JPH0430961B2 - - Google Patents

Info

Publication number
JPH0430961B2
JPH0430961B2 JP60147612A JP14761285A JPH0430961B2 JP H0430961 B2 JPH0430961 B2 JP H0430961B2 JP 60147612 A JP60147612 A JP 60147612A JP 14761285 A JP14761285 A JP 14761285A JP H0430961 B2 JPH0430961 B2 JP H0430961B2
Authority
JP
Japan
Prior art keywords
gel
water
weight
dvs
molecular weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP60147612A
Other languages
English (en)
Japanese (ja)
Other versions
JPS61138601A (ja
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of JPS61138601A publication Critical patent/JPS61138601A/ja
Publication of JPH0430961B2 publication Critical patent/JPH0430961B2/ja
Granted legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/731Cellulose; Quaternized cellulose derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP60147612A 1984-12-06 1985-07-04 架橋ヒアルロン酸ゲル組成物 Granted JPS61138601A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US678895 1984-12-06
US06/678,895 US4582865A (en) 1984-12-06 1984-12-06 Cross-linked gels of hyaluronic acid and products containing such gels

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP1232667A Division JPH0637575B2 (ja) 1984-12-06 1989-09-06 架橋ヒアルロン酸ゲル組成物及び製造法

Publications (2)

Publication Number Publication Date
JPS61138601A JPS61138601A (ja) 1986-06-26
JPH0430961B2 true JPH0430961B2 (2) 1992-05-25

Family

ID=24724742

Family Applications (2)

Application Number Title Priority Date Filing Date
JP60147612A Granted JPS61138601A (ja) 1984-12-06 1985-07-04 架橋ヒアルロン酸ゲル組成物
JP1232667A Expired - Lifetime JPH0637575B2 (ja) 1984-12-06 1989-09-06 架橋ヒアルロン酸ゲル組成物及び製造法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP1232667A Expired - Lifetime JPH0637575B2 (ja) 1984-12-06 1989-09-06 架橋ヒアルロン酸ゲル組成物及び製造法

Country Status (9)

Country Link
US (1) US4582865A (2)
JP (2) JPS61138601A (2)
AU (2) AU569157B2 (2)
CA (1) CA1230186A (2)
DE (2) DE3546811C2 (2)
FR (1) FR2574414B1 (2)
GB (4) GB2168067B (2)
IT (1) IT1187737B (2)
SE (2) SE460792B (2)

