JP6502939B2 - 骨粗鬆症の処置及び予防のためのガストリン拮抗薬 - Google Patents
骨粗鬆症の処置及び予防のためのガストリン拮抗薬 Download PDFInfo
- Publication number
- JP6502939B2 JP6502939B2 JP2016533607A JP2016533607A JP6502939B2 JP 6502939 B2 JP6502939 B2 JP 6502939B2 JP 2016533607 A JP2016533607 A JP 2016533607A JP 2016533607 A JP2016533607 A JP 2016533607A JP 6502939 B2 JP6502939 B2 JP 6502939B2
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- Prior art keywords
- gastrin
- bone
- hypergastrinemia
- cells
- ovariectomy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361907980P | 2013-11-22 | 2013-11-22 | |
| US61/907,980 | 2013-11-22 | ||
| PCT/US2014/066832 WO2015077572A1 (en) | 2013-11-22 | 2014-11-21 | Gastrin antagonists (eg yf476, netazepide) for treatment and prevention of osteoporosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016538295A JP2016538295A (ja) | 2016-12-08 |
| JP2016538295A5 JP2016538295A5 (2) | 2017-12-28 |
| JP6502939B2 true JP6502939B2 (ja) | 2019-04-17 |
Family
ID=52118000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016533607A Active JP6502939B2 (ja) | 2013-11-22 | 2014-11-21 | 骨粗鬆症の処置及び予防のためのガストリン拮抗薬 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10709714B2 (2) |
| EP (1) | EP3071206B1 (2) |
| JP (1) | JP6502939B2 (2) |
| KR (1) | KR102254957B1 (2) |
| CN (1) | CN106163527A (2) |
| AU (1) | AU2014352875B2 (2) |
| BR (1) | BR112016011727A2 (2) |
| CA (1) | CA2929858C (2) |
| DK (1) | DK3071206T3 (2) |
| ES (1) | ES2870538T3 (2) |
| MX (1) | MX2016006657A (2) |
| PL (1) | PL3071206T3 (2) |
| RU (1) | RU2693484C1 (2) |
| WO (1) | WO2015077572A1 (2) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10881667B2 (en) | 2018-10-30 | 2021-01-05 | City University Of Hong Kong | Method and composition for treating epilepsy |
| US11285161B2 (en) | 2019-04-26 | 2022-03-29 | City University Of Hong Kong | Method and composition for treating mental disorder and pain associated with nerve damage |
| CN110935005A (zh) * | 2019-11-19 | 2020-03-31 | 宁波大学 | 一种丙谷二肽的新用途 |
| CN115770266B (zh) * | 2023-01-30 | 2023-05-09 | 云南中医药大学 | 一种用于治疗绝经后骨质疏松的药物组合物 |
Family Cites Families (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989005812A1 (fr) * | 1987-12-22 | 1989-06-29 | Yoshitomi Pharmaceutical Industries, Ltd. | Composes de thienodiazepine et leur utilisation en medecine |
| JPH0374328A (ja) | 1989-08-04 | 1991-03-28 | Warner Lambert Co | 薬学的活性を有する中枢コレシストキニン拮抗剤 |
| US5399565A (en) | 1990-07-17 | 1995-03-21 | Eli Lilly And Company | Pyrazolidinone CCK and gastrin antagonists and pharmaceutical formulations therof |
| FI932928A0 (fi) | 1990-12-25 | 1993-06-24 | Yamanouchi Pharma Co Ltd | Nya bensodiazepinderivat |
| CA2110986A1 (en) | 1991-07-12 | 1993-01-21 | Geoffrey Neil Woodruff | Cholecystokinin antagonists useful in the treatment of panic attacks |
| EP0638560A4 (en) | 1991-10-11 | 1995-03-29 | Yoshitomi Pharmaceutical | MEDICINE FOR OSTEOPOROSIS AND DIAZEPINE COMPOUND *. |
| WO1993012817A1 (en) * | 1991-12-20 | 1993-07-08 | Warner-Lambert Company | Therapeutic combinations useful in the treatment of gastroesophageal reflux disease |
| IL104853A (en) | 1992-02-27 | 1997-11-20 | Yamanouchi Pharma Co Ltd | Benzodiazepine derivatives, their preparation and pharmaceutical compositions containing them |
