JPH01502930A - 改良された分析技術およびそのための装置 - Google Patents

改良された分析技術およびそのための装置

Info

Publication number: JPH01502930A
Authority: JP; Japan
Prior art keywords: optical structure; binding partner; sample; specific binding; ligand
Prior art date: 1987-03-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP63502231A

Other languages

English (en)

Japanese (ja)

Inventor

ソーヤーズ，クレイグ　ジョージ

ドレイク，ローズマリー　アン　ルーシー

Original Assignee

アレス‐セロノ　リサーチ　アンド　ディベロップメント　リミティド　パートナーシップ

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-03-10

Filing date

1988-03-09

Publication date

1989-10-05

1988-03-09 Application filed by アレス‐セロノ　リサーチ　アンド　ディベロップメント　リミティド　パートナーシップ filed Critical アレス‐セロノ　リサーチ　アンド　ディベロップメント　リミティド　パートナーシップ

1989-10-05 Publication of JPH01502930A publication Critical patent/JPH01502930A/ja

Status Pending legal-status Critical Current

Links

238000004458 analytical method Methods 0.000 title description 19
230000003287 optical effect Effects 0.000 claims description 23
239000003446 ligand Substances 0.000 claims description 19
238000000034 method Methods 0.000 claims description 16
230000005855 radiation Effects 0.000 claims description 13
230000009870 specific binding Effects 0.000 claims description 13
238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims description 13
239000000463 material Substances 0.000 claims description 11
229910052751 metal Inorganic materials 0.000 claims description 8
239000002184 metal Substances 0.000 claims description 8
239000000427 antigen Substances 0.000 claims description 7
102000036639 antigens Human genes 0.000 claims description 7
108091007433 antigens Proteins 0.000 claims description 7
230000015572 biosynthetic process Effects 0.000 claims description 4
230000001678 irradiating effect Effects 0.000 claims description 4
238000012360 testing method Methods 0.000 claims description 3
230000001747 exhibiting effect Effects 0.000 claims 1
239000000523 sample Substances 0.000 description 12
238000009739 binding Methods 0.000 description 11
230000027455 binding Effects 0.000 description 10
239000007788 liquid Substances 0.000 description 9
239000002245 particle Substances 0.000 description 5
239000000126 substance Substances 0.000 description 5
239000010408 film Substances 0.000 description 4
239000010409 thin film Substances 0.000 description 4
238000000149 argon plasma sintering Methods 0.000 description 3
230000000694 effects Effects 0.000 description 3
239000012491 analyte Substances 0.000 description 2
239000003153 chemical reaction reagent Substances 0.000 description 2
230000000295 complement effect Effects 0.000 description 2
238000001514 detection method Methods 0.000 description 2
238000005286 illumination Methods 0.000 description 2
229920003023 plastic Polymers 0.000 description 2
238000012545 processing Methods 0.000 description 2
241000282994 Cervidae Species 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
238000003556 assay Methods 0.000 description 1
239000012472 biological sample Substances 0.000 description 1
230000005540 biological transmission Effects 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
230000003139 buffering effect Effects 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
238000012875 competitive assay Methods 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
230000008021 deposition Effects 0.000 description 1
230000005284 excitation Effects 0.000 description 1
238000012921 fluorescence analysis Methods 0.000 description 1
239000007850 fluorescent dye Substances 0.000 description 1
239000011888 foil Substances 0.000 description 1
239000011521 glass Substances 0.000 description 1
229910052734 helium Inorganic materials 0.000 description 1
239000001307 helium Substances 0.000 description 1
SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
238000001746 injection moulding Methods 0.000 description 1
230000003993 interaction Effects 0.000 description 1
230000031700 light absorption Effects 0.000 description 1
238000003754 machining Methods 0.000 description 1
230000013011 mating Effects 0.000 description 1
238000005259 measurement Methods 0.000 description 1
238000000465 moulding Methods 0.000 description 1
230000009871 nonspecific binding Effects 0.000 description 1
239000013618 particulate matter Substances 0.000 description 1
239000000376 reactant Substances 0.000 description 1
238000002310 reflectometry Methods 0.000 description 1
238000011160 research Methods 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
229910052814 silicon oxide Inorganic materials 0.000 description 1
229910052709 silver Inorganic materials 0.000 description 1
239000004332 silver Substances 0.000 description 1
241000894007 species Species 0.000 description 1
239000000758 substrate Substances 0.000 description 1
238000007738 vacuum evaporation Methods 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
- G01N21/553—Attenuated total reflection and using surface plasmons
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
- G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
- G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
- G01N33/553—Metal or metal coated

Landscapes

Health & Medical Sciences (AREA)
Immunology (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Physics & Mathematics (AREA)
General Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Pathology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Urology & Nephrology (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Food Science & Technology (AREA)
Microbiology (AREA)
Cell Biology (AREA)
Optics & Photonics (AREA)
Inorganic Chemistry (AREA)
Plasma & Fusion (AREA)
Investigating Or Analysing Materials By Optical Means (AREA)
Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

