JP2019506430A5 - - Google Patents
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- JP2019506430A5 JP2019506430A5 JP2018544555A JP2018544555A JP2019506430A5 JP 2019506430 A5 JP2019506430 A5 JP 2019506430A5 JP 2018544555 A JP2018544555 A JP 2018544555A JP 2018544555 A JP2018544555 A JP 2018544555A JP 2019506430 A5 JP2019506430 A5 JP 2019506430A5
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- 150000001875 compounds Chemical class 0.000 claims 20
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 125000004432 carbon atom Chemical group C* 0.000 claims 11
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 9
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 8
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- 206010012289 Dementia Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- -1 NR 8 Inorganic materials 0.000 claims 4
- 208000034799 Tauopathies Diseases 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 230000000750 progressive effect Effects 0.000 claims 4
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 3
- 102000005744 Glycoside Hydrolases Human genes 0.000 claims 3
- 108010031186 Glycoside Hydrolases Proteins 0.000 claims 3
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000002619 bicyclic group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 208000002339 Frontotemporal Lobar Degeneration Diseases 0.000 claims 2
- 206010018341 Gliosis Diseases 0.000 claims 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 201000007201 aphasia Diseases 0.000 claims 2
- 208000017004 dementia pugilistica Diseases 0.000 claims 2
- 230000007387 gliosis Effects 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- KPPVNWGJXFMGAM-UUILKARUSA-N (e)-2-methyl-1-(6-methyl-3,4-dihydro-2h-quinolin-1-yl)but-2-en-1-one Chemical compound CC1=CC=C2N(C(=O)C(/C)=C/C)CCCC2=C1 KPPVNWGJXFMGAM-UUILKARUSA-N 0.000 claims 1
- 125000004008 6 membered carbocyclic group Chemical group 0.000 claims 1
- 208000023697 ABri amyloidosis Diseases 0.000 claims 1
- 208000017227 ADan amyloidosis Diseases 0.000 claims 1
- 208000014644 Brain disease Diseases 0.000 claims 1
- 208000004434 Calcinosis Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000004051 Chronic Traumatic Encephalopathy Diseases 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 1
- 201000010374 Down Syndrome Diseases 0.000 claims 1
- 208000032274 Encephalopathy Diseases 0.000 claims 1
- 208000003098 Ganglion Cysts Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 201000000162 ITM2B-related cerebral amyloid angiopathy 1 Diseases 0.000 claims 1
- 201000000194 ITM2B-related cerebral amyloid angiopathy 2 Diseases 0.000 claims 1
- 208000001089 Multiple system atrophy Diseases 0.000 claims 1
- 206010068871 Myotonic dystrophy Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000014060 Niemann-Pick disease Diseases 0.000 claims 1
- 206010033799 Paralysis Diseases 0.000 claims 1
- 208000027089 Parkinsonian disease Diseases 0.000 claims 1
- 206010034010 Parkinsonism Diseases 0.000 claims 1
- 102000029797 Prion Human genes 0.000 claims 1
- 108091000054 Prion Proteins 0.000 claims 1
- 208000024777 Prion disease Diseases 0.000 claims 1
- 208000018642 Semantic dementia Diseases 0.000 claims 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 1
- 208000037065 Subacute sclerosing leukoencephalitis Diseases 0.000 claims 1
- 206010042297 Subacute sclerosing panencephalitis Diseases 0.000 claims 1
- 208000005400 Synovial Cyst Diseases 0.000 claims 1
- 208000026911 Tuberous sclerosis complex Diseases 0.000 claims 1
