MA38341B1 - Modulateurs d'enzymes de modification par méthylation, compositions et utilisations associées - Google Patents

Modulateurs d'enzymes de modification par méthylation, compositions et utilisations associées

Info

Publication number
MA38341B1
MA38341B1 MA38341A MA38341A MA38341B1 MA 38341 B1 MA38341 B1 MA 38341B1 MA 38341 A MA38341 A MA 38341A MA 38341 A MA38341 A MA 38341A MA 38341 B1 MA38341 B1 MA 38341B1
Authority
MA
Morocco
Prior art keywords
compositions
methylation modification
modification enzyme
enzyme modulators
modulators
Prior art date
Application number
MA38341A
Other languages
English (en)
Other versions
MA38341A1 (fr
Inventor
Brian Albrecht
James Audia
Andrew Cook
Les Dakin
Martin Duplessis
Victor Gehling
Jean-Christophe Harmange
Christopher Nasveschuk
Rishi Vaswani
Original Assignee
Constellation Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50239937&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA38341(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/US2013/025639 external-priority patent/WO2013120104A2/fr
Application filed by Constellation Pharmaceuticals Inc filed Critical Constellation Pharmaceuticals Inc
Publication of MA38341A1 publication Critical patent/MA38341A1/fr
Publication of MA38341B1 publication Critical patent/MA38341B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des agents ayant la formule structurelle (ii) pour moduler des enzymes de modification par méthylation des histones, des compositions et des utilisations de ceux-ci, par exemple, en tant qu'agents anticancéreux.
MA38341A 2013-02-11 2014-02-11 Modulateurs d'enzymes de modification par méthylation, compositions et utilisations associées MA38341B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US2013/025639 WO2013120104A2 (fr) 2012-02-10 2013-02-11 Modulateurs d'enzymes de modification par méthylation, leurs compositions et utilisations
PCT/US2014/015706 WO2014124418A1 (fr) 2013-02-11 2014-02-11 Modulateurs d'enzymes de modification par méthylation, compositions et utilisations associées

Publications (2)

Publication Number Publication Date
MA38341A1 MA38341A1 (fr) 2018-01-31
MA38341B1 true MA38341B1 (fr) 2018-11-30

Family

ID=50239937

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38341A MA38341B1 (fr) 2013-02-11 2014-02-11 Modulateurs d'enzymes de modification par méthylation, compositions et utilisations associées

Country Status (16)

Country Link
EP (1) EP2953941B1 (fr)
KR (1) KR102219441B1 (fr)
CN (1) CN105102446B (fr)
CL (1) CL2015002239A1 (fr)
CR (1) CR20150457A (fr)
IL (1) IL239985B (fr)
MA (1) MA38341B1 (fr)
ME (1) ME02730B (fr)
PE (1) PE20160044A1 (fr)
PH (1) PH12015501720A1 (fr)
PL (1) PL2953941T3 (fr)
RS (1) RS56207B1 (fr)
SG (1) SG11201506077XA (fr)
SI (1) SI2953941T1 (fr)
TW (1) TWI629273B (fr)
WO (1) WO2014124418A1 (fr)

