成生物制品有限公司	β-内酰胺酶制剂及其用途
CN108135915B (zh) *	2015-07-30	2021-06-25	武田药品工业株式会社	片剂
WO2018195205A1 (en) *	2017-04-18	2018-10-25	Sensient Colors Llc	Dosage form coating composition and method of making and using the same
JP7710850B2 (ja) *	2017-12-29	2025-07-22	ラクソンメディカルアーゲー	薬物送達システム
KR20190092805A (ko)	2018-01-31	2019-08-08	삼진제약주식회사	아세틸살리실산 및 란소프라졸을 포함하는 약학적 조성물
WO2022049310A1 (en) *	2020-09-07	2022-03-10	Cyprumed Gmbh	Improved pharmaceutical formulations of glp-1 receptor agonists
EP4091605A1 (en)	2021-05-19	2022-11-23	G.L. Pharma GmbH	Pharmaceutical tablet comprising acetylsalicylic acid
KR20230149188A (ko)	2022-04-19	2023-10-26	한미약품 주식회사	아세틸살리실산 및 프로톤 펌프 저해제를 포함하는 약학적 조성물
EP4512405A4 (en) *	2022-04-19	2026-04-22	Hanmi Pharmaceutical Co Ltd	Pharmaceutical composition comprising acetylsalicylic acid and a proton pump inhibitor
KR20240043707A (ko)	2022-09-27	2024-04-03	한미약품 주식회사	아세틸살리실산 및 프로톤 펌프 저해제를 포함하는 약학적 조성물

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6150978A (ja)	1984-08-16	1986-03-13	Takeda Chem Ind Ltd	ピリジン誘導体およびその製造法
JPH072761B2 (ja)	1985-03-20	1995-01-18	不二パウダル株式会社	微結晶セルロ−ス球形顆粒及びその製造法
JP2820829B2 (ja)	1991-03-07	1998-11-05	武田薬品工業株式会社	有核散剤およびその製造方法
JPH04346930A (ja)	1991-05-25	1992-12-02	Sumitomo Pharmaceut Co Ltd	安定なアスピリン腸溶錠
SE9600070D0 (sv)	1996-01-08	1996-01-08	Astra Ab	New oral pharmaceutical dosage forms
JP3828648B2 (ja)	1996-11-14	2006-10-04	武田薬品工業株式会社	２−（２−ピリジルメチルスルフィニル）ベンズイミダゾール系化合物の結晶およびその製造法
TW385306B (en)	1996-11-14	2000-03-21	Takeda Chemical Industries Ltd	Method for producing crystals of benzimidazole derivatives
US6235311B1 (en)	1998-03-18	2001-05-22	Bristol-Myers Squibb Company	Pharmaceutical composition containing a combination of a statin and aspirin and method
DK2263660T3 (en) *	1998-05-18	2018-01-02	Takeda Pharmaceuticals Co	Orally disintegrating tablets.
ATE291418T1 (de)	1998-07-28	2005-04-15	Takeda Pharmaceutical	Leicht zerfallende feste zubereitung
TWI289557B (en)	1999-06-17	2007-11-11	Takeda Chemical Industries Ltd	A crystal of a hydrate of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole
KR100775802B1 (ko)	2000-04-28	2007-11-12	다케다 야쿠힌 고교 가부시키가이샤	광학 활성 술폭시드 유도체의 제조 방법
CN100562318C (zh)	2000-05-15	2009-11-25	武田药品工业株式会社	晶体的制备方法
ATE511508T1 (de)	2000-12-01	2011-06-15	Takeda Pharmaceutical	Verfahren zur kristallisation von (r)- oder (s)- lansoprazol
US8206741B2 (en) *	2001-06-01	2012-06-26	Pozen Inc.	Pharmaceutical compositions for the coordinated delivery of NSAIDs
EP2260837A1 (en) *	2001-06-01	2010-12-15	Pozen, Inc.	Pharmaceutical compositions for the coordinated delivery of NSAIDs
EP1718303A4 (en)	2004-02-10	2010-09-01	Santarus Inc	COMBINATION OF INHIBITOR OF PROTON PUMP, BUFFER AND NON-STEROIDAL ANTI-INFLAMMATORY DRUG
US20080166407A1 (en) *	2005-07-29	2008-07-10	Shalaby Shalaby W	Solid oral formulations for combination therapy
DE102005047616A1 (de) *	2005-10-05	2007-05-31	Bayer Healthcare Ag	Kombination
AR057181A1 (es) *	2005-11-30	2007-11-21	Astra Ab	Nueva forma de dosificacion de combinacion
JP5529404B2 (ja)	2008-09-05	2014-06-25	東和薬品株式会社	アスピリン腸溶錠
AU2010266026B2 (en)	2009-06-25	2014-08-07	Nuvo Pharmaceuticals (Ireland) Designated Activity Company	Method for treating a patient in need of aspirin therapy
US20130064891A1 (en) *	2010-05-21	2013-03-14	Ashok Sahoo	Pharmaceutical compositions of nsaid and acid inhibitor
SG190717A1 (en) *	2010-12-03	2013-07-31	Takeda Pharmaceutical	Orally disintegrating tablet

2012
- 2012-11-29 SG SG11201402400YA patent/SG11201402400YA/en unknown
- 2012-11-29 TW TW101144687A patent/TWI630002B/zh not_active IP Right Cessation
- 2012-11-29 CA CA2857457A patent/CA2857457C/en not_active Expired - Fee Related
- 2012-11-29 JP JP2014525239A patent/JP5925318B2/ja active Active
- 2012-11-29 EP EP12805787.4A patent/EP2785331B1/en not_active Not-in-force
- 2012-11-29 KR KR1020147017678A patent/KR101952478B1/ko not_active Expired - Fee Related
- 2012-11-29 CN CN201280067760.3A patent/CN104080446B/zh not_active Expired - Fee Related
- 2012-11-29 US US14/361,554 patent/US9433632B2/en not_active Expired - Fee Related
- 2012-11-29 WO PCT/JP2012/081583 patent/WO2013081177A1/en not_active Ceased
- 2012-11-29 ES ES12805787.4T patent/ES2561098T3/es active Active
- 2012-11-29 MY MYPI2014701426A patent/MY186477A/en unknown
- 2012-11-29 UY UY0001034478A patent/UY34478A/es not_active Application Discontinuation
- 2012-11-29 AR ARP120104489A patent/AR089032A1/es not_active Application Discontinuation
2014
- 2014-05-29 PH PH12014501218A patent/PH12014501218A1/en unknown
2016
- 2016-08-02 US US15/226,612 patent/US10238605B2/en not_active Expired - Fee Related

Publication	Publication Date	Title
JP2014533656A5 (2)	2016-01-21
KR101908748B1 (ko)	2018-10-16	구강내 붕괴정
US9486446B2 (en)	2016-11-08	Orally disintegrating solid preparation
CA2823166C (en)	2019-04-09	Orally disintegrating tablet
JP5925318B2 (ja)	2016-05-25	有核錠
CA2994073C (en)	2023-09-05	Tablet comprising a core of acetylsalicylic acid with enteric coating and an outer layer with a potassium-competitive acid blocker
JP6364406B2 (ja)	2018-07-25	口腔内崩壊錠
EP2424365A1 (en)	2012-03-07	Orally disintegrating tablet compositions comprising combinations of non-opioid and opioid analgesics
AU2017285390B2 (en)	2022-09-29	Stable orally disintegrating pharmaceutical compositions
TWI606847B (zh)	2017-12-01	口腔內崩解錠
HK1197581B (en)	2016-07-22	Dry coated tablet