Families Citing this family (298)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0611694B2 (ja) * 1985-01-29 1994-02-16 生化学工業株式会社 皮膚化粧料
US4863907A (en) * 1984-06-29 1989-09-05 Seikagaku Kogyo Co., Ltd. Crosslinked glycosaminoglycans and their use
US5128326A (en) * 1984-12-06 1992-07-07 Biomatrix, Inc. Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
US5099013A (en) * 1985-03-12 1992-03-24 Biomatrix, Inc, Hylan preparation and method of recovery thereof from animal tissues
US4713448A (en) * 1985-03-12 1987-12-15 Biomatrix, Inc. Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues
US4851521A (en) * 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
US5202431A (en) * 1985-07-08 1993-04-13 Fidia, S.P.A. Partial esters of hyaluronic acid
DE3684887D1 (de) * 1985-11-29 1992-05-21 Biomatrix Inc Arzneistoffabgabesysteme auf basis von hyaluronan, dessen derivaten und salzen sowie verfahren zu deren herstellung.
IT1198449B (it) * 1986-10-13 1988-12-21 F I D I Farmaceutici Italiani Esteri di alcoli polivalenti di acido ialuronico
AU610512B2 (en) * 1986-12-11 1991-05-23 Biomatrix Incorporated Improved hyaluronate-poly (ethylene oxide) mixtures
AU604542B2 (en) * 1987-03-19 1990-12-20 Arthropharm Pty Ltd Polysulphated polysaccharide complexes
US4795741A (en) * 1987-05-06 1989-01-03 Biomatrix, Inc. Compositions for therapeutic percutaneous embolization and the use thereof
GB8713662D0 (en) * 1987-06-11 1987-07-15 Skandigen Ab Hyaluronic acid derivatives
US4937270A (en) * 1987-09-18 1990-06-26 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US5527893A (en) * 1987-09-18 1996-06-18 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US6610669B1 (en) 1987-09-18 2003-08-26 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US5017229A (en) * 1990-06-25 1991-05-21 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US6174999B1 (en) 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
AU619760B2 (en) * 1987-12-10 1992-02-06 Genzyme Biosurgery Corporation Hylan preparation and method of recovery thereof from animal tissues
US4888016A (en) * 1988-02-10 1989-12-19 Langerman David W "Spare parts" for use in ophthalmic surgical procedures
IT1219587B (it) * 1988-05-13 1990-05-18 Fidia Farmaceutici Polisaccaridi carbossiilici autoreticolati
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
JPH0662678B2 (ja) * 1988-11-28 1994-08-17 電気化学工業株式会社 ヒアルロン酸固定化蛋白質及びその製造方法
US4973473A (en) * 1989-06-23 1990-11-27 Revlon, Inc. Skin care preparation
US5356883A (en) * 1989-08-01 1994-10-18 Research Foundation Of State University Of N.Y. Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use
CA1340994C (en) * 1989-09-21 2000-05-16 Rudolf Edgar Dr. Falk Treatment of conditions and disease
US5153174A (en) * 1989-10-30 1992-10-06 Union Carbide Chemicals & Plastics Inc. Polymer mixtures useful in skin care
WO1992000745A1 (en) * 1990-07-03 1992-01-23 Autogenesis Technologies, Inc. Collagen-based viscoelastic solution for visco-surgery
US5246698A (en) * 1990-07-09 1993-09-21 Biomatrix, Inc. Biocompatible viscoelastic gel slurries, their preparation and use
US5143724A (en) * 1990-07-09 1992-09-01 Biomatrix, Inc. Biocompatible viscoelastic gel slurries, their preparation and use
US5990096A (en) * 1990-09-18 1999-11-23 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US5910489A (en) * 1990-09-18 1999-06-08 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
US5824658A (en) * 1990-09-18 1998-10-20 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
CA2061703C (en) * 1992-02-20 2002-07-02 Rudolf E. Falk Formulations containing hyaluronic acid
US5639738A (en) * 1992-02-20 1997-06-17 Hyal Pharmaceutical Corporation Treatment of basal cell carcinoma and actinic keratosis employing hyaluronic acid and NSAIDs
US5219360A (en) * 1991-05-10 1993-06-15 Fortis Research Corporation Mammary prosthesis fill and method of making same
EP0516026A1 (en) * 1991-05-28 1992-12-02 Takeda Chemical Industries, Ltd. Hydrogel and method of producing same
US5234914A (en) * 1991-06-11 1993-08-10 Patent Biopharmaceutics, Inc. Methods of treating hemorrhoids and anorecial disease
US5792753A (en) * 1991-07-03 1998-08-11 Hyal Pharmaceutical Corporation Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs
US6022866A (en) * 1991-07-03 2000-02-08 Hyal Pharmaceutical Corporation Use of hyaluronic acid and forms to prevent arterial restenosis
US5990095A (en) * 1991-07-03 1999-11-23 Hyal Pharmaceutical Corporation Use of hyaluronic acid and forms to prevent arterial restenosis
US5977088A (en) * 1991-07-03 1999-11-02 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
WO1994007505A1 (en) * 1991-07-03 1994-04-14 Norpharmco Inc. Use of hyaluronic acid and forms to prevent arterial restenosis
US5817644A (en) * 1991-07-03 1998-10-06 Hyal Pharmaceutical Corporation Targeting of dosages of medicine and therapeutic agents
US6103704A (en) * 1991-07-03 2000-08-15 Hyal Pharmaceutical Corporation Therapeutic methods using hyaluronic acid
JPH0539480U (ja) * 1991-10-31 1993-05-28 ジユーキ株式会社 ミシンの針棒
EP0544259A1 (en) * 1991-11-27 1993-06-02 Lignyte Co., Ltd. Water insoluble biocompatible hyaluronic and polyion complex and method of making the same
DE4200080A1 (de) * 1992-01-03 1993-09-30 Reinmueller Johannes Pharmazeutische Zusammensetzung zur Wund-, Narben- und Keloidbehandlung
CA2072918A1 (en) * 1992-02-14 1993-08-15 Jian Qin Modified polysaccharides having improved absorbent properties and process for the preparation thereof
CA2061567C (en) * 1992-02-20 1998-02-03 Rudolf E. Falk Use of hyaluronic acid to repair ischemia reperfusion damage
US6136793A (en) * 1992-02-20 2000-10-24 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US6218373B1 (en) 1992-02-20 2001-04-17 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US5767106A (en) * 1992-02-21 1998-06-16 Hyal Pharmaceutical Corporation Treatment of disease and conditions associated with macrophage infiltration
US6114314A (en) * 1992-02-21 2000-09-05 Hyal Pharmaceutical Corp. Formulations containing hyaluronic acid
DE69321285T2 (de) * 1992-05-15 1999-03-04 Shiseido Co. Ltd., Tokio/Tokyo Äusserliches Hautpräparat
IT1260154B (it) * 1992-07-03 1996-03-28 Lanfranco Callegaro Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn)
WO1994021299A1 (en) * 1993-03-19 1994-09-29 Medinvent A composition and a method for tissue augmentation
US5437867A (en) * 1993-03-19 1995-08-01 Collaborative Laboratories Solubilizing, thickening and emulsifying cosmetic composition and process for preparation of same
US5531716A (en) * 1993-09-29 1996-07-02 Hercules Incorporated Medical devices subject to triggered disintegration
US5616568A (en) * 1993-11-30 1997-04-01 The Research Foundation Of State University Of New York Functionalized derivatives of hyaluronic acid
