JP2015536308A5 - - Google Patents

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JP2015536308A5
JP2015536308A5 JP2015537017A JP2015537017A JP2015536308A5 JP 2015536308 A5 JP2015536308 A5 JP 2015536308A5 JP 2015537017 A JP2015537017 A JP 2015537017A JP 2015537017 A JP2015537017 A JP 2015537017A JP 2015536308 A5 JP2015536308 A5 JP 2015536308A5
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cancer
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gene
amino acid
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JP2015537017A
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JP6351182B2 (ja
JP2015536308A (ja
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Priority claimed from PCT/US2013/065112 external-priority patent/WO2014062720A2/en
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JP2015537017A 2012-10-15 2013-10-15 ガンの治療方法 Active JP6351182B2 (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201261714145P 2012-10-15 2012-10-15
US201261714140P 2012-10-15 2012-10-15
US201261714045P 2012-10-15 2012-10-15
US61/714,145 2012-10-15
US61/714,045 2012-10-15
US61/714,140 2012-10-15
US201361758972P 2013-01-31 2013-01-31
US61/758,972 2013-01-31
US201361780703P 2013-03-13 2013-03-13
US61/780,703 2013-03-13
US201361786277P 2013-03-14 2013-03-14
US61/786,277 2013-03-14
PCT/US2013/065112 WO2014062720A2 (en) 2012-10-15 2013-10-15 Methods of treating cancer

Related Child Applications (1)

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JP2018012593A Division JP2018062535A (ja) 2012-10-15 2018-01-29 ガンの治療方法

Publications (3)

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JP2015536308A JP2015536308A (ja) 2015-12-21
JP2015536308A5 true JP2015536308A5 (2) 2017-01-12
JP6351182B2 JP6351182B2 (ja) 2018-07-04

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JP2015537017A Active JP6351182B2 (ja) 2012-10-15 2013-10-15 ガンの治療方法
JP2018012593A Withdrawn JP2018062535A (ja) 2012-10-15 2018-01-29 ガンの治療方法
JP2019162839A Withdrawn JP2020011971A (ja) 2012-10-15 2019-09-06 ガンの治療方法
JP2021089951A Withdrawn JP2021120420A (ja) 2012-10-15 2021-05-28 ガンの治療方法
JP2023215651A Pending JP2024029066A (ja) 2012-10-15 2023-12-21 ガンの治療方法

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JP2018012593A Withdrawn JP2018062535A (ja) 2012-10-15 2018-01-29 ガンの治療方法
JP2019162839A Withdrawn JP2020011971A (ja) 2012-10-15 2019-09-06 ガンの治療方法
JP2021089951A Withdrawn JP2021120420A (ja) 2012-10-15 2021-05-28 ガンの治療方法
JP2023215651A Pending JP2024029066A (ja) 2012-10-15 2023-12-21 ガンの治療方法

Country Status (23)

