|
WO2007079139A2
(en)
|
2005-12-28 |
2007-07-12 |
Vertex Pharmaceuticals, Inc. |
Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
|
|
MX2010007419A
(es)
|
2008-01-04 |
2010-11-12 |
Intellikine Inc |
Ciertas entidades quimicas, composiciones y metodos.
|
|
US8193182B2
(en)
|
2008-01-04 |
2012-06-05 |
Intellikine, Inc. |
Substituted isoquinolin-1(2H)-ones, and methods of use thereof
|
|
KR101763656B1
(ko)
|
2009-06-29 |
2017-08-01 |
인사이트 홀딩스 코포레이션 |
Ｐｉ3ｋ 저해물질로서의 피리미디논
|
|
US8759359B2
(en)
|
2009-12-18 |
2014-06-24 |
Incyte Corporation |
Substituted heteroaryl fused derivatives as PI3K inhibitors
|
|
US20130018039A1
(en)
*
|
2010-03-31 |
2013-01-17 |
Bodmer Vera Q |
Imidazolyl-imidazoles as kinase inhibitors
|
|
EP2558463A1
(en)
|
2010-04-14 |
2013-02-20 |
Incyte Corporation |
Fused derivatives as i3 inhibitors
|
|
WO2011163195A1
(en)
|
2010-06-21 |
2011-12-29 |
Incyte Corporation |
Fused pyrrole derivatives as pi3k inhibitors
|
|
WO2012080729A2
(en)
*
|
2010-12-14 |
2012-06-21 |
Electrophoretics Limited |
CASEIN KINASE 1δ (CK1δ) INHIBITORS
|
|
EP3660016A1
(en)
|
2010-12-20 |
2020-06-03 |
Incyte Holdings Corporation |
N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors
|
|
US8754114B2
(en)
|
2010-12-22 |
2014-06-17 |
Incyte Corporation |
Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
|
|
ES2637113T3
(es)
|
2011-01-10 |
2017-10-10 |
Infinity Pharmaceuticals, Inc. |
Procedimientos para preparar isoquinolinonas y formas sólidas de isoquinolinonas
|
|
US9108984B2
(en)
|
2011-03-14 |
2015-08-18 |
Incyte Corporation |
Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
|
|
GB201104267D0
(en)
|
2011-03-14 |
2011-04-27 |
Cancer Rec Tech Ltd |
Pyrrolopyridineamino derivatives
|
|
WO2012135009A1
(en)
|
2011-03-25 |
2012-10-04 |
Incyte Corporation |
Pyrimidine-4,6-diamine derivatives as pi3k inhibitors
|
|
AR087701A1
(es)
|
2011-08-31 |
2014-04-09 |
Japan Tobacco Inc |
Derivados de pirazol con actividad inhibidora de sglt1
|
|
PT3513793T
(pt)
|
2011-09-02 |
2021-05-10 |
Incyte Holdings Corp |
Heterociclilaminas como inibidores de pi3k
|
|
AP2014007606A0
(en)
|
2011-10-07 |
2014-05-31 |
Takeda Pharmaceutical |
1-Arylcarbonyl-4-oxy-piperidine compounds useful for the treatment of neurodegenerative diseases
|
|
KR101987514B1
(ko)
|
2011-10-18 |
2019-06-10 |
아스텔라스세이야쿠 가부시키가이샤 |
이환식 헤테로환 화합물
|
|
AR090037A1
(es)
|
2011-11-15 |
2014-10-15 |
Xention Ltd |
Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio
|
|
BR112014013138B1
(pt)
|
2011-12-01 |
2022-06-28 |
Chemocentryx, Inc |
Compostos de anilinas substituídas como antagonistas de ccr(4) e composição farmacêutica compreendendo os mesmos
|
|
AR090548A1
(es)
|
2012-04-02 |
2014-11-19 |
Incyte Corp |
Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
|
|
RS58514B1
(sr)
|
2012-06-13 |
2019-04-30 |
Incyte Holdings Corp |
Supstituisana triciklična jedinjenja kao inhibitori fgfr
|
|
CN104364239B
(zh)
|
2012-06-13 |
2017-08-25 |
霍夫曼-拉罗奇有限公司 |
二氮杂螺环烷烃和氮杂螺环烷烃
|
|
US8828998B2
(en)
|
2012-06-25 |
2014-09-09 |
Infinity Pharmaceuticals, Inc. |
Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
|
|
WO2014007228A1
(ja)
|
2012-07-03 |
2014-01-09 |
小野薬品工業株式会社 |
ソマトスタチン受容体作動活性を有する化合物およびその医薬用途
|
|
WO2014009891A1
(en)
*
|
2012-07-11 |
2014-01-16 |
Piramal Enterprises Limited |
Heterocyclic compounds for use in the treatment of cancers
|
|
US9388185B2
(en)
|
2012-08-10 |
2016-07-12 |
Incyte Holdings Corporation |
Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
|
|
ES2877570T3
(es)
|
2012-08-22 |
2021-11-17 |
Univ Cornell |
Métodos para inhibir fascina
|
|
MX365851B
(es)
*
|
2012-08-24 |
2019-06-17 |
Treventis Corp |
Compuestos de benzofurazano anti-amiloides y metodos.
|
|
CN102850341B
(zh)
*
|
2012-09-05 |
2015-02-18 |
浙江工业大学 |
一种噻二唑类化合物及其制备与应用
|
|
GB201216018D0
(en)
|
2012-09-07 |
2012-10-24 |
Cancer Rec Tech Ltd |
Pharmacologically active compounds
|
|
MX368615B
(es)
|
2012-09-25 |
2019-10-09 |
Hoffmann La Roche |
Derivados bicíclicos como inhibidores de la autotaxina (atx) que son inhibidores de la producción de ácido lisofosfatídico (lpa) y el uso de los mismos.