JP63502231A 1987-03-10 1988-03-09 改良された分析技術およびそのための装置 Pending JPH01502930A (ja)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8705650		1987-03-10
GB878705650A GB8705650D0 (en)	1987-03-10	1987-03-10	Assay technique

Publications (1)

Publication Number	Publication Date
JPH01502930A true JPH01502930A (ja)	1989-10-05

Family

ID=10613686

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP63502231A Pending JPH01502930A (ja)	1987-03-10	1988-03-09	改良された分析技術およびそのための装置

Country Status (5)

Country	Link
EP (1)	EP0304461A1 (fr)
JP (1)	JPH01502930A (fr)
AU (1)	AU1391288A (fr)
GB (1)	GB8705650D0 (fr)
WO (1)	WO1988007202A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH10307141A (ja) *	1997-04-14	1998-11-17	Boehringer Mannheim Gmbh	プラズモン共鳴および蛍光検出を用いた生体分子相互作用の同時検出法
JP2003533692A (ja) *	2000-05-06	2003-11-11	ツェプトゼンスアクチエンゲゼルシャフト	多重分析対象物測定及びその使用のための格子導波路構造
JP2005521052A (ja) *	2002-03-20	2005-07-14	ウイスコンシンアラムニリサーチファンデーション	ナノ構造化基体の光学的画像化
JP2011226925A (ja) *	2010-04-20	2011-11-10	National Institute Of Advanced Industrial & Technology	周期構造を有するマイクロプレート及びその製造方法
JP2014016372A (ja) *	2013-10-29	2014-01-30	National Institute Of Advanced Industrial & Technology	周期構造を有するマイクロプレート、並びに、それを用いた表面プラズモン励起増強蛍光顕微鏡、蛍光マイクロプレートリーダーおよび特異的な抗原抗体反応の検出方法
WO2015155799A1 (fr) *	2014-04-08	2015-10-15	コニカミノルタ株式会社	Dispositif et procédé de mesure de fluorescence améliorée par plasmons de surface

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1321488C (fr)	1987-08-22	1993-08-24	Martin Francis Finlan	Detecteurs biologiques
GB8801807D0 (en) *	1988-01-27	1988-02-24	Amersham Int Plc	Biological sensors
US5478755A (en) *	1988-07-25	1995-12-26	Ares Serono Research & Development Ltd.	Long range surface plasma resonance immunoassay
GB8817710D0 (en) *	1988-07-25	1988-09-01	Ares Serono Res & Dev Ltd	Method of assay
GB8924951D0 (en) *	1989-11-04	1989-12-28	Fisons Plc	Device and methods
JPH05504195A (ja) *	1990-02-22	1993-07-01	ザ・ロイヤル・インステイチユーシヨン・フオー・ジ・アドバンスメント・オブ・ラーニング　（マクギル・ユニバーシテイ）	固相干渉イムノアッセイ系
NL9001052A (nl) *	1990-05-02	1991-12-02	Tno	Werkwijze voor het bepalen van een specifiek ligand in een vloeibaar monster met behulp van een evanescent veld, alsook een daarvoor geschikt onderdeel van de benodigde meetinrichting.
EP0517930B1 (fr) *	1991-06-08	1995-05-24	Hewlett-Packard GmbH	Procédé et appareil pour détecter la présence et/ou la concentration de biomolécules
GB9120000D0 (en) *	1991-09-19	1991-11-06	British Gas Plc	Optical sensing
US5846843A (en) *	1996-11-18	1998-12-08	The University Of Toledo	Sensor using long range surface plasmon resonance with diffraction double-grating
US5776785A (en) *	1996-12-30	1998-07-07	Diagnostic Products Corporation	Method and apparatus for immunoassay using fluorescent induced surface plasma emission
DE19903576C2 (de) *	1999-01-29	2001-02-22	Bodenseewerk Perkin Elmer Co	Quantitative Bestimmung von Analyten in einem heterogenen System
DE10064146A1 (de) *	2000-12-22	2002-07-04	Andreas Hofmann	Biosensor und verfahren zu seiner Herstellung
DE102004027957A1 (de) *	2004-06-08	2005-12-29	Carl Zeiss Jena Gmbh	Verfahren und Anordnung zur Untersuchung der Wechselwirkung von Biomolekülen
GB2431233A (en) *	2005-10-14	2007-04-18	E2V Tech	Molecular detector arrangement
PT103601B (pt) *	2006-11-09	2008-10-14	Biosurfit Sa	Dispositivo de detecção baseado no efeito de ressonância de plasmão de superfície
DE202007014923U1 (de)	2007-10-24	2009-02-26	Bioscitec Gmbh	Wannenförmiges Behältnis für optisch zu analysierende Testobjekte und Herstellungsvorrichtung dafür