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US (7) US9688665B2 (2)
EP (2) EP3659606A1 (2)
JP (5) JP6351182B2 (2)
KR (3) KR102021642B1 (2)
CN (2) CN110898067A (2)
AU (4) AU2013331368A1 (2)
BR (1) BR112015008447A2 (2)
CA (2) CA2887243C (2)
CY (1) CY1122186T1 (2)
ES (1) ES2750199T3 (2)
HR (1) HRP20191814T1 (2)
HU (1) HUE046790T2 (2)
IL (4) IL308613A (2)
LT (1) LT2908823T (2)
MX (2) MX376008B (2)
NZ (2) NZ746054A (2)
PL (1) PL2908823T3 (2)
PT (1) PT2908823T (2)
RS (1) RS59541B1 (2)
RU (2) RU2677276C2 (2)
SI (1) SI2908823T1 (2)
SM (1) SMT201900593T1 (2)
WO (1) WO2014062720A2 (2)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011160206A1 (en) 2010-06-23 2011-12-29 Morin Ryan D Biomarkers for non-hodgkin lymphomas and uses thereof
JO3363B1 (ar) 2011-04-13 2019-03-13 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
US9051269B2 (en) 2011-11-18 2015-06-09 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
JP5989805B2 (ja) 2012-02-10 2016-09-07 コンステレーション・ファーマシューティカルズ・インコーポレイテッドConstellation Pharmaceuticals,Inc. メチル基変更酵素の調節物質、組成物及びその使用
US9394283B2 (en) 2012-04-13 2016-07-19 Epizyme, Inc. Salt form of a human histone methyltransferase EZH2 inhibitor
CA2887243C (en) 2012-10-15 2024-04-09 Epizyme, Inc. Methods of treating cancer
PE20150887A1 (es) 2012-10-15 2015-06-04 Epizyme Inc Compuestos de benceno sustituidos
DK2935222T3 (en) 2012-12-21 2019-01-07 Epizyme Inc PRMT5 INHIBITORS AND APPLICATIONS THEREOF
US9745305B2 (en) 2013-03-15 2017-08-29 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
US9969716B2 (en) 2013-08-15 2018-05-15 Constellation Pharmaceuticals, Inc. Indole derivatives as modulators of methyl modifying enzymes, compositions and uses thereof
KR102142177B1 (ko) 2013-10-16 2020-08-07 에피자임, 인코포레이티드 Ezh2 억제용 하이드로클로라이드 염 형태
EP3057594A4 (en) * 2013-10-18 2017-06-07 Epizyme, Inc. Method of treating cancer
CA2931263A1 (en) 2013-12-06 2015-06-11 Epizyme, Inc. Combination therapy for treating cancer
IL285201B2 (en) * 2014-06-17 2024-05-01 Epizyme Inc EZH2 inhibitors for the treatment of lymphoma
EP3158086B1 (en) 2014-06-19 2021-03-24 Memorial Sloan-Kettering Cancer Center Biomarkers for response to ezh2 inhibitors
IL310279A (en) * 2014-10-16 2024-03-01 Epizyme Inc Method for treating cancer
HUE062159T2 (hu) * 2014-11-17 2023-10-28 Epizyme Inc Módszer a rák kezelésére N-((4,6-dimetil-2-oxo-l,2-dihidropiridin-3-il)metil)-5-(etil(tetrahidro-2H -pirán-4-il)amino)-4-metil-4'-(morfolinmetil)-[1,1'-bifenil]-3-karboxamiddal
AR102767A1 (es) 2014-12-05 2017-03-22 Lilly Co Eli Inhibidores de ezh2
EP3236962A2 (en) 2014-12-23 2017-11-01 University of Copenhagen Treatment of cancer by inhibiting ezh2 activity
CN108135908A (zh) 2015-04-20 2018-06-08 Epizyme股份有限公司 用于治疗癌症的组合疗法
EP3307713A4 (en) 2015-06-10 2019-01-23 Epizyme, Inc. EZH2 INHIBITOR FOR THE TREATMENT OF LYMPHOMA
KR20180042356A (ko) 2015-08-24 2018-04-25 에피자임, 인코포레이티드 암 치료 방법
TW201718598A (zh) 2015-08-27 2017-06-01 美國禮來大藥廠 Ezh2抑制劑
US10577350B2 (en) 2015-08-28 2020-03-03 Constellation Pharmaceuticals, Inc. Crystalline forms of (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide
JP7013369B2 (ja) * 2015-09-25 2022-02-15 エピザイム,インコーポレイティド Ezh2阻害剤により卵巣の悪性ラブドイド腫瘍(mrto)/高カルシウム血症型の卵巣の小細胞癌(sccoht)を処置するための方法
MX394355B (es) * 2015-10-06 2025-03-24 Epizyme Inc Método de tratamiento de meduloblastoma con un inhibidor de ezh2.
WO2017079757A1 (en) * 2015-11-06 2017-05-11 Epizyme, Inc. Pediatric dosing for treatment of cancer with an ezh2 inhibitor
CN105440023A (zh) * 2015-12-10 2016-03-30 江苏理工学院 Epz-6438的合成方法
WO2017132518A1 (en) 2016-01-29 2017-08-03 Epizyme, Inc. Combination therapy for treating cancer