|
|
CN103739594A
(zh)
*
|
2012-10-17 |
2014-04-23 |
南京大学 |
一类含吡嗪环和三氮唑结构的席夫碱类衍生物及其制法
|
|
AU2013337717B2
(en)
|
2012-11-01 |
2018-10-25 |
Infinity Pharmaceuticals, Inc. |
Treatment of cancers using PI3 kinase isoform modulators
|
|
EP2925744B1
(en)
|
2012-11-27 |
2020-12-30 |
Thomas Helledays Stiftelse För Medicinsk Forskning |
Pyrimidine-2,4-diamine derivatives for treatment of cancer
|
|
US9266892B2
(en)
|
2012-12-19 |
2016-02-23 |
Incyte Holdings Corporation |
Fused pyrazoles as FGFR inhibitors
|
|
WO2014103801A1
(ja)
*
|
2012-12-28 |
2014-07-03 |
株式会社新日本科学 |
イミダゾピリジン誘導体を有効成分として含むｏｃｔ３活性阻害剤又はｏｃｔ３検出剤
|
|
WO2014124458A1
(en)
*
|
2013-02-11 |
2014-08-14 |
The Regents Of The University Of California |
Compositions and methods for treating neurodegenerative diseases
|
|
AR095079A1
(es)
|
2013-03-12 |
2015-09-16 |
Hoffmann La Roche |
Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
|
|
US9776996B2
(en)
|
2013-03-15 |
2017-10-03 |
Epizyme, Inc. |
Substituted 6,5-fused bicyclic heteroaryl compounds
|
|
HK1220325A1
(zh)
|
2013-03-15 |
2017-05-05 |
Whitehead Institute For Biomedical Research |
苯并咪唑衍生物及其用途
|
|
US9045477B2
(en)
|
2013-03-15 |
2015-06-02 |
Epizyme, Inc. |
Substituted 6,5-fused bicyclic heteroaryl compounds
|
|
PH12015502383B1
(en)
|
2013-04-19 |
2023-02-03 |
Incyte Holdings Corp |
Bicyclic heterocycles as fgfr inhibitors
|
|
US9238034B2
(en)
*
|
2013-07-09 |
2016-01-19 |
The Translational Genomics Research Institute |
FN14 antagonists and therapeutic uses thereof
|
|
US9797882B2
(en)
|
2013-07-09 |
2017-10-24 |
The Translational Genomics Research Institute |
Method of screening for a compound for inhibitory activity of FN14-tweak interaction
|
|
TWI649308B
(zh)
|
2013-07-24 |
2019-02-01 |
小野藥品工業股份有限公司 |
喹啉衍生物
|
|
GB201314452D0
(en)
|
2013-08-13 |
2013-09-25 |
Ostara Biomedical Ltd |
Embryo implantation
|
|
RU2570907C2
(ru)
*
|
2013-10-21 |
2015-12-20 |
Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" |
Производные 3-ациламинопиридин-2(1h)-она, применимые как ингибиторы серин-треониновой протеинкиназы gsk3b в качестве лекарственных препаратов для лечения диабета ii типа.
|
|
WO2015077572A1
(en)
|
2013-11-22 |
2015-05-28 |
CL BioSciences LLC |
Gastrin antagonists (eg yf476, netazepide) for treatment and prevention of osteoporosis
|
|
DK3074400T3
(en)
|
2013-11-26 |
2018-01-15 |
Hoffmann La Roche |
Octahydro-cyclobuta [1,2-c; 3,4-c '] dipyrrole derivatives as autotaxin inhibitors
|
|
GB201321738D0
(en)
*
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic Agents
|
|
US10087151B2
(en)
|
2014-01-09 |
2018-10-02 |
The J. David Gladstone Institutes, A Testimentary Trust Established Under The Will Of J. David Gladstone |
Substituted benzoxazine and related compounds
|
|
MA39219B1
(fr)
|
2014-01-29 |
2018-11-30 |
Glaxosmithkline Ip Dev Ltd |
Nouveaux composés inhibiteurs de la kinase lrrk2 utilisés pour le traitement du parkinson, de l’alzheimer et de la sclérose latérale amyotrophique
|
|
RU2016134751A
(ru)
|
2014-01-29 |
2018-03-02 |
Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед |
Соединения
|
|
ES2919024T3
(es)
|
2014-02-11 |
2022-07-21 |
Mitokinin Inc |
Composiciones y procedimientos que utilizan las mismas para el tratamiento de enfermedades neurodegenerativas y mitocondriales
|
|
US9527835B2
(en)
|
2014-02-13 |
2016-12-27 |
Incyte Corporation |
Cyclopropylamines as LSD1 inhibitors
|
|
EP3105218B1
(en)
|
2014-02-13 |
2019-09-25 |
Incyte Corporation |
Cyclopropylamines as lsd1 inhibitors
|
|
JP6602779B2
(ja)
|
2014-02-13 |
2019-11-06 |
インサイト・コーポレイション |
Ｌｓｄ１阻害剤としてのシクロプロピルアミン類
|
|
EP3105219B9
(en)
|
2014-02-13 |
2018-10-03 |
Incyte Corporation |
Cyclopropylamines as lsd1 inhibitors
|
|
US9573946B2
(en)
|
2014-02-20 |
2017-02-21 |
Novita Pharmaceuticals, Inc. |
Compounds and methods for inhibiting fascin
|
|
RS58976B1
(sr)
|
2014-02-27 |
2019-08-30 |
Treventis Corp |
Antiamiloidna jedinjenja koja sadrže benzofuran
|
|
CA2937616A1
(en)
|
2014-03-26 |
2015-10-01 |
F. Hoffmann-La Roche Ag |
Bicyclic compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors
|
|
EA032357B1
(ru)
|
2014-03-26 |
2019-05-31 |
Ф. Хоффманн-Ля Рош Аг |
Конденсированные [1,4]диазепиновые соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa)
|
|
EP3129361A4
(en)
*
|
2014-04-11 |
2017-11-15 |
Emory University |
Treatment of neurodegenerative diseases with asparagine endopeptidase (aep) inhibitors and compositions related thereto
