JPH0247476B2 - - Google Patents

Info

Publication number
JPH0247476B2
JPH0247476B2 JP56116321A JP11632181A JPH0247476B2 JP H0247476 B2 JPH0247476 B2 JP H0247476B2 JP 56116321 A JP56116321 A JP 56116321A JP 11632181 A JP11632181 A JP 11632181A JP H0247476 B2 JPH0247476 B2 JP H0247476B2
Authority
JP
Japan
Prior art keywords
alkyl group
desoxy
dianhydro
nitrate
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP56116321A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5764700A (en
Inventor
Kuretsushinku Kurausu
Sundaa Chatajii Shuyamu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dokutoru Uirumaaru Shuwaabe Unto Co KG GmbH
Original Assignee
Dokutoru Uirumaaru Shuwaabe Unto Co KG GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dokutoru Uirumaaru Shuwaabe Unto Co KG GmbH filed Critical Dokutoru Uirumaaru Shuwaabe Unto Co KG GmbH
Publication of JPS5764700A publication Critical patent/JPS5764700A/ja
Publication of JPH0247476B2 publication Critical patent/JPH0247476B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
JP56116321A 1980-07-25 1981-07-24 1,4;3,6-dianhydrohexitol substituted with purine base, manufacture and drug composition Granted JPS5764700A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803028273 DE3028273A1 (de) 1980-07-25 1980-07-25 Durch purinbasen substituierte 1.4;3.6-dianhydro-hexit-nitrate

Publications (2)

Publication Number Publication Date
JPS5764700A JPS5764700A (en) 1982-04-19
JPH0247476B2 true JPH0247476B2 (2) 1990-10-19

Family

ID=6108126

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56116321A Granted JPS5764700A (en) 1980-07-25 1981-07-24 1,4;3,6-dianhydrohexitol substituted with purine base, manufacture and drug composition

Country Status (7)

Country Link
US (2) US4479951A (2)
EP (1) EP0044928B1 (2)
JP (1) JPS5764700A (2)
AT (1) ATE12117T1 (2)
CA (1) CA1190544A (2)
DE (1) DE3028273A1 (2)
ES (1) ES503486A0 (2)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3028288A1 (de) * 1980-07-25 1982-02-25 Fa. Dr. Willmar Schwabe, 7500 Karlsruhe Gegebenenfalls n-substituierte aminodesoxy-1.4;3.6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und deren verwendung
JPS6094992A (ja) * 1983-10-28 1985-05-28 Sankyo Co Ltd グリゼオ−ル酸誘導体
DE3421072A1 (de) * 1984-06-06 1985-12-12 Heinrich Mack Nachf., 7918 Illertissen 1,4:3,6-dianhydro-hexit-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE8817122U1 (de) * 1988-12-22 1993-02-04 Boehringer Ingelheim Kg, 55218 Ingelheim Neue Xanthinderivate mit Adenosinantogenistischer Wirkung
CA2014520C (en) * 1989-04-17 1996-07-16 Fumio Suzuki Hexitol derivatives
EP0538194B1 (de) * 1991-10-17 1997-06-04 Novartis AG Bicyclische Nukleoside, Oligonukleotide, Verfahren zu deren Herstellung und Zwischenprodukte
WO1994002497A1 (en) * 1992-07-15 1994-02-03 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Sulfo-derivatives of adenosine
AU683287B2 (en) 1993-07-23 1997-11-06 Merrell Pharmaceuticals Inc. Novel 9-N-bicyclic nucleoside agents useful as selective inhibitors of proinflammatory cytokines
US5994361A (en) * 1994-06-22 1999-11-30 Biochem Pharma Substituted purinyl derivatives with immunomodulating activity
US5786360A (en) * 1996-11-19 1998-07-28 Link Technology Incorporated A1 adenosine receptor antagonists
JP2006518390A (ja) * 2003-02-19 2006-08-10 エンダシア，インコーポレイテッド Ａ１アデノシンレセプターアンタゴニスト
CA2528385C (en) * 2003-06-06 2011-03-15 Endacea, Inc. A1 adenosine receptor antogonists
WO2004110379A2 (en) * 2003-06-09 2004-12-23 Endacea, Inc. A1 adenosine receptor antagonists
US8127691B2 (en) * 2004-03-03 2012-03-06 Fitzpatrick Technologies, Llc SMC pallet
US20060081158A1 (en) * 2004-10-19 2006-04-20 Fitzpatrick Technologies, L.L.C. Pultrusion pallet
US20070017423A1 (en) * 2005-07-19 2007-01-25 Ingham Terry L Pallet With Recycled Components
US20070017422A1 (en) * 2005-07-19 2007-01-25 Fitzpatrick Technologies, Llc Pallet with composite components
US8261673B2 (en) * 2007-09-26 2012-09-11 Fitzpatrick Technologies Pallet with lead board

