JPH03294229A - 新しい生物的に分解可能な注射可能なミクロスフェア、これらの新しいミクロスフェアの調製方法及びそれらを含む注射可能な懸濁液 - Google Patents

新しい生物的に分解可能な注射可能なミクロスフェア、これらの新しいミクロスフェアの調製方法及びそれらを含む注射可能な懸濁液

Info

Publication number: JPH03294229A
Authority: JP; Japan
Prior art keywords: group; carbon atoms; microspheres; formula; copolymer
Prior art date: 1989-11-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP2306374A

Other languages

English (en)

Japanese (ja)

Inventor

Cohen Gerard

ジェラール・コーエン

Dubois Jean-Luc

ジャンリュク・デュボワ

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi Aventis France

Original Assignee

Roussel Uclaf SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-15

Filing date

1990-11-14

Publication date

1991-12-25

1990-11-14 Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA

1991-12-25 Publication of JPH03294229A publication Critical patent/JPH03294229A/ja

Status Pending legal-status Critical Current

Links

239000004005 microsphere Substances 0.000 title claims abstract description 31
238000000034 method Methods 0.000 title claims description 15
239000000725 suspension Substances 0.000 title description 2
AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims abstract description 38
229920001577 copolymer Polymers 0.000 claims abstract description 22
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 22
JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 claims abstract description 14
230000001833 anti-estrogenic effect Effects 0.000 claims abstract description 14
239000000328 estrogen antagonist Substances 0.000 claims abstract description 14
150000003431 steroids Chemical class 0.000 claims abstract description 13
229940046836 anti-estrogen Drugs 0.000 claims abstract description 12
239000004310 lactic acid Substances 0.000 claims abstract description 10
235000014655 lactic acid Nutrition 0.000 claims abstract description 10
239000003814 drug Substances 0.000 claims abstract description 4
239000002904 solvent Substances 0.000 claims abstract 7
239000012074 organic phase Substances 0.000 claims abstract 5
239000012071 phase Substances 0.000 claims abstract 4
239000003995 emulsifying agent Substances 0.000 claims abstract 3
239000000839 emulsion Substances 0.000 claims abstract 2
125000004432 carbon atom Chemical group C* 0.000 claims description 41
239000000126 substance Substances 0.000 claims description 26
125000000217 alkyl group Chemical group 0.000 claims description 18
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 18
239000000583 progesterone congener Substances 0.000 claims description 10
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 8
239000002253 acid Substances 0.000 claims description 8
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 8
229920006395 saturated elastomer Polymers 0.000 claims description 7
125000000304 alkynyl group Chemical group 0.000 claims description 6
125000003710 aryl alkyl group Chemical group 0.000 claims description 6
229910052799 carbon Inorganic materials 0.000 claims description 6
125000005842 heteroatom Chemical group 0.000 claims description 6
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims description 6
229910052757 nitrogen Inorganic materials 0.000 claims description 6
125000003342 alkenyl group Chemical group 0.000 claims description 5
230000000694 effects Effects 0.000 claims description 5
125000000547 substituted alkyl group Chemical group 0.000 claims description 5
125000000732 arylene group Chemical group 0.000 claims description 4
125000004429 atom Chemical group 0.000 claims description 4
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
229910052760 oxygen Inorganic materials 0.000 claims description 4
239000001301 oxygen Substances 0.000 claims description 4
150000003839 salts Chemical class 0.000 claims description 4
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 3
229940079593 drug Drugs 0.000 claims description 3
125000001424 substituent group Chemical group 0.000 claims description 3
125000004070 6 membered heterocyclic group Chemical group 0.000 claims description 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 2
125000004423 acyloxy group Chemical group 0.000 claims description 2
125000001931 aliphatic group Chemical group 0.000 claims description 2
125000003118 aryl group Chemical group 0.000 claims description 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
125000004433 nitrogen atom Chemical group N* 0.000 claims description 2
125000000962 organic group Chemical group 0.000 claims description 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
239000011593 sulfur Substances 0.000 claims description 2
229910052717 sulfur Inorganic materials 0.000 claims description 2