|
|
WO2015160975A2
(en)
|
2014-04-16 |
2015-10-22 |
Infinity Pharmaceuticals, Inc. |
Combination therapies
|
|
US9840482B2
(en)
*
|
2014-04-19 |
2017-12-12 |
Sunshine Lake Pharma Co., Ltd. |
Sulfonamide derivatives and pharmaceutical applications thereof
|
|
HUE057317T2
(hu)
*
|
2014-04-23 |
2022-04-28 |
Dart Neuroscience Llc |
Helyettesített [1,2,4]triazolo[1,5-A]pirimidin-7-IL vegyületeket tartalmazó készítmények mint PDE2 inhibítorok
|
|
WO2015170218A1
(en)
|
2014-05-07 |
2015-11-12 |
Pfizer Inc. |
Tropomyosin-related kinase inhibitors
|
|
CN104059060B
(zh)
*
|
2014-05-30 |
2017-08-01 |
西安交通大学 |
一种5‑(1h‑吲哚‑3‑亚甲基)‑1,3‑噻唑烷‑4‑酮类衍生物及其合成方法和应用
|
|
US10064869B2
(en)
|
2014-06-04 |
2018-09-04 |
Thomas Helledays Stiftelse For Medicinsk Forskning |
MTH1 inhibitors for treatment of inflammatory and autoimmune conditions
|
|
WO2015187088A1
(en)
|
2014-06-04 |
2015-12-10 |
Thomas Helledays Stiftelse För Medicinsk Forskning |
Mth1 inhibitors for treatment of cancer
|
|
WO2015191677A1
(en)
|
2014-06-11 |
2015-12-17 |
Incyte Corporation |
Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors
|
|
US9758523B2
(en)
|
2014-07-10 |
2017-09-12 |
Incyte Corporation |
Triazolopyridines and triazolopyrazines as LSD1 inhibitors
|
|
WO2016007731A1
(en)
|
2014-07-10 |
2016-01-14 |
Incyte Corporation |
Imidazopyridines and imidazopyrazines as lsd1 inhibitors
|
|
US9695180B2
(en)
|
2014-07-10 |
2017-07-04 |
Incyte Corporation |
Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
|
|
US9695167B2
(en)
|
2014-07-10 |
2017-07-04 |
Incyte Corporation |
Substituted triazolo[1,5-a]pyridines and triazolo[1,5-a]pyrazines as LSD1 inhibitors
|
|
MX2017001103A
(es)
*
|
2014-07-31 |
2017-04-27 |
Merck Patent Gmbh |
Derivados de indolizina que son aplicables a enfermedades neurodegenerativas.
|
|
EP3189070A4
(en)
|
2014-08-04 |
2018-06-27 |
Drexel University |
Novel compounds and methods of treating or ameliorating an il-1r-mediated disease or disorder using same
|
|
JO3589B1
(ar)
|
2014-08-06 |
2020-07-05 |
Novartis Ag |
مثبطات كيناز البروتين c وطرق استخداماتها
|
|
KR20170063954A
(ko)
|
2014-10-07 |
2017-06-08 |
버텍스 파마슈티칼스 인코포레이티드 |
낭성 섬유증 막횡단 전도도 조절자의 조정제의 공-결정
|
|
US10851105B2
(en)
|
2014-10-22 |
2020-12-01 |
Incyte Corporation |
Bicyclic heterocycles as FGFR4 inhibitors
|
|
GB201419579D0
(en)
*
|
2014-11-03 |
2014-12-17 |
Iomet Pharma Ltd |
Pharmaceutical compound
|
|
TWI568737B
(zh)
|
2014-11-05 |
2017-02-01 |
達特神經科學（開曼）有限責任公司 |
作為ｐｄｅ２抑制劑之經取代的５－甲基－［１，２，４］三唑并［１，５－ａ］嘧啶－２－胺化合物
|
|
ES2749726T3
(es)
|
2014-12-25 |
2020-03-23 |
Ono Pharmaceutical Co |
Derivado de quinolina
|
|
GB201501302D0
(en)
|
2015-01-27 |
2015-03-11 |
Ostara Biomedical Ltd |
Embryo implantation
|
|
MA41551A
(fr)
|
2015-02-20 |
2017-12-26 |
Incyte Corp |
Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
|
|
US9580423B2
(en)
|
2015-02-20 |
2017-02-28 |
Incyte Corporation |
Bicyclic heterocycles as FGFR4 inhibitors
|
|
TWI712601B
(zh)
|
2015-02-20 |
2020-12-11 |
美商英塞特公司 |
作為fgfr抑制劑之雙環雜環
|
|
SG10201907576SA
(en)
|
2015-02-27 |
2019-09-27 |
Incyte Corp |
Salts of pi3k inhibitor and processes for their preparation
|
|
WO2016149756A1
(en)
|
2015-03-23 |
2016-09-29 |
The University Of Melbourne |
Treatment of respiratory diseases
|
|
EP3277689B1
(en)
|
2015-04-03 |
2019-09-04 |
Incyte Corporation |
Heterocyclic compounds as lsd1 inhibitors
|
|
MA41898A
(fr)
|
2015-04-10 |
2018-02-13 |
Hoffmann La Roche |
Dérivés de quinazolinone bicyclique
|
|
ES2898922T3
(es)
*
|
2015-04-30 |
2022-03-09 |
Musc Found For Res Dev |
Compuestos de oxindol y composiciones farmacéuticas de los mismos
|
|
US9988401B2
(en)
|
2015-05-11 |
2018-06-05 |
Incyte Corporation |
Crystalline forms of a PI3K inhibitor
|
|
US9732097B2
(en)
|
2015-05-11 |
2017-08-15 |
Incyte Corporation |
Process for the synthesis of a phosphoinositide 3-kinase inhibitor
|
|
GB201508276D0
(en)
|
2015-05-14 |
2015-06-24 |
Electrophoretics Ltd |
A casein kinase 1 delta inhibitor
|
|
GB201509134D0
(en)
|
2015-05-28 |
2015-07-15 |
Electrophoretics Ltd |
Biomolecules involved in Alzheimer's disease
|
|
MX2017015456A
(es)
*
|
2015-06-01 |
2018-11-29 |
Bantam Pharmaceutical Llc |
Compuestos de pirazol y pirrol sustituidos y metodos para su uso por inhibición de iniciación de traducción y tratamiento de enfermedades y trastornos relacionados con ellos.
