JPH0216732B2 - - Google Patents

Info

Publication number: JPH0216732B2
Authority: JP; Japan
Prior art keywords: nana; cmp; acid; pharmaceutical composition; composition according
Prior art date: 1983-03-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP3634184A

Other languages

English (en)

Japanese (ja)

Other versions

JPS606618A (ja

Inventor

Mitsukori Pietoro

Dekorute Enio

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

CHII ERE CHII CO DEI RISERUKA CHIMIKA SpA

Original Assignee

CHII ERE CHII CO DEI RISERUKA CHIMIKA SpA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-03-01

Filing date

1984-02-29

Publication date

1990-04-18

1984-02-29 Application filed by CHII ERE CHII CO DEI RISERUKA CHIMIKA SpA filed Critical CHII ERE CHII CO DEI RISERUKA CHIMIKA SpA

1985-01-14 Publication of JPS606618A publication Critical patent/JPS606618A/ja

1990-04-18 Publication of JPH0216732B2 publication Critical patent/JPH0216732B2/ja

Status Granted legal-status Critical Current

Links

239000002253 acid Substances 0.000 claims description 15
IERHLVCPSMICTF-XVFCMESISA-N cytidine 5'-monophosphate Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O1 IERHLVCPSMICTF-XVFCMESISA-N 0.000 claims description 13
IERHLVCPSMICTF-UHFFFAOYSA-N cytidine monophosphate Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(COP(O)(O)=O)O1 IERHLVCPSMICTF-UHFFFAOYSA-N 0.000 claims description 13
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
210000003169 central nervous system Anatomy 0.000 claims description 8
210000001428 peripheral nervous system Anatomy 0.000 claims description 8
239000008194 pharmaceutical composition Substances 0.000 claims description 8
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
239000000203 mixture Substances 0.000 claims description 6
230000001575 pathological effect Effects 0.000 claims description 6
239000004480 active ingredient Substances 0.000 claims description 5
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 4
229930195725 Mannitol Natural products 0.000 claims description 4
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 4
229910000397 disodium phosphate Inorganic materials 0.000 claims description 4
235000019800 disodium phosphate Nutrition 0.000 claims description 4
239000000594 mannitol Substances 0.000 claims description 4
235000010355 mannitol Nutrition 0.000 claims description 4
LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims description 4
239000001488 sodium phosphate Substances 0.000 claims description 3
239000008215 water for injection Substances 0.000 claims description 3
239000013543 active substance Substances 0.000 claims 2
201000010099 disease Diseases 0.000 claims 1
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235000011009 potassium phosphates Nutrition 0.000 claims 1
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230000000638 stimulation Effects 0.000 claims 1
TXCIAUNLDRJGJZ-BILDWYJOSA-N CMP-N-acetyl-beta-neuraminic acid Chemical compound O1[C@@H]([C@H](O)[C@H](O)CO)[C@H](NC(=O)C)[C@@H](O)C[C@]1(C(O)=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(N)C=C2)=O)O1 TXCIAUNLDRJGJZ-BILDWYJOSA-N 0.000 description 31
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SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 description 13
YZEUHQHUFTYLPH-UHFFFAOYSA-N 2-nitroimidazole Chemical compound [O-][N+](=O)C1=NC=CN1 YZEUHQHUFTYLPH-UHFFFAOYSA-N 0.000 description 11
241000700159 Rattus Species 0.000 description 11
PCDQPRRSZKQHHS-CCXZUQQUSA-N Cytarabine Triphosphate Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 PCDQPRRSZKQHHS-CCXZUQQUSA-N 0.000 description 10
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SQVRNKJHWKZAKO-PFQGKNLYSA-N N-acetyl-beta-neuraminic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-PFQGKNLYSA-N 0.000 description 7
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SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 7
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 7
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
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ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
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VLSMHEGGTFMBBZ-OOZYFLPDSA-N kainic acid Chemical compound CC(=C)[C@H]1CN[C@H](C(O)=O)[C@H]1CC(O)=O VLSMHEGGTFMBBZ-OOZYFLPDSA-N 0.000 description 6
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UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
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HDFRDWFLWVCOGP-UHFFFAOYSA-N carbonothioic O,S-acid Chemical class OC(S)=O HDFRDWFLWVCOGP-UHFFFAOYSA-N 0.000 description 2
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WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 2
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GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 2
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CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 description 2
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SMATWHWTSTWTSA-UHFFFAOYSA-N 1-(5-nitro-1h-imidazol-2-yl)propan-1-ol Chemical compound CCC(O)C1=NC=C([N+]([O-])=O)N1 SMATWHWTSTWTSA-UHFFFAOYSA-N 0.000 description 1
PDQZJILHHPRLIX-UHFFFAOYSA-N 2-(1-ethylsulfanylpropyl)-5-nitro-1H-imidazole Chemical compound CCC(SCC)C=1NC(=CN=1)[N+](=O)[O-] PDQZJILHHPRLIX-UHFFFAOYSA-N 0.000 description 1
WFIYPADYPQQLNN-UHFFFAOYSA-N 2-[2-(4-bromopyrazol-1-yl)ethyl]isoindole-1,3-dione Chemical compound C1=C(Br)C=NN1CCN1C(=O)C2=CC=CC=C2C1=O WFIYPADYPQQLNN-UHFFFAOYSA-N 0.000 description 1
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229920005989 resin Polymers 0.000 description 1
208000022670 retrobulbar neuritis Diseases 0.000 description 1
239000012266 salt solution Substances 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
230000001568 sexual effect Effects 0.000 description 1
239000002002 slurry Substances 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000011877 solvent mixture Substances 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
208000002320 spinal muscular atrophy Diseases 0.000 description 1
239000008227 sterile water for injection Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
125000000547 substituted alkyl group Chemical group 0.000 description 1
239000000758 substrate Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
230000005062 synaptic transmission Effects 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
238000002054 transplantation Methods 0.000 description 1
230000008733 trauma Effects 0.000 description 1
230000000472 traumatic effect Effects 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
210000003901 trigeminal nerve Anatomy 0.000 description 1
230000004614 tumor growth Effects 0.000 description 1
230000007306 turnover Effects 0.000 description 1
239000012138 yeast extract Substances 0.000 description 1
-1 β-ethylthioethyl Chemical group 0.000 description 1