JP2019508406A (ja) * 2016-02-08 2019-03-28 エピザイム,インコーポレイティド 癌を処置する方法
WO2017201585A1 (en) * 2016-05-26 2017-11-30 Genea Ip Holdings Pty Ltd Modulators of dux4 for regulation of muscle function
WO2017210395A1 (en) 2016-06-01 2017-12-07 Epizyme, Inc. Use of ezh2 inhibitors for treating cancer
US20200129519A1 (en) * 2016-06-08 2020-04-30 Genentech, Inc. Diagnostic and therapeutic methods for cancer
EP3471830A4 (en) 2016-06-17 2020-02-26 Epizyme Inc EZH2 INHIBITORS TO TREAT CANCER
US20190192521A1 (en) * 2016-08-15 2019-06-27 The Wistar Institute Of Anatomy And Biology Methods of Treating Arid1A-Mutated Cancers With HDAC6 Inhibitors and EZH2 Inhibitors
WO2018049000A1 (en) * 2016-09-08 2018-03-15 The General Hospital Corporation Treatment of cancers having alterations within the swi/snf chromatin remodeling complex
CN109843870A (zh) 2016-10-19 2019-06-04 星座制药公司 Ezh2抑制剂的合成
AU2017351638A1 (en) 2016-10-26 2019-06-13 Genea Biocells USA (Holdings), Inc. Improved generation of muscle lineage cells and therapeutic uses thereof
CN108314677B (zh) 2017-01-17 2020-06-30 安徽中科拓苒药物科学研究有限公司 一种ezh2抑制剂及其用途
JP7324144B2 (ja) * 2017-02-02 2023-08-09 エピザイム,インコーポレイティド 癌処置様式
US10266542B2 (en) 2017-03-15 2019-04-23 Mirati Therapeutics, Inc. EZH2 inhibitors
US11642346B2 (en) 2017-03-31 2023-05-09 Epizyme, Inc. Combination therapy for treating cancer
EP3630080A4 (en) 2017-06-02 2021-03-10 Epizyme, Inc. USE OF EZH2 INHIBITORS TO TREAT CANCER
US12178854B2 (en) 2017-07-19 2024-12-31 Children's Medical Center Corporation Compositions and methods for treating diseases associated with an imprinting defect
MX2020001875A (es) 2017-08-18 2020-07-29 Tragara Pharmaceuticals Inc Forma polimorfica de tg02.
WO2019050924A1 (en) 2017-09-05 2019-03-14 Epizyme, Inc. POLY THERAPY FOR THE TREATMENT OF CANCER
BR112020008325A2 (pt) 2017-11-14 2020-10-20 Pfizer Inc. terapias de combinação com o inibidor de ezh2
MX2020007974A (es) 2018-01-31 2020-09-07 Mirati Therapeutics Inc Inhibidores de complejo represivo polycomb 2 (prc2).
EP3823671B1 (en) * 2018-07-09 2024-02-07 Fondation Asile Des Aveugles Inhibition of prc2 subunits to treat eye disorders
TWI798532B (zh) * 2019-03-25 2023-04-11 大陸商深圳微芯生物科技股份有限公司 Kdm5a基因和atrx基因的應用
US20220154295A1 (en) * 2019-03-27 2022-05-19 The Johns Hopkins University Methods and materials for assessing and treating cancer
US12421228B2 (en) 2019-04-22 2025-09-23 Mirati Therapeutics, Inc. Naphthyridine derivatives as PRC2 inhibitors
EP3958854B1 (en) 2019-04-22 2025-06-04 University of Pittsburgh - of The Commonwealth System of Higher Education Tg02 for use in treating gliomas in pediatric subjects
EP3976044A4 (en) * 2019-06-03 2024-08-07 Icahn School of Medicine at Mount Sinai Compounds and methods for inhibiting cancers via rest inhibition
EP3980422A1 (en) 2019-06-05 2022-04-13 Mirati Therapeutics, Inc. Imidazo[1,2-c]pyrimidine derivatives as prc2 inhibitors for treating cancer
JP2022539556A (ja) 2019-06-28 2022-09-12 エイエルエス・セラピー・デベロップメント・インスティテュート ジペプチドリピートタンパク質の阻害
US20230181543A1 (en) * 2020-02-28 2023-06-15 The Wistar Institute Of Anatomy And Biology Treatment of carm1-overexpressing and/or arid1a mutant cancers with ire-1/xbp-1 inhibitors
AU2021293943A1 (en) * 2020-06-18 2023-02-23 Epizyme, Inc. SMARCA4 inhibition for the treatment of cancer
CN111773387A (zh) * 2020-07-08 2020-10-16 北京大学 一种通过改变bin1剪切体比例改善心脏横管结构的方法
EP4392034A1 (en) 2021-08-25 2024-07-03 Institut National de la Santé et de la Recherche Médicale (INSERM) Use of ezh2 inhibitors for the treatment of aortic valve stenosis
CN116019916A (zh) * 2021-10-27 2023-04-28 蚌埠医学院第一附属医院 非小细胞肺癌靶点arid1a及其抑制剂在制备肺癌治疗药物中的用途

