JPH03184909A - Cleaning agent composition having low stimulative property - Google Patents

Abstract

PURPOSE:To obtain the title composition having high safety, reduced stimulative property to skin and hair and mild action and having excellent foaming force and cleaning force by combining a specific anionic surfactant with a specific amphoteric surfactant. CONSTITUTION:The aimed cleaning composition having low stimulative property and containing an anionic surfactant [e.g. palm oil fatty acid sulfuric acid sodium salt of N-polyoxyethylene(4EO) palm oil fatty acid sulfuric acid sodium salt] expressed by formula I (R1 is 7-17C alkyl or alkenyl; M1 is alkali metal; n is 2-5) and amphoteric surfactant [e.g. 2-[dimethyl(2-hydroxy-3-desiloxypropyl) ammonio]ethylphosphate, etc.] as active ingredients. The aimed composition has remarkably low stimulative property to skin while satisfying essential conditions as a cleaning agent such as foaming property and cleaning property.

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to a detergent composition that satisfies essential requirements for a detergent, such as foaming properties and cleansing properties, and has extremely low irritation to the skin. It is.

[Conventional technology]

Conventionally, surfactants and surfactant compositions with strong protein denaturing power have caused severe roughness when used repeatedly, whereas surfactants and surfactant compositions with low protein denaturing power (for example, shampoos) ) is well known to be less likely to cause skin disorders such as rough hands even when used for a long period of time, and to have extremely low irritation to the skin.

On the other hand, anionic surfactants represented by the general formula <A) below are used in detergents such as facial cleansers and shampoos due to their excellent detergency, but they also have protein denaturing power and skin irritation. It has the disadvantage of being highly sensitive and prone to skin problems such as rough hands. Against this background and with the advancement of living standards, there is a strong demand for the development of low skin irritation surfactants and cleaning compositions that are highly safe for the human body. is the current situation.

[Problem to be solved by the invention]

As a result of intensive research aimed at improving the drawbacks of the prior art, the present inventors have determined that an appropriate amount of the amphoteric surfactant represented by form (B) described in Japanese Patent Application No. 1983-206616 has been determined as follows. - When mixed with the anionic surfactant represented by type (A), it satisfies the essential requirements as a detergent such as foaming properties and detergency, but has low protein denaturation power and causes skin problems such as rough hands. The present inventors have discovered that it is possible to obtain a detergent composition that hardly causes skin irritation and has extremely low skin irritation, and has completed the present invention.

An object of the present invention is to provide a detergent composition that satisfies essential requirements for a detergent such as foaming properties and cleansing properties, and has extremely low irritation to the skin.

[Means to solve the problem]

The present invention has the general formula (^) R, CNII (CIl□CHJ). SO3M+
・・・・・・・・・・・・(A) (In the above formula, R1 is an alkyl group or alkenyl group having 7 to 17 carbon atoms, formerly an alkali metal, and n is a number of 2 to 5.) Contains an anionic surfactant represented by the following and an amphoteric surfactant represented by the general formula (b) (in the above formula, R2 represents an alkyl group having 10 to 18 carbon atoms) as active ingredients. It is a hypoallergenic cleaning composition.

The anionic surfactant represented by the above-mentioned format (A) in the present invention is, for example, N-polyoxyethylene (4E
,Ol) sodium coconut oil fatty acid amide sulfate, N-polyoxyethylene (4B, 0.) sodium oleic acid amide sulfate, N-polyoxyethylene (4E, O,) potassium lauric acid amide sulfate, N-polyoxyethylene (
2E, O,) palmidic acid ξdosulfuric acid, lithium, N
- Polyoxyethylene (3E, 0.) Potassium caprylic acid odosulfate, N-polyoxyethylene (5E.

0,) sodium stearamide sulfate, N polyoxyethylene (3E, O,) sodium laurate azide sulfate, and the like.

In addition, as the amphoteric surfactant represented by the above-mentioned format (B), for example, 2-[dimethyl(2-hydroxy-3
-desyloxyprobyl)ammonio]ethyl phosphate (hereinafter referred to as compound 1).

2-[dimethyl(2-hydroxy-3-dodecyloxybrobyl)ammonio]ethyl phosphate (compound 2
), 2-(dimethyl(2-hydroxy-3-tetradecyloxypropyl)ammonio)ethyl phosphate (compound 3), 2-(dimethyl(2-hydroxy-
Examples thereof include 3-hexadecyloxypropyl)ammonio]ethyl phosphate (compound 4), 2-C dimethyl(2-hydroxy-3-octadecyloxypropyl)ammonio]ethylphosphate (compound 5), and the like.

The anionic surfactant represented by the above-mentioned type (A) has sufficient surfactant properties such as foaming properties and detergent properties, but has a rather strong protein denaturing power, and when used alone, it does not achieve the desired effect. Hypoallergenic cleaning products are not available.

On the other hand, the amphoteric surfactant represented by the above-mentioned form (B) has very low protein denaturation power and weak irritation, but has foaming properties and
It has only moderate surfactant ability such as detergency.

By combining the anionic surfactant represented by the above-mentioned form (A) and the amphoteric surfactant represented by the above-mentioned form (B), the viscosity increases and the criticality increases more than when each is used alone. Phenomena such as a decrease in micelle concentration occur, and surfactant properties such as foaming and detergent properties are reduced by the above-mentioned type (
It is not inferior to the case of the anionic surfactant represented by A) alone, and at the same time, the protein denaturation power is as high as that of the above-mentioned type (B).
It was possible to significantly reduce the amount of water to almost the same level as when using the amphoteric surfactant alone.

