JPH0367056B2 - - Google Patents

Info

Publication number: JPH0367056B2
Authority: JP; Japan
Prior art keywords: insulin; zinc; hexamer; solution; content
Prior art date: 1982-02-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

JP58016303A

Other languages

English (en)

Japanese (ja)

Other versions

JPS58192818A (ja

Inventor

Yorugen Beirugaaruto Burange Iensu

Haberundo Subendo

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

NOBO NORUDEISUKU AB

Original Assignee

NOBO NORUDEISUKU AB

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-02-05

Filing date

1983-02-04

Publication date

1991-10-21

1983-02-04 Application filed by NOBO NORUDEISUKU AB filed Critical NOBO NORUDEISUKU AB

1983-11-10 Publication of JPS58192818A publication Critical patent/JPS58192818A/ja

1991-10-21 Publication of JPH0367056B2 publication Critical patent/JPH0367056B2/ja

Status Granted legal-status Critical Current

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 324
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HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 71
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PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims description 31
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PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 21
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KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 18
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 17
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JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 4
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Classifications

- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K13/00—Apparatus or processes specially adapted for manufacturing or adjusting assemblages of electric components
- H05K13/06—Wiring by machine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Zoology (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Manufacturing & Machinery (AREA)
Microelectronics & Electronic Packaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

JP58016303A 1982-02-05 1983-02-04 インシュリン製剤 Granted JPS58192818A (ja)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK49182		1982-02-05
DK491/82		1982-02-05

Publications (2)

Publication Number	Publication Date
JPS58192818A JPS58192818A (ja)	1983-11-10
JPH0367056B2 true JPH0367056B2 (2)	1991-10-21

Family

ID=8094159

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP58016303A Granted JPS58192818A (ja)	1982-02-05	1983-02-04	インシュリン製剤

Country Status (22)

Country	Link
US (1)	US4476118A (2)
JP (1)	JPS58192818A (2)
AT (1)	AT382780B (2)
AU (1)	AU549981B2 (2)
BE (1)	BE895832A (2)
CA (1)	CA1203476A (2)
CH (1)	CH657530A5 (2)
DE (1)	DE3303860A1 (2)
ES (1)	ES519533A0 (2)
FI (1)	FI78616C (2)
FR (1)	FR2521009B1 (2)
GB (1)	GB2114573B (2)
GR (1)	GR77388B (2)
IE (1)	IE54548B1 (2)
IT (1)	IT1178455B (2)
LU (1)	LU84632A1 (2)
NL (1)	NL187269C (2)
NO (1)	NO161204C (2)
NZ (1)	NZ203189A (2)
PT (1)	PT76195B (2)
SE (1)	SE460948B (2)
ZA (1)	ZA83742B (2)