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WO2016130396A1 (fr) * 2015-02-13 2016-08-18 Constellation Pharmaceuticals, Inc. Modulateurs d'enzymes de modification méthylique, compositions et utilisations associées
US20180214519A1 (en) 2015-07-24 2018-08-02 Constellation Pharmaceuticals, Inc. Combination therapies for modulation of histone methyl modifying enzymes
WO2017023671A1 (fr) 2015-08-03 2017-02-09 Constellation Pharmaceuticals, Inc. Inhibiteurs d'ezh2 et modulation de la fonction des cellules t régulatrices
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TW201718598A (zh) 2015-08-27 2017-06-01 美國禮來大藥廠 Ｅｚｈ２抑制劑
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EP3548032A2 (fr) 2016-12-02 2019-10-09 Epizyme, Inc. Combinaison thérapeutique pour traiter le cancer
TW201831181A (zh) 2017-01-19 2018-09-01 日商第一三共股份有限公司 用以用於治療ｈｔｌｖ－１相關脊髓病之醫藥組成物
US10266542B2 (en) 2017-03-15 2019-04-23 Mirati Therapeutics, Inc. EZH2 inhibitors
US11642346B2 (en) 2017-03-31 2023-05-09 Epizyme, Inc. Combination therapy for treating cancer
US20230201212A1 (en) 2017-06-13 2023-06-29 Epizyme, Inc. Inhibitors of ezh2 and methods of use thereof
US20210161883A1 (en) 2017-07-10 2021-06-03 Constellation Pharmaceuticals, Inc. Ezh2 inhibitor-induced gene expression
WO2019094552A1 (fr) * 2017-11-09 2019-05-16 Constellation Pharmaceuticals, Inc. Modulateurs d'enzymes de modification du méthyle, compositions et utilisations associées
BR112020008325A2 (pt) 2017-11-14 2020-10-20 Pfizer Inc. terapias de combinação com o inibidor de ezh2
CN109879790B (zh) * 2017-12-06 2022-09-20 华东师范大学 以吲哚或吲哚类似物为母核结构的酰胺类小分子有机化合物、用途及其制备方法
CN111757734A (zh) 2017-12-28 2020-10-09 星座制药公司 通过组合疗法的ezh2抑制剂的药代动力学增强
MX2020007974A (es) 2018-01-31 2020-09-07 Mirati Therapeutics Inc Inhibidores de complejo represivo polycomb 2 (prc2).
CN110229151B (zh) * 2018-03-06 2021-09-10 上海海和药物研究开发股份有限公司 吲嗪类化合物、其制备方法及用途
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EP3823671B1 (fr) 2018-07-09 2024-02-07 Fondation Asile Des Aveugles Inhibition de sous-unités de prc2 permettant de traiter des troubles oculaires
US12180205B2 (en) 2018-09-19 2024-12-31 Biogen Ma Inc. O-glycoprotein-2-acetamido-2-deoxy-3-d-glucopyranosidase inhibitors
ES2968733T3 (es) 2018-12-05 2024-05-13 Biogen Ma Inc Derivados morfolinilo, piperazinilo, oxazepanilo y diazepanilo útiles como inhibidores de o-glicoproteína-2-acetamido-2-desoxi-3-d-glucopiranosidasa
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JP7504898B2 (ja) 2019-02-04 2024-06-24 バイオジェン・エムエイ・インコーポレイテッド 二環式エーテルｏ－糖タンパク質－２－アセトアミド－２－デオキシ－３－ｄ－グルコピラノシダーゼ阻害剤
JP7663503B2 (ja) 2019-03-08 2025-04-16 バイオジェン・エムエイ・インコーポレイテッド アゼチジニルｏ－糖タンパク質－２－アセトアミド－２－デオキシ－３－ｄ－グルコピラノシダーゼ阻害剤
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AR120324A1 (es) 2019-10-29 2022-02-09 Biogen Ma Inc Inhibidores de o-glucoproteína-2-acetamido-2-deoxi-3-d-glucopiranosidasa espirocíclica
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Also Published As

Publication number Publication date
IL239985B (en) 2018-11-29
ME02730B (fr) 2017-10-20
PE20160044A1 (es) 2016-02-11
SI2953941T1 (sl) 2017-08-31
PL2953941T3 (pl) 2017-11-30
HK1218648A1 (en) 2017-03-03
CN105102446A (zh) 2015-11-25
PH12015501720B1 (en) 2015-11-09
PH12015501720A1 (en) 2015-11-09
CL2015002239A1 (es) 2016-02-05
WO2014124418A1 (fr) 2014-08-14
TW201443038A (zh) 2014-11-16
EP2953941A1 (fr) 2015-12-16
CN105102446B (zh) 2018-01-23
CR20150457A (es) 2015-10-20
RS56207B1 (sr) 2017-11-30
KR20150119201A (ko) 2015-10-23
TWI629273B (zh) 2018-07-11
IL239985A0 (en) 2015-09-24
SG11201506077XA (en) 2015-08-28
MA38341A1 (fr) 2018-01-31
EP2953941B1 (fr) 2017-04-05
KR102219441B1 (ko) 2021-02-23

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