| MY128102A (en) | 1993-02-17 | 2007-01-31 | Chugai Pharmaceutical Co Ltd | Indolin-2-one-derivatives |
| GB2282595A (en) | 1993-08-25 | 1995-04-12 | Yamanouchi Pharma Co Ltd | Benzodiazepine derivatives |
| IT1261255B (it) | 1993-09-09 | 1996-05-09 | Rotta Research Lab | Derivati acidi poliamidici ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico. |
| US5750353A (en) | 1995-12-11 | 1998-05-12 | New England Medical Center Hospitals, Inc. | Assay for non-peptide agonists to peptide hormone receptors |
| IL124808A0 (en) | 1995-12-11 | 1999-01-26 | New England Medical Center Inc | Assay for and uses of peptide hormone receptor ligands |
| US5922883A (en) | 1996-04-03 | 1999-07-13 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US20040001842A1 (en) | 1997-05-12 | 2004-01-01 | Dov Michaeli | Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors |
| ES2227833T3 (es) | 1997-05-12 | 2005-04-01 | Aphton Corporation | Composiciones inmunogenicas para el receptor cck-b/gastrina y metodos para el tratamiento de tumores. |
| KR100699574B1 (ko) | 1998-05-15 | 2007-03-23 | 리셉터 바이오로직스 인크 | 종양 치료를 위한 조합 치료 |
| CA2333770A1 (en) | 1998-06-04 | 1999-12-09 | Abbott Laboratories | Cell adhesion-inhibiting antinflammatory compounds |
| US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| US6541669B1 (en) | 1998-06-08 | 2003-04-01 | Theravance, Inc. | β2-adrenergic receptor agonists |
| WO2000044722A1 (en) | 1999-01-29 | 2000-08-03 | Chugai Seiyaku Kabushiki Kaisha | Chondrongenesis promotors and indolin-2-one derivatives |
| WO2000075145A1 (en) | 1999-06-03 | 2000-12-14 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| US20030191279A1 (en) | 1999-08-27 | 2003-10-09 | Goldstein Steven Wayne | Urea derivatives useful as anticancer agents |
| US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
| DE60026348T2 (de) | 1999-11-05 | 2006-10-19 | Societe De Conseils De Recherches Et D`Applications Scientifiques (S.C.R.A.S.) | Heterocyclische verbindungen und ihre verwendung als medikamente |
| AU3003701A (en) | 1999-11-19 | 2001-05-30 | Axxima Pharmaceuticals Ag | Inhibitors of helicobacter pylori induced gastrointestinal diseases |
| WO2001077685A2 (en) | 2000-04-10 | 2001-10-18 | The General Hospital Corporation | Diagnosis and treatment of gastrointestinal disease |
| WO2002000651A2 (en) | 2000-06-27 | 2002-01-03 | Bristol-Myers Squibb Pharma Company | Factor xa inhibitors |
| JP2005508838A (ja) | 2001-03-23 | 2005-04-07 | アフトン コーポレーション | 膵癌の組合せ治療 |
| US20040138285A1 (en) | 2001-04-27 | 2004-07-15 | Makoto Okazaki | Chondrogenesis promoters |
| US20090191232A1 (en) | 2001-05-04 | 2009-07-30 | Gevas Philip C | Combination therapy for the treatment of tumors |
| WO2002092096A1 (en) | 2001-05-11 | 2002-11-21 | Yamanouchi Pharmaceutical Co., Ltd. | Antitumor agents |
| AUPR738301A0 (en) | 2001-08-30 | 2001-09-20 | Starpharma Limited | Chemotherapeutic agents |
| BR0213317A (pt) | 2001-11-13 | 2004-10-13 | Black James Foundation | Uso de um composto, método de tratar um distúrbio relacionado com gastrina, composição farmacêutica, kit, usos de uma composição, e de um inibidor de bomba de próton, métodos de preparar uma composição farmacêutica e um composto, e, composto |
| US20040127492A1 (en) | 2002-02-19 | 2004-07-01 | Pharmacia Corporation | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 |
