JPH04500802A - ヒルジンペプチド - Google Patents

ヒルジンペプチド

Info

Publication number
JPH04500802A
JPH04500802A JP1507630A JP50763089A JPH04500802A JP H04500802 A JPH04500802 A JP H04500802A JP 1507630 A JP1507630 A JP 1507630A JP 50763089 A JP50763089 A JP 50763089A JP H04500802 A JPH04500802 A JP H04500802A
Authority
JP
Japan
Prior art keywords
peptide
composition
hirudin
thrombin
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1507630A
Other languages
English (en)
Japanese (ja)
Inventor
マラガノア，ジョン　エム
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biogen Inc
Original Assignee
Biogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Inc filed Critical Biogen Inc
Publication of JPH04500802A publication Critical patent/JPH04500802A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP1507630A 1988-09-29 1989-04-24 ヒルジンペプチド Pending JPH04500802A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25115088A 1988-09-29 1988-09-29
US251,150 1988-09-29

Publications (1)

Publication Number Publication Date
JPH04500802A true JPH04500802A (ja) 1992-02-13

Family

ID=22950691

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1507630A Pending JPH04500802A (ja) 1988-09-29 1989-04-24 ヒルジンペプチド

Country Status (5)

Country Link
JP (1) JPH04500802A (da)
DK (1) DK210590A (da)
FI (1) FI904330A0 (da)
HU (1) HUT55799A (da)
WO (1) WO1990003391A1 (da)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02264664A (ja) * 1988-11-01 1990-10-29 Baxter Internatl Inc 抗血栓性材料およびその製造方法
JP2002112782A (ja) * 2000-10-04 2002-04-16 Ajinomoto Co Inc 抗血栓活性を有する蛋白質及びその製造法
JP2014212736A (ja) * 2013-04-26 2014-11-17 株式会社Ｌｓｉメディエンス トロンビン含有試薬及び測定方法
JP2015107967A (ja) * 2008-12-29 2015-06-11 ロンザ・ブレーヌ・エスエーＬｏｎｚａ Ｂｒａｉｎｅ Ｓａ ビバリルジンの製造方法

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
FR2667071A1 (fr) * 1990-09-26 1992-03-27 Adir Nouveaux derives de peptides et de pseudopeptides therapeutiquement actifs dans la cascade de coagulation sanguine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
DE4103649A1 (de) * 1991-02-07 1992-08-13 Basf Ag Neue antikoagulatorisch wirksame peptide
US5750088A (en) 1993-03-30 1998-05-12 The Dupont Merck Pharmaceutical Company Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals
US6808698B1 (en) 1999-03-26 2004-10-26 Bristol-Myers Squibb Pharma Company Method for localization of blood clots
US6254852B1 (en) 1999-07-16 2001-07-03 Dupont Pharmaceuticals Company Porous inorganic targeted ultrasound contrast agents
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
US7319149B2 (en) 2003-06-13 2008-01-15 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US7317104B2 (en) 2003-06-13 2008-01-08 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US7795205B2 (en) * 2004-04-12 2010-09-14 Canyon Pharmaceuticals, Inc. Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
WO2010054503A1 (zh) * 2008-11-17 2010-05-20 中国人民解放军军事医学科学院生物工程研究所 抗凝血多肽及其应用
GB0915519D0 (en) * 2009-09-04 2009-10-07 King S College London Ntithrombotic compounds
BR102017005783A2 (pt) * 2017-03-21 2018-10-02 Fund Butantan processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos
CN117088966A (zh) * 2022-12-29 2023-11-21 江苏诺泰澳赛诺生物制药股份有限公司 一种比伐芦定杂质的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3342139A1 (de) * 1983-11-22 1985-05-30 Ciba-Geigy Ag, Basel Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel
US4649039A (en) * 1984-07-03 1987-03-10 E. I. Du Pont De Nemours And Company Radiolabeling of methionine-containing proteins and peptides

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02264664A (ja) * 1988-11-01 1990-10-29 Baxter Internatl Inc 抗血栓性材料およびその製造方法
JP2002112782A (ja) * 2000-10-04 2002-04-16 Ajinomoto Co Inc 抗血栓活性を有する蛋白質及びその製造法
JP2015107967A (ja) * 2008-12-29 2015-06-11 ロンザ・ブレーヌ・エスエーＬｏｎｚａ Ｂｒａｉｎｅ Ｓａ ビバリルジンの製造方法
JP2014212736A (ja) * 2013-04-26 2014-11-17 株式会社Ｌｓｉメディエンス トロンビン含有試薬及び測定方法

Also Published As

Publication number Publication date
FI904330A7 (fi) 1990-09-03
HUT55799A (en) 1991-06-28
DK210590A (da) 1991-03-27
WO1990003391A1 (en) 1990-04-05
DK210590D0 (da) 1990-09-03
FI904330A0 (fi) 1990-09-03
HU894117D0 (en) 1991-05-28

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