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US5455044A (en) 1993-05-14 1995-10-03 Depotech Corporation Method for treating neurological disorders
US5763263A (en) 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
US7229774B2 (en) 2001-08-02 2007-06-12 Regents Of The University Of Michigan Expression profile of prostate cancer
SI2238982T1 (sl) 2003-06-27 2013-01-31 Astellas Pharma Inc. Terapevtsko sredstvo za mehkotkivni sarkom
WO2009006577A2 (en) * 2007-07-03 2009-01-08 The Regents Of The University Of Michigan Compositions and methods for inhibiting ezh2
US20120114670A1 (en) * 2007-10-02 2012-05-10 University Of Rochester Methods and compositions related to synergistic responses to oncogenic mutations
US20110064664A1 (en) * 2007-10-08 2011-03-17 The Board Of Regents Of The University Of Texas System Methods and compositions involving chitosan nanoparticles
US20110251216A1 (en) * 2010-02-19 2011-10-13 The Regents Of The University Of Michigan Compositions and methods for inhibiting ezh2
EA023788B1 (ru) 2010-05-07 2016-07-29 ГЛЭКСОСМИТКЛАЙН ЭлЭлСи Производные индола и фармацевтические композиции на их основе
WO2012005805A1 (en) 2010-05-07 2012-01-12 Glaxosmithkline Llc Azaindazoles
JP5864546B2 (ja) 2010-05-07 2016-02-17 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC インダゾール
WO2012071096A2 (en) * 2010-09-03 2012-05-31 The Johns Hopkins University Arid1a and ppp2r1a mutations in cancer
US9175331B2 (en) 2010-09-10 2015-11-03 Epizyme, Inc. Inhibitors of human EZH2, and methods of use thereof
BR112013005806B1 (pt) 2010-09-10 2022-05-10 Epizyme, Inc Métodos para detectar se um indivíduo é um candidato para o tratamento com ou responsivo a um inibidor de ezh2 e usos terapêuticos do dito inibidor de ezh2
US20130310379A1 (en) * 2010-11-19 2013-11-21 Constellation Pharmaceuticals Modulators of methyl modifying enzymes, compositions and uses thereof
EP2646020B1 (en) 2010-12-01 2016-09-21 Glaxosmithkline LLC Indoles
WO2012118812A2 (en) 2011-02-28 2012-09-07 Epizyme, Inc. Substituted 6,5-fused bicyclic heteroaryl compounds
US20140296248A1 (en) 2011-04-04 2014-10-02 Stichting het Nederlands Kanker Instiuut-Antoni van Leeuwenhoek ziekenhuis Methods and compositions for predicting resistance to anticancer treatment
TW201733984A (zh) * 2011-04-13 2017-10-01 雅酶股份有限公司 經取代之苯化合物
JO3363B1 (ar) 2011-04-13 2019-03-13 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
KR20140033384A (ko) 2011-05-16 2014-03-18 울리커 누베르 신규한 암 치료제 및 방법
EP2755962B1 (en) 2011-09-13 2017-03-01 Glaxosmithkline LLC Azaindazoles
CA2850570A1 (en) * 2011-09-30 2013-04-04 Glaxosmithkline Llc Methods of treating cancer
WO2013059944A1 (en) 2011-10-28 2013-05-02 British Columbia Cancer Agency Branch Epigenetic regulators and uses thereof
JP5989805B2 (ja) 2012-02-10 2016-09-07 コンステレーション・ファーマシューティカルズ・インコーポレイテッドConstellation Pharmaceuticals,Inc. メチル基変更酵素の調節物質、組成物及びその使用
RU2704445C2 (ru) 2012-03-12 2019-10-28 Эпизайм, Инк. Ингибиторы ezh2 человека и способы их применения