| DE10207037A1 (de) | 2002-02-20 | 2003-08-28 | Bayer Cropscience Gmbh | 2-Amino-4-bicyclyamino-6H-1,3.5-triazine, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| UA79804C2 (en) | 2002-07-03 | 2007-07-25 | Janssen Pharmaceutica Nv | Cck-1 receptor modulators |
| US20030049698A1 (en) | 2002-10-08 | 2003-03-13 | Wang Timothy C. | Diagnosis and treatment of gastrointestinal disease |
| KR20050119666A (ko) | 2003-03-28 | 2005-12-21 | 얀센 파마슈티카 엔.브이. | 벤조[1,2,5]티아디아졸 화합물 |
| WO2004101533A1 (en) | 2003-05-12 | 2004-11-25 | Janssen Pharmaceutica, N.V. | 1, 3, 4-benzotriazepin-2-one salts and their use as cck receptor ligands |
| GB0310865D0 (en) | 2003-05-12 | 2003-06-18 | Black James Foundation | Gastrin and cholecystokinin receptor ligands |
| WO2005007107A2 (en) | 2003-07-11 | 2005-01-27 | University Of Massachusetts | Histamine and cck2/gastrin receptor blockade in the treatment of acid-peptic disease and cancer |
| SI1651621T1 (sl) | 2003-08-08 | 2008-12-31 | Janssen Pharmaceutica Nv | 2-(kinoksalin-5-ilsulfonilamino)-benzamidne spojine kot modulatorji CCK2 |
| US20070293482A1 (en) | 2004-03-19 | 2007-12-20 | Novartis Pharmaceuticals Corporation | Process for Preparing Benzodiazepines |
| US7429604B2 (en) | 2004-06-15 | 2008-09-30 | Bristol Myers Squibb Company | Six-membered heterocycles useful as serine protease inhibitors |
| US7947833B2 (en) | 2004-08-04 | 2011-05-24 | Janssen Pharmaceutica Nv | Preparation of quinoxaline compounds |
| CA2581426A1 (en) | 2004-09-24 | 2006-04-06 | Janssen Pharmaceutica, N.V. | Sulfonamide compounds |
| WO2006044352A2 (en) | 2004-10-12 | 2006-04-27 | Janssen Pharmaceutica N.V. | Canine cholecystokinin 1 receptor materials and their use |
| AU2005302669A1 (en) | 2004-10-27 | 2006-05-11 | Neurogen Corporation | Diaryl ureas as CB1 antagonists |
| CA2579227A1 (en) | 2004-11-04 | 2006-05-18 | Neurogen Corporation | Arylalkyl ureas as cb1 antagonists |
| GB0425196D0 (en) | 2004-11-15 | 2004-12-15 | Black James Foundation | Gastrin and cholecystokinin receptor ligands |
| US20090291977A1 (en) | 2004-12-17 | 2009-11-26 | Madoka Jinno | Chromane Derivatives Useful As Acid Pump Antagonists |
| DE602006013094D1 (de) | 2005-01-19 | 2010-05-06 | Zeria Pharm Co Ltd | Krebsmittel |
| AR053713A1 (es) | 2005-04-20 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos heterociclicos y sus usos como agentes terapeuticos |
| AU2006255047B2 (en) | 2005-06-06 | 2011-09-15 | The Board Of Trustees Of The University Of Illinois | Compositions and methods for treating sleep disorders |
| DE602006009105D1 (de) | 2005-06-14 | 2009-10-22 | Raqualia Pharma Inc | Chroman-substituierte benzimidazolderivate als säurepumpenantagonisten |
| ES2324354T3 (es) | 2005-07-29 | 2009-08-05 | Rottapharm S.P.A. | Combinacion terapeutica de itriglumida e inhibidores de la bomba de protones en el tratamiento de trastornos gastrointestinales y relacionados. |
| WO2007026218A2 (en) | 2005-09-01 | 2007-03-08 | Pfizer Japan Inc. | Chromane substituted 2-alkyl imidazopyridine derivatives and use thereof as acid pump antagonists |
| WO2007031860A1 (en) | 2005-09-15 | 2007-03-22 | Pfizer Japan Inc. | Indane substituted benzimidazoles and their use as acid pump inhibitors |