Landscapes

Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)

JP3634184A 1983-03-01 1984-02-29 ５−アセトアミド−３，５−ジデオキシ−ｄ−グリセロ−ｄ−ガラクトノヌロサミン酸のシチジンモノホスフエ−ト含有医薬組成物 Granted JPS606618A (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IT83341/83A IT1175061B (it)	1983-03-01	1983-03-01	Applicazione terapeutica del citidin monofosfato dell'acido 5-acetamido-3,5-dideossi-d-glicero-d-galattononulo saminico
IT83341/A/83		1983-03-01
IT83371/A/83		1983-04-20

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
JP1215137A Division JPH0276894A (ja)	1983-03-01	1989-08-23	５―アセトアミド―３，５―ジデオキシ―ｄ―グリセロ―ｄ―ガラクトノヌロサミン酸のシチジンモノホスフェートの製造方法

Publications (2)

Publication Number	Publication Date
JPS606618A JPS606618A (ja)	1985-01-14
JPH0216732B2 true JPH0216732B2 (de)	1990-04-18

Family

ID=11320404

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP3634184A Granted JPS606618A (ja)	1983-03-01	1984-02-29	５−アセトアミド−３，５−ジデオキシ−ｄ−グリセロ−ｄ−ガラクトノヌロサミン酸のシチジンモノホスフエ−ト含有医薬組成物

Country Status (2)

Country	Link
JP (1)	JPS606618A (de)
IT (1)	IT1175061B (de)

1983
- 1983-03-01 IT IT83341/83A patent/IT1175061B/it active
1984
- 1984-02-29 JP JP3634184A patent/JPS606618A/ja active Granted

Also Published As

Publication number	Publication date
IT1175061B (it)	1987-07-01
IT8383341A0 (it)	1983-03-01
JPS606618A (ja)	1985-01-14

Publication	Publication Date	Title
EP0120328B1 (de)	1988-10-19	Pharmazeutische Zusammensetzung welche 5-Acetamido-3,5-Dideoxy-D-Glycero-D-Galactononulosaminsäure Cytidin Monophosphat enthält
US4329302A (en)	1982-05-11	Synthetic phosphoglycerides possessing platelet activating properties
Schauer	1973	Chemistry and biology of the acylneuraminic acids
Maley et al.	1956	The synthesis of α-D-Glucosamine-1-phosphate and N-Acetyl-α-D-glucosamine-1-phosphate. Enzymatic formation of uridine Diphosphoglucosamine1
MXPA04001831A (es)	2004-07-08	Nuevos derivados sinteticos de gangliosidos y composiciones de los mismos.
HU199860B (en)	1990-03-28	Process for producing ganglioside derivatives and pharmaceutical compositions comprising such active ingredient
JPS60501259A (ja)	1985-08-08	免疫刺激活性をもつ単糖類化合物
Bolhuis et al.	1987	Ganglioside storage, hexosarninidase lability, and urinary oligosaccharides in adult Sandhoff's disease
DE69713514T2 (de)	2003-01-09	Festphasenträgeroberfläche die toxin-bindende oligosaccharide enthalten
WO2013004086A1 (zh)	2013-01-10	果糖基化芒果苷及其制备方法与用途
GB2179945A (en)	1987-03-18	New saccharides, their preparation and pharmacetical compositions containing them
Sufrin et al.	1980	Halogenated L-fucose and D-galactose analogs: synthesis and metabolic effects
JPH0216732B2 (de)	1990-04-18
RU2177788C2 (ru)	2002-01-10	Средство для профилактики и лечения инфекционных заболеваний и коррекции патологических состояний живого организма
JPS61176598A (ja)	1986-08-08	シチジン−ジホスフエ−ト−コリンのアシル化誘導体、その製造方法及びその治療的使用
AU754370B2 (en)	2002-11-14	Natural antitumor or antiviral substances and use of the same
US5811539A (en)	1998-09-22	Process for isolating and purifying nucleotide-activated sugars from biological sources
CA1243971A (en)	1988-11-01	Method for producing cytidine monophosphate of 5- acetamido-3,5-dideoxy-d-glycero-d- galactononulosaminic acid
Ponpipom et al.	1987	Inhibition of delayed hypersensitivity reactions by cinnamyl 1-thioglycosides
US7094557B2 (en)	2006-08-22	2-Methyl-3-butenyl-1-pyrophosphoric acid salt and agent for treating lymphocytes
DE3626915A1 (de)	1988-02-11	Verfahren zur enzymatischen synthese eines n-acetylneuraminsaeure-haltigen trisaccharids
Basu	1966	Studies on the biosynthesis of gangliosides
JP3547163B2 (ja)	2004-07-28	無血清培地を用いた物質生産方法
US4504474A (en)	1985-03-12	Synthetic phosphoglycerides possessing platelet activating properties
JPH02111785A (ja)	1990-04-24	スフインゴ糖脂質