|
|
WO2016202758A1
(en)
|
2015-06-18 |
2016-12-22 |
Bayer Pharma Aktiengesellschaft |
Substituted 2-(1h-pyrazol-1-yl)-1h-benzimidazole compounds
|
|
WO2016202756A1
(en)
|
2015-06-18 |
2016-12-22 |
Bayer Pharma Aktiengesellschaft |
Substituted 2-(1h-pyrazol-1-yl)-1h-benzimidazole compounds
|
|
WO2017000277A1
(en)
|
2015-07-01 |
2017-01-05 |
Merck Sharp & Dohme Corp. |
Substituted triazolo bicycliccompounds as pde2 inhibitors
|
|
CN108290855A
(zh)
*
|
2015-07-01 |
2018-07-17 |
西北大学 |
被取代的喹唑啉化合物及其调节葡糖脑苷脂酶活性的用途
|
|
MY189367A
(en)
|
2015-08-12 |
2022-02-08 |
Incyte Corp |
Salts of an lsd1 inhibitor
|
|
CN105061462B
(zh)
*
|
2015-08-18 |
2017-05-24 |
沈阳药科大学 |
含有酰胺的四氢苯并[4,5]噻吩并[2,3‑d]嘧啶类化合物及其应用
|
|
CA2992889A1
(en)
*
|
2015-09-04 |
2017-03-09 |
F. Hoffmann-La Roche Ag |
Phenoxymethyl derivatives
|
|
SG11201801856XA
(en)
|
2015-09-18 |
2018-04-27 |
Kaken Pharmaceutical Co Ltd |
Biaryl derivative and medicine containing same
|
|
JP6876685B2
(ja)
|
2015-09-24 |
2021-05-26 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
Ａｔｘ阻害剤としての二環式化合物
|
|
AU2016328436B2
(en)
|
2015-09-24 |
2020-05-14 |
F. Hoffmann-La Roche Ag |
New bicyclic compounds as dual ATX/CA inhibitors
|
|
BR112017026682A2
(pt)
|
2015-09-24 |
2018-08-14 |
Hoffmann La Roche |
novos compostos bicíclicos como inibidores de dupla ação de atx/ca
|
|
WO2017050732A1
(en)
|
2015-09-24 |
2017-03-30 |
F. Hoffmann-La Roche Ag |
Bicyclic compounds as atx inhibitors
|
|
JP6740354B2
(ja)
*
|
2015-10-05 |
2020-08-12 |
ザ トラスティーズ オブ コロンビア ユニバーシティー イン ザ シティー オブ ニューヨーク |
オートファジーの流れ及びホスホリパーゼｄ及びタウを含むタンパク質凝集体のクリアランスの活性化剤ならびにタンパク質症の治療方法
|
|
GB201517523D0
(en)
|
2015-10-05 |
2015-11-18 |
Ostara Biomedical Ltd |
Methods and compositions for managing reproduction
|
|
WO2017063966A1
(en)
|
2015-10-13 |
2017-04-20 |
Bayer Pharma Aktiengesellschaft |
Substituted 2-(1h-pyrazol-1-yl)-benzothiazole compounds
|
|
ES2765738T3
(es)
*
|
2015-11-02 |
2020-06-10 |
Janssen Pharmaceutica Nv |
Compuesto de [1,2,4]triazolo[1,5-a]pirimidin-7-ilo
|
|
WO2017097182A1
(zh)
*
|
2015-12-07 |
2017-06-15 |
成都海创药业有限公司 |
喹啉类化合物及其制备方法和作为尿酸盐转运体抑制剂类药物的用途
|
|
US20200375996A1
(en)
*
|
2015-12-15 |
2020-12-03 |
D.E. Shaw Research, Llc |
Method of treating neurodegenerative disorders by rescuing alpha-synuclein toxicity
|
|
CN107840826B
(zh)
*
|
2016-09-19 |
2021-07-09 |
西华大学 |
1h-吲唑类衍生物及其作为ido抑制剂的用途
|
|
CN107033087B
(zh)
*
|
2016-02-04 |
2020-09-04 |
西华大学 |
1h-吲唑-4-胺类化合物及其作为ido抑制剂的用途
|
|
WO2017133258A1
(zh)
*
|
2016-02-04 |
2017-08-10 |
西华大学 |
1h-吲唑类衍生物及其作为ido抑制剂的用途
|
|
TWI833686B
(zh)
|
2016-04-22 |
2024-03-01 |
美商英塞特公司 |
Lsd1 抑制劑之調配物
|
|
CA3026149A1
(en)
|
2016-06-02 |
2017-12-07 |
Cadent Therapeutics, Inc. |
Potassium channel modulators
|
|
MX388576B
(es)
|
2016-06-07 |
2025-03-20 |
Jacobio Pharmaceuticals Co Ltd |
Derivados heterociclicos novedosos utiles como inhibidores de shp2.