| WO2007072142A2 (en) | 2005-12-19 | 2007-06-28 | Pfizer Japan Inc. | Benzimidazole-5-carboxamide derivatives |
| DE602006014996D1 (de) | 2005-12-19 | 2010-07-29 | Raqualia Pharma Inc | Chromansubstituierte benzimidazole und ihre verwendung als säurepumpenhemmer |
| JP2009530262A (ja) | 2006-03-17 | 2009-08-27 | ラクオリア創薬株式会社 | クロマン誘導体 |
| JP2009533362A (ja) | 2006-04-12 | 2009-09-17 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | キナーゼ媒介性疾患を治療するための複素環式置換ビスアリール尿素のn−オキシド |
| FR2901473B1 (fr) | 2006-05-24 | 2010-08-13 | Oreal | Procede de defrisage des fibres keratiniques avec un moyen de chauffage et une amide |
| FR2901472B1 (fr) | 2006-05-24 | 2010-08-13 | Oreal | Procede de defrisage des fibres keratiniques avec un moyen de chauffage et des agents denaturants |
| ATE512969T1 (de) | 2006-09-21 | 2011-07-15 | Raqualia Pharma Inc | Benzimidazolderivate als selektive säurepumpenhemmer |
| WO2008046082A2 (en) | 2006-10-12 | 2008-04-17 | Xenon Pharmaceuticals Inc. | Use of heterocyclic compounds as therapeutic agents |
| WO2008059373A1 (en) | 2006-11-17 | 2008-05-22 | Raqualia Pharma Inc. | Imidazo [1, 2-a] pyrazine derivatives and their use as acid pump antagonists |
| JP2008222557A (ja) | 2007-03-08 | 2008-09-25 | Kotobuki Seiyaku Kk | ピロロ[3,2−d]ピリミジン誘導体及びこれを有効成分とする医薬組成物 |
| WO2008114123A1 (en) | 2007-03-21 | 2008-09-25 | Raqualia Pharma Inc. | Spiro benzimidazole derivatives as acid pump inhibitors |
| WO2008124518A1 (en) | 2007-04-03 | 2008-10-16 | Janssen Pharmaceutica N.V. | Oxo-dihydroisoindole sulfonamide compounds as modulators of the cck2 receptor |
| WO2008124524A2 (en) | 2007-04-03 | 2008-10-16 | Janssen Pharmaceutica N.V. | Aryl sulfonamide compounds as modulators of the cck2 receptor |
| WO2009000413A1 (en) | 2007-06-26 | 2008-12-31 | Sanofi-Aventis | A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles |
| RU2379043C2 (ru) | 2007-08-02 | 2010-01-20 | Закрытое акционерное общество "Биологические исследования и системы" | Фармацевтическая композиция для профилактики и лечения остеопороза у женщин в период менопаузы |
| US20110105515A1 (en) | 2007-08-07 | 2011-05-05 | President And Fellows Of Harvard College | Targeting the oncoprotein nucleophosmin |
| AR073578A1 (es) | 2008-09-15 | 2010-11-17 | Priaxon Ag | Pirrolidin-2-onas |
| WO2010036316A1 (en) | 2008-09-24 | 2010-04-01 | Yangbo Feng | Urea and carbamate compounds and analogs as kinase inhibitors |
| JPWO2010113458A1 (ja) | 2009-03-31 | 2012-10-04 | ゼリア新薬工業株式会社 | 1,5−ベンゾジアゼピン誘導体の製造法 |
| EP2452680B1 (en) | 2009-07-09 | 2019-12-18 | RaQualia Pharma Inc. | Acid pump antagonist for the treatment of diseases involved in abnormal gastrointestinal motility |
| EP2480549B1 (en) | 2009-09-24 | 2015-04-08 | Fundación Centro Nacional De Investigaciones Oncológicas Carlos III | Fused imidazo[3,2-d]pyrazines as PI3 kinase inhibitors |
| HRP20160967T1 (hr) | 2009-10-06 | 2016-10-07 | Millennium Pharmaceuticals, Inc. | Heterociklički spojevi korisni kao pdk1 inhibitori |
| US9181414B2 (en) | 2009-11-13 | 2015-11-10 | Plastipak Packaging, Inc. | Oxygen scavengers, compositions comprising the scavengers, and articles made from the compositions |
| WO2011063164A2 (en) | 2009-11-18 | 2011-05-26 | Steady Sleep Rx Co., Inc. | Sustained release cannabinoid medicaments |