US5585361A (en) 1994-06-07 1996-12-17 Genzyme Corporation Methods for the inhibition of platelet adherence and aggregation
US6294202B1 (en) 1994-10-06 2001-09-25 Genzyme Corporation Compositions containing polyanionic polysaccharides and hydrophobic bioabsorbable polymers
US5690961A (en) * 1994-12-22 1997-11-25 Hercules Incorporated Acidic polysaccharides crosslinked with polycarboxylic acids and their uses
US5498705A (en) * 1995-02-22 1996-03-12 Kimberly-Clark Corporation Modified polysaccharides having improved absorbent properties and process for the preparation thereof
US5612321A (en) * 1995-06-22 1997-03-18 Hercules Incorporated Antioxidant grafted polysaccharides
US5827937A (en) * 1995-07-17 1998-10-27 Q Med Ab Polysaccharide gel composition
US5897880A (en) 1995-09-29 1999-04-27 Lam Pharmaceuticals, Llc. Topical drug preparations
WO1997017023A1 (en) 1995-11-07 1997-05-15 Fusion Medical Technologies, Inc. Methods and articles for fusing polysaccharide-containing matrix layers to tissue
US6132462A (en) * 1995-12-22 2000-10-17 Santen Pharmaceutical Co., Ltd. Copolymers formed from three components and intraocular lenses made thereof
SE9601368D0 (sv) * 1996-04-11 1996-04-11 Pharmacia Biotech Ab Process for the production of a porous cross-linked polysaccharide gel
US6060534A (en) 1996-07-11 2000-05-09 Scimed Life Systems, Inc. Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties
US6368356B1 (en) 1996-07-11 2002-04-09 Scimed Life Systems, Inc. Medical devices comprising hydrogel polymers having improved mechanical properties
JP4771563B2 (ja) 1996-12-06 2011-09-14 アムジエン・インコーポレーテツド Il−1媒介疾患を処置するためにil−1インヒビターを使用する組合せ療法
US6294170B1 (en) 1997-08-08 2001-09-25 Amgen Inc. Composition and method for treating inflammatory diseases
GB2322864A (en) * 1997-03-07 1998-09-09 Polybiomed Ltd Gel for application to the human or animal body
US6709873B1 (en) * 1997-04-09 2004-03-23 Isodiagnostika Inc. Method for production of antibodies to specific sites of rapamycin
WO1998054224A1 (en) * 1997-05-28 1998-12-03 Tapic International Co., Ltd. Collagen gel
US5945457A (en) * 1997-10-01 1999-08-31 A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science Process for preparing biologically compatible polymers and their use in medical devices
US5897988A (en) * 1998-01-21 1999-04-27 Yale University Process and system for selection of mature sperm by surface membrane determinants for assisted reproduction
PT939086E (pt) * 1998-02-27 2004-07-30 Stichting Hippomedics Processo para produzir o acido hialuronico reticulado
US6630457B1 (en) 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
IT1303738B1 (it) * 1998-11-11 2001-02-23 Aquisitio S P A Processo di reticolazione di polisaccaridi carbossilati.
US7375096B1 (en) * 1998-12-04 2008-05-20 California Institute Of Technology Method of preparing a supramolecular complex containing a therapeutic agent and a multi-dimensional polymer network
CA2356849C (en) * 1998-12-16 2008-06-03 Sca Hygiene Products Zeist B.V. Acidic superabsorbent polysaccharides
GB9902412D0 (en) * 1999-02-03 1999-03-24 Fermentech Med Ltd Process
GB9902652D0 (en) 1999-02-05 1999-03-31 Fermentech Med Ltd Process
WO2000049084A1 (en) * 1999-02-19 2000-08-24 Denki Kagaku Kogyo Kabushiki Kaisha Hyaluronic acid gel composition, process for producing the same, and medical material containing the same
US6472379B1 (en) 1999-03-15 2002-10-29 Trustees Of Boston University Angiogenesis inhibition
US20040048021A1 (en) * 1999-03-19 2004-03-11 Wan Barbara Y. F. Surface modification of substrates
CA2366897C (en) * 1999-04-06 2009-11-17 Andrew B. Onderdonk Immunomodulatory compositions and methods of use thereof
US6288043B1 (en) * 1999-06-18 2001-09-11 Orquest, Inc. Injectable hyaluronate-sulfated polysaccharide conjugates
WO2001006973A1 (en) 1999-07-28 2001-02-01 United States Surgical Corporation Hyaluronic acid anti-adhesion barrier
KR100721752B1 (ko) 2000-01-24 2007-05-25 쿠라레 메디카루 가부시키가이샤 수팽윤성 고분자 겔 및 그 제조법
US6521223B1 (en) * 2000-02-14 2003-02-18 Genzyme Corporation Single phase gels for the prevention of adhesions
US6749865B2 (en) * 2000-02-15 2004-06-15 Genzyme Corporation Modification of biopolymers for improved drug delivery
KR100375299B1 (ko) 2000-10-10 2003-03-10 주식회사 엘지생명과학 히알루론산의 가교결합형 아마이드 유도체와 이의 제조방법
AU2399502A (en) * 2000-11-14 2002-05-27 R Labs Bvi Nv Cross-linked hyaluronic acid-laminin gels and use thereof in cell culture and medical implants
ATE312076T1 (de) * 2001-02-22 2005-12-15 Anika Therapeutics Inc Thiol-modifizierte hyaluronan-derivate
US20020172712A1 (en) * 2001-03-19 2002-11-21 Alan Drizen Antiemetic, anti-motion sustained release drug delivery system
US6913765B2 (en) * 2001-03-21 2005-07-05 Scimed Life Systems, Inc. Controlling resorption of bioresorbable medical implant material
US8580290B2 (en) * 2001-05-08 2013-11-12 The Board Of Regents Of The University Of Oklahoma Heparosan-based biomaterials and coatings and methods of production and use thereof
US20030216758A1 (en) * 2001-12-28 2003-11-20 Angiotech Pharmaceuticals, Inc. Coated surgical patches
US20060153893A1 (en) * 2002-04-08 2006-07-13 Denki Kagaku Kogyo Kabushiki Kaisha Therapeutic composition for bone infectious disease
US8313760B2 (en) * 2002-05-24 2012-11-20 Angiotech International Ag Compositions and methods for coating medical implants
EP2075014B9 (en) * 2002-05-24 2012-02-01 Angiotech International Ag Compositions and methods for coating medical implants
DE10223310A1 (de) * 2002-05-24 2003-12-11 Biotronik Mess & Therapieg Verfahren zum Beschichten von Implantaten mit einer Polysaccharid-Lage
AU2003299509A1 (en) * 2002-06-21 2004-05-13 University Of Utah Research Foundation Crosslinked compounds and methods of making and using thereof
US7034127B2 (en) * 2002-07-02 2006-04-25 Genzyme Corporation Hydrophilic biopolymer-drug conjugates, their preparation and use
US7338433B2 (en) 2002-08-13 2008-03-04 Allergan, Inc. Remotely adjustable gastric banding method
NZ538266A (en) * 2002-08-16 2007-05-31 Denki Kagaku Kogyo Kk Separate type medical material
ES2617452T3 (es) * 2002-08-28 2017-06-19 Apollo Endosurgery, Inc Dispositivo de banda gástrica resistente a la fatiga
BRPI0314042B8 (pt) 2002-09-06 2021-05-25 Calando Pharmaceuticals Inc polímeros à base de ciclodextrina para o fornecimento de agentes terapêuticos ligados a eles por covalência
DE10252816B4 (de) * 2002-11-13 2008-02-14 Schwan-Stabilo Cosmetics Gmbh & Co. Kg Kosmetische Zubereitung, sowie ein Verfahren zu ihrer Herstellung und ihre Verwendung
US7816316B2 (en) * 2002-11-21 2010-10-19 Chugai Seiyaku Kabushiki Kaisha Sustained release drug carrier
TWI251596B (en) * 2002-12-31 2006-03-21 Ind Tech Res Inst Method for producing a double-crosslinked hyaluronate material
LT5098B (lt) 2003-03-28 2004-01-26 Alvyda GUDELEVI�I�T� Kremų kompozicijos senstančiai odai
