JPH0338246B2 - - Google Patents

Info

Publication number: JPH0338246B2
Authority: JP; Japan
Prior art keywords: lysine; skin; acyl; poultices; drug
Prior art date: 1984-05-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP8970584A

Other languages

English (en)

Japanese (ja)

Other versions

JPS60233011A (ja

Inventor

Masumi Koishi

Koichiro Sagawa

Masahiro Takehara

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ajinomoto Co Inc

Original Assignee

Ajinomoto Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-05-04

Filing date

1984-05-04

Publication date

1991-06-10

1984-05-04 Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc

1984-05-04 Priority to JP8970584A priority Critical patent/JPS60233011A/ja

1985-11-19 Publication of JPS60233011A publication Critical patent/JPS60233011A/ja

1991-06-10 Publication of JPH0338246B2 publication Critical patent/JPH0338246B2/ja

Status Granted legal-status Critical Current

Links

KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 19
239000004472 Lysine Substances 0.000 claims description 18
125000002252 acyl group Chemical group 0.000 claims description 4
125000001931 aliphatic group Chemical group 0.000 claims description 4
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
229910052799 carbon Inorganic materials 0.000 claims description 2
125000004432 carbon atom Chemical group C* 0.000 claims description 2
235000018977 lysine Nutrition 0.000 description 18
239000003814 drug Substances 0.000 description 16
229940079593 drug Drugs 0.000 description 15
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 10
239000000546 pharmaceutical excipient Substances 0.000 description 9
239000000843 powder Substances 0.000 description 8
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
239000005995 Aluminium silicate Substances 0.000 description 6
235000012211 aluminium silicate Nutrition 0.000 description 6
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 6
238000000034 method Methods 0.000 description 6
OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 6
MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 6
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 5
235000011187 glycerol Nutrition 0.000 description 5
XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 4
CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 4
239000008213 purified water Substances 0.000 description 4
239000005844 Thymol Substances 0.000 description 3
150000001875 compounds Chemical class 0.000 description 3
235000014113 dietary fatty acids Nutrition 0.000 description 3
230000000694 effects Effects 0.000 description 3
239000000194 fatty acid Substances 0.000 description 3
229930195729 fatty acid Natural products 0.000 description 3
150000004665 fatty acids Chemical class 0.000 description 3
238000004898 kneading Methods 0.000 description 3
239000007788 liquid Substances 0.000 description 3
239000001525 mentha piperita l. herb oil Substances 0.000 description 3
235000019477 peppermint oil Nutrition 0.000 description 3
150000003839 salts Chemical class 0.000 description 3
239000000454 talc Substances 0.000 description 3
229910052623 talc Inorganic materials 0.000 description 3
229960000790 thymol Drugs 0.000 description 3
NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 2
DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 2
LVYLCBNXHHHPSB-UHFFFAOYSA-N 2-hydroxyethyl salicylate Chemical compound OCCOC(=O)C1=CC=CC=C1O LVYLCBNXHHHPSB-UHFFFAOYSA-N 0.000 description 2
PDQICKRFOKDJCH-UHFFFAOYSA-N 6-amino-2-(dodecanoylamino)hexanoic acid Chemical compound CCCCCCCCCCCC(=O)NC(C(O)=O)CCCCN PDQICKRFOKDJCH-UHFFFAOYSA-N 0.000 description 2
OLDGKSQBWGEFNM-UHFFFAOYSA-N 6-amino-2-(hexadecanoylamino)hexanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)NC(C(O)=O)CCCCN OLDGKSQBWGEFNM-UHFFFAOYSA-N 0.000 description 2
206010040880 Skin irritation Diseases 0.000 description 2
-1 acyl lysine Chemical compound 0.000 description 2
150000007933 aliphatic carboxylic acids Chemical class 0.000 description 2
239000000440 bentonite Substances 0.000 description 2
229910000278 bentonite Inorganic materials 0.000 description 2
SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
KVYGGMBOZFWZBQ-UHFFFAOYSA-N benzyl nicotinate Chemical compound C=1C=CN=CC=1C(=O)OCC1=CC=CC=C1 KVYGGMBOZFWZBQ-UHFFFAOYSA-N 0.000 description 2
229960000846 camphor Drugs 0.000 description 2
YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 description 2
239000004744 fabric Substances 0.000 description 2
FODTZLFLDFKIQH-FSVGXZBPSA-N gamma-Oryzanol (TN) Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)O[C@@H]2C([C@@H]3CC[C@H]4[C@]5(C)CC[C@@H]([C@@]5(C)CC[C@@]54C[C@@]53CC2)[C@H](C)CCC=C(C)C)(C)C)=C1 FODTZLFLDFKIQH-FSVGXZBPSA-N 0.000 description 2