- 208000018756 Variant Creutzfeldt-Jakob disease Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 238000009825 accumulation Methods 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 210000004227 basal ganglia Anatomy 0.000 claims 1
- 230000003542 behavioural effect Effects 0.000 claims 1
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 230000002308 calcification Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 229910052805 deuterium Inorganic materials 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 206010014599 encephalitis Diseases 0.000 claims 1
- 201000006061 fatal familial insomnia Diseases 0.000 claims 1
- 201000005649 gangliocytoma Diseases 0.000 claims 1
- 201000008361 ganglioneuroma Diseases 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 206010023497 kuru Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 210000002682 neurofibrillary tangle Anatomy 0.000 claims 1
- 210000004498 neuroglial cell Anatomy 0.000 claims 1
- 210000004940 nucleus Anatomy 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 229910052709 silver Inorganic materials 0.000 claims 1
- 239000004332 silver Substances 0.000 claims 1
- 230000002123 temporal effect Effects 0.000 claims 1
- 208000009999 tuberous sclerosis Diseases 0.000 claims 1
- 0 CC1N=CC2C#**=CN=C2*C1 Chemical compound CC1N=CC2C#**=CN=C2*C1 0.000 description 5
- ZXXZYOWGFPUZHH-UHFFFAOYSA-N CC(C)(C)Cc(cc1)cc2c1[s]nc2 Chemical compound CC(C)(C)Cc(cc1)cc2c1[s]nc2 ZXXZYOWGFPUZHH-UHFFFAOYSA-N 0.000 description 1
- RBIWKLXJDAZWCU-SREVYHEPSA-N CC(C)(C)c1nc(N)c(C/C=C\C#C)[s]1 Chemical compound CC(C)(C)c1nc(N)c(C/C=C\C#C)[s]1 RBIWKLXJDAZWCU-SREVYHEPSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201621006643 | 2016-02-25 | ||
| IN201621006643 | 2016-02-25 | ||
| PCT/EP2017/054280 WO2017144639A1 (en) | 2016-02-25 | 2017-02-24 | Glycosidase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019506430A JP2019506430A (ja) | 2019-03-07 |
| JP2019506430A5 true JP2019506430A5 (2) | 2020-03-26 |
Family
ID=58159077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018544555A Withdrawn JP2019506430A (ja) | 2016-02-25 | 2017-02-24 | グリコシダーゼ阻害剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10556902B2 (2) |
| EP (1) | EP3419972B1 (2) |
| JP (1) | JP2019506430A (2) |
| KR (3) | KR20180132626A (2) |
| CN (1) | CN108884078A (2) |
| AU (1) | AU2017222964B2 (2) |
| CA (2) | CA3012624A1 (2) |
| IL (1) | IL268501B1 (2) |
| MA (3) | MA43680A (2) |
| MX (1) | MX2018010191A (2) |
| WO (1) | WO2017144639A1 (2) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3868752A1 (en) | 2014-08-28 | 2021-08-25 | Asceneuron SA | Glycosidase inhibitors |
| AU2017222958B2 (en) * | 2016-02-25 | 2019-07-18 | Asceneuron S. A. | Glycosidase inhibitors |
| CN108884078A (zh) | 2016-02-25 | 2018-11-23 | 阿森纽荣股份公司 | 糖苷酶抑制剂 |
| WO2018153508A2 (en) * | 2017-02-24 | 2018-08-30 | Asceneuron S.A. | Sulfoximine glycosidase inhibitors |
| SG11201807012QA (en) | 2016-02-25 | 2018-09-27 | Asceneuron S A | Acid addition salts of piperazine derivatives |
| US11261183B2 (en) | 2016-02-25 | 2022-03-01 | Asceneuron Sa | Sulfoximine glycosidase inhibitors |
| EP3555087A1 (en) | 2016-12-16 | 2019-10-23 | Janssen Pharmaceutica NV | Monocyclic oga inhibitor compounds |
| WO2018154133A1 (en) * | 2017-02-27 | 2018-08-30 | Janssen Pharmaceutica Nv | [1,2,4]-triazolo [1,5-a]-pyrimidinyl derivatives substituted with piperidine, morpholine or piperazine as oga inhibitors |
| WO2019037860A1 (en) | 2017-08-24 | 2019-02-28 | Asceneuron S.A. | LINEAR INHIBITORS OF GLYCOSIDASE |
| TWI726329B (zh) | 2018-06-22 | 2021-05-01 | 美商美國禮來大藥廠 | 2,3-二氫呋喃并[2,3-b]吡啶化合物 |
| US11999726B2 (en) | 2018-07-31 | 2024-06-04 | Eli Lilly And Company | 5-methyl-4-fluoro-thiazol-2-yl compounds |