|
|
SG11201811237WA
(en)
|
2016-06-24 |
2019-01-30 |
Infinity Pharmaceuticals Inc |
Combination therapies
|
|
WO2018011681A1
(en)
|
2016-07-14 |
2018-01-18 |
Pfizer Inc. |
Novel pyrimidine carboxamides as inhibitors of vanin-1 enzyme
|
|
ES2901059T3
(es)
*
|
2016-08-09 |
2022-03-21 |
Zincure Corp |
Composición farmacéutica para el tratamiento de apoplejía basado en la inhibición de AMPK
|
|
US11084807B2
(en)
|
2016-08-18 |
2021-08-10 |
Vidac Pharama Ltd. |
Piperazine derivatives, pharmaceutical compositions and methods of use thereof
|
|
SI3507291T1
(sl)
|
2016-09-02 |
2021-11-30 |
Cyclerion Therapeutics, Inc. |
Kondenzirani biciklični SGS stimulatorji
|
|
CN106432235B
(zh)
*
|
2016-10-19 |
2018-02-02 |
南通大学 |
靶向CDK和DNA的β‑咔啉衍生物及其制备方法和医药用途
|
|
JP2019533022A
(ja)
|
2016-10-24 |
2019-11-14 |
ユマニティ セラピューティクス，インコーポレーテッド |
化合物及びその使用
|
|
MX385576B
(es)
*
|
2016-11-02 |
2025-03-18 |
Janssen Pharmaceutica Nv |
Derivados de [1,2,4]triazol[1,5-a]pirimidina como inhibidores de pde2
|
|
CA3038916A1
(en)
|
2016-11-02 |
2018-05-11 |
Janssen Pharmaceutica Nv |
[1,2,4]triazolo[1,5-a]pyrimidine compounds as pde2 inhibitors
|
|
AU2017353313C1
(en)
*
|
2016-11-02 |
2022-06-09 |
Janssen Pharmaceutica Nv |
(1,2,4)triazolo(1,5-a)pyrimidine compounds as PDE2 inhibitors
|
|
EP3538101B1
(en)
|
2016-11-14 |
2024-06-19 |
Virginia Commonwealth University |
Inhibitors of cancer and/or metastasis
|
|
WO2018094106A2
(en)
|
2016-11-16 |
2018-05-24 |
University Of South Florida |
ALLOSTERIC ANTAGONISTS OF GPRC6a AND THEIR USE IN MITIGATING PROTEINOPATHIES
|
|
EP3566055B1
(en)
|
2017-01-06 |
2025-03-12 |
Janssen Pharmaceutica NV |
Scd inhibitor for the treatment of neurological disorders
|
|
AU2018208458B2
(en)
*
|
2017-01-10 |
2020-07-16 |
ETH Zürich |
Cell-protective compounds and their use
|
|
SI3571193T1
(sl)
|
2017-01-23 |
2022-04-29 |
Cadent Therapeutics, Inc. |
Modulatorji kalijevega kanalčka
|
|
CN106748969B
(zh)
*
|
2017-01-23 |
2019-06-18 |
南阳师范学院 |
一种n-(4-苄基哌啶基)-阿魏酰胺化合物、制备方法及其用途
|
|
CN106831573B
(zh)
*
|
2017-01-23 |
2019-05-24 |
南阳师范学院 |
(n-1,2,3,4-四氢异喹啉基)-阿魏酰胺化合物、制备方法及其应用
|
|
TWI779007B
(zh)
|
2017-01-26 |
2022-10-01 |
日商小野藥品工業股份有限公司 |
喹啉衍生物的乙磺酸鹽
|
|
MX394556B
(es)
*
|
2017-02-01 |
2025-03-24 |
Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd |
Derivados de n1-(4-(5-(ciclopropilmetil)-1-metil-1h-pirazol-4-il) piridin-2-il) ciclohexano-1,4-diamina y compuestos relacionados como inhibidores de ck1 y/o irak1 para tratar cáncer.
|
|
CN109700798A
(zh)
*
|
2017-03-01 |
2019-05-03 |
浙江大学 |
苯并吡喃黄酮结构类型雄激素受体拮抗剂及其应用
|
|
RU2019132254A
(ru)
|
2017-03-16 |
2021-04-16 |
Ф. Хоффманн-Ля Рош Аг |
Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca
|
|
JP7090099B2
(ja)
|
2017-03-16 |
2022-06-23 |
エフ．ホフマン－ラ ロシュ アーゲー |
Ａｔｘインヒビターとしての新規二環式化合物
|
|
LT3483164T
(lt)
|
2017-03-20 |
2020-05-11 |
Forma Therapeutics, Inc. |
Pirolpirolo kompozicijos kaip piruvato kinazės (pkr) aktyvatoriai
|
|
EA202190196A1
(ru)
|
2017-03-23 |
2021-08-31 |
Джакобио Фармасьютикалс Ко., Лтд. |
Новые гетероциклические производные, применимые в качестве ингибиторов shp2
|
|
MX388196B
(es)
|
2017-04-26 |
2025-03-19 |
Basilea Pharm Int Ag |
Procesos para la preparacion de furazanobencimidazoles y formas cristalinas de estos.
