JPH04505610A - エナンチオマー的に純粋なポリ置換された１，４―ジヒドロピリジンの製法 - Google Patents

エナンチオマー的に純粋なポリ置換された１，４―ジヒドロピリジンの製法

Info

Publication number
JPH04505610A
JPH04505610A JP2503175A JP50317590A JPH04505610A JP H04505610 A JPH04505610 A JP H04505610A JP 2503175 A JP2503175 A JP 2503175A JP 50317590 A JP50317590 A JP 50317590A JP H04505610 A JPH04505610 A JP H04505610A
Authority
JP
Japan
Prior art keywords
methyl
alkyl
carboethoxy
formula
dihydropyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2503175A
Other languages
English (en)
Japanese (ja)
Inventor
ガンドルフィ，カルメロ・エー
フリゲリオ，マルコ
リバ，カルロ
ザリアーニ，アンドレア
ロング，ジョルジオ
ディ・デミニコ，ロベルト
Original Assignee
ベーリンガー・マンハイム・イタリア・ソシエタ・ペル・アチオニ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ベーリンガー・マンハイム・イタリア・ソシエタ・ペル・アチオニ filed Critical ベーリンガー・マンハイム・イタリア・ソシエタ・ペル・アチオニ
Publication of JPH04505610A publication Critical patent/JPH04505610A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
JP2503175A 1989-02-17 1990-02-15 エナンチオマー的に純粋なポリ置換された１，４―ジヒドロピリジンの製法 Pending JPH04505610A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT8919477A IT1230752B (it) 1989-02-17 1989-02-17 Processo per la preparazione di 1,4 diidropiridine polisostituite in forma enantiomericamente pura.
IT19477A/89 1989-02-17

Publications (1)

Publication Number Publication Date
JPH04505610A true JPH04505610A (ja) 1992-10-01

Family

ID=11158352

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2503175A Pending JPH04505610A (ja) 1989-02-17 1990-02-15 エナンチオマー的に純粋なポリ置換された１，４―ジヒドロピリジンの製法

Country Status (17)

Country Link
US (1) US5245039A (fr)
EP (2) EP0458823B1 (fr)
JP (1) JPH04505610A (fr)
KR (1) KR0155557B1 (fr)
AT (1) ATE95813T1 (fr)
AU (1) AU630928B2 (fr)
CA (1) CA2047741A1 (fr)
DE (1) DE69003936T2 (fr)
DK (1) DK0458823T3 (fr)
ES (1) ES2060144T3 (fr)
FI (1) FI95371C (fr)
HU (1) HUT62270A (fr)
IE (1) IE66498B1 (fr)
IT (1) IT1230752B (fr)
NO (1) NO177186C (fr)
RU (1) RU2069658C1 (fr)
WO (1) WO1990009376A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571827A (en) * 1990-03-13 1996-11-05 Sepracor Inc. Methods and compositions for treating hypertension, angina and other disorders using optically pure s(-) nitrendipine
CA2125149A1 (fr) * 1991-12-02 1993-06-10 James W. Young Methodes et compositions pour le traitement de l'hypertension, de l'angor et d'autres affections par l'administration de s(-)felodipine optiquement pure
US5834496A (en) * 1991-12-02 1998-11-10 Sepracor, Inc. Methods for treating hypertension using optically pure S(-) felodipine
ES2055655B1 (es) * 1992-09-22 1995-03-01 Elmuquimica Farm Sl Procedimiento de obtencion de 2,6-dimetil-4-(2-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-isobutil-5-metil.
ES2055653B1 (es) * 1992-09-22 1995-03-01 Elmuquimica Farm Sl Procedimiento de obtencion del 2,6-dimetil-4-(3-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-isopropil-5-(2-metoxi)etil.
ES2055654B1 (es) * 1992-09-22 1995-03-01 Elmuquimica Farm Sl Procedimiento de obtencion de 2,6-dimetil-4-(3-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-etil-5-metil.
ES2055652B1 (es) * 1992-09-22 1995-03-01 Elmuquimica Farm Sl Procedimiento de obtencion de 2,6-dimetil-4-(2,3-diclorofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-etil-5-metil.
GB9405833D0 (en) * 1994-03-24 1994-05-11 Pfizer Ltd Separation of the enantiomers of amlodipine
FR2719585B1 (fr) * 1994-05-05 1996-08-02 Lafon Labor Procédé d'obtention de 1,4-dihydropyridines optiquement pures.
US5554621A (en) * 1995-06-07 1996-09-10 Bristol-Myers Squibb Company Dihydropyridine NPY antagonists: nitrogen heterocyclic derivatives
TWI246921B (en) * 2000-04-11 2006-01-11 Sankyo Co Stabilized pharmaceutical composition with calcium blocker
ITMI20012434A1 (it) 2001-11-20 2003-05-20 Dompe Spa Acidi 2-aril-propionici e composizioni farmaceutiche che li contengono

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3447169A1 (de) * 1984-12-22 1986-07-03 Bayer Ag, 5090 Leverkusen Optisch aktive nitrodihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln
WO1987000836A1 (fr) * 1985-08-06 1987-02-12 Boehringer Biochemia Robin S.P.A. 1,4-dihydropyridines pharmaceutiquement actives a substitution 2-thiomethyle
EP0225175A3 (fr) * 1985-11-28 1988-12-28 FISONS plc Dérivés de dihydropyridine, leur procédé de préparation et les compositions pharmaceutiques les contenant
US4920225A (en) * 1986-12-22 1990-04-24 Laboratoires Syntex S.A. Resolution of 1,4-dihydropyridine derivatives
WO1988007525A1 (fr) * 1987-03-27 1988-10-06 Byk Gulden Lomberg Chemische Fabrik Gmbh Enantiomeres de 1,4-dihydropyridine
AU1541188A (en) * 1987-03-27 1988-11-02 Byk Gulden Lomberg Chemische Fabrik Gmbh New optically active compounds

Also Published As

Publication number Publication date
CA2047741A1 (fr) 1990-08-18
ATE95813T1 (de) 1993-10-15
FI913861A0 (fi) 1991-08-15
EP0458823A1 (fr) 1991-12-04
IT1230752B (it) 1991-10-29
KR910700234A (ko) 1991-03-14
NO177186C (no) 1995-08-02
IT8919477A0 (it) 1989-02-17
AU5090490A (en) 1990-09-05
WO1990009376A1 (fr) 1990-08-23
EP0458823B1 (fr) 1993-10-13
RU2069658C1 (ru) 1996-11-27
DK0458823T3 (da) 1994-02-21
FI95371C (fi) 1996-01-25
DE69003936D1 (de) 1993-11-18
IE900584L (en) 1990-08-17
EP0383320A1 (fr) 1990-08-22
DE69003936T2 (de) 1994-03-31
KR0155557B1 (ko) 1998-11-16
NO177186B (no) 1995-04-24
US5245039A (en) 1993-09-14
NO913188D0 (no) 1991-08-15
ES2060144T3 (es) 1994-11-16
AU630928B2 (en) 1992-11-12
HUT62270A (en) 1993-04-28
FI95371B (fi) 1995-10-13
NO913188L (no) 1991-08-15
IE66498B1 (en) 1996-01-10

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