FR2861734B1 (fr) 2003-04-10 2006-04-14 Corneal Ind Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus
AU2003901834A0 (en) 2003-04-17 2003-05-01 Clearcoll Pty Ltd Cross-linked polysaccharide compositions
JP2004323454A (ja) * 2003-04-25 2004-11-18 Chisso Corp 薬剤
EP1624935B1 (en) * 2003-05-15 2016-09-28 The University of Utah Research Foundation Anti-adhesion composites and methods os use thereof
ES2226567B1 (es) * 2003-06-20 2006-07-01 Universidad De Santiago De Compostela Nanoparticulas de acido hialuronico.
DE10328816A1 (de) 2003-06-21 2005-01-05 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Implantierbare Stimulationselektrode mit einer Beschichtung zur Erhöhung der Gewebsverträglichkeit
DE10328815A1 (de) * 2003-06-21 2005-01-05 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Beschichtungssystem für Implantate zur Erhöhung der Gewebsverträglichkeit
ES2232287B1 (es) * 2003-07-04 2006-11-01 Advanced In Vitro Cell Technologies, S.L. Nanoparticulas de derivados polioxietilenados.
JP2007500027A (ja) * 2003-07-30 2007-01-11 アンタイス エス.エイ. 生物医学的な使用のための複合マトリックス
JP4511470B2 (ja) * 2003-10-29 2010-07-28 帝人株式会社 ヒアルロン酸化合物、そのハイドロゲルおよび関節軟骨損傷治療用材料
CA2536192A1 (en) * 2003-11-20 2005-06-09 Angiotech International Ag Soft tissue implants and anti-scarring agents
US20080176205A1 (en) * 2003-12-04 2008-07-24 University Of Utah Research Foundation Process and Formulation to Improve Viability of Stored Cells and Tissue
CA2550718C (en) * 2003-12-30 2013-11-05 Genzyme Corporation Cohesive gels from cross-linked hyaluronan and/or hylan, their preparation and use
US8524213B2 (en) * 2003-12-30 2013-09-03 Genzyme Corporation Polymeric materials, their preparation and use
BRPI0507075B1 (pt) 2004-01-23 2016-02-23 Allergan Inc faixa gástrica ajustável de peça única fixável desprendidamente
WO2005087147A1 (en) * 2004-03-08 2005-09-22 Endoart S.A. Closure system for tubular organs
KR101244519B1 (ko) * 2004-03-17 2013-03-18 젠자임 코포레이션 항점착 분무
AU2004317849B2 (en) * 2004-03-18 2011-03-31 Allergan, Inc. Apparatus and method for volume adjustment of intragastric balloons
WO2006078282A2 (en) 2004-04-28 2006-07-27 Angiotech Biomaterials Corporation Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
ES2246694B1 (es) * 2004-04-29 2007-05-01 Instituto Cientifico Y Tecnologico De Navarra, S.A. Nanoparticulas pegiladas.
ES2246695B1 (es) * 2004-04-29 2007-05-01 Instituto Cientifico Y Tecnologico De Navarra, S.A. Composicion estimuladora de la respuesta inmunitaria que comprende nanoparticulas a base de un copolimero de metil vinil eter y anhidrido maleico.
WO2005113608A1 (en) * 2004-05-20 2005-12-01 Mentor Corporation Method of covalently linking hyaluronan and chitosan
EP1750769B1 (en) * 2004-05-20 2013-01-23 Mentor Worldwide LLC Methods for making injectable polymer hydrogels
ITMI20041373A1 (it) 2004-07-09 2004-10-09 Lima Lto S P A N-metil-ammidi di carbossimetilcellulosa acido alginico o carbossimetalamido
TW200612991A (en) 2004-09-07 2006-05-01 Chugai Pharmaceutical Co Ltd Process for producing water-soluble hyaluronic acid modification
CN101056891B (zh) * 2004-11-15 2010-05-26 株式会社资生堂 交联透明质酸凝胶的制备方法
CN101107270B (zh) * 2004-11-24 2011-11-23 诺维信生物制药丹麦公司 用二乙烯基砜交联透明质酸的方法
PT1835923E (pt) * 2004-12-30 2013-11-04 Genzyme Corp Regimes para viscossuplementação intra-articular
AU2005100176A4 (en) * 2005-03-01 2005-04-07 Gym Tv Pty Ltd Garbage bin clip
US8251888B2 (en) * 2005-04-13 2012-08-28 Mitchell Steven Roslin Artificial gastric valve
DE102005030614B4 (de) * 2005-06-30 2014-05-08 Biotissue Ag Zellfreies Transplantat, dessen Verwendung, Verfahren zu dessen Herstellung, dabei hergestellte Matrix mit Gel und Verfahren zur Herstellung dieser Matrix mit Gel
EP1911769B1 (en) * 2005-08-04 2013-10-30 Teijin Limited Cellulose derivative
CA2620663A1 (en) * 2005-09-02 2007-03-08 Colbar Lifescience Ltd. Cross-linked polysaccharide and protein matrices and methods for their preparation
CA2623106C (en) 2005-09-19 2013-12-24 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
CA2633978A1 (en) 2005-12-14 2007-06-21 Anika Therapeutics, Inc. Bioabsorbable implant of hyaluronic acid derivative for treatment of osteochondral and chondral defects
CA2633957A1 (en) * 2005-12-14 2007-06-21 Anika Therapeutics, Inc. Treatment of arthritis and other musculoskeletal disorders with crosslinked hyaluronic acid
US8043206B2 (en) 2006-01-04 2011-10-25 Allergan, Inc. Self-regulating gastric band with pressure data processing
US7798954B2 (en) * 2006-01-04 2010-09-21 Allergan, Inc. Hydraulic gastric band with collapsible reservoir
EP2492285A1 (en) 2006-03-07 2012-08-29 ProChon Biotech Ltd. Hydrazido derivatives of hyaluronic acid
US7674781B2 (en) * 2006-04-28 2010-03-09 Heather Sheardown Hyaluronic acid-retaining polymers
ITMI20061726A1 (it) * 2006-09-11 2008-03-12 Fidia Farmaceutici Derivati crosslinkati a base di acido ialuronico reticolato via click chemistry
CN101522164B (zh) * 2006-09-13 2014-03-26 提升肤质产品公司 用于治疗皮肤的化妆品组合物及其方法
JP5030219B2 (ja) * 2007-07-19 2012-09-19 眞知子 瀧上 カルボキシメチルセルロースアルカリ塩のゲルの製造方法及びそれによって得られたカルボキシメチルセルロースアルカリ塩のゲル
DE102006047346A1 (de) * 2006-10-06 2008-04-10 Transtissue Technologies Gmbh Matrix-Gel-Transplantat ohne Zellen
EP2106263B1 (en) * 2007-01-04 2016-12-21 Hepacore Ltd. Water soluble reactive derivatives of carboxy polysaccharides and fibrinogen conjugates thereof
US20080176958A1 (en) 2007-01-24 2008-07-24 Insert Therapeutics, Inc. Cyclodextrin-based polymers for therapeutics delivery
US8529951B1 (en) 2007-02-21 2013-09-10 Anand Ramamurthi Elastogenic cues and methods for using same
EP2143446B1 (en) * 2007-05-01 2019-07-24 National University Corporation Tokyo Medical and Dental University Hybrid gel comprising chemically crosslinked hyaluronic acid derivative and pharmaceutical composition comprising the same
US20080293637A1 (en) * 2007-05-23 2008-11-27 Allergan, Inc. Cross-linked collagen and uses thereof
US8658148B2 (en) 2007-06-22 2014-02-25 Genzyme Corporation Chemically modified dendrimers
FR2918377B1 (fr) 2007-07-05 2010-10-08 Estelle Piron Gel co-reticule de polysaccharides
US8318695B2 (en) 2007-07-30 2012-11-27 Allergan, Inc. Tunably crosslinked polysaccharide compositions
US20110077737A1 (en) * 2007-07-30 2011-03-31 Allergan, Inc. Tunably Crosslinked Polysaccharide Compositions
US8697044B2 (en) 2007-10-09 2014-04-15 Allergan, Inc. Crossed-linked hyaluronic acid and collagen and uses thereof
JP5670196B2 (ja) 2007-11-16 2015-02-18 バイセプト セラピューティクス、インク. 紫斑を治療する組成物および方法
US8394784B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having multi-stage bioactive agent delivery
US8394782B2 (en) * 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
US20090143348A1 (en) * 2007-11-30 2009-06-04 Ahmet Tezel Polysaccharide gel compositions and methods for sustained delivery of drugs