|
|
EP3634406B1
(en)
*
|
2017-05-12 |
2023-09-06 |
Board of Trustees of The Southern Illinois University on behalf of Southern Illinois University Edwardsville |
3,4,5-trisubstituted-1,2,4-triazoles and 3,4,5-trisubstituted-3-thio-1,2,4-triazoles and uses thereof
|
|
AR111960A1
(es)
|
2017-05-26 |
2019-09-04 |
Incyte Corp |
Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
|
|
UY37759A
(es)
|
2017-06-09 |
2019-01-31 |
Novartis Ag |
Compuestos y composiciones para inducir condrogénesis
|
|
US20200223837A1
(en)
*
|
2017-06-14 |
2020-07-16 |
European Molecular Biology Laboratory |
Benzofuran amides and heteroaromatic analogues thereof for use in therapy
|
|
AU2018290225A1
(en)
|
2017-06-21 |
2020-01-23 |
Mitokinin, Inc. |
Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease
|
|
GB201710851D0
(en)
*
|
2017-07-06 |
2017-08-23 |
Galápagos Nv |
Novel compounds and pharmaceutical compositions thereof for the treatment of fibrosis
|
|
EP4467143B1
(en)
|
2017-07-10 |
2026-03-11 |
Celgene Corporation |
Method for preparing 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-l-yl)-3-fluorobenzonitrile
|
|
AU2018300150A1
(en)
|
2017-07-11 |
2020-01-30 |
Vertex Pharmaceuticals Incorporated |
Carboxamides as modulators of sodium channels
|
|
JP7159173B2
(ja)
*
|
2017-09-11 |
2022-10-24 |
保土谷化学工業株式会社 |
ピリミジン環構造を有する化合物および有機エレクトロルミネッセンス素子
|
|
TWI795440B
(zh)
|
2017-09-15 |
2023-03-11 |
美商佛瑪治療公司 |
作為ＣＢＰ／ｐ３００抑制劑之四氫─咪唑並喹啉化合物
|
|
US11826363B2
(en)
|
2017-10-13 |
2023-11-28 |
Ono Pharmaceutical Co., Ltd. |
Therapeutic agent for solid cancers, which comprises Axl inhibitor as active ingredient
|
|
HUE070649T2
(hu)
|
2017-10-19 |
2025-06-28 |
Teijin Pharma Ltd |
Benzimidazol-származékok és felhasználásuk
|
|
CA3083000A1
(en)
|
2017-10-24 |
2019-05-02 |
Yumanity Therapeutics, Inc. |
Compounds and uses thereof
|
|
US20200339591A1
(en)
*
|
2017-12-21 |
2020-10-29 |
Gliapharm Sa |
Compositions and methods of treatment for neurological disorders comprising a dementia
|
|
SG11202004971YA
(en)
*
|
2017-12-21 |
2020-06-29 |
Gliapharm Sa |
Compositions and methods of treatment for neurological disorders comprising motor neuron diseases
|
|
TWI877770B
(zh)
|
2018-02-27 |
2025-03-21 |
美商英塞特公司 |
作為a2a / a2b抑制劑之咪唑并嘧啶及三唑并嘧啶
|
|
EP3762383B1
(en)
*
|
2018-03-06 |
2023-12-06 |
The United States of America, as represented by the Secretary, Department of Health and Human Services |
Positive allosteric modulators of dopamine 1 receptor and method of use thereof
|
|
EP3543231A1
(en)
*
|
2018-03-19 |
2019-09-25 |
ETH Zurich |
Compounds for treating cns- and neurodegenerative diseases
|
|
WO2019183587A1
(en)
|
2018-03-23 |
2019-09-26 |
Yumanity Therapeutics, Inc. |
Compounds and uses thereof
|
|
HRP20241288T1
(hr)
|
2018-05-04 |
2024-12-06 |
Incyte Corporation |
Čvrsti oblici fgfr inhibitora i postupci za njihovu proizvodnju
|
|
AU2019262579B2
(en)
|
2018-05-04 |
2024-09-12 |
Incyte Corporation |
Salts of an FGFR inhibitor
|
|
TWI815887B
(zh)
*
|
2018-05-15 |
2023-09-21 |
美商愛彼特生物製藥股份有限公司 |
經取代的2,2'-雙嘧啶基化合物、其類似物及其使用方法
|
|
EP3810610A1
(en)
|
2018-05-18 |
2021-04-28 |
Incyte Corporation |
Fused pyrimidine derivatives as a2a / a2b inhibitors
|
|
SG11202011680YA
(en)
|
2018-06-01 |
2020-12-30 |
Incyte Corp |
Dosing regimen for the treatment of pi3k related disorders
|
|
GB201810092D0
(en)
|
2018-06-20 |
2018-08-08 |
Ctxt Pty Ltd |
Compounds
|
|
GB201810581D0
(en)
|
2018-06-28 |
2018-08-15 |
Ctxt Pty Ltd |
Compounds
|
|
US10870648B2
(en)
|
2018-06-29 |
2020-12-22 |
Forma Therapeutics, Inc. |
Inhibiting CREB binding protein (CBP)
|
|
WO2020010197A1
(en)
|
2018-07-05 |
2020-01-09 |
Incyte Corporation |
Fused pyrazine derivatives as a2a / a2b inhibitors
|
|
KR20210068399A
(ko)
*
|
2018-08-06 |
2021-06-09 |
더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 주니어 유니버시티 |
신경퇴행성 질병의 치료를 위한 피피에이알지씨1알파 활성제로서 2-아릴벤즈이미다졸
|
|
KR102817790B1
(ko)
|
2018-08-29 |
2025-06-05 |
케모센트릭스, 인크. |
C-c 케모카인 수용체 4(ccr4) 길항제 및 하나 이상의 면역 체크포인트 억제제를 사용한 병용 요법
|
|
US10968200B2
(en)
|
2018-08-31 |
2021-04-06 |
Incyte Corporation |
Salts of an LSD1 inhibitor and processes for preparing the same
|
|
US11278527B2
(en)
|
2018-09-04 |
2022-03-22 |
Brown University |
Compositions and methods for the modulation of the corticotropin releasing factor binding protein and the treatment of alcohol use disorder
|
|
CA3111848A1
(en)
*
|
2018-09-09 |
2020-03-12 |
Qanatpharma Ag |
