JPH0561920B2 - - Google Patents

Info

Publication number: JPH0561920B2
Authority: JP; Japan
Prior art keywords: fragment; hind; nucleic acid; restriction enzyme; probe
Prior art date: 1986-02-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

JP62042442A

Other languages

English (en)

Japanese (ja)

Other versions

JPS62205800A (ja

Inventor

Ranki Maruyuto

Sederundo Hansu

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Orion Oyj

Original Assignee

Orion Yhtyma Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-02-27

Filing date

1987-02-25

Publication date

1993-09-07

1987-02-25 Application filed by Orion Yhtyma Oy filed Critical Orion Yhtyma Oy

1987-09-10 Publication of JPS62205800A publication Critical patent/JPS62205800A/ja

1993-09-07 Publication of JPH0561920B2 publication Critical patent/JPH0561920B2/ja

Status Granted legal-status Critical Current

Links

239000000523 sample Substances 0.000 claims description 145
150000007523 nucleic acids Chemical class 0.000 claims description 91
108020004707 nucleic acids Proteins 0.000 claims description 90
102000039446 nucleic acids Human genes 0.000 claims description 90
238000012360 testing method Methods 0.000 claims description 81
239000012634 fragment Substances 0.000 claims description 61
108091008146 restriction endonucleases Proteins 0.000 claims description 57
108090000623 proteins and genes Proteins 0.000 claims description 45
238000009396 hybridization Methods 0.000 claims description 40
239000013612 plasmid Substances 0.000 claims description 39
108020004414 DNA Proteins 0.000 claims description 38
238000000034 method Methods 0.000 claims description 33
239000013598 vector Substances 0.000 claims description 21
239000003153 chemical reaction reagent Substances 0.000 claims description 12
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238000003199 nucleic acid amplification method Methods 0.000 claims description 10
101150074155 DHFR gene Proteins 0.000 claims description 9
108010022394 Threonine synthase Proteins 0.000 claims description 9
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238000006243 chemical reaction Methods 0.000 claims description 8
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238000004445 quantitative analysis Methods 0.000 claims description 4
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238000002955 isolation Methods 0.000 claims 1
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238000005259 measurement Methods 0.000 description 24
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CKTSBUTUHBMZGZ-SHYZEUOFSA-N 2'‐deoxycytidine Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 CKTSBUTUHBMZGZ-SHYZEUOFSA-N 0.000 description 2
CKTSBUTUHBMZGZ-UHFFFAOYSA-N Deoxycytidine Natural products O=C1N=C(N)C=CN1C1OC(CO)C(O)C1 CKTSBUTUHBMZGZ-UHFFFAOYSA-N 0.000 description 2
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239000002202 Polyethylene glycol Substances 0.000 description 2
102000052708 Recessive Genes Human genes 0.000 description 2
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238000009835 boiling Methods 0.000 description 2
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239000007788 liquid Substances 0.000 description 2
239000002777 nucleoside Substances 0.000 description 2
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229920001223 polyethylene glycol Polymers 0.000 description 2
102000004169 proteins and genes Human genes 0.000 description 2
239000012488 sample solution Substances 0.000 description 2
239000001226 triphosphate Substances 0.000 description 2
235000011178 triphosphate Nutrition 0.000 description 2
238000005406 washing Methods 0.000 description 2
108091093088 Amplicon Proteins 0.000 description 1