125000004434 sulfur atom Chemical group 0.000 claims description 2
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 6
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 4
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
239000003960 organic solvent Substances 0.000 claims 3
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
239000008346 aqueous phase Substances 0.000 claims 2
229940102213 injectable suspension Drugs 0.000 claims 2
238000002360 preparation method Methods 0.000 claims 2
KVQZTSMGPIUHME-HKBOAZHASA-N (8S,13S,14S)-13-but-2-enyl-2,6,7,8,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-one Chemical compound C(=CC)C[C@@]12CCC[C@H]1[C@@H]1CCC3=CC(CCC3=C1CC2)=O KVQZTSMGPIUHME-HKBOAZHASA-N 0.000 claims 1
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical group CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 1
239000004372 Polyvinyl alcohol Substances 0.000 claims 1
150000001875 compounds Chemical class 0.000 claims 1
125000004663 dialkyl amino group Chemical group 0.000 claims 1
230000008020 evaporation Effects 0.000 claims 1
238000001704 evaporation Methods 0.000 claims 1
125000001183 hydrocarbyl group Chemical group 0.000 claims 1
125000000468 ketone group Chemical group 0.000 claims 1
LTHCSWBWNVGEFE-UHFFFAOYSA-N octanamide Chemical compound CCCCCCCC(N)=O LTHCSWBWNVGEFE-UHFFFAOYSA-N 0.000 claims 1
229920000747 poly(lactic acid) Polymers 0.000 claims 1
229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 1
239000004626 polylactic acid Substances 0.000 claims 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
229920000053 polysorbate 80 Polymers 0.000 claims 1
229920002451 polyvinyl alcohol Polymers 0.000 claims 1
235000010413 sodium alginate Nutrition 0.000 claims 1
239000000661 sodium alginate Substances 0.000 claims 1
229940005550 sodium alginate Drugs 0.000 claims 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
238000010792 warming Methods 0.000 claims 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
150000000795 D-homosteroids Chemical class 0.000 abstract 1
150000002875 norsteroids Chemical class 0.000 abstract 1
238000003756 stirring Methods 0.000 abstract 1
150000007513 acids Chemical class 0.000 description 7
239000004480 active ingredient Substances 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
125000002252 acyl group Chemical group 0.000 description 2
-1 alkanesulfonic acids Chemical class 0.000 description 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
150000001721 carbon Chemical group 0.000 description 2
XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
HHLFWLYXYJOTON-UHFFFAOYSA-N glyoxylic acid Chemical compound OC(=O)C=O HHLFWLYXYJOTON-UHFFFAOYSA-N 0.000 description 2
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
125000006017 1-propenyl group Chemical group 0.000 description 1
125000000530 1-propynyl group Chemical group [H]C([H])([H])C#C* 0.000 description 1
BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
239000005711 Benzoic acid Substances 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
235000011054 acetic acid Nutrition 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
235000003704 aspartic acid Nutrition 0.000 description 1
235000010233 benzoic acid Nutrition 0.000 description 1
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
235000015165 citric acid Nutrition 0.000 description 1
CCIVGXIOQKPBKL-UHFFFAOYSA-N ethanesulfonic acid Chemical class CCS(O)(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-N 0.000 description 1
235000019253 formic acid Nutrition 0.000 description 1
239000001530 fumaric acid Substances 0.000 description 1
239000000321 herbal drug Substances 0.000 description 1
241000411851 herbal medicine Species 0.000 description 1
150000002419 homosteroids Chemical group 0.000 description 1
150000002430 hydrocarbons Chemical group 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
150000002576 ketones Chemical group 0.000 description 1
238000011866 long-term treatment Methods 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
229910017604 nitric acid Inorganic materials 0.000 description 1
235000006408 oxalic acid Nutrition 0.000 description 1
235000011007 phosphoric acid Nutrition 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
235000019260 propionic acid Nutrition 0.000 description 1
125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 description 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
230000002123 temporal effect Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Steroid Compounds (AREA)
Manufacturing Of Micro-Capsules (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