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3979184A (en) *	1975-05-27	1976-09-07	General Electric Company	Diagnostic device for visually detecting presence of biological particles
DE3135196A1 (de) *	1981-09-05	1983-03-17	Merck Patent Gmbh, 6100 Darmstadt	Verfahren, mittel und vorrichtung zur bestimmung biologischer komponenten
CA1237645A (fr) *	1982-12-21	1988-06-07	John H. Fisher	Technique analytique
US4978503A (en) *	1984-06-13	1990-12-18	Ares-Serono Research & Development Limited Partnership	Devices for use in chemical test procedures
US4647544A (en) *	1984-06-25	1987-03-03	Nicoli David F	Immunoassay using optical interference detection
GB8423204D0 (en) *	1984-09-14	1984-10-17	Comtech Res Unit	Assay technique and equipment
GB8618133D0 (en) *	1986-07-24	1986-09-03	Pa Consulting Services	Biosensors

1987
- 1987-03-10 GB GB878705650A patent/GB8705650D0/en active Pending
1988
- 1988-03-09 EP EP88902172A patent/EP0304461A1/fr not_active Withdrawn
- 1988-03-09 JP JP63502231A patent/JPH01502930A/ja active Pending
- 1988-03-09 WO PCT/GB1988/000176 patent/WO1988007202A1/fr not_active Ceased
- 1988-03-09 AU AU13912/88A patent/AU1391288A/en not_active Abandoned

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH10307141A (ja) *	1997-04-14	1998-11-17	Boehringer Mannheim Gmbh	プラズモン共鳴および蛍光検出を用いた生体分子相互作用の同時検出法
JP2003533692A (ja) *	2000-05-06	2003-11-11	ツェプトゼンスアクチエンゲゼルシャフト	多重分析対象物測定及びその使用のための格子導波路構造
JP2005521052A (ja) *	2002-03-20	2005-07-14	ウイスコンシンアラムニリサーチファンデーション	ナノ構造化基体の光学的画像化
JP2011226925A (ja) *	2010-04-20	2011-11-10	National Institute Of Advanced Industrial & Technology	周期構造を有するマイクロプレート及びその製造方法
JP2014016372A (ja) *	2013-10-29	2014-01-30	National Institute Of Advanced Industrial & Technology	周期構造を有するマイクロプレート、並びに、それを用いた表面プラズモン励起増強蛍光顕微鏡、蛍光マイクロプレートリーダーおよび特異的な抗原抗体反応の検出方法
WO2015155799A1 (fr) *	2014-04-08	2015-10-15	コニカミノルタ株式会社	Dispositif et procédé de mesure de fluorescence améliorée par plasmons de surface
JPWO2015155799A1 (ja) *	2014-04-08	2017-04-13	コニカミノルタ株式会社	表面プラズモン増強蛍光測定装置および表面プラズモン増強蛍光測定方法

Also Published As

Publication number	Publication date
WO1988007202A1 (fr)	1988-09-22
GB8705650D0 (en)	1987-04-15
AU1391288A (en)	1988-10-10
EP0304461A1 (fr)	1989-03-01

Publication	Publication Date	Title
EP0167335B1 (fr)	1991-11-27	Méthode de détection d'une réaction de liaison entre un ligand et un antiligand
EP0670043B1 (fr)	1999-01-27	Dosage de ligand par modulation d'interference
USRE33581E (en)	1991-04-30	Immunoassay using optical interference detection
US7221457B2 (en)	2007-05-22	Imaging platform for nanoparticle detection applied to SPR biomolecular interaction analysis
US6859280B2 (en)	2005-02-22	Imaging apparatus and method
EP0304461A1 (fr)	1989-03-01	Technique amelioree d'analyse et appareil prevu a cet effet
US5350697A (en)	1994-09-27	Scattered light detection apparatus
US7713751B2 (en)	2010-05-11	Method of optical detection of binding of a material component to a sensor substance due to a biological, chemical or physical interaction and apparatus for its embodiment (variants)
JPH0627703B2 (ja)	1994-04-13	物質の選択的検出および測定物質内の屈折率変化検知を行なう光学センサ
JP2002502967A (ja)	2002-01-29	ルミネッセンスを測定する方法及び装置
WO1998021571A1 (fr)	1998-05-22	Utilisation de biocapteurs pour diagnostiquer des maladies des plantes
JPH03502604A (ja)	1991-06-13	分析方法
JP2572829B2 (ja)	1997-01-16	導波管センサー
EP1390719A1 (fr)	2004-02-25	Appareil et procede d'imagerie
EP0647321A1 (fr)	1995-04-12	Procede de determination d'immunocomplexes multiples sur une surfface par spectroscopie
JP7756407B1 (ja)	2025-10-20	イムノアッセイ方法及びイムノアッセイ装置
JP2005077396A (ja)	2005-03-24	分析用光導波路
AU670252B2 (en)	1996-07-11	Ligand assay using interference modulation
NO884985L (no)	1988-11-09	Forbedret evalueringsteknikk og apparat for utoevelse av denne.
Laing et al.	2007	12 High-Resolution Label Free Detection Applied to Protein Microarray Research
CA2149784A1 (fr)	1994-06-09	Detection de ligands par modulation d'interference