JP2806958B2 - アプロチニン相同体及び酵母におけるアプロチニン及びアプロチニン相同体の生成方法 - Google Patents

アプロチニン相同体及び酵母におけるアプロチニン及びアプロチニン相同体の生成方法

Info

Publication number
JP2806958B2
JP2806958B2 JP63507339A JP50733988A JP2806958B2 JP 2806958 B2 JP2806958 B2 JP 2806958B2 JP 63507339 A JP63507339 A JP 63507339A JP 50733988 A JP50733988 A JP 50733988A JP 2806958 B2 JP2806958 B2 JP 2806958B2
Authority
JP
Japan
Prior art keywords
aprotinin
amino acid
native
gene
homolog
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP63507339A
Other languages
English (en)
Japanese (ja)
Other versions
JPH03502519A (ja
Inventor
ノリス，クイェルド
ノリス，ファニー
ビョルン，セレン，エリク
Original Assignee
ノボ‐ノルディスク アクティーゼルスカブ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ノボ‐ノルディスク アクティーゼルスカブ filed Critical ノボ‐ノルディスク アクティーゼルスカブ
Publication of JPH03502519A publication Critical patent/JPH03502519A/ja
Application granted granted Critical
Publication of JP2806958B2 publication Critical patent/JP2806958B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
JP63507339A 1987-08-28 1988-08-26 アプロチニン相同体及び酵母におけるアプロチニン及びアプロチニン相同体の生成方法 Expired - Fee Related JP2806958B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK450187A DK450187D0 (da) 1987-08-28 1987-08-28 Fremgangsmaade til fremstilling af proteiner
DK4501/87 1987-08-28

Publications (2)

Publication Number Publication Date
JPH03502519A JPH03502519A (ja) 1991-06-13
JP2806958B2 true JP2806958B2 (ja) 1998-09-30

Family

ID=8134111

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63507339A Expired - Fee Related JP2806958B2 (ja) 1987-08-28 1988-08-26 アプロチニン相同体及び酵母におけるアプロチニン及びアプロチニン相同体の生成方法

Country Status (8)

Country Link
EP (1) EP0375718B1 (da)
JP (1) JP2806958B2 (da)
AT (1) ATE113986T1 (da)
DE (1) DE3852105T2 (da)
DK (1) DK450187D0 (da)
FI (1) FI104428B (da)
NO (1) NO177967C (da)
WO (1) WO1989001968A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591603A (en) * 1987-08-28 1997-01-07 Novo Nordisk A/S Process for preparing aprotinin and aprotinin analogs in yeast cells
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
DK105489D0 (da) * 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
US7413537B2 (en) 1989-09-01 2008-08-19 Dyax Corp. Directed evolution of disulfide-bonded micro-proteins
DE3930522A1 (de) * 1989-09-13 1991-03-21 Bayer Ag Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben
US5258302A (en) * 1990-07-03 1993-11-02 The Salk Institute Biotechnology/Industrial Associates, Inc. DNA for expression of aprotinin in methylotrophic yeast cells
IL99585A0 (en) * 1990-10-01 1992-08-18 Novo Nordisk As Aprotinin analogues,their production and pharmaceutical compositions containing them
EP1820858B1 (en) 1991-03-01 2009-08-12 Dyax Corporation Chimeric protein comprising micro-protein having two or more disulfide bonds and embodiments thereof
DE4417353A1 (de) * 1994-05-18 1996-01-25 Bayer Ag Verfahren zur Herstellung von rekombinantem Aprotinin und rekombinanten Aprotinin Varianten mit der natürlichen N-terminlaen Sequenz

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
US5219569A (en) * 1985-04-22 1993-06-15 Genentech, Inc. Protease resistant urokinase
DE3930522A1 (de) * 1989-09-13 1991-03-21 Bayer Ag Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ＥＭＢＯ Ｊ．５（１２） （１９８６） Ｐ．３２１９−３２２５

Also Published As

Publication number Publication date
NO177967B (no) 1995-09-18
NO900920L (no) 1990-04-25
JPH03502519A (ja) 1991-06-13
WO1989001968A1 (en) 1989-03-09
EP0375718A1 (en) 1990-07-04
FI900991A0 (fi) 1990-02-27
FI104428B (fi) 2000-01-31
DE3852105T2 (de) 1995-03-23
DE3852105D1 (de) 1994-12-15
EP0375718B1 (en) 1994-11-09
NO900920D0 (no) 1990-02-27
DK450187D0 (da) 1987-08-28
ATE113986T1 (de) 1994-11-15
NO177967C (no) 1995-12-27

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Legal Events

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