| WO2020039029A1 (en) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Spiro compounds as glycosidase inhibitors |
| WO2020039028A1 (en) * | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Tetrahydro-benzoazepine glycosidase inhibitors |
| WO2020039027A1 (en) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Pyrrolidine glycosidase inhibitors |
| IL280841B2 (en) * | 2018-08-22 | 2024-12-01 | Asceneuron S A | Succinate and fumarate acid addition salts of piperazine derivatives useful as glycosidase inhibitors |
| CN111039946A (zh) * | 2018-10-15 | 2020-04-21 | 上海轶诺药业有限公司 | 一类咪唑并芳环类化合物的制备和应用 |
| WO2021123291A1 (en) * | 2019-12-18 | 2021-06-24 | Janssen Pharmaceutica Nv | Oga inhibitor compounds |
| GB202012969D0 (en) * | 2020-08-19 | 2020-09-30 | Univ Of Oxford | Inhibitor compounds |
| WO2024083820A1 (en) | 2022-10-18 | 2024-04-25 | Institut National de la Santé et de la Recherche Médicale | Method and composition for determining the level of o-glcnacylation in horses |
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| WO2018153508A2 (en) | 2017-02-24 | 2018-08-30 | Asceneuron S.A. | Sulfoximine glycosidase inhibitors |
| CN108884078A (zh) | 2016-02-25 | 2018-11-23 | 阿森纽荣股份公司 | 糖苷酶抑制剂 |
| SG11201807012QA (en) | 2016-02-25 | 2018-09-27 | Asceneuron S A | Acid addition salts of piperazine derivatives |
| US10344021B2 (en) | 2016-02-25 | 2019-07-09 | Asceneuron S A | Process for the separation of enantiomers of piperazine derivatives |
| AU2017222958B2 (en) * | 2016-02-25 | 2019-07-18 | Asceneuron S. A. | Glycosidase inhibitors |
| US11186564B2 (en) | 2016-08-04 | 2021-11-30 | Sunovion Pharmaceuticals Inc. | Dual NAV1.2/5HT2a inhibitors for treating CNS disorders |
| US20190359609A1 (en) | 2016-12-16 | 2019-11-28 | Janssen Pharmaceutica Nv | Bicyclic oga inhibitor compounds |
| EP3555087A1 (en) | 2016-12-16 | 2019-10-23 | Janssen Pharmaceutica NV | Monocyclic oga inhibitor compounds |
| TWI654978B (zh) | 2017-01-27 | 2019-04-01 | 美商美國禮來大藥廠 | 5－甲基－1,2,4－二唑－3－基化合物 |
| AU2018216040A1 (en) | 2017-02-06 | 2019-06-20 | Janssen Pharmaceutica Nv | OGA inhibitor compounds |
| WO2018154133A1 (en) | 2017-02-27 | 2018-08-30 | Janssen Pharmaceutica Nv | [1,2,4]-triazolo [1,5-a]-pyrimidinyl derivatives substituted with piperidine, morpholine or piperazine as oga inhibitors |
| AR111693A1 (es) | 2017-05-25 | 2019-08-07 | Lilly Co Eli | Compuestos de 5-metil-1,3,4-oxadiazol-2-ilo con actividad inhibitoria de oga |
-
2017
- 2017-02-24 CN CN201780011549.2A patent/CN108884078A/zh active Pending
- 2017-02-24 MA MA043680A patent/MA43680A/fr unknown
- 2017-02-24 JP JP2018544555A patent/JP2019506430A/ja not_active Withdrawn
- 2017-02-24 MX MX2018010191A patent/MX2018010191A/es unknown
- 2017-02-24 WO PCT/EP2017/054280 patent/WO2017144639A1/en not_active Ceased
- 2017-02-24 US US16/078,155 patent/US10556902B2/en active Active
- 2017-02-24 EP EP17707012.5A patent/EP3419972B1/en active Active
- 2017-02-24 CA CA3012624A patent/CA3012624A1/en not_active Withdrawn
- 2017-02-24 KR KR1020187025755A patent/KR20180132626A/ko not_active Withdrawn
- 2017-02-24 AU AU2017222964A patent/AU2017222964B2/en not_active Revoked
- 2017-08-24 MA MA047574A patent/MA47574A/fr unknown
- 2017-08-24 MA MA047573A patent/MA47573A/fr unknown
- 2017-08-24 US US16/488,163 patent/US10995090B2/en active Active
- 2017-08-24 KR KR1020237005097A patent/KR102620279B1/ko active Active
- 2017-08-24 CA CA3053200A patent/CA3053200C/en active Active
- 2017-08-24 KR KR1020197027278A patent/KR20190118184A/ko not_active Abandoned
-
2019
- 2019-08-05 IL IL268501A patent/IL268501B1/en unknown
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