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2852506A (en) * 1955-10-31 1958-09-16 American Cyanamid Co Method of preparing aminodeoxyglycosidopurines
US3886186A (en) * 1971-04-29 1975-05-27 American Home Prod Mononitrate esters of 1,4:3,6-dianhydro-d-glucitol
US4000137A (en) * 1975-06-10 1976-12-28 American Home Products Corporation Antitumor derivatives of periodate-oxidized nucleosides
US4087603A (en) * 1976-09-27 1978-05-02 Eli Lilly And Company Antifungal antibiotics
US4065488A (en) * 1977-02-24 1977-12-27 American Home Products Corporation Process for preparing 1,4:3,6-dianhydro-D-glucitol 2-nitrate
JPS55113786A (en) * 1979-02-23 1980-09-02 Toyo Jozo Co Ltd Novel substance, nepranosin b or f and its preparation
IL59664A0 (en) * 1979-04-05 1980-06-30 Wuelfing J Kg Xanthine derivatives,process for their preparation and their use in pharmaceutical compositions
DE3028272A1 (de) * 1980-07-25 1982-02-25 Fa. Dr. Willmar Schwabe, 7500 Karlsruhe Durch purinbasen substituierte alkylamino-desoxy-1.4;3.6-dianhydro-hexit-nitrate, verfahren zu ihrer herstellung und pharmazeutische zubereitung

Also Published As

Publication number Publication date
ES8204994A1 (es) 1982-05-16
US4479951A (en) 1984-10-30
DE3028273C2 (2) 1989-12-14
CA1190544A (en) 1985-07-16
US4622324A (en) 1986-11-11
EP0044928A1 (de) 1982-02-03
JPS5764700A (en) 1982-04-19
ATE12117T1 (de) 1985-03-15
DE3028273A1 (de) 1982-02-25
EP0044928B1 (de) 1985-03-13
ES503486A0 (es) 1982-05-16

Similar Documents

Publication Publication Date Title
JPH0247476B2 (2)
JP7627974B2 (ja) Ｃｄｋ７キナーゼ阻害剤として使用される化合物およびその適用
CN116234807B (zh) 喹唑啉类化合物
JPH01168689A (ja) Ｋ−２５２誘導体
JPH03173889A (ja) キサンチン誘導体
JPS61246184A (ja) ジアンヒドロヘキシツト誘導体、その製造方法およびその医薬としての用途
US20210403485A1 (en) Pyrazolopyrimidine derivative as selective trk inhibitor
PT89903B (pt) Processo para a preparacao de derivados de purinil piperazina 6-substituida
OA11661A (en) Derivatives of isosorbid mononitrate, utilization as vasodilator agents with reduced tolerance.
CZ396591A3 (en) Enantiomers of 1,4-dihydropyridine process of their preparation and pharmaceutical compositions prepared therefrom
US7371737B2 (en) 2-substituted-6-trifluoromethyl purine derivatives with adenosine-A3 antagonistic activity
KR20250086779A (ko) 치환 피페라진 유도체의 결정 및 이의 제조 방법
US20170027945A1 (en) Novel Compounds
AU2018238996B2 (en) Pharmaceutical composition for preventing and treating glaucoma, containing adenosine derivative
CA1186687A (en) Alkylaminodesoxy-1.4;3.6-dianhydrohexitol nitrates substituted by purine bases, processes for their preparation and pharmaceutical compositions
CA2579302A1 (en) 2-substituted-6-trifluoromethyl purine derivatives with adenosine-a3 antagonistic activity
JP2954647B2 (ja) ヘキシトール誘導体
CA1184916A (en) 2-0- and 5-0-substituted 1.4;3.6-dianhydrohexitol mononitrates, processes for their preparation and pharmaceutical composition
JPS637550B2 (2)
JPS62270586A (ja) イソヘキシドヌクレオシドおよびその組成物
EP0290885A2 (en) 1,4:3,6-Dianhydrosorbitol 2-mono-nitrate and 5-mononitrate esters, a process for the preparation thereof and pharmaceutical compositions therefrom
JPS5951263A (ja) 硝酸ピリジルアルキルエステル化合物、その製造法およびそれを含有する医薬製剤
CS198166B2 (en) Method of producing new 1,1-disubstituted octahydroindolo/2,3-a/quinolizines
HAYASHI et al. 1, 4: 3, 6-Dianhydrohexitol nitrate derivatives. I. Synthesis and antianginal activity of alkylpiperazine derivatives
JP2843671B2 (ja) キサンチン誘導体