AU2013237226A1 (en) * 2012-03-19 2014-10-09 Emory University Quinazoline compounds and their use in therapy
SG10201608579UA (en) 2012-04-13 2016-12-29 Epizyme Inc Combination therapy for treating cancer
US9394283B2 (en) 2012-04-13 2016-07-19 Epizyme, Inc. Salt form of a human histone methyltransferase EZH2 inhibitor
US9562041B2 (en) 2012-05-16 2017-02-07 Glaxosmithkline Llc Enhancer of zeste homolog 2 inhibitors
CA2887243C (en) 2012-10-15 2024-04-09 Epizyme, Inc. Methods of treating cancer
PE20150887A1 (es) 2012-10-15 2015-06-04 Epizyme Inc Compuestos de benceno sustituidos
US20140120083A1 (en) 2012-11-01 2014-05-01 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
WO2014092905A1 (en) 2012-12-10 2014-06-19 Children's Medical Center Corporation Methods and assays for combination treatment of cancer
CA2894222A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. 1,4-pyridone bicyclic heteroaryl compounds
WO2014100646A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. 1,4-pyridone compounds
MA38341B1 (fr) 2013-02-11 2018-11-30 Constellation Pharmaceuticals Inc Modulateurs d'enzymes de modification par méthylation, compositions et utilisations associées
CA2903572A1 (en) 2013-03-15 2014-10-23 Epizyme, Inc. Substituted benzene compounds
US9776996B2 (en) 2013-03-15 2017-10-03 Epizyme, Inc. Substituted 6,5-fused bicyclic heteroaryl compounds
US9243001B2 (en) 2013-03-15 2016-01-26 Epizyme, Inc. Substituted benzene compounds
US9045477B2 (en) 2013-03-15 2015-06-02 Epizyme, Inc. Substituted 6,5-fused bicyclic heteroaryl compounds
WO2014176047A1 (en) 2013-04-25 2014-10-30 Novartis Ag Markers for ezh2 inhibitors
WO2014177982A1 (en) 2013-04-30 2014-11-06 Glaxosmithkline Intellectual Property (No.2) Limited Enhancer of zeste homolog 2 inhibitors
EP3004096A1 (en) 2013-06-06 2016-04-13 Glaxosmithkline Intellectual Property (No. 2) Limited Enhancer of zeste homolog 2 inhibitors
AU2014288839B2 (en) 2013-07-10 2017-02-02 Glaxosmithkline Intellectual Property (No.2) Limited Enhancer of Zeste Homolog 2 inhibitors
EP3022195A2 (en) 2013-07-19 2016-05-25 Epizyme, Inc. Substituted 6,5-fused bicyclic heteroaryl compounds
WO2015010049A1 (en) 2013-07-19 2015-01-22 Epizyme, Inc. Substituted benzene compounds
KR102142177B1 (ko) 2013-10-16 2020-08-07 에피자임, 인코포레이티드 Ezh2 억제용 하이드로클로라이드 염 형태
EP3057594A4 (en) 2013-10-18 2017-06-07 Epizyme, Inc. Method of treating cancer
CA2931263A1 (en) 2013-12-06 2015-06-11 Epizyme, Inc. Combination therapy for treating cancer
WO2015103431A1 (en) 2013-12-31 2015-07-09 Memorial Sloan-Kettering Cancer Center Compositions and methods for the diagnosis and treatment of ovarian cancers that are associated with reduced smarca4 gene expression or protein function
US20160361309A1 (en) 2014-02-26 2016-12-15 Glaxosmithkline Intellectual Property (No.2) Limited Methods of treating cancer patients responding to ezh2 inhibitor gsk126