229960000905 indomethacin Drugs 0.000 description 2
230000002401 inhibitory effect Effects 0.000 description 2
238000002156 mixing Methods 0.000 description 2
239000000203 mixture Substances 0.000 description 2
230000035790 physiological processes and functions Effects 0.000 description 2
230000029058 respiratory gaseous exchange Effects 0.000 description 2
230000036556 skin irritation Effects 0.000 description 2
231100000475 skin irritation Toxicity 0.000 description 2
229920003169 water-soluble polymer Polymers 0.000 description 2
239000011787 zinc oxide Substances 0.000 description 2
DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 1
HCJMNOSIAGSZBM-UHFFFAOYSA-N 6-methylsalicylic acid Chemical compound CC1=CC=CC(O)=C1C(O)=O HCJMNOSIAGSZBM-UHFFFAOYSA-N 0.000 description 1
241000723346 Cinnamomum camphora Species 0.000 description 1
208000034656 Contusions Diseases 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
201000004624 Dermatitis Diseases 0.000 description 1
229920002085 Dialdehyde starch Polymers 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
208000010201 Exanthema Diseases 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
206010061218 Inflammation Diseases 0.000 description 1
239000005909 Kieselgur Substances 0.000 description 1
235000006679 Mentha X verticillata Nutrition 0.000 description 1
235000002899 Mentha suaveolens Nutrition 0.000 description 1
235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
208000000112 Myalgia Diseases 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
208000010040 Sprains and Strains Diseases 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
239000000853 adhesive Substances 0.000 description 1
230000001070 adhesive effect Effects 0.000 description 1
230000001919 adrenal effect Effects 0.000 description 1
210000004100 adrenal gland Anatomy 0.000 description 1
125000003368 amide group Chemical group 0.000 description 1
235000001014 amino acid Nutrition 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
125000003277 amino group Chemical group 0.000 description 1
239000002280 amphoteric surfactant Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
206010003246 arthritis Diseases 0.000 description 1
229950004580 benzyl nicotinate Drugs 0.000 description 1
229940116229 borneol Drugs 0.000 description 1
CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 1
229930008380 camphor Natural products 0.000 description 1
229960002504 capsaicin Drugs 0.000 description 1
235000017663 capsaicin Nutrition 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
230000008602 contraction Effects 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
239000003599 detergent Substances 0.000 description 1
DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 1
239000010642 eucalyptus oil Substances 0.000 description 1
229940044949 eucalyptus oil Drugs 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
201000005884 exanthem Diseases 0.000 description 1
238000009472 formulation Methods 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
229960002389 glycol salicylate Drugs 0.000 description 1
229910052736 halogen Inorganic materials 0.000 description 1
150000002367 halogens Chemical class 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
125000001183 hydrocarbyl group Chemical group 0.000 description 1
125000001165 hydrophobic group Chemical group 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
230000005923 long-lasting effect Effects 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
230000007721 medicinal effect Effects 0.000 description 1
229940041616 menthol Drugs 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
229960001047 methyl salicylate Drugs 0.000 description 1
208000013465 muscle pain Diseases 0.000 description 1
239000003921 oil Substances 0.000 description 1
235000019198 oils Nutrition 0.000 description 1
239000003002 pH adjusting agent Substances 0.000 description 1
229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
229920000915 polyvinyl chloride Polymers 0.000 description 1
239000004800 polyvinyl chloride Substances 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
235000018102 proteins Nutrition 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
206010037844 rash Diseases 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
229920005989 resin Polymers 0.000 description 1
239000011347 resin Substances 0.000 description 1
206010039073 rheumatoid arthritis Diseases 0.000 description 1
RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1