| CA2812043A1 (en) | 2010-04-23 | 2011-10-27 | Kineta, Inc. | Pyrimidinedione anti-viral compounds |
| WO2012021837A2 (en) | 2010-08-12 | 2012-02-16 | Senomyx, Inc. | Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer |
| US20120231083A1 (en) | 2010-11-18 | 2012-09-13 | The Board Of Trustees Of The University Of Illinois | Sustained release cannabinoid medicaments |
| WO2012068516A2 (en) | 2010-11-18 | 2012-05-24 | Pier Pharmaceuticals | Low dose cannabinoid medicaments |
| EP2651405A2 (en) | 2010-12-14 | 2013-10-23 | Electrophoretics Limited | Casein kinase 1 (ck1 ) inhibitors |
| WO2013017480A1 (en) | 2011-07-29 | 2013-02-07 | Cellzome Limited | Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors |
| WO2013017479A1 (en) | 2011-07-29 | 2013-02-07 | Cellzome Limited | Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors |
| ES2736603T3 (es) | 2011-11-07 | 2020-01-03 | Massachusetts Inst Technology | Complejos de wolframio oxo alquilideno para la metátesis de olefinas selectiva de Z |
| US10080805B2 (en) | 2012-02-24 | 2018-09-25 | Purdue Research Foundation | Cholecystokinin B receptor targeting for imaging and therapy |
| WO2013158928A2 (en) | 2012-04-18 | 2013-10-24 | Elcelyx Therapeutics, Inc. | Chemosensory receptor ligand-based therapies |
| TWI610916B (zh) | 2012-08-03 | 2018-01-11 | 廣東東陽光藥業有限公司 | 作爲丙型肝炎抑制劑的橋環化合物及其在藥物中的應用 |
| US8952009B2 (en) | 2012-08-06 | 2015-02-10 | Amgen Inc. | Chroman derivatives as TRPM8 inhibitors |
-
2014
- 2014-11-21 DK DK14815149.1T patent/DK3071206T3/da active
- 2014-11-21 AU AU2014352875A patent/AU2014352875B2/en active Active
- 2014-11-21 CA CA2929858A patent/CA2929858C/en active Active
- 2014-11-21 ES ES14815149T patent/ES2870538T3/es active Active
- 2014-11-21 KR KR1020167015759A patent/KR102254957B1/ko active Active
- 2014-11-21 CN CN201480073822.0A patent/CN106163527A/zh active Pending
- 2014-11-21 WO PCT/US2014/066832 patent/WO2015077572A1/en not_active Ceased
- 2014-11-21 MX MX2016006657A patent/MX2016006657A/es unknown
- 2014-11-21 US US14/550,233 patent/US10709714B2/en active Active
- 2014-11-21 EP EP14815149.1A patent/EP3071206B1/en active Active
- 2014-11-21 BR BR112016011727A patent/BR112016011727A2/pt not_active Application Discontinuation
- 2014-11-21 JP JP2016533607A patent/JP6502939B2/ja active Active
- 2014-11-21 RU RU2016124538A patent/RU2693484C1/ru active
- 2014-11-21 PL PL14815149T patent/PL3071206T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112016011727A2 (pt) | 2017-08-08 |
| JP2016538295A (ja) | 2016-12-08 |
| EP3071206A1 (en) | 2016-09-28 |
| RU2016124538A (ru) | 2017-12-27 |
| CA2929858A1 (en) | 2015-05-28 |
| KR102254957B1 (ko) | 2021-05-25 |
| WO2015077572A1 (en) | 2015-05-28 |
| EP3071206B1 (en) | 2021-02-17 |
| US20150148339A1 (en) | 2015-05-28 |
| RU2693484C1 (ru) | 2019-07-03 |
| DK3071206T3 (da) | 2021-05-25 |
| AU2014352875A8 (en) | 2016-06-30 |
| US10709714B2 (en) | 2020-07-14 |
| PL3071206T3 (pl) | 2022-01-17 |
| CA2929858C (en) | 2022-03-29 |
| AU2014352875A1 (en) | 2016-05-26 |
| ES2870538T3 (es) | 2021-10-27 |
| KR20160088891A (ko) | 2016-07-26 |
| CN106163527A (zh) | 2016-11-23 |
| AU2014352875B2 (en) | 2019-10-24 |
| MX2016006657A (es) | 2016-10-12 |
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