FR2924615B1 (fr) 2007-12-07 2010-01-22 Vivacy Lab Hydrogel cohesif biodegradable.
CN101878230B (zh) * 2007-12-19 2012-11-21 赢创高施米特有限公司 乳液中的交联透明质酸
RU2366666C1 (ru) * 2007-12-20 2009-09-10 Институт синтетических полимерных материалов (ИСПМ) им. Н.С. Ениколопова РАН Способ получения сшитых солей гиалуроновой кислоты в водной среде
US7763268B2 (en) * 2008-01-18 2010-07-27 The Research Foundation Of State University Of New York Load bearing hydrogel implants
RU2386640C2 (ru) * 2008-06-25 2010-04-20 Институт синтетических полимерных материалов (ИСПМ) им. Н.С. Ениколопова РАН Способ получения модифицированной рибофлавином сшитой соли гиалуроновой кислоты
RU2386641C2 (ru) * 2008-07-09 2010-04-20 Институт синтетических полимерных материалов (ИСПМ) им. Н.С. Ениколопова РАН Способ получения модифицированной ретинолом сшитой соли гиалуроновой кислоты
RU2387671C1 (ru) * 2008-07-30 2010-04-27 Институт синтетических полимерных материалов (ИСПМ) им. Н.С. Ениколопова РАН Способ получения модифицированной витаминами сшитой соли гиалуроновой кислоты
RU2387670C1 (ru) * 2008-07-30 2010-04-27 Институт синтетических полимерных материалов (ИСПМ) им. Н.С. Ениколопова РАН Способ получения модифицированной фолиевой кислотой сшитой соли гиалуроновой кислоты
US8357795B2 (en) * 2008-08-04 2013-01-22 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
ES2658609T3 (es) 2008-09-02 2018-03-12 Tautona Group Lp Hilos de ácido hialurónico y/o derivados de los mismos, métodos para fabricar los mismos, y usos de los mismos
TWI387620B (zh) * 2008-09-23 2013-03-01 Scivision Biotech Inc 交聯透明質酸之製造方法
WO2010038231A1 (en) 2008-10-02 2010-04-08 L.R.R.& D. Ltd. Interface layer wound dressing
EP2362762A1 (en) * 2008-10-06 2011-09-07 Allergan Medical Sàrl Mechanical gastric band with cushions
US20100305397A1 (en) * 2008-10-06 2010-12-02 Allergan Medical Sarl Hydraulic-mechanical gastric band
CN101721349B (zh) 2008-10-16 2011-07-20 常州百瑞吉生物医药有限公司 可注射原位交联水凝胶及其制备方法和用途
US20100185049A1 (en) 2008-10-22 2010-07-22 Allergan, Inc. Dome and screw valves for remotely adjustable gastric banding systems
CZ301555B6 (cs) 2008-11-06 2010-04-14 Cpn S. R. O. Zpusob prípravy DTPA sítovaných derivátu kyseliny hyaluronové a jejich modifikace
US8679470B2 (en) 2008-11-28 2014-03-25 Luromed Llc Composition using cross-linked hyaluronic acid for topical cosmetic and therapeutic applications
JP2010202522A (ja) * 2009-02-27 2010-09-16 Shiseido Co Ltd 耐塩性増粘剤及びそれを配合した化粧料
AU2010232547A1 (en) * 2009-04-02 2011-10-27 Allergan, Inc. Hair-like shaped hydrogels for soft tissue augmentation
US9371402B2 (en) 2009-04-09 2016-06-21 Scivision Biotech Inc. Method for producing cross-linked hyaluronic acid
EP2424583A2 (en) * 2009-05-01 2012-03-07 Allergan, Inc. Laparoscopic gastric band with active agents
US20110184229A1 (en) * 2009-05-01 2011-07-28 Allergan, Inc. Laparoscopic gastric band with active agents
IT1399351B1 (it) 2009-06-16 2013-04-16 Fidia Farmaceutici Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi
CN102573941B (zh) 2009-07-30 2014-10-29 卡比兰生物外科公司 改性透明质酸聚合物组合物和相关的方法
US20110137112A1 (en) * 2009-08-28 2011-06-09 Allergan, Inc. Gastric band with electric stimulation
WO2011031400A2 (en) * 2009-08-28 2011-03-17 Allergan, Inc. Gastric band with electric stimulation
US8273725B2 (en) 2009-09-10 2012-09-25 Genzyme Corporation Stable hyaluronan/steroid formulation
US8247390B2 (en) * 2009-09-28 2012-08-21 Luromed Llc Modified hydrophilic polymers containing hydrophobic groups
AU2010321533A1 (en) * 2009-11-23 2012-05-31 Cerulean Pharma Inc. Cyclodextrin-based polymers for therapeutic delivery
US20110171311A1 (en) * 2010-01-13 2011-07-14 Allergan Industrie, Sas Stable hydrogel compositions including additives
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
US20110171286A1 (en) * 2010-01-13 2011-07-14 Allergan, Inc. Hyaluronic acid compositions for dermatological use
US8758221B2 (en) * 2010-02-24 2014-06-24 Apollo Endosurgery, Inc. Source reservoir with potential energy for remotely adjustable gastric banding system
US8840541B2 (en) * 2010-02-25 2014-09-23 Apollo Endosurgery, Inc. Pressure sensing gastric banding system
KR101764451B1 (ko) 2010-03-12 2017-08-02 알러간 인더스트리 에스에이에스 피부 상태 개선을 위한 히알루론안 폴리머 및 만니톨을 포함하는 유체 조성물
EP3078388B1 (en) 2010-03-22 2019-02-20 Allergan, Inc. Cross-linked hydrogels for soft tissue augmentation
US20110270024A1 (en) 2010-04-29 2011-11-03 Allergan, Inc. Self-adjusting gastric band having various compliant components
US9028394B2 (en) 2010-04-29 2015-05-12 Apollo Endosurgery, Inc. Self-adjusting mechanical gastric band
US9044298B2 (en) 2010-04-29 2015-06-02 Apollo Endosurgery, Inc. Self-adjusting gastric band
US20110270025A1 (en) 2010-04-30 2011-11-03 Allergan, Inc. Remotely powered remotely adjustable gastric band system
US8517915B2 (en) 2010-06-10 2013-08-27 Allergan, Inc. Remotely adjustable gastric banding system
CA2805008C (en) 2010-07-12 2015-05-12 Shin Poong Pharmaceutical Co., Ltd. Filler composition for tissue augmentation comprising a hydrogel of hyaluronic acid cross-linked with alkylene diamine
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
US8697057B2 (en) 2010-08-19 2014-04-15 Allergan, Inc. Compositions and soft tissue replacement methods
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
US20120059216A1 (en) 2010-09-07 2012-03-08 Allergan, Inc. Remotely adjustable gastric banding system
US8961393B2 (en) 2010-11-15 2015-02-24 Apollo Endosurgery, Inc. Gastric band devices and drive systems
CZ303548B6 (cs) 2011-01-05 2012-11-28 Contipro Pharma A.S. Zdravotní prípravek tvorící jód, zpusob jeho prípravy a bandáž, která jej obsahuje
WO2012140650A2 (en) 2011-04-12 2012-10-18 Hepacore Ltd. Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof
US9381269B2 (en) 2011-04-13 2016-07-05 Avent, Inc. Biosorbable wound treatment device, process for making, and method of using the same
ES2537411T3 (es) 2011-04-20 2015-06-08 Carbylan Therapeutics, Inc. Composiciones formadoras de gel in situ
ITTO20110428A1 (it) 2011-05-13 2012-11-14 Rottapharm Spa Esteri dell'acido ialuronico, loro preparazione ed uso in dermatologia
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
KR102238406B1 (ko) 2011-06-03 2021-04-08 알러간 인더스트리 에스에이에스 항산화제를 포함하는 피부 충전제 조성물
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
WO2012171335A1 (en) 2011-06-16 2012-12-20 The Hong Kong University Of Science And Technology Multi-vinylsulfone containing molecule
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy
RU2613887C2 (ru) 2011-08-10 2017-03-21 Гликорес 2000 С.Р.Л. Устойчивый к расщеплению сшитый низкомолекулярный гиалуронат
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
US20140256695A1 (en) * 2011-11-11 2014-09-11 Phi Nguyen Injectable filler