Landscapes

Medicinal Preparation (AREA)

JP8970584A 1984-05-04 1984-05-04 パツプ剤 Granted JPS60233011A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP8970584A JPS60233011A (ja)	1984-05-04	1984-05-04	パツプ剤

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP8970584A JPS60233011A (ja)	1984-05-04	1984-05-04	パツプ剤

Publications (2)

Publication Number	Publication Date
JPS60233011A JPS60233011A (ja)	1985-11-19
JPH0338246B2 true JPH0338246B2 (de)	1991-06-10

Family

ID=13978191

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP8970584A Granted JPS60233011A (ja)	1984-05-04	1984-05-04	パツプ剤

Country Status (1)

Country	Link
JP (1)	JPS60233011A (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2003301654A1 (en) *	2002-10-22	2004-05-13	Dainippon Pharmaceutical Co., Ltd.	Stabilized composition

1984
- 1984-05-04 JP JP8970584A patent/JPS60233011A/ja active Granted

Also Published As

Publication number	Publication date
JPS60233011A (ja)	1985-11-19

Publication	Publication Date	Title
CA1202240A (en)	1986-03-25	Transdermal 2-(4-isobutylphenyl)-propionic acid medication and methods
KR840003414A (ko)	1984-09-08	3-히드록시부탄산 또는 이 산으로부터 유도된 염을 함유하는 약학적 조성물과, 의약품으로 사용할 수 있는 3-히드록시부탄산으로부터 유도된 화합물
JPH0215023A (ja)	1990-01-18	麻酔性／皮膚加湿組成物およびその製造方法
UA124181C2 (uk)	2021-07-28	Знеболююча композиція місцевої дії
KR880000091A (ko)	1988-03-23	국소용 약제학적 조성물 이의 제조방법 및 이의 용도
JP2013515002A5 (de)	2017-07-20
JPH03505450A (ja)	1991-11-28	胃腸病用の経皮抗分泌剤
JPH08175986A (ja)	1996-07-09	経皮活性を示す５−アミノレブリン酸含有薬学組成物
KR970032872A (ko)	1997-07-22	아세틸살리실산을 함유하는 피부 손상 처치용 약물
ES2861052T3 (es)	2021-10-05	Composición tópica que comprende oxibutinina para el tratamiento de la hiperhidrosis
WO2014163030A1 (ja)	2014-10-09	馬の炎症治療のための製剤
KR100543558B1 (ko)	2006-01-20	덱스케토프로펜 트로메타몰을 함유하는 반고형 약제
CA2145968A1 (en)	1995-10-06	Topical antipruritic composition
JPH0338246B2 (de)	1991-06-10
JP2002356430A (ja)	2002-12-13	吉草酸酢酸プレドニゾロン及び抗ヒスタミン剤を含む皮膚外用剤
EP0030023A3 (de)	1981-09-02	Heterocyclische Verbindung und ihre Herstellung, sie enthaltende pharmazeutische Zusammensetzungen und die Verwendung der Verbindung und der Zusammensetzung in der Medizin
US5444076A (en)	1995-08-22	Pharmaceutical preparation for topical application
JPH083069A (ja)	1996-01-09	経皮吸収促進剤及び皮膚外用剤
RU2144816C1 (ru)	2000-01-27	Ранозаживляющая композиция "леста"
JPH11199482A (ja)	1999-07-27	外用剤組成物
EP0252033B1 (de)	1990-12-27	N-(2,6-Dichlor-m-tolyl)anthranilsäure (Mechlophenaminsäure) enthaltenden Gel-Arzneiform zur Verwendung in der Lokaltherapie
JP2764261B2 (ja)	1998-06-11	外用消炎鎮痛剤
JP7253328B2 (ja)	2023-04-06	外用医薬組成物
JP2003055185A5 (de)	2008-07-24
JPS61200918A (ja)	1986-09-05	外用消炎鎮痛剤