That is, by combining the anionic surfactant represented by the above-mentioned form (A) and the amphoteric surfactant represented by the above-mentioned form (B) to form a complex, a synergistic effect is clearly exerted. This made it possible to obtain a mild detergent composition that maintains excellent surfactant ability and has low protein denaturation ability.

The mixing ratio (weight ratio) of (A):(B) is 3:
The ratio is in the range of 1 to 1:20, and the content of (A) + (B) is preferably 10 to 50% by weight based on the total amount of the cleaning agent. If the mixing ratio is outside this range or if a large amount of other anionic surfactant is added to disrupt the balance of the system, the desired effect of lowering protein denaturation performance cannot be obtained.

The cleaning composition of the present invention may optionally contain ingredients commonly added to cleaning agents, such as higher alcohols, lanolin derivatives, protein derivatives, oily ingredients such as fatty acid esters of polyethylene glycol, propylene glycol, glycerin, polyethylene glycol, etc. Moisturizing ingredients such as glycol, nonionic surfactants such as fatty acid alkalolamide, polyoxyethylene alkyl ether, and alkylamine oxide, water-soluble polymer substances (anionic, nonionic,
(including cationic ones), sequestering agents, preservatives, bactericidal agents, pH adjusters, ultraviolet absorbers, antioxidants, pigments, fragrances, and the like.

〔Example〕

Next, the present invention will be explained in detail with reference to Examples, but the present invention is not limited thereto. Prior to the examples, the test methods employed in each example will be explained.

(Foaming test method) Test was performed using the Ross Miles test method (ASTMD 117353). In addition, the evaluation criteria were set as follows.

○...Good foaming, foam volume 200mj! More than △...
Foaming is normal, foam volume is 150m42 or more, 200mI! , Less than x...Poor foaming Foam amount Less than 150 mff1 (Cleanability test method) 7% lanolin on a 5 cm x 5 cm wool muslin cloth
and Sudan If 0.005% chloroform solution 0
, 4 ml was evenly applied and dried, and the contaminated cloth was
Approximately 1ooml containing 40rr+IV of detergent solution
The cloth was placed in a glass cylinder and shaken for 15 minutes in a constant temperature bath at 40"C. The contaminated cloth was thoroughly rinsed under running water and dried. The reflectance was examined and the cleaning rate was determined using the following formula.

In addition, the evaluation criteria were set as follows.

○: Good cleaning performance Cleaning efficiency 80% or more △: Normal cleaning performance Washing efficiency 60% or more but less than 80% The egg white Aldagon denaturation rate when the sample is added to the albumin pH7 buffer solution at a sample concentration of 1% is calculated at 220nf.
It was measured using the absorption peak of fi.

Ho: Height of the 220 nm absorption peak of ovalbumin Hs: 2 when the sample is added to the ovalbumin buffer solution
The criteria for evaluating the height of the 20 nm absorption peak was set as follows.

◎: Ovalbumin denaturation rate less than 30% ○: Ovalbumin denaturation rate 30% or more and less than 60% Δ: Ovalbumin denaturation rate 60% or more and less than 80% ×: Ovalbumin denaturation rate 80% or more (rough hand test method) Each For each sample, a panel of 10 people in total, 5 men and 5 men, was used, with one hand on either the left or right, at a test concentration of 5% and a temperature of 35°.
An operation of immersing the other hand in the aqueous solution of C and water at the same temperature for 10 minutes was performed twice a day for 2 consecutive days, and the difference in rough skin between the left and right hands was visually determined.

0 ◎... Extremely weak hand roughness 0-1 out of 10 people noticed rough hands on the sample side ○... Slightly weak hand roughness 2-4 out of 10 people found hand roughness on the sample side Δ...・Slightly rough hands 5-7 out of 10 people observed rough hands on the sample side ×...Extremely rough hands 8-10 out of 10 IO people found rough hands on the sample side Examples 1-8, comparison Examples 1 to 2 A shampoo consisting of the formulation shown in Table 1 was prepared,
Table 1 shows the results of examining its foaming properties, cleaning properties, protein denaturation rate, and roughness.

As is clear from Table 1, the shampoo of the present invention had excellent properties. On the other hand, the above-format (B)
Comparative Example 1, which lacks the amphoteric surfactant represented by the protein denaturation rate 1, is undesirable due to poor hand roughness, and Comparative Example 2, which lacks the anionic surfactant represented by the above-mentioned form (^), exhibits no foaming. It was unfavorable due to its poor performance and cleanability.

1 Example 9 A body shampoo consisting of the following formulation was prepared.

(Weight%) Compound 16 Compound 46 Glycerin 2 Flavor
0.3 water
The results of examining the foaming properties, cleansing properties, protein denaturation rate, and roughness on hands of the remaining body shampoo were ○, O20, and ◎, respectively.

〔Effect of the invention〕

As described above, the present invention provides a hypoallergenic cleansing agent that is highly safe, has a mild action with little irritation to the skin and hair, and has excellent foaming and cleaning power. It is clear that

3

Claims (1)

[Claims] General formula (A) ▲There are mathematical formulas, chemical formulas, tables, etc.▼・・・・・・・・・
...(A) (In the above formula, R_1 is an alkyl group or alkenyl group having 7 to 17 carbon atoms, M_1 is an alkali metal, and n is a number from 2 to 5.) An anionic surfactant represented by and General formula (B) ▲There are mathematical formulas, chemical formulas, tables, etc.▼・・・・・・・・・
...(B) (In the above formula, R_2 represents an alkyl group having 10 to 18 carbon atoms.) A hypoallergenic cleaning composition containing an amphoteric surfactant represented by the following as an active ingredient.