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BRPI0513508B1 (pt) *	2004-07-19	2021-06-01	Biocon Limited	Conjugados de insulina-oligômero, formulações e usos desses
JP4808785B2 (ja)	2005-12-28	2011-11-02	ノボ・ノルデイスク・エー／エス	インスリン組成物および組成物の製造方法
US20090136538A1 (en) *	2006-05-22	2009-05-28	Jan Jezek	Stable vaccine formulation
GB0700523D0 (en) *	2007-01-11	2007-02-21	Insense Ltd	The Stabilisation Of Proteins
ES2841379T3 (es)	2007-03-13	2021-07-08	Jds Therapeutics Llc	Procedimientos y composiciones para la liberación sostenida de cromo
US9034818B2 (en) *	2007-06-13	2015-05-19	Novo Nordisk A/S	Pharmaceutical formulations comprising an insulin derivative
WO2009002867A2 (en)	2007-06-26	2008-12-31	Nutrition 21, Inc.	Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement
JP5241849B2 (ja) *	2007-11-16	2013-07-17	ノボ・ノルデイスク・エー／エス	インスリン及びインスリン分泌性ペプチドを含む薬学的組成物
EP2328607A1 (en) *	2008-07-16	2011-06-08	Arecor Limited	Stable formulation of a therapeutic protein
EP2341940A1 (en) *	2008-07-16	2011-07-13	Arecor Limited	The stabilisation of proteins
AU2009309623B9 (en) *	2008-10-30	2014-10-02	Novo Nordisk A/S	Treating diabetes melitus using insulin injections with less than daily injection frequency
US9060927B2 (en)	2009-03-03	2015-06-23	Biodel Inc.	Insulin formulations for rapid uptake
DK2632478T3 (da)	2010-10-27	2019-10-07	Novo Nordisk As	Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller
AU2012223282B2 (en)	2011-03-01	2017-02-02	Nutrition 21, Llc	Compositions of insulin and chromium for the treatment and prevention of diabetes, hypoglycemia and related disorders
EP2919804B1 (fr)	2012-11-13	2018-01-31	Adocia	Formulation à action rapide d'insuline comprenant un composé anionique substitué
US9707275B2 (en) *	2012-12-19	2017-07-18	Wockhardt Limited	Stable aqueous composition comprising human insulin or an analogue or derivative thereof
JP2016505601A (ja)	2012-12-26	2016-02-25	ウォックハートリミテッド	医薬組成物
TWI780236B (zh) *	2013-02-04	2022-10-11	法商賽諾菲公司	胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物
JP2016519127A (ja)	2013-04-30	2016-06-30	ノヴォノルディスクアー／エス	新規投与レジメン
WO2015084694A2 (en) *	2013-12-04	2015-06-11	Merck Sharp & Dohme Corp.	Method for preparing crystalline insulin
AR102869A1 (es)	2014-12-16	2017-03-29	Lilly Co Eli	Composiciones de insulina de rápida acción
JO3749B1 (ar)	2015-08-27	2021-01-31	Lilly Co Eli	تركيبات إنسولين سريعة المفعول
CA3014308A1 (en)	2016-02-11	2017-08-17	Nutrition 21, Llc	Chromium containing compositions for improving health and fitness
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KR20190140048A (ko)	2017-06-01	2019-12-18	일라이 릴리 앤드 캄파니	신속-작용 인슐린 조성물
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FR1263220A (fr) *	1958-08-01	1961-06-09	Novo Terapeutisk Labor As	Procédé de production d'une préparation d'insuline à action rapide
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WO1983003054A1 (en) *	1982-03-03	1983-09-15	Johansen, Kristian, Betton	A proces for producing an insulin preparation

1983
- 1983-02-03 FI FI830375A patent/FI78616C/fi not_active IP Right Cessation
- 1983-02-04 IE IE220/83A patent/IE54548B1/en not_active IP Right Cessation
- 1983-02-04 GR GR70416A patent/GR77388B/el unknown
- 1983-02-04 NL NLAANVRAGE8300440,A patent/NL187269C/xx not_active IP Right Cessation
- 1983-02-04 BE BE6/47775A patent/BE895832A/fr not_active IP Right Cessation
- 1983-02-04 ES ES519533A patent/ES519533A0/es active Granted
- 1983-02-04 US US06/463,730 patent/US4476118A/en not_active Expired - Lifetime
- 1983-02-04 NZ NZ203189A patent/NZ203189A/en unknown
- 1983-02-04 JP JP58016303A patent/JPS58192818A/ja active Granted
- 1983-02-04 CH CH657/83A patent/CH657530A5/de not_active IP Right Cessation
- 1983-02-04 AT AT0038983A patent/AT382780B/de not_active IP Right Cessation
- 1983-02-04 CA CA000420907A patent/CA1203476A/en not_active Expired
- 1983-02-04 IT IT19420/83A patent/IT1178455B/it active
- 1983-02-04 FR FR8301790A patent/FR2521009B1/fr not_active Expired
- 1983-02-04 ZA ZA83742A patent/ZA83742B/xx unknown
- 1983-02-04 DE DE19833303860 patent/DE3303860A1/de active Granted
- 1983-02-04 GB GB08303133A patent/GB2114573B/en not_active Expired
- 1983-02-04 AU AU11136/83A patent/AU549981B2/en not_active Expired
- 1983-02-04 SE SE8300598A patent/SE460948B/sv not_active IP Right Cessation
- 1983-02-04 PT PT76195A patent/PT76195B/pt unknown
- 1983-02-04 NO NO830385A patent/NO161204C/no not_active IP Right Cessation
- 1983-02-04 LU LU84632A patent/LU84632A1/de unknown