Use of casein kinase 1 inhibitors for treating vascular diseases
|
|
CR20210175A
(es)
|
2018-09-18 |
2021-06-01 |
Nikang Therapeutics Inc |
Derivados de anillo tricíclico condensado como inhibidores de la fosfatasa de homología a src 2 (shp2)
|
|
EP3853206B1
(en)
|
2018-09-19 |
2024-04-10 |
Novo Nordisk Health Care AG |
Treating sickle cell disease with a pyruvate kinase r activating compound
|
|
EP3852791B1
(en)
|
2018-09-19 |
2024-07-03 |
Novo Nordisk Health Care AG |
Activating pyruvate kinase r
|
|
US20210393623A1
(en)
|
2018-09-26 |
2021-12-23 |
Jacobio Pharmaceuticals Co., Ltd. |
Novel Heterocyclic Derivatives Useful as SHP2 Inhibitors
|
|
CA3116339A1
(en)
|
2018-10-22 |
2020-04-30 |
Cadent Therapeutics, Inc. |
Crystalline forms of potassium channel modulators
|
|
KR102880470B1
(ko)
*
|
2018-10-23 |
2025-11-03 |
다이이찌 산쿄 가부시키가이샤 |
바이아릴 유도체
|
|
JP7614646B2
(ja)
|
2018-11-07 |
2025-01-16 |
ティアンリ バイオテック プロプライエタリ リミテッド |
呼吸器疾患の処置のための化合物及び組成物
|
|
CN109503563B
(zh)
*
|
2018-12-10 |
2020-05-12 |
济南大学 |
多功能乙酰胆碱酯酶抑制剂及其应用
|
|
KR102128509B1
(ko)
*
|
2018-12-19 |
2020-07-01 |
한국과학기술연구원 |
말단 아민기에 아릴 또는 헤테로아릴기가 치환된 신규한 히드라존 유도체 및 이의 용도
|
|
CA3125626A1
(en)
*
|
2019-01-04 |
2020-07-09 |
Bellbrook Labs, Llc |
Inhibitors of cgas activity as therapeutic agents
|
|
WO2020146682A1
(en)
|
2019-01-10 |
2020-07-16 |
Vertex Pharmaceuticals Incorporated |
Carboxamides as modulators of sodium channels
|
|
US12440481B2
(en)
|
2019-01-10 |
2025-10-14 |
Vertex Pharmaceuticals Incorporated |
Esters and carbamates as modulators of sodium channels
|
|
WO2020154571A1
(en)
|
2019-01-24 |
2020-07-30 |
Yumanity Therapeutics, Inc. |
Compounds and uses thereof
|
|
TWI829857B
(zh)
|
2019-01-29 |
2024-01-21 |
美商英塞特公司 |
作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
|
|
US11628162B2
(en)
|
2019-03-08 |
2023-04-18 |
Incyte Corporation |
Methods of treating cancer with an FGFR inhibitor
|
|
WO2020190791A1
(en)
|
2019-03-15 |
2020-09-24 |
Forma Therapeutics, Inc. |
Inhibiting cyclic amp-responsive element-binding protein (creb)
|
|
CN114072395A
(zh)
*
|
2019-04-26 |
2022-02-18 |
新基公司 |
杂环化合物及其治疗蠕虫感染和疾病的用途
|
|
AR119731A1
(es)
|
2019-05-17 |
2022-01-05 |
Novartis Ag |
Inhibidores del inflamasoma nlrp3
|
|
DK4299135T3
(da)
|
2019-06-18 |
2025-09-08 |
Pfizer |
Benzisoxazol-sulfonamid-derivater
|
|
US11591329B2
(en)
|
2019-07-09 |
2023-02-28 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
|
MX2022001019A
(es)
|
2019-07-31 |
2022-02-22 |
Ribon Therapeutics Inc |
Amidas heterobiciclicas como inhibidoras del cumulo de diferenciacion 38 (cd38).
|
|
RU2746423C2
(ru)
*
|
2019-09-02 |
2021-04-13 |
Общество с ограниченной ответственностью "Научно-исследовательский институт ХимРар" (ООО "НИИ ХимРар") |
Ингибитор вируса гепатита В (ВГВ)
|
|
HRP20251148T1
(hr)
|
2019-09-19 |
2025-11-21 |
Novo Nordisk Health Care Ag |
Pripravci koji aktiviraju piruvat-kinazu r (pkr)
|
|
WO2021067374A1
(en)
|
2019-10-01 |
2021-04-08 |
Incyte Corporation |
Bicyclic heterocycles as fgfr inhibitors
|
|
CA3157361A1
(en)
|
2019-10-14 |
2021-04-22 |
Incyte Corporation |
Bicyclic heterocycles as fgfr inhibitors
|
|
WO2021076728A1
(en)
|
2019-10-16 |
2021-04-22 |
Incyte Corporation |
Bicyclic heterocycles as fgfr inhibitors
|
|
EA202192047A1
(ru)
|
2019-11-13 |
2021-12-08 |
Юманити Терапьютикс, Инк. |
Соединения и их применение
|
|
EP4066832A4
(en)
|
2019-11-14 |
2024-01-03 |
Zincure Corp. |
Pharmaceutical composition for treating multiple sclerosis on basis of ampk inhibitory function and zinc homeostasis control function
|
|
JP7832891B2
(ja)
|
2019-12-04 |
2026-03-18 |
インサイト・コーポレイション |
Ｆｇｆｒ阻害剤の誘導体
|
|
CA3163875A1
(en)
|
2019-12-04 |
2021-06-10 |
Incyte Corporation |
Tricyclic heterocycles as fgfr inhibitors
|
|
BR112022010924A2
(pt)
|
2019-12-06 |
2022-09-06 |
Vertex Pharma |
Tetra-hidrofuranos substituídos como moduladores de canais de sódio
|
|
US12012409B2
(en)
|
2020-01-15 |
2024-06-18 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
|
AR122711A1
(es)
*
|
2020-06-25 |
2022-09-28 |
Alchemedicine Inc |
COMPUESTO HETEROCÍCLICO COMO INHIBIDOR DE CASEÍNA QUINASA 1d Y/O QUINASA 5 TIPO RECEPTOR DE ACTIVINA
|
|
AU2021325872A1
(en)
*
|
2020-08-10 |
2023-03-16 |
Dana-Farber Cancer Institute, Inc. |
Substituted 1,2,4-oxadiazoles as small molecule inhibitors of ubiquitin-specific protease 28
|
|
MX2023003170A
(es)
*
|
2020-09-17 |
2023-03-27 |
Janssen Pharmaceutica Nv |
Moduladores de la caseina cinasa 1 delta.
