JP6419836B2 - ヘテロサイクルと縮合した大環状第ｘｉａ因子阻害剤 - Google Patents

ヘテロサイクルと縮合した大環状第ｘｉａ因子阻害剤 Download PDF

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JP6419836B2
JP6419836B2 JP2016549270A JP2016549270A JP6419836B2 JP 6419836 B2 JP6419836 B2 JP 6419836B2 JP 2016549270 A JP2016549270 A JP 2016549270A JP 2016549270 A JP2016549270 A JP 2016549270A JP 6419836 B2 JP6419836 B2 JP 6419836B2
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JP2017504640A5 (2
JP2017504640A (ja
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アンドリュー・ケイ・ディルガー
ジェイムズ・アール・コート
インダワティ・デ・ルッカ
ファン・ティアナン
ウー・ヤン
ワン・ユーフェン
クマール・バラシャンムガ・パビセッティ
ウィリアム・アール・ユーイング
イェヘン・ジュー
ルース・アール・ウェクスラー
ドナルド・ジェイ・ピー・ピント
マイケル・ジェイ・オーワット
レオン・エム・スミス・ザ・セカンド
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2016549270A 2014-01-31 2015-01-30 ヘテロサイクルと縮合した大環状第ｘｉａ因子阻害剤 Active JP6419836B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461933948P 2014-01-31 2014-01-31
US61/933,948 2014-01-31
PCT/US2015/013647 WO2015116882A1 (en) 2014-01-31 2015-01-30 Macrocyclic factor xia inhibitors condensed with heterocycles

Publications (3)

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JP2017504640A JP2017504640A (ja) 2017-02-09
JP2017504640A5 JP2017504640A5 (2) 2018-03-08
JP6419836B2 true JP6419836B2 (ja) 2018-11-07

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Country Status (24)

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US (3) US20170057961A1 (2)
EP (1) EP3099688B1 (2)
JP (1) JP6419836B2 (2)
CN (1) CN106459051B (2)
AR (1) AR099228A1 (2)
BR (1) BR112016016741B1 (2)
CA (1) CA2937738C (2)
CY (1) CY1120534T1 (2)
DK (1) DK3099688T3 (2)
EA (1) EA032650B1 (2)
ES (1) ES2655540T3 (2)
HR (1) HRP20172002T1 (2)
HU (1) HUE038060T2 (2)
LT (1) LT3099688T (2)
MX (1) MX2016009385A (2)
NO (1) NO2760821T3 (2)
PL (1) PL3099688T3 (2)
PT (1) PT3099688T (2)
RS (1) RS56785B1 (2)
SI (1) SI3099688T1 (2)
SM (1) SMT201800024T1 (2)
TW (1) TWI703144B (2)
UY (1) UY35972A (2)
WO (1) WO2015116882A1 (2)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018525368A (ja) * 2015-07-29 2018-09-06 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ アルキルまたはシクロアルキルＰ２’基を担持する大員環の第ＸＩａ因子阻害剤

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KR101937514B1 (ko) 2011-10-14 2019-01-10 브리스톨-마이어스 스큅 컴퍼니 인자 xia 억제제로서의 치환된 테트라히드로이소퀴놀린 화합물
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CN107074821B (zh) 2014-09-04 2020-05-22 百时美施贵宝公司 为fxia抑制剂的二酰胺大环化合物
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CN110922412A (zh) * 2018-09-20 2020-03-27 复旦大学 具有抗精神病作用药物化合物的不对称合成方法
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KR20220031680A (ko) * 2019-07-08 2022-03-11 게리 샤프 이노베이션즈 엘엘씨 고콘트라스트의 소형 편광 기반 콜리메이터
JP7286001B2 (ja) * 2019-07-23 2023-06-02 メッドシャイン ディスカバリー インコーポレイテッド 第ＸＩａ因子阻害剤としての大環状誘導体
TW202229280A (zh) * 2020-10-12 2022-08-01 美商必治妥美雅史谷比公司 （６ｒ，１０ｓ）－１０－｛４－［５－氯－２－（４－氯－１ｈ－１，２，３－三唑－１－基）苯基］－６－側氧基－１（６ｈ）－嘧啶基｝－１－（二氟甲基）－６－甲基－１，４，７，８，９，１０－六氫－１１，１５－（亞甲橋基）吡唑并［４，３－ｂ］［１，７］二氮雜環十四炔－５（６ｈ）－酮之製備方法
CN117603208A (zh) * 2021-04-21 2024-02-27 上海美悦生物科技发展有限公司 FXIa抑制剂及其药物组合物、制备方法和用途
KR20260032556A (ko) * 2023-06-30 2026-03-09 심천 사루브리스 퍼머수티칼스 컴퍼니 리미티드 다치환된 거대환식 화합물 및 이의 제조 방법과 용도

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