206010008805 Chromosomal abnormalities Diseases 0.000 description 1
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241000252203 Clupea harengus Species 0.000 description 1
102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
102000016911 Deoxyribonucleases Human genes 0.000 description 1
108010053770 Deoxyribonucleases Proteins 0.000 description 1
201000010374 Down Syndrome Diseases 0.000 description 1
102100030708 GTPase KRas Human genes 0.000 description 1
101710113436 GTPase KRas Proteins 0.000 description 1
FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
102000003960 Ligases Human genes 0.000 description 1
108090000364 Ligases Proteins 0.000 description 1
241000699666 Mus <mouse, genus> Species 0.000 description 1
241000699670 Mus sp. Species 0.000 description 1
108700019961 Neoplasm Genes Proteins 0.000 description 1
102000048850 Neoplasm Genes Human genes 0.000 description 1
206010029260 Neuroblastoma Diseases 0.000 description 1
102000043276 Oncogene Human genes 0.000 description 1
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
238000000246 agarose gel electrophoresis Methods 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
238000000376 autoradiography Methods 0.000 description 1
229960002685 biotin Drugs 0.000 description 1
235000020958 biotin Nutrition 0.000 description 1
239000011616 biotin Substances 0.000 description 1
239000000872 buffer Substances 0.000 description 1
229910052793 cadmium Inorganic materials 0.000 description 1
BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 1
230000000711 cancerogenic effect Effects 0.000 description 1
238000004113 cell culture Methods 0.000 description 1
230000011712 cell development Effects 0.000 description 1
108091092356 cellular DNA Proteins 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000010367 cloning Methods 0.000 description 1
230000007547 defect Effects 0.000 description 1
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201000010099 disease Diseases 0.000 description 1
208000035475 disorder Diseases 0.000 description 1
238000000605 extraction Methods 0.000 description 1
230000008175 fetal development Effects 0.000 description 1
210000003754 fetus Anatomy 0.000 description 1
210000002950 fibroblast Anatomy 0.000 description 1
235000019514 herring Nutrition 0.000 description 1
210000005260 human cell Anatomy 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
230000003100 immobilizing effect Effects 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
239000003550 marker Substances 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
229960000485 methotrexate Drugs 0.000 description 1
231100000219 mutagenic Toxicity 0.000 description 1
230000003505 mutagenic effect Effects 0.000 description 1
210000004940 nucleus Anatomy 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
210000002826 placenta Anatomy 0.000 description 1
238000003793 prenatal diagnosis Methods 0.000 description 1
238000002203 pretreatment Methods 0.000 description 1
230000000644 propagated effect Effects 0.000 description 1
102000016914 ras Proteins Human genes 0.000 description 1
108010014186 ras Proteins Proteins 0.000 description 1
239000004576 sand Substances 0.000 description 1
238000000926 separation method Methods 0.000 description 1
208000000587 small cell lung carcinoma Diseases 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
108010051423 streptavidin-agarose Proteins 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Immunology (AREA)
Analytical Chemistry (AREA)
Genetics & Genomics (AREA)
Physics & Mathematics (AREA)
Pathology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Hospice & Palliative Care (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)