Also Published As

Publication number	Publication date
IE830220L (en)	1983-08-05
FR2521009B1 (fr)	1987-07-17
SE8300598L (sv)	1983-08-06
AU1113683A (en)	1983-08-11
NO161204B (no)	1989-04-10
GB2114573B (en)	1985-05-01
GR77388B (2)	1984-09-11
CA1203476A (en)	1986-04-22
AU549981B2 (en)	1986-02-20
GB8303133D0 (en)	1983-03-09
JPS58192818A (ja)	1983-11-10
GB2114573A (en)	1983-08-24
FI830375A0 (fi)	1983-02-03
FR2521009A1 (fr)	1983-08-12
PT76195A (en)	1983-03-01
ZA83742B (en)	1983-11-30
ES8500060A1 (es)	1984-10-16
LU84632A1 (fr)	1983-09-08
FI78616B (fi)	1989-05-31
SE460948B (sv)	1989-12-11
ATA38983A (de)	1986-09-15
IT1178455B (it)	1987-09-09
IE54548B1 (en)	1989-11-08
NZ203189A (en)	1985-07-31
DE3303860A1 (de)	1983-08-18
NO161204C (no)	1989-07-19
SE8300598D0 (sv)	1983-02-04
PT76195B (en)	1986-01-27
NL187269B (nl)	1991-03-01
NO830385L (no)	1983-08-08
AT382780B (de)	1987-04-10
US4476118A (en)	1984-10-09
NL8300440A (nl)	1983-09-01
IT8319420A0 (it)	1983-02-04
NL187269C (nl)	1991-08-01
DE3303860C2 (2)	1989-12-28
FI830375L (fi)	1983-08-06
FI78616C (fi)	1989-09-11
ES519533A0 (es)	1984-10-16
CH657530A5 (de)	1986-09-15
BE895832A (fr)	1983-08-04

Publication	Publication Date	Title
JPH0367056B2 (2)	1991-10-21
FI80595B (fi)	1990-03-30	Foerfarande foer framstaellning av en vattenhaltig insulinloesning som aer fysikaliskt stabiliserad mot graensytepolymerisation.
US6034054A (en)	2000-03-07	Stable insulin formulations
US6734162B2 (en)	2004-05-11	Mixed buffer system for stabilizing polypeptide formulations
US4472385A (en)	1984-09-18	Stabilized insulin preparations and method for their production
JP2002500196A (ja)	2002-01-08	安定化させたインスリン組成物
WO2018115901A1 (en)	2018-06-28	Glucagon-like peptide 1 (glp-1) receptor agonist compositions
EP1283051B1 (en)	2006-06-14	Stable insulin formulations
JP4064455B2 (ja)	2008-03-19	成長ホルモンおよびロイシンを含んでなる医薬製剤
JP2020527396A5 (2)	2021-08-19
JPH0366290B2 (2)	1991-10-16
US10952973B2 (en)	2021-03-23	Production method of pregabalin-containing composition and pregabalin-containing composition
JPH0366291B2 (2)	1991-10-16
DK150813B (da)	1987-06-29	Fremgangsmaade til fremstilling af stabiliserede insulinoploesninger
JPH10298102A (ja)	1998-11-10	カルシトニン注射液
JPH07138184A (ja)	1995-05-30	エルカトニン水性注射用製剤
JP2000219641A (ja)	2000-08-08	薬物の血液脳関門透過性向上方法
DK149833B (da)	1986-10-13	Fremgangsmaade til fremstilling af et oploest zinkinsulinpraeparat, derer fysisk stabilt