JP2306374A 1989-11-15 1990-11-14 新しい生物的に分解可能な注射可能なミクロスフェア、これらの新しいミクロスフェアの調製方法及びそれらを含む注射可能な懸濁液 Pending JPH03294229A (ja)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR898914976A FR2654337B1 (fr)	1989-11-15	1989-11-15	Nouvelles microspheres injectables biodegradables procede de preparation et suspensions injectables les renfermant.
FR89-14976		1989-11-15

Publications (1)

Publication Number	Publication Date
JPH03294229A true JPH03294229A (ja)	1991-12-25

Family

ID=9387417

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2306374A Pending JPH03294229A (ja)	1989-11-15	1990-11-14	新しい生物的に分解可能な注射可能なミクロスフェア、これらの新しいミクロスフェアの調製方法及びそれらを含む注射可能な懸濁液

Country Status (13)

Country	Link
JP (1)	JPH03294229A (da)
AT (1)	AT400298B (da)
BE (1)	BE1005511A4 (da)
CA (1)	CA2029940A1 (da)
CH (1)	CH681691A5 (da)
DE (1)	DE4036425A1 (da)
DK (1)	DK270990A (da)
FR (1)	FR2654337B1 (da)
GB (1)	GB2239798B (da)
IT (1)	IT1242010B (da)
LU (1)	LU87836A1 (da)
NL (1)	NL9002492A (da)
SE (1)	SE9003570L (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU222501B1 (hu) *	1991-06-28	2003-07-28	Endorecherche Inc.	MPA-t vagy MGA-t tartalmazó nyújtott hatóanyag-felszabadulású gyógyászati készítmény és eljárás előállítására
ZA924811B (en) *	1991-06-28	1993-12-29	Endorecherche Inc	Controlled release systems and low dose androgens
RU2128055C1 (ru) *	1992-12-07	1999-03-27	Такеда Кемикал Индастриз Лтд.	Фармацевтическая композиция замедленного высвобождения и способ ее получения
DE69405491T2 (de) *	1993-06-24	1998-02-19	Lilly Co Eli	Antiöstrogene 2-Phenyl-3-Aroylbenzothiophene als hypoglykämische Mittel
US5910492A (en) *	1995-06-05	1999-06-08	Takeda Chemical Industries, Ltd.	Osteogenic promoting pharmaceutical composition
EP2210585A1 (en)	2009-01-16	2010-07-28	Exelgyn	SPRM pharmaceutical compositions methods of treatment using them