EP3114125A1 (en) 2014-03-07 2017-01-11 Glaxosmithkline Intellectual Property (No. 2) Limited Enhancer of zeste homolog 2 inhibitors
MX382033B (es) 2014-03-19 2025-03-13 Infinity Pharmaceuticals Inc Compuestos heterocíclicos para utilizarlos en el tratamiento de trastornos mediados por pi3k-gamma.
WO2015193768A1 (en) 2014-06-17 2015-12-23 Pfizer Inc. Aryl fused lactams as ezh2 modulators
IL285201B2 (en) 2014-06-17 2024-05-01 Epizyme Inc EZH2 inhibitors for the treatment of lymphoma
EP3158086B1 (en) 2014-06-19 2021-03-24 Memorial Sloan-Kettering Cancer Center Biomarkers for response to ezh2 inhibitors
US20170217941A1 (en) 2014-06-25 2017-08-03 Epizyme, Inc. Substituted benzene and 6,5-fused bicyclic heteroaryl compounds
SG11201701704XA (en) 2014-09-05 2017-04-27 Arqule Inc Compositions and methods for treating proliferation disorders
IL310279A (en) 2014-10-16 2024-03-01 Epizyme Inc Method for treating cancer
HUE062159T2 (hu) 2014-11-17 2023-10-28 Epizyme Inc Módszer a rák kezelésére N-((4,6-dimetil-2-oxo-l,2-dihidropiridin-3-il)metil)-5-(etil(tetrahidro-2H -pirán-4-il)amino)-4-metil-4'-(morfolinmetil)-[1,1'-bifenil]-3-karboxamiddal
CN108135908A (zh) 2015-04-20 2018-06-08 Epizyme股份有限公司 用于治疗癌症的组合疗法
EP3307713A4 (en) 2015-06-10 2019-01-23 Epizyme, Inc. EZH2 INHIBITOR FOR THE TREATMENT OF LYMPHOMA
KR20180042356A (ko) 2015-08-24 2018-04-25 에피자임, 인코포레이티드 암 치료 방법
JP7013369B2 (ja) 2015-09-25 2022-02-15 エピザイム,インコーポレイティド Ezh2阻害剤により卵巣の悪性ラブドイド腫瘍(mrto)/高カルシウム血症型の卵巣の小細胞癌(sccoht)を処置するための方法
MX394355B (es) 2015-10-06 2025-03-24 Epizyme Inc Método de tratamiento de meduloblastoma con un inhibidor de ezh2.
WO2017079757A1 (en) 2015-11-06 2017-05-11 Epizyme, Inc. Pediatric dosing for treatment of cancer with an ezh2 inhibitor
EP3386513A2 (en) 2015-12-07 2018-10-17 Epizyme Inc Inhibitors of ezh2 and methods of use thereof
WO2017132518A1 (en) 2016-01-29 2017-08-03 Epizyme, Inc. Combination therapy for treating cancer
JP2019508406A (ja) 2016-02-08 2019-03-28 エピザイム,インコーポレイティド 癌を処置する方法
WO2017210395A1 (en) 2016-06-01 2017-12-07 Epizyme, Inc. Use of ezh2 inhibitors for treating cancer
US20200129519A1 (en) 2016-06-08 2020-04-30 Genentech, Inc. Diagnostic and therapeutic methods for cancer
EP3471830A4 (en) 2016-06-17 2020-02-26 Epizyme Inc EZH2 INHIBITORS TO TREAT CANCER
JP7324144B2 (ja) 2017-02-02 2023-08-09 エピザイム,インコーポレイティド 癌処置様式
US11642346B2 (en) 2017-03-31 2023-05-09 Epizyme, Inc. Combination therapy for treating cancer
EP3630080A4 (en) 2017-06-02 2021-03-10 Epizyme, Inc. USE OF EZH2 INHIBITORS TO TREAT CANCER
US20230201212A1 (en) 2017-06-13 2023-06-29 Epizyme, Inc. Inhibitors of ezh2 and methods of use thereof
WO2019050924A1 (en) 2017-09-05 2019-03-14 Epizyme, Inc. POLY THERAPY FOR THE TREATMENT OF CANCER
KR20220130698A (ko) 2019-12-20 2022-09-27 에피자임, 인코포레이티드 Ezh2 억제제의 결정질 하이드로브로마이드 염, 이의 제조 및 암의 치료에 유용한 약학적 조성물
AU2021280314A1 (en) 2020-05-28 2022-12-08 Epizyme, Inc. Use of EZH2 inhibitors for treating cancer

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