JP3917863B2 - Ｐｄｅ４アイソザイムの選択的阻害薬として有用なニコチンアミドベンゾ縮合複素環誘導体 - Google Patents

Ｐｄｅ４アイソザイムの選択的阻害薬として有用なニコチンアミドベンゾ縮合複素環誘導体 Download PDF

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Publication number: JP3917863B2
Authority: JP; Japan
Prior art keywords: formula; methyl; nicotinamide; benzo; oxy
Prior art date: 2000-01-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

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JP2001557868A

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English (en)

Japanese (ja)

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JP2003522176A (ja

Inventor

マーファット，アンソニー

チャンバー，ロバート・ジェームズ

Original Assignee

ファイザー・プロダクツ・インク

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-31

Filing date

2001-01-30

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2007-05-23

2001-01-30 Application filed by ファイザー・プロダクツ・インク filed Critical ファイザー・プロダクツ・インク

2003-07-22 Publication of JP2003522176A publication Critical patent/JP2003522176A/ja

2007-05-23 Application granted granted Critical

2007-05-23 Publication of JP3917863B2 publication Critical patent/JP3917863B2/ja

2021-01-30 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

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YLVAGBJBSYSJJJ-UHFFFAOYSA-N CC(C(C(c(cc1)ccc1SC)=O)N1)NC1=O Chemical compound CC(C(C(c(cc1)ccc1SC)=O)N1)NC1=O YLVAGBJBSYSJJJ-UHFFFAOYSA-N 0.000 description 1
GRNSAEXUTAGBSL-UHFFFAOYSA-N CC(C)(c1ccc(CN(CC=C)CC=C)cc1)O Chemical compound CC(C)(c1ccc(CN(CC=C)CC=C)cc1)O GRNSAEXUTAGBSL-UHFFFAOYSA-N 0.000 description 1
NDHOQAPKKVXVEH-UHFFFAOYSA-N CC(C)C(C(C)C)C(c(cc1OC)ccc1OCCCCCOc(cc1)ccc1C(N)=N)=O Chemical compound CC(C)C(C(C)C)C(c(cc1OC)ccc1OCCCCCOc(cc1)ccc1C(N)=N)=O NDHOQAPKKVXVEH-UHFFFAOYSA-N 0.000 description 1
NPFVRBCDMFKOPY-UHFFFAOYSA-N CC(C1)C(c2cc(-[n]3cncc3)c[s]2)=NNC1=O Chemical compound CC(C1)C(c2cc(-[n]3cncc3)c[s]2)=NNC1=O NPFVRBCDMFKOPY-UHFFFAOYSA-N 0.000 description 1
BEIZIEZPGSIQGR-UHFFFAOYSA-N CS(Nc1ccc(Oc(cc2)ccc2F)[s]1)(=O)=O Chemical compound CS(Nc1ccc(Oc(cc2)ccc2F)[s]1)(=O)=O BEIZIEZPGSIQGR-UHFFFAOYSA-N 0.000 description 1
YEEZWCHGZNKEEK-UHFFFAOYSA-N Cc(cccc1)c1S(NC(c1cc(OC)c(Cc(c2c3)c[n](C)c2ccc3NC(OC2CCCC2)=O)cc1)=O)(=O)=O Chemical compound Cc(cccc1)c1S(NC(c1cc(OC)c(Cc(c2c3)c[n](C)c2ccc3NC(OC2CCCC2)=O)cc1)=O)(=O)=O YEEZWCHGZNKEEK-UHFFFAOYSA-N 0.000 description 1
ZGSYVUBKPBUTDW-UHFFFAOYSA-N NCc1ccc(C2(CC2)O)cc1 Chemical compound NCc1ccc(C2(CC2)O)cc1 ZGSYVUBKPBUTDW-UHFFFAOYSA-N 0.000 description 1
DABPGEIBZBRJFL-UHFFFAOYSA-N OC(c(cccn1)c1Oc1cc2n[s]nc2cc1)=O Chemical compound OC(c(cccn1)c1Oc1cc2n[s]nc2cc1)=O DABPGEIBZBRJFL-UHFFFAOYSA-N 0.000 description 1
0 [*+]c1ccc(*)[s]1 Chemical compound [*+]c1ccc(*)[s]1 0.000 description 1

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- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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JP2001557868A 2000-01-31 2001-01-30 Ｐｄｅ４アイソザイムの選択的阻害薬として有用なニコチンアミドベンゾ縮合複素環誘導体 Expired - Fee Related JP3917863B2 (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US17928400P	2000-01-31	2000-01-31
US60/179,284		2000-01-31
PCT/IB2001/000124 WO2001057036A1 (fr)	2000-01-31	2001-01-30	Derives benzocondenses heterocycliques de nicotinamide utiles comme inhibiteurs selectifs d'isozymes pde4

Publications (2)

Publication Number	Publication Date
JP2003522176A JP2003522176A (ja)	2003-07-22
JP3917863B2 true JP3917863B2 (ja)	2007-05-23

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JP2001557868A Expired - Fee Related JP3917863B2 (ja)	2000-01-31	2001-01-30	Ｐｄｅ４アイソザイムの選択的阻害薬として有用なニコチンアミドベンゾ縮合複素環誘導体

