JPH0317811B2 - - Google Patents

Info

Publication number: JPH0317811B2
Authority: JP; Japan
Prior art keywords: weight; hydrochloride; parts; maleic anhydride; drug
Prior art date: 1985-06-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP13592085A

Other languages

English (en)

Japanese (ja)

Other versions

JPS61293931A (ja

Inventor

Juji Makino

Hideo Matsuki

Yoshiki Suzuki

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Teijin Ltd

Original Assignee

Teijin Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-06-24

Filing date

1985-06-24

Publication date

1991-03-11

1985-06-24 Application filed by Teijin Ltd filed Critical Teijin Ltd

1985-06-24 Priority to JP13592085A priority Critical patent/JPS61293931A/ja

1986-01-06 Priority to DE8686300039T priority patent/DE3686275T2/de

1986-01-06 Priority to EP86300039A priority patent/EP0187703B1/fr

1986-01-10 Priority to US06/817,649 priority patent/US4814176A/en

1986-06-03 Priority to DE8686304192T priority patent/DE3676235D1/de

1986-06-03 Priority to EP86304192A priority patent/EP0207638B1/fr

1986-06-04 Priority to US06/870,480 priority patent/US4755544A/en

1986-12-24 Publication of JPS61293931A publication Critical patent/JPS61293931A/ja

1987-07-29 Priority to MYPI87001164A priority patent/MY101593A/en

1991-03-11 Publication of JPH0317811B2 publication Critical patent/JPH0317811B2/ja

Status Granted legal-status Critical Current

Links

239000003814 drug Substances 0.000 claims description 31
229940079593 drug Drugs 0.000 claims description 28
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HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 18
CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 13
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VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
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GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
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JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
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FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 2
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QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
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AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol hydrochloride Natural products C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 2
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IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 description 2
ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 2
KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 1
UHSXRTHJCJGEKG-UQKRIMTDSA-N (1s)-1-[(3,4,5-trimethoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinolin-2-ium-6,7-diol;chloride Chemical compound Cl.COC1=C(OC)C(OC)=CC(C[C@H]2C3=CC(O)=C(O)C=C3CCN2)=C1 UHSXRTHJCJGEKG-UQKRIMTDSA-N 0.000 description 1
LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
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VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
CIVCELMLGDGMKZ-UHFFFAOYSA-N 2,4-dichloro-6-methylpyridine-3-carboxylic acid Chemical compound CC1=CC(Cl)=C(C(O)=O)C(Cl)=N1 CIVCELMLGDGMKZ-UHFFFAOYSA-N 0.000 description 1
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NKQVYJRZBVRXRU-UHFFFAOYSA-N 2-methyl-2-(methylamino)propanenitrile Chemical compound CNC(C)(C)C#N NKQVYJRZBVRXRU-UHFFFAOYSA-N 0.000 description 1
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DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 description 1
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DOQPXTMNIUCOSY-UHFFFAOYSA-N [4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl]-[2-(3,4-dimethoxyphenyl)ethyl]-methylazanium;chloride Chemical compound [H+].[Cl-].C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 DOQPXTMNIUCOSY-UHFFFAOYSA-N 0.000 description 1
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239000010452 phosphate Substances 0.000 description 1
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229960002508 pindolol Drugs 0.000 description 1
JZQKKSLKJUAGIC-UHFFFAOYSA-N pindolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=C1C=CN2 JZQKKSLKJUAGIC-UHFFFAOYSA-N 0.000 description 1
229960005414 pirbuterol Drugs 0.000 description 1
FFNMBRCFFADNAO-UHFFFAOYSA-N pirenzepine hydrochloride Chemical compound [H+].[H+].[Cl-].[Cl-].C1CN(C)CCN1CC(=O)N1C2=NC=CC=C2NC(=O)C2=CC=CC=C21 FFNMBRCFFADNAO-UHFFFAOYSA-N 0.000 description 1
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239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000000843 powder Substances 0.000 description 1
229960002386 prazosin hydrochloride Drugs 0.000 description 1
WFXFYZULCQKPIP-UHFFFAOYSA-N prazosin hydrochloride Chemical compound [H+].[Cl-].N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1=CC=CO1 WFXFYZULCQKPIP-UHFFFAOYSA-N 0.000 description 1
229960005205 prednisolone Drugs 0.000 description 1
OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
150000003180 prostaglandins Chemical class 0.000 description 1
238000010298 pulverizing process Methods 0.000 description 1
229950000112 serrapeptase Drugs 0.000 description 1
108010038132 serratiopeptidase Proteins 0.000 description 1
JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 description 1
229940033331 soy sterol Drugs 0.000 description 1
210000003802 sputum Anatomy 0.000 description 1
208000024794 sputum Diseases 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
229960005202 streptokinase Drugs 0.000 description 1
229960000894 sulindac Drugs 0.000 description 1
MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 description 1
229960004940 sulpiride Drugs 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
WFWLQNSHRPWKFK-ZCFIWIBFSA-N tegafur Chemical compound O=C1NC(=O)C(F)=CN1[C@@H]1OCCC1 WFWLQNSHRPWKFK-ZCFIWIBFSA-N 0.000 description 1
229960001674 tegafur Drugs 0.000 description 1
229960005105 terbutaline sulfate Drugs 0.000 description 1
KFVSLSTULZVNPG-UHFFFAOYSA-N terbutaline sulfate Chemical compound [O-]S([O-])(=O)=O.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1 KFVSLSTULZVNPG-UHFFFAOYSA-N 0.000 description 1
WUBVEMGCQRSBBT-UHFFFAOYSA-N tert-butyl 4-(trifluoromethylsulfonyloxy)-3,6-dihydro-2h-pyridine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(OS(=O)(=O)C(F)(F)F)=CC1 WUBVEMGCQRSBBT-UHFFFAOYSA-N 0.000 description 1
229960000278 theophylline Drugs 0.000 description 1
229950009883 tocopheryl nicotinate Drugs 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
229960000363 trapidil Drugs 0.000 description 1
229960005294 triamcinolone Drugs 0.000 description 1
GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
229960002117 triamcinolone acetonide Drugs 0.000 description 1
YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
229960001177 trimetazidine Drugs 0.000 description 1
229960000881 verapamil hydrochloride Drugs 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Landscapes

Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

JP13592085A 1985-01-11 1985-06-24 徐放性医薬品組成物 Granted JPS61293931A (ja)

Priority Applications (8)

Application Number	Priority Date	Filing Date	Title
JP13592085A JPS61293931A (ja)	1985-06-24	1985-06-24	徐放性医薬品組成物
DE8686300039T DE3686275T2 (de)	1985-01-11	1986-01-06	Praeparate mit verzoegerter freisetzung.
EP86300039A EP0187703B1 (fr)	1985-01-11	1986-01-06	Préparations à libération prolongée
US06/817,649 US4814176A (en)	1985-01-11	1986-01-10	Sustained release preparation
DE8686304192T DE3676235D1 (de)	1985-06-04	1986-06-03	Arzneizubereitung mit verzoegerter wirkstoffabgabe.
EP86304192A EP0207638B1 (fr)	1985-06-04	1986-06-03	Préparation pharmaceutique à liberation prolongé
US06/870,480 US4755544A (en)	1985-06-04	1986-06-04	Sustained release preparation
MYPI87001164A MY101593A (en)	1985-06-04	1987-07-29	Sustained release preparation.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP13592085A JPS61293931A (ja)	1985-06-24	1985-06-24	徐放性医薬品組成物

Publications (2)

Publication Number	Publication Date
JPS61293931A JPS61293931A (ja)	1986-12-24
JPH0317811B2 true JPH0317811B2 (fr)	1991-03-11

Family

ID=15162936

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP13592085A Granted JPS61293931A (ja)	1985-01-11	1985-06-24	徐放性医薬品組成物

Country Status (1)

Country	Link
JP (1)	JPS61293931A (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1216043E (pt) *	1999-10-01	2003-09-30	Degussa	Forma de libertacao retardada contendo (derivados de) acido alfa-lipoico
FR2802424B1 (fr) *	1999-12-17	2002-02-15	Adir	Comprime matriciel permettant la liberation prolongee de trimetazidine apres administration par voie orale

1985
- 1985-06-24 JP JP13592085A patent/JPS61293931A/ja active Granted

Also Published As

Publication number	Publication date
JPS61293931A (ja)	1986-12-24

Legal Events

Date	Code	Title	Description
2004-03-11	LAPS	Cancellation because of no payment of annual fees

Publication	Publication Date	Title
EP0207638B1 (fr)	1990-12-19	Préparation pharmaceutique à liberation prolongé
JP2916152B2 (ja)	1999-07-05	薬物放出速度調節型製剤
JP2528130B2 (ja)	1996-08-28	経口投与形体の徐放性医薬組成物
JP4077886B2 (ja)	2008-04-23	不溶性薬剤の持効性ヘテロ分散ヒドロゲル系
AU595801B2 (en)	1990-04-12	Oral pharmaceutical composition
CA2251816C (fr)	2004-07-06	Systemes d'hydrogels heterodisperses - medicaments amorphes a liberation prolongee
JP4072597B2 (ja)	2008-04-09	持続性製剤
ES2304980T3 (es)	2008-11-01	Sistemas de matriz de liberacion sostenida para farmacos altamente solubles.
US20060127478A1 (en)	2006-06-15	Oral dosage formulation
JPH1029936A (ja)	1998-02-03	アセタミノフェンの持続放出性処方
JP2001511156A (ja)	2001-08-07	高いバイオアベイラビリティーを有するフェノフィブレート医薬組成物及びそれを調製するための方法
JPH10513481A (ja)	1998-12-22	医薬製剤
WO2009034541A2 (fr)	2009-03-19	Formes galéniques à libération contrôlée à base de trimétazidine
JPH09143073A (ja)	1997-06-03	持続性ニフエジピン製剤
EP0231826A2 (fr)	1987-08-12	Comprimé de théophylline à libération retardée
JPH1017497A (ja)	1998-01-20	徐放性製剤およびその製造方法
US20060088594A1 (en)	2006-04-27	Highly compressible controlled delivery compositions of metformin
JP2004504278A (ja)	2004-02-12	キノロン抗生物質の徐放性製剤及びその製造方法。
WO2003105848A1 (fr)	2003-12-24	Composition medicamenteuse a liberation prolongee
JP3962108B2 (ja)	2007-08-22	スクラルファート含有製剤組成物
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