JPH0212931B2 - - Google Patents

Info

Publication number: JPH0212931B2
Authority: JP; Japan
Prior art keywords: ethylene oxide; menthanylphenol; adduct; injection; active
Prior art date: 1986-10-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP24838686A

Other languages

English (en)

Japanese (ja)

Other versions

JPS63104919A (ja

Inventor

Seigo Fukushima

Kazumaro Furuse

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Eisai Co Ltd

Original Assignee

Eisai Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-10-21

Filing date

1986-10-21

Publication date

1990-03-30

1986-10-21 Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd

1986-10-21 Priority to JP24838686A priority Critical patent/JPS63104919A/ja

1988-05-10 Publication of JPS63104919A publication Critical patent/JPS63104919A/ja

1990-03-30 Publication of JPH0212931B2 publication Critical patent/JPH0212931B2/ja

Status Granted legal-status Critical Current

Links

IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 19
GHMKDZIUDKBFIR-UHFFFAOYSA-N 4-(5-methyl-2-propan-2-ylcyclohexyl)phenol Chemical compound CC(C)C1CCC(C)CC1C1=CC=C(O)C=C1 GHMKDZIUDKBFIR-UHFFFAOYSA-N 0.000 claims description 15
239000007924 injection Substances 0.000 claims description 5
238000002347 injection Methods 0.000 claims description 5
239000002246 antineoplastic agent Substances 0.000 claims description 4
239000004480 active ingredient Substances 0.000 claims description 3
239000013543 active substance Substances 0.000 description 8
239000000243 solution Substances 0.000 description 5
238000012360 testing method Methods 0.000 description 5
150000001875 compounds Chemical class 0.000 description 4
239000012153 distilled water Substances 0.000 description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
241000700159 Rattus Species 0.000 description 3
239000003708 ampul Substances 0.000 description 3
239000008103 glucose Substances 0.000 description 3
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
230000001093 anti-cancer Effects 0.000 description 2
238000009472 formulation Methods 0.000 description 2
238000001990 intravenous administration Methods 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
239000000203 mixture Substances 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
230000004083 survival effect Effects 0.000 description 2
FAMJUFMHYAFYNU-JTQLQIEISA-N (4r)-1-methyl-4-propan-2-ylcyclohexene Chemical compound CC(C)[C@@H]1CCC(C)=CC1 FAMJUFMHYAFYNU-JTQLQIEISA-N 0.000 description 1
ZVJYNDILACLBLH-UHFFFAOYSA-N 2-(5-methyl-2-propan-2-ylcyclohexyl)phenol Chemical compound CC(C)C1CCC(C)CC1C1=CC=CC=C1O ZVJYNDILACLBLH-UHFFFAOYSA-N 0.000 description 1
NMXDTPBZWZGMMO-UHFFFAOYSA-N 4-(2-methyl-5-propan-2-ylcyclohexyl)phenol Chemical compound C1C(C(C)C)CCC(C)C1C1=CC=C(O)C=C1 NMXDTPBZWZGMMO-UHFFFAOYSA-N 0.000 description 1
206010003445 Ascites Diseases 0.000 description 1
201000009030 Carcinoma Diseases 0.000 description 1
229940126062 Compound A Drugs 0.000 description 1
239000001293 FEMA 3089 Substances 0.000 description 1
NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
241000699666 Mus <mouse, genus> Species 0.000 description 1
241000699670 Mus sp. Species 0.000 description 1
206010028980 Neoplasm Diseases 0.000 description 1
208000006268 Sarcoma 180 Diseases 0.000 description 1
230000007059 acute toxicity Effects 0.000 description 1
231100000403 acute toxicity Toxicity 0.000 description 1
239000003513 alkali Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
230000037396 body weight Effects 0.000 description 1
201000011510 cancer Diseases 0.000 description 1
239000003054 catalyst Substances 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
239000002537 cosmetic Substances 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
238000001802 infusion Methods 0.000 description 1
239000007972 injectable composition Substances 0.000 description 1
238000011081 inoculation Methods 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
238000007912 intraperitoneal administration Methods 0.000 description 1
229960001112 menfegol Drugs 0.000 description 1
238000000034 method Methods 0.000 description 1
239000002357 osmotic agent Substances 0.000 description 1
-1 p-menthanyl phenyl Chemical group 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
229940051841 polyoxyethylene ether Drugs 0.000 description 1
229920000056 polyoxyethylene ether Polymers 0.000 description 1
239000000934 spermatocidal agent Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1

Landscapes

Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

JP24838686A 1986-10-21 1986-10-21 メンタニルフエノ−ルエチレンオキサイド付加物からなる抗癌剤 Granted JPS63104919A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP24838686A JPS63104919A (ja)	1986-10-21	1986-10-21	メンタニルフエノ−ルエチレンオキサイド付加物からなる抗癌剤

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP24838686A JPS63104919A (ja)	1986-10-21	1986-10-21	メンタニルフエノ−ルエチレンオキサイド付加物からなる抗癌剤

Publications (2)

Publication Number	Publication Date
JPS63104919A JPS63104919A (ja)	1988-05-10
JPH0212931B2 true JPH0212931B2 (da)	1990-03-30

Family

ID=17177331

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP24838686A Granted JPS63104919A (ja)	1986-10-21	1986-10-21	メンタニルフエノ−ルエチレンオキサイド付加物からなる抗癌剤

Country Status (1)

Country	Link
JP (1)	JPS63104919A (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5651291B2 (ja) *	2008-04-11	2015-01-07	株式会社センカファーマシー	ポリエチレングリコールの誘導体およびその中間体の製造方法

1986
- 1986-10-21 JP JP24838686A patent/JPS63104919A/ja active Granted

Also Published As

Publication number	Publication date
JPS63104919A (ja)	1988-05-10

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