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3773919A (en) *	1969-10-23	1973-11-20	Du Pont	Polylactide-drug mixtures
US4293539A (en) *	1979-09-12	1981-10-06	Eli Lilly And Company	Controlled release formulations and method of treatment
US4389330A (en) *	1980-10-06	1983-06-21	Stolle Research And Development Corporation	Microencapsulation process
ZA8231B (en) *	1981-01-09	1982-11-24	Roussel Uclaf	New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
FR2528434B1 (fr) *	1982-06-11	1985-07-19	Roussel Uclaf	Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament
US4530840A (en) *	1982-07-29	1985-07-23	The Stolle Research And Development Corporation	Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
FR2537980B1 (fr) *	1982-12-17	1986-12-19	Sandoz Sa	Derives d'acides hydroxycarboxyliques oligomeres, leur preparation et leur utilisation
ES533260A0 (es) *	1983-06-15	1985-02-01	Schering Ag	Procedimiento para la preparacion de 13a-alquilgonanos
GB8327256D0 (en) *	1983-10-12	1983-11-16	Ici Plc	Steroid derivatives
JPS60100516A (ja) *	1983-11-04	1985-06-04	Takeda Chem Ind Ltd	徐放型マイクロカプセルの製造法
DE3347126A1 (de) *	1983-12-22	1985-07-11	Schering AG, 1000 Berlin und 4709 Bergkamen	11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
FR2566779B2 (fr) *	1984-06-29	1987-03-06	Roussel Uclaf	Nouveaux derives steroides substitues en 11b, leur procede de preparation et leur application comme medicaments
CA1256638A (en) *	1984-07-06	1989-06-27	Motoaki Tanaka	Polymer and its production
FR2573657B1 (fr) *	1984-11-29	1989-05-12	Roussel Uclaf	Produit comprenant une substance antiprogestomimetique et une substance uterotonique
DE3533175A1 (de) *	1985-09-13	1987-03-19	Schering Ag	Antigestagene zur verschiebung der endometrialen reifung
FR2596395B1 (fr) *	1986-03-26	1989-05-26	Roussel Uclaf	Nouveaux steroides comportant un cycle spirannique en position 17, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
US4758435A (en) *	1986-08-11	1988-07-19	American Cyanamid Company	Estradiol implant composition and method for preparation
DE3633244A1 (de) *	1986-09-26	1988-03-31	Schering Ag	Antigestagene zur hemmung der uterinen prostaglandinsynthese
EP0310542B1 (de) *	1987-10-01	1994-06-08	Schering Aktiengesellschaft	Antigestagen- und antiöstrogenwirksame Verbindungen zur Behandlung hormonabhängiger Tumoren
DE3733478A1 (de) *	1987-10-01	1989-04-13	Schering Ag	Antigestagen- und antioestrogenwirksame verbindungen zur geburtseinleitung und zum schwangerschaftsabbruch sowie zur behandlung gynaekologischer stoerungen und hormonabhaengiger tumore
DE3744054A1 (de) *	1987-12-21	1989-06-29	Schering Ag	Verwendung von antigestagenen zur herstellung von arzneimitteln
BE1004905A4 (fr) *	1987-12-30	1993-02-23	Roussel Uclaf	Nouveaux derives 17beta-oh 19-nor steroides substitues en 17alpha, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant.
JP2670680B2 (ja) *	1988-02-24	1997-10-29	株式会社ビーエムジー	生理活性物質含有ポリ乳酸系微小球およびその製造法

1989
- 1989-11-15 FR FR898914976A patent/FR2654337B1/fr not_active Expired - Fee Related
1990
- 1990-11-08 LU LU87836A patent/LU87836A1/fr unknown
- 1990-11-09 SE SE9003570A patent/SE9003570L/ not_active Application Discontinuation
- 1990-11-09 BE BE9001062A patent/BE1005511A4/fr not_active IP Right Cessation
- 1990-11-13 DK DK270990A patent/DK270990A/da not_active Application Discontinuation
- 1990-11-13 IT IT48470A patent/IT1242010B/it active IP Right Grant
- 1990-11-14 CA CA002029940A patent/CA2029940A1/fr not_active Abandoned
- 1990-11-14 JP JP2306374A patent/JPH03294229A/ja active Pending
- 1990-11-14 CH CH3611/90A patent/CH681691A5/fr not_active IP Right Cessation
- 1990-11-15 AT AT0231390A patent/AT400298B/de not_active IP Right Cessation
- 1990-11-15 DE DE4036425A patent/DE4036425A1/de not_active Withdrawn
- 1990-11-15 NL NL9002492A patent/NL9002492A/nl not_active Application Discontinuation
- 1990-11-15 GB GB9024862A patent/GB2239798B/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ATA231390A (de)	1995-04-15
CA2029940A1 (fr)	1991-05-16
DK270990D0 (da)	1990-11-13
BE1005511A4 (fr)	1993-08-31
FR2654337B1 (fr)	1994-08-05
GB9024862D0 (en)	1991-01-02
IT9048470A1 (it)	1992-05-13
LU87836A1 (fr)	1991-05-07
CH681691A5 (da)	1993-05-14
DK270990A (da)	1991-05-16
SE9003570D0 (sv)	1990-11-09
FR2654337A1 (fr)	1991-05-17
IT9048470A0 (it)	1990-11-13
GB2239798B (en)	1993-10-27
IT1242010B (it)	1994-02-02
AT400298B (de)	1995-11-27
SE9003570L (sv)	1991-05-16
DE4036425A1 (de)	1991-05-16
GB2239798A (en)	1991-07-17
NL9002492A (nl)	1991-06-03

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