JPH04501662A - 混合給送組換え酵母発酵 - Google Patents

混合給送組換え酵母発酵

Info

Publication number
JPH04501662A
JPH04501662A JP1510384A JP51038489A JPH04501662A JP H04501662 A JPH04501662 A JP H04501662A JP 1510384 A JP1510384 A JP 1510384A JP 51038489 A JP51038489 A JP 51038489A JP H04501662 A JPH04501662 A JP H04501662A
Authority
JP
Japan
Prior art keywords
methanol
fermentation
recombinant
glycerol
mut
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1510384A
Other languages
English (en)
Japanese (ja)
Inventor
ブライアリー，ラッセル・アーサー
シーゲル，ロバート・スティーヴン
ブッシニアウ，クリストファー・マイケル
クレイグ，ウィリアム・スコット
ホルツ，グレゴリー・クライド
デイヴィス，ジュネーブ・ルース
バックフォルツ，リチャード・ゴードン
シル，グレゴリー・パトリック
ワンドラック，リリアン・マーガレット
ディガン，メアリー・エレン
ハーポールド，マイケル・ミラー
レア，スティーヴン・ヴァーノン
エリス，スティーヴン・ブラッドリー
ウィリアムズ，マーク・エドワード
Original Assignee
ザ・サルク・インスティチュート・バイオテクノロジー／インダストリアル・アソシエイツ・インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/265,446 external-priority patent/US4875200A/en
Priority claimed from US07/323,964 external-priority patent/US5102789A/en
Application filed by ザ・サルク・インスティチュート・バイオテクノロジー／インダストリアル・アソシエイツ・インコーポレーテッド filed Critical ザ・サルク・インスティチュート・バイオテクノロジー／インダストリアル・アソシエイツ・インコーポレーテッド
Publication of JPH04501662A publication Critical patent/JPH04501662A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462—Lysozyme (3.2.1.17)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
JP1510384A 1988-09-26 1989-09-25 混合給送組換え酵母発酵 Pending JPH04501662A (ja)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US24944688A 1988-09-26 1988-09-26
US249,446 1988-09-26
US07/265,446 US4875200A (en) 1988-11-01 1988-11-01 Illuminating bezel
US265,446 1988-11-01
US31151789A 1989-02-13 1989-02-13
US311,517 1989-02-13
US07/323,964 US5102789A (en) 1989-03-15 1989-03-15 Production of epideramal growth factor in pichia pastoris yeast cells
US323,964 1989-03-15

Publications (1)

Publication Number Publication Date
JPH04501662A true JPH04501662A (ja) 1992-03-26

Family

ID=27500320

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1510384A Pending JPH04501662A (ja) 1988-09-26 1989-09-25 混合給送組換え酵母発酵

Country Status (6)