FR2983483B1 (fr) 2011-12-02 2014-11-14 Vivacy Lab Procede de substitution et reticulation simultanees d'un polysaccharide via ses fonctions hydroxyles
US8876694B2 (en) 2011-12-07 2014-11-04 Apollo Endosurgery, Inc. Tube connector with a guiding tip
JP6316537B2 (ja) * 2011-12-20 2018-04-25 三洋化成工業株式会社 分岐ヒアルロン酸及びその製造方法
US8961394B2 (en) 2011-12-20 2015-02-24 Apollo Endosurgery, Inc. Self-sealing fluid joint for use with a gastric band
WO2013109959A1 (en) * 2012-01-18 2013-07-25 University Of Kansas Hyaluronic acid particles and their use in biomedical applications
CA2869128C (en) 2012-03-30 2022-07-26 The Board Of Regents Of The University Of Oklahoma High molecular weight heparosan polymers and methods of production and use thereof
CZ2012282A3 (cs) 2012-04-25 2013-11-06 Contipro Biotech S.R.O. Zesítovaný derivát hyaluronanu, zpusob jeho prípravy, hydrogel a mikrovlákna na jeho bázi
ITPD20120173A1 (it) 2012-05-31 2013-12-01 Fidia Farmaceutici "nuovo sistema di rilascio di proteine idrofobiche"
WO2014055493A1 (en) 2012-10-02 2014-04-10 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
US20160228603A1 (en) * 2013-04-12 2016-08-11 Miba Medical Inc. Body augmentation device
EP3617236B1 (en) * 2013-06-28 2024-07-31 Galderma S.A. Shaped cross-linked hyaluronic acid product
CN103333349A (zh) * 2013-06-28 2013-10-02 陕西巨子生物技术有限公司 一种注射用透明质酸-胶原蛋白复合水凝胶及其制备方法
EP2832378A2 (en) 2013-08-01 2015-02-04 Ivis Technologies S R L Adhesive biopolymer for use as a temporary replacement of the epithelium
TWI482634B (zh) * 2013-10-24 2015-05-01 Ind Tech Res Inst 生醫組合物
KR101459070B1 (ko) 2013-12-09 2014-11-17 (주) 뉴메딕 지속성을 갖는 히알루론산 겔 조성물
AR099900A1 (es) 2014-04-01 2016-08-24 Merz Pharma Gmbh & Co Kgaa Rellenos para tejidos blandos con polisacáridos con persistencia mejorada, kit, procedimiento, uso
EP4574179A3 (en) 2014-08-15 2025-10-01 The Johns Hopkins University Composite material for tissue restoration
EP3200838B1 (en) 2014-09-30 2019-09-18 Allergan Industrie, SAS Stable hydrogel compositions including additives
KR101694121B1 (ko) 2014-10-28 2017-01-10 (주)헵틸와이 이중 가교구조의 생체친화형 다공성 시트 및 그 제조방법
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
KR101521058B1 (ko) 2014-12-08 2015-05-15 이노팜 주식회사 생체적합성 조성물 및 이의 제조방법
CN104530460A (zh) * 2014-12-19 2015-04-22 大连理工大学 糖基化高分子材料及其制备方法
WO2016128783A1 (en) 2015-02-09 2016-08-18 Allergan Industrie Sas Compositions and methods for improving skin appearance
HUE047971T2 (hu) 2015-02-13 2020-05-28 Allergan Ind Sas Az arcelemek - például az áll - formázására, megnagyobbítására vagy korrekciójára szolgáló implantátumok
US9855317B2 (en) 2015-04-27 2018-01-02 Reflex Medical, Inc. Systems and methods for sympathetic cardiopulmonary neuromodulation
US10836840B2 (en) * 2015-06-30 2020-11-17 Merz Pharma Gmbh & Co. Kgaa Method for producing crosslinked hyaluronic acid
KR101818705B1 (ko) 2015-07-20 2018-01-16 포항공과대학교 산학협력단 약물이 충전된 히알루론산 가교물 하이드로겔 및 이의 이용
KR20170025778A (ko) 2015-08-31 2017-03-08 대화제약 주식회사 항산화제를 포함하는 생체 적합성 고분자 히알루론산 유도체 및 그 히알루론산의 가교결합물
ES2776825T3 (es) * 2015-11-18 2020-08-03 Lifecell Corp Malla recubierta de hidrogel
US11246879B2 (en) 2016-02-09 2022-02-15 Tulai Therapeutics, Inc. Methods, agents, and devices for local neuromodulation of autonomic nerves
KR101866310B1 (ko) 2016-05-31 2018-06-11 주식회사 글랜젠 생체 내 지속성 및 항산화 작용이 향상된 진피 충전재 조성물 및 이의 제조방법
US11154547B2 (en) 2016-06-29 2021-10-26 Tulavi Therapeutics, Inc. Treatment of sepsis and related inflammatory conditions by local neuromodulation of the autonomic nervous system
WO2018053276A1 (en) * 2016-09-16 2018-03-22 Glycologix, Llc Sulfated glycosaminoglycan biomaterials as proteoglycan mimics
CZ2016826A3 (cs) 2016-12-22 2018-07-04 Contipro A.S. Léčivý prostředek s nosičem na bázi hyaluronanu a/nebo jeho derivátů, způsob výroby a použití
US20200230288A1 (en) 2017-02-02 2020-07-23 Amtixbio Co., Ltd Hydrogel using, as substrate, hyaluronic acid derivative modified with gallol group and use thereof
US20190240335A1 (en) 2018-02-07 2019-08-08 Promedon S.A. Biocompatible Hydrogel Compositions
EP3773732A4 (en) * 2018-03-29 2022-07-27 Ramesh S. Ayyala METHODS AND COMPOSITIONS FOR THE ADMINISTRATION OF A THERAPEUTIC AGENT
CA3099732A1 (en) 2018-05-09 2019-11-14 The Johns Hopkins University Nanofiber-hydrogel composites for cell and tissue delivery
ES3060255T3 (en) 2018-05-09 2026-03-25 Univ Johns Hopkins Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration
BR112020024654B1 (pt) 2018-06-15 2024-02-27 Croma-Pharma Gmbh Composição de hidrogel estéril, unidade de aplicação para injeção,seus usos, método cosmético, enchimento de tecido mole, e implante ou depósito
WO2019238954A1 (en) 2018-06-15 2019-12-19 Croma-Pharma Gmbh Hydrogel composition comprising a crosslinked polymer
US20210315587A1 (en) 2018-07-02 2021-10-14 Tulavi Therapeutics, Inc. Methods and devices for in situ formed nerve cap with rapid release
CN117598837A (zh) 2018-07-02 2024-02-27 图拉维治疗股份有限公司 原位形成神经帽的方法和装置
EP3804769B1 (en) 2018-07-06 2025-05-21 Lg Chem, Ltd. Hyaluronic acid filler having high viscoelasticity and high cohesiveness
EP3804770B1 (en) 2018-07-10 2023-12-06 Lg Chem, Ltd. Hyaluronic acid filler having high lift capacity and low injection force
RS67193B1 (sr) 2018-12-20 2025-10-31 Lg Chemical Ltd Filer sa odličnim svojstvima filera koji obuhvata hidrogel hijaluronske kiseline
CN113226388B (zh) 2018-12-21 2023-07-25 株式会社Lg化学 具有优异的填充性能的包含透明质酸水凝胶的填充剂
KR102162724B1 (ko) 2020-03-24 2020-10-07 바이오플러스 주식회사 가교 히알루론산 겔 및 이의 제조 방법
US20230119326A1 (en) * 2020-03-31 2023-04-20 Kureha Corporation Bioabsorbable medical material
WO2021229544A1 (en) * 2020-05-14 2021-11-18 Allergan Pharmaceuticals International Limited Compositions comprising tropoelastin crosslinked to hyaluronic acid and methods of use thereof
KR102366394B1 (ko) * 2021-01-05 2022-02-23 조광용 고팽윤성 히알루론산 비드 겔
KR20220106283A (ko) 2021-01-22 2022-07-29 (주)앰틱스바이오 자가 가교형 히알루론산 유도체 기반 창상피복재
KR102598899B1 (ko) * 2021-05-13 2023-11-07 주식회사 바이오스탠다드 히알루론산 기반 기능성 하이드로겔 복합체 및 이의 제조방법
US20250090719A1 (en) * 2021-07-30 2025-03-20 Regents Of The University Of Minnesota Biomaterials for embolization and drug delivery
US11980699B2 (en) 2021-09-01 2024-05-14 Shanghai Qisheng Biological Preparation Co., Ltd. Cartilage regeneration using injectable, in situ polymerizable collagen compositions containing chondrocytes or stem cells
CN117915964A (zh) 2021-09-09 2024-04-19 太阳生物公司 6臂peg水凝胶随时间推移的溶胶-凝胶转换
WO2023125689A1 (en) 2021-12-28 2023-07-06 Shanghai Qisheng Biological Preparation Co., Ltd. Hyaluronic acid-collagen copolymer compositions and medical applications thereof
WO2024172910A1 (en) * 2023-02-15 2024-08-22 Lifesprout, Inc. Modified crosslinked polymers
WO2025091137A1 (en) 2023-11-02 2025-05-08 Volumina Medical Sa Implantable device compositions including ester bonds