|
|
US11801243B2
(en)
|
2020-09-23 |
2023-10-31 |
Forma Therapeutics, Inc. |
Bromodomain inhibitors for androgen receptor-driven cancers
|
|
US11795168B2
(en)
|
2020-09-23 |
2023-10-24 |
Forma Therapeutics, Inc. |
Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP)
|
|
GB202101734D0
(en)
*
|
2021-02-08 |
2021-03-24 |
Cerevance Inc |
Novel Compounds
|
|
AU2022222470A1
(en)
|
2021-02-19 |
2023-09-21 |
Sudo Biosciences Limited |
Tyk2 inhibitors and uses thereof
|
|
CA3208361A1
(en)
|
2021-02-19 |
2022-08-25 |
Anjali Pandey |
Tyk2 inhibitors and uses thereof
|
|
EP4294806A1
(en)
|
2021-02-19 |
2023-12-27 |
Sudo Biosciences Limited |
Tyk2 inhibitors and uses thereof
|
|
US12128035B2
(en)
|
2021-03-19 |
2024-10-29 |
Novo Nordisk Health Care Ag |
Activating pyruvate kinase R
|
|
WO2022221170A1
(en)
|
2021-04-12 |
2022-10-20 |
Incyte Corporation |
Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent
|
|
CN121851016A
(zh)
*
|
2021-04-21 |
2026-04-14 |
长春金赛药业有限责任公司 |
含咪唑稠环类衍生物、其制备方法及其在医药上的应用
|
|
SMT202500481T1
(it)
|
2021-06-04 |
2026-01-12 |
Vertex Pharma |
N-(idrossialchil(etero)aril)tetraidrofuran carbossammidi come modulatori di canali del sodio
|
|
US11939331B2
(en)
|
2021-06-09 |
2024-03-26 |
Incyte Corporation |
Tricyclic heterocycles as FGFR inhibitors
|
|
CA3220155A1
(en)
|
2021-06-09 |
2022-12-15 |
Incyte Corporation |
Tricyclic heterocycles as fgfr inhibitors
|
|
EP4416146A4
(en)
*
|
2021-10-15 |
2025-11-05 |
Lomond Therapeutics Inc |
1H-PYRAZOLO[4,3-C]QUINOLINE SUBSTITUTES, THEIR PREPARATION PROCESSES AND THEIR USE
|
|
WO2023205463A1
(en)
|
2022-04-22 |
2023-10-26 |
Vertex Pharmaceuticals Incorporated |
Heteroaryl compounds for the treatment of pain
|
|
CN115466211B
(zh)
*
|
2022-06-09 |
2024-02-23 |
中国人民解放军空军军医大学 |
一种n-苯基喹啉-4-胺类化合物及其应用
|
|
JP2025525514A
(ja)
*
|
2022-07-14 |
2025-08-05 |
シャンハイ、レイジング、ファーマシューティカル、カンパニー、リミテッド |
Ｔｐｋアゴニスト及びそれを用いた神経変性疾患の治療方法
|
|
US12600722B2
(en)
|
2022-07-18 |
2026-04-14 |
Incyte Corporation |
Tetracyclic compounds as DGK inhibitors
|
|
US12600723B2
(en)
|
2022-07-18 |
2026-04-14 |
Incyte Corporation |
Tetracyclic compounds as DGK inhibitors
|
|
UY40374A
(es)
|
2022-08-03 |
2024-02-15 |
Novartis Ag |
Inhibidores de inflamasoma nlrp3
|
|
CN119855819B
(zh)
*
|
2022-10-19 |
2025-10-28 |
长春金赛药业有限责任公司 |
一种nk3r拮抗剂的晶型及其制备方法和应用
|
|
CN120917015A
(zh)
*
|
2023-01-20 |
2025-11-07 |
元启(苏州)生物制药有限公司 |
Srpk1抑制剂和使用方法
|
|
PY2404641A
(es)
*
|
2023-01-30 |
2024-10-03 |
Eurofarma Laboratorios S A |
COMPUESTOS FENÓLICOS BLOQUEADORES DE Nav 1.7 Y/O Nav 1.8, SUS PROCESOS DE OBTENCIÓN, SUS COMPOSICIONES, SUS USOS, LOS MÉTODOS DE TRATAMIENTO DE LOS MISMOS Y SUS KITS
|
|
EP4660182A1
(en)
*
|
2023-01-30 |
2025-12-10 |
Eurofarma Laboratórios S.A. |
Nav1.7- and/or nav1.8-inhibiting aryl pyridine compounds, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits
|
|
IT202400002560A1
(it)
*
|
2024-02-07 |
2025-08-07 |
Univ Pisa |
Inibitori della proteina rock per uso nel trattamento della fibrosi polmonare
|
|
CN118666857B
(zh)
*
|
2024-06-26 |
2025-02-25 |
江西农业大学 |
一种喹啉类化合物及其在农用杀菌剂中的应用
|
|
CN119060061B
(zh)
*
|
2024-08-26 |
2025-09-16 |
浙江师范大学 |
一类苯并嘧啶硫醚类化合物作为sting蛋白小分子抑制剂的应用
|
|
WO2026062521A2
(en)
|
2024-09-18 |
2026-03-26 |
Institute Of Molecular And Clinical Ophthalmology Basel (Iob) |
Methods and compounds for promoting survival of photoreceptors
|