Country Link
EP (1) EP0436625A4 (da)
JP (1) JPH04501662A (da)
AU (1) AU4332589A (da)
DK (1) DK55191A (da)
IL (1) IL91765A0 (da)
WO (1) WO1990003431A1 (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2145740T3 (es) * 1990-08-02 2000-07-16 Indu Parikh Composiciones de factor de crecimiento, preparacion y uso.
US5434135A (en) * 1990-08-02 1995-07-18 Indu Parikh Growth factor compositions, preparation and use
US5612198A (en) * 1990-09-04 1997-03-18 The Salk Institute Production of insulin-like growth factor-1 in methylotrophic yeast cells
CA2090969C (en) * 1990-09-04 2001-08-21 Russell Arthur Brierley Production of insulin-like growth factor-1 in methylotrophic yeast cells
WO1992013951A1 (en) * 1991-02-04 1992-08-20 The Salk Institute Biotechnology/Industrial Associates, Inc. Production of human serum albumin in methylotrophic yeast cells
EP0578746B1 (en) * 1991-04-01 2002-07-03 Merck & Co., Inc. GENES WHICH INFLUENCE $i(PICHIA) PROTEOLYTIC ACTIVITY, AND USES THEREFOR
GB9402832D0 (en) * 1994-02-15 1994-04-06 Smith Kline Beecham Biolog S A Novel process
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
US6471956B1 (en) 1994-08-17 2002-10-29 The Rockefeller University Ob polypeptides, modified forms and compositions thereto
US6124448A (en) * 1994-08-17 2000-09-26 The Rockfeller University Nucleic acid primers and probes for the mammalian OB gene
US6124439A (en) * 1994-08-17 2000-09-26 The Rockefeller University OB polypeptide antibodies and method of making
US6001968A (en) 1994-08-17 1999-12-14 The Rockefeller University OB polypeptides, modified forms and compositions
US6048837A (en) * 1994-08-17 2000-04-11 The Rockefeller University OB polypeptides as modulators of body weight
US6350730B1 (en) 1994-08-17 2002-02-26 The Rockefeller University OB polypeptides and modified forms as modulators of body weight
DK0911416T3 (da) * 1997-10-01 2006-08-14 Dsm Ip Assets Bv Fremgangsmåde til fremstilling af protein
US6451572B1 (en) 1998-06-25 2002-09-17 Cornell Research Foundation, Inc. Overexpression of phytase genes in yeast systems
US6773911B1 (en) 1998-11-23 2004-08-10 Amgen Canada Inc. Apoptosis-inducing factor
AU3910000A (en) * 1999-03-22 2000-10-09 Zymogenetics Inc. Improved methods for producing proteins in transformed (pichia)
US6258559B1 (en) 1999-03-22 2001-07-10 Zymogenetics, Inc. Method for producing proteins in transformed Pichia
US6841370B1 (en) 1999-11-18 2005-01-11 Cornell Research Foundation, Inc. Site-directed mutagenesis of Escherichia coli phytase
EP1450627B1 (en) 2001-10-31 2012-09-05 Phytex, Llc Use of phytase containing animal food
US6793911B2 (en) * 2002-02-05 2004-09-21 Abb Lummus Global Inc. Nanocrystalline inorganic based zeolite and method for making same
EP1604008B1 (en) 2002-09-13 2010-12-22 Cornell Research Foundation, Inc. Using mutations to improve aspergillus phytases
US7919297B2 (en) 2006-02-21 2011-04-05 Cornell Research Foundation, Inc. Mutants of Aspergillus niger PhyA phytase and Aspergillus fumigatus phytase
US8540984B2 (en) 2006-08-03 2013-09-24 Cornell Research Foundation, Inc. Phytases with improved thermal stability
JP5290997B2 (ja) * 2007-01-26 2013-09-18 ノボザイムス アクティーゼルスカブ ピキアにおけるメタノール誘導性プロモーターからのメタノール非依存的誘導の方法
US8192734B2 (en) 2007-07-09 2012-06-05 Cornell University Compositions and methods for bone strengthening
CN106191181B (zh) 2016-07-22 2019-12-13 江苏江山聚源生物技术有限公司 一种毕赤酵母表达重组蛋白的发酵工艺
KR102616335B1 (ko) * 2017-02-28 2023-12-21 브이아이비 브이지더블유 경구 단백질 전달을 위한 수단 및 방법
CN116004557A (zh) * 2022-11-28 2023-04-25 西安德诺海思医疗科技有限公司 重组超氧化物歧化酶的制备方法
WO2025077804A1 (en) * 2023-10-12 2025-04-17 Chengdu Kanghua Biological Products Co., Ltd. Methanol monitoring method for the fermentation process of methanotrophic yeast

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3486452T2 (de) * 1983-10-03 1997-11-06 Chiron Corp., Emeryville, Calif. Superoxiddismutase und deren Expression in Mikroorganismen
US4895800A (en) * 1985-11-26 1990-01-23 Phillips Petroleum Company Yeast production of hepatitis B surface antigen
CA1340063C (en) * 1987-11-02 1998-09-29 Mary Ellen Digan Production of animal lysozyme c via secretion from pichia pastoris and composition therefor

Also Published As

Publication number Publication date
IL91765A0 (en) 1990-06-10
WO1990003431A1 (en) 1990-04-05
EP0436625A4 (en) 1991-08-21
EP0436625A1 (en) 1991-07-17
DK55191D0 (da) 1991-03-26
DK55191A (da) 1991-05-24
AU4332589A (en) 1990-04-18

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