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1047380B (de) * 1954-08-18 1958-12-24 American Home Prod Verfahren zur Herstellung einer hyaluronidasefreien, teilweise depolymerisierte Hyaluronsaeure enthaltenden waessrigen Traegerloesung fuer Arzneimittel
DE1043589B (de) * 1956-01-02 1958-11-13 Kisaku Ibe Haut- und Haarpflegemittel und Verfahren zu ihrer Herstellung
US3357784A (en) * 1964-09-30 1967-12-12 Kendall & Co Exposure to intense ultraviolet light to improve characteristics of cellulosic fabrics in divinyl sulfone and glyoxal cross-linking processes
SE361320B (2) * 1972-03-14 1973-10-29 Exploaterings Ab Tbf
US4152170A (en) 1975-06-18 1979-05-01 Sumitomo Chemical Company, Ltd. Cross-linked pullulan
GB1515963A (en) * 1975-07-15 1978-06-28 Massachusetts Inst Technology Crosslinked collagen-mucopolysaccharide composite materials
US4141973A (en) * 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
US4303676A (en) * 1980-03-21 1981-12-01 Balazs Endre A Hyaluronate based compositions and cosmetic formulations containing same
JPS59162779A (ja) * 1983-03-04 1984-09-13 Toshiba Corp 周波数変換装置の制御方法
US4448718A (en) * 1983-09-13 1984-05-15 Massachusetts Institute Of Technology Method for the preparation of collagen-glycosaminoglycan composite materials
US4500676A (en) * 1983-12-15 1985-02-19 Biomatrix, Inc. Hyaluronate modified polymeric articles
CA1238043A (en) * 1983-12-15 1988-06-14 Endre A. Balazs Water insoluble preparations of hyaluronic acid and processes therefor
US4487865A (en) * 1983-12-15 1984-12-11 Biomatrix, Inc. Polymeric articles modified with hyaluronate
US4713448A (en) * 1985-03-12 1987-12-15 Biomatrix, Inc. Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues

Also Published As

Publication number Publication date
AU569157B2 (en) 1988-01-21
FR2574414B1 (fr) 1987-07-03
AU4304585A (en) 1986-06-12
IT8522089A0 (it) 1985-09-09
SE8503486L (sv) 1986-06-07
GB8512072D0 (en) 1985-06-19
GB2181147A (en) 1987-04-15
DE3520008A1 (de) 1986-06-19
DE3520008C2 (2) 1991-10-10
DE3546811C2 (2) 1993-09-02
GB8618719D0 (en) 1986-09-10
FR2574414A1 (fr) 1986-06-13
GB8817772D0 (en) 1988-09-01
AU7217387A (en) 1987-08-27
JPS61138601A (ja) 1986-06-26
GB2205848A (en) 1988-12-21
JPH02138346A (ja) 1990-05-28
SE8503486D0 (sv) 1985-07-15
SE8901672L (sv) 1989-05-10
GB2181148B (en) 1989-06-07
GB2181148A (en) 1987-04-15
CA1230186A (en) 1987-12-08
US4582865A (en) 1986-04-15
GB2181147B (en) 1989-06-07
JPH0637575B2 (ja) 1994-05-18
GB2205848B (en) 1989-05-24
GB2168067A (en) 1986-06-11
SE8901672D0 (sv) 1989-05-10
GB8618720D0 (en) 1986-09-10
IT1187737B (it) 1987-12-23
GB2168067B (en) 1989-06-07
AU572419B2 (en) 1988-05-05
SE460792B (sv) 1989-11-20
SE501828C2 (sv) 1995-05-22

Similar Documents

Publication Publication Date Title
JPH0430961B2 (2)
US4605691A (en) Cross-linked gels of hyaluronic acid and products containing such gels
US4636524A (en) Cross-linked gels of hyaluronic acid and products containing such gels
EP0224987B1 (en) Drug delivery systems based on hyaluronan, derivatives thereof and their salts and method of producing same
US5128326A (en) Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
CA1276143C (en) Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues
US5246698A (en) Biocompatible viscoelastic gel slurries, their preparation and use
JP3399526B2 (ja) ヒアルロン酸の非水溶性誘導体
EP0466300A2 (en) Biocompatible viscoelastic gel slurries, their preparation and use
EP0291177A2 (en) Novel compositions for percutaneous embolization
CN106397846B (zh) 一种交联透明质酸钠及其制备方法与应用
CA2578678C (en) Photoreactive polysaccharide, photocrosslinked polysaccharide products, the method of making them and medical materials therefrom
US7521434B2 (en) Cross-linked gels of hyaluronic acid with hydrophobic polymers and processes for making them
CN117298355B (zh) 一种包裹性透明质酸凝胶组合物及其制备方法与应用
Al-Sibani et al. Effect of hyaluronic acid initial concentration on cross-linking efficiency of hyaluronic acid–based hydrogels used in biomedical and cosmetic applications
CN109851716B (zh) 一种具有温度敏感特性的水溶性壳聚糖及其制备方法
LU501136B1 (en) Method for preparing medical modified sodium hyaluronate and polycaprolactone gel
JP4460662B2 (ja) 溶解速度が制御されたヒアルロン酸ゲル及びその製造方法
KR0144372B1 (ko) 키틴과 셀루로오즈가 컨쥬게이트된 수용성 수지 및 그 제조방법
CN118307800A (zh) 一种除去交联透明质酸钠凝胶中交联剂的方法
MXPA06001060A (en) Complex matrix for biomedical use
HK1011502B (en) Biocompatible viscoelastic gel slurries, their preparation and use

Legal Events

Date Code Title Description
R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term