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US (1)	US7354941B2 (fr)
EP (1)	EP1252158B1 (fr)
JP (1)	JP3917863B2 (fr)
KR (1)	KR20020072299A (fr)
CN (1)	CN1404481A (fr)
AP (1)	AP2002002589A0 (fr)
AR (1)	AR027337A1 (fr)
AT (1)	ATE293624T1 (fr)
AU (1)	AU2700201A (fr)
BG (1)	BG106852A (fr)
BR (1)	BR0107964A (fr)
CA (1)	CA2398182C (fr)
CO (1)	CO5261634A1 (fr)
CZ (1)	CZ20022410A3 (fr)
DE (1)	DE60110205T2 (fr)
EA (1)	EA004885B1 (fr)
EE (1)	EE200200425A (fr)
ES (1)	ES2238415T3 (fr)
GE (1)	GEP20043302B (fr)
GT (1)	GT200100022A (fr)
HN (1)	HN2001000019A (fr)
HU (1)	HUP0204262A2 (fr)
IL (1)	IL150641A0 (fr)
IS (1)	IS6421A (fr)
MA (1)	MA26870A1 (fr)
MX (1)	MXPA02007419A (fr)
NO (1)	NO20023613L (fr)
NZ (1)	NZ519547A (fr)
OA (1)	OA12169A (fr)
PA (1)	PA8511201A1 (fr)
PE (1)	PE20011058A1 (fr)
PL (1)	PL357995A1 (fr)
PT (1)	PT1252158E (fr)
PY (1)	PY0102109A (fr)
SK (1)	SK10142002A3 (fr)
SV (1)	SV2002000299A (fr)
TN (1)	TNSN01020A1 (fr)
TR (1)	TR200201880T2 (fr)
UY (1)	UY26569A1 (fr)
WO (1)	WO2001057036A1 (fr)
ZA (1)	ZA200206033B (fr)

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2001
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Publication number	Publication date
AP2002002589A0 (en)	2002-09-30
JP2003522176A (ja)	2003-07-22
IS6421A (is)	2002-06-13
HN2001000019A (es)	2001-09-06
PA8511201A1 (es)	2002-12-11
US7354941B2 (en)	2008-04-08
EE200200425A (et)	2003-10-15
EP1252158B1 (fr)	2005-04-20
WO2001057036A1 (fr)	2001-08-09
SK10142002A3 (sk)	2003-11-04
EP1252158A1 (fr)	2002-10-30
CZ20022410A3 (cs)	2003-08-13
PT1252158E (pt)	2005-09-30
PY0102109A (es)	2003-10-01
CO5261634A1 (es)	2003-03-31
ZA200206033B (en)	2003-07-29
IL150641A0 (en)	2003-02-12
GEP20043302B (en)	2004-02-10
TR200201880T2 (tr)	2002-11-21
SV2002000299A (es)	2002-07-03
NO20023613L (no)	2002-09-30
UY26569A1 (es)	2001-08-27
BR0107964A (pt)	2002-10-29
KR20020072299A (ko)	2002-09-14
EA004885B1 (ru)	2004-08-26
NZ519547A (en)	2004-03-26
BG106852A (bg)	2003-02-28
AU2700201A (en)	2001-08-14
MXPA02007419A (es)	2002-12-09
CN1404481A (zh)	2003-03-19
AR027337A1 (es)	2003-03-26
MA26870A1 (fr)	2004-12-20
CA2398182A1 (fr)	2001-08-09
PE20011058A1 (es)	2001-10-23
TNSN01020A1 (fr)	2005-11-10
OA12169A (en)	2006-05-08
ES2238415T3 (es)	2005-09-01
PL357995A1 (en)	2004-08-09
GT200100022A (es)	2001-10-19
US20030186989A1 (en)	2003-10-02
HUP0204262A2 (hu)	2003-04-28
CA2398182C (fr)	2007-03-13
DE60110205D1 (de)	2005-05-25
EA200200662A1 (ru)	2002-12-26
NO20023613D0 (no)	2002-07-30
ATE293624T1 (de)	2005-05-15
DE60110205T2 (de)	2006-01-26

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Publication	Publication Date	Title
US7354941B2 (en)	2008-04-08	Nicotinamide benzofused-heterocyclyl derivatives useful as selective inhibitors of PDE4 isozymes
US6740655B2 (en)	2004-05-25	Pyrimidine carboxamides useful as inhibitors of PDE4 isozymes
US6953810B2 (en)	2005-10-11	Nicotinamide biaryl derivatives useful as inhibitors of PDE4 isozymes
US6894041B2 (en)	2005-05-17	Oxazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes
US20020111495A1 (en)	2002-08-15	Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
JP2002284766A (ja)	2002-10-03	Ｐｄｅ４アイソザイムの阻害剤として活性なニコチンアミド酸類、アミド類およびそれらの模倣剤
US7250518B2 (en)	2007-07-31	Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
AU2002220966A1 (en)	2002-08-12	Nicotinamide biaryl derivatives useful as inhibitors of PDE4 isozymes