JP62042442A 1986-02-27 1987-02-25 核酸分子の定量法およびそれに用いる試薬 Granted JPS62205800A (ja)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FI860836A FI76119C (fi)	1986-02-27	1986-02-27	Kvantitativ bestaemning av nukleinsyramolekyler och reagensfoerpackning som anvaends vid foerfarandet.
FI860836		1986-02-27

Publications (2)

Publication Number	Publication Date
JPS62205800A JPS62205800A (ja)	1987-09-10
JPH0561920B2 true JPH0561920B2 (de)	1993-09-07

Family

ID=8522222

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP62042442A Granted JPS62205800A (ja)	1986-02-27	1987-02-25	核酸分子の定量法およびそれに用いる試薬

Country Status (26)

Country	Link
JP (1)	JPS62205800A (de)
KR (1)	KR870008033A (de)
AT (1)	AT393511B (de)
AU (1)	AU603562B2 (de)
BE (1)	BE1001168A4 (de)
CA (1)	CA1287558C (de)
CH (1)	CH675593A5 (de)
DD (1)	DD270383A5 (de)
DE (1)	DE3706285A1 (de)
DK (1)	DK174784B1 (de)
ES (1)	ES2061411A6 (de)
FI (1)	FI76119C (de)
FR (1)	FR2594849B1 (de)
GB (1)	GB2187283B (de)
HU (1)	HU201808B (de)
IE (1)	IE66904B1 (de)
IL (1)	IL81695A (de)
IS (1)	IS3197A7 (de)
IT (1)	IT1202581B (de)
LU (1)	LU86792A1 (de)
NL (1)	NL195097C (de)
NO (1)	NO175380C (de)
NZ (1)	NZ219421A (de)
PT (1)	PT84368B (de)
SE (1)	SE468816B (de)
ZA (1)	ZA871401B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5714380A (en)	1986-10-23	1998-02-03	Amoco Corporation	Closed vessel for isolating target molecules and for performing amplification
IL86724A (en)	1987-06-19	1995-01-24	Siska Diagnostics Inc	Methods and kits for amplification and testing of nucleic acid sequences
EP0304845A3 (de) *	1987-08-28	1991-03-06	Profile Diagnostic Sciences Inc.	Verfahren und Zusammensetzung zum Nachweis der Genexpression
EP0341904B1 (de) *	1988-05-09	1995-03-29	Temple University of the Commonwealth System of Higher Education	Verfahren zur Voraussage der Wirksamkeit einer antineoplastichen Behandlung bei einzelnen Patienten
AU629845B2 (en) *	1988-08-30	1992-10-15	Abbott Laboratories	Detection and amplification of target nucleic acid sequences
WO1990014440A1 (en) *	1989-05-18	1990-11-29	The United States Of America, Represented By The Secretary, United States Department Of Commerce	RNA PROBE FOR DETECTING c-fes mRNA
US5232829A (en) *	1989-09-29	1993-08-03	Hoffmann-La Roche Inc.	Detection of chlamydia trachomatis by polymerase chain reaction using biotin labelled lina primers and capture probes
DK138090D0 (da) *	1990-06-06	1990-06-06	Novo Nordisk As	Diagnostisk analysemetode
ES2092056T3 (es) *	1991-09-23	1996-11-16	Pfizer	Procedimiento para detectar arnm y adn especificos en celulas.
US6300058B1 (en)	1992-01-29	2001-10-09	Hitachi Chemical Research Center, Inc.	Method for measuring messenger RNA
GB9210916D0 (en) *	1992-05-21	1992-07-08	Isis Innovation	Nucleic acid quantification
US5580971A (en) *	1992-07-28	1996-12-03	Hitachi Chemical Company, Ltd.	Fungal detection system based on rRNA probes
CA2140763A1 (en) *	1992-07-28	1994-02-03	Masato Mitsuhashi	Gene detection system
ES2055661B1 (es) *	1993-01-20	1995-03-01	Univ Malaga	Determinacion de la expresion genica por captura especifica de arn y su cuantificacion directa por electroforesis capilar en zona libre.
GB9309966D0 (en) *	1993-05-14	1993-06-30	Nordion Int Inc	Detection of prostrate-specific antigen in breast tumors
GB9415489D0 (en) *	1994-08-01	1994-09-21	Nordion Int Inc	Detection of prostate-specific antigen in amniotic fluid
AT401062B (de) *	1994-09-26	1996-06-25	Immuno Ag	Verfahren zur quantifizierung von nukleinsäuren
CN102822352B (zh) *	2010-03-31	2015-07-29	有限会社山口技术特许机构	利用核酸色谱法的肺炎病原菌的检出方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4442203A (en) *	1981-06-30	1984-04-10	Massachusetts Institute Of Technology	Gene amplification assay for detecting tumor promoters
FI63596C (fi) *	1981-10-16	1983-07-11	Orion Yhtymae Oy	Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
AU555146B2 (en) *	1982-03-15	1986-09-11	Trustees Of Columbia University In The City Of New York, The	Method for intorducing cloned, amplifiable genes into eucaryotic cells and for producing proteinaceous products materials
CA1252046A (en) *	1982-11-04	1989-04-04	Martin J. Cline	Methods for oncogenic detection
FI71768C (fi) *	1984-02-17	1987-02-09	Orion Yhtymae Oy	Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning.
US4675283A (en) *	1984-07-19	1987-06-23	Massachusetts Institute Of Technology	Detection and isolation of homologous, repeated and amplified nucleic acid sequences
FI72146C (fi) *	1985-01-02	1987-04-13	Orion Yhtymae Oy	Foerfarande foer identifiering av nukleinsyror.
FR2583771B1 (fr) *	1985-06-21	1988-12-09	Centre Nat Rech Scient	Sequences d'adn d'archaebacteries homologues a l'oncogene v-myc, proteines codees par ces sequences, leurs procedes d'obtention et leurs applications immunologiques

1986
- 1986-02-27 FI FI860836A patent/FI76119C/fi not_active IP Right Cessation
1987
- 1987-02-25 JP JP62042442A patent/JPS62205800A/ja active Granted
- 1987-02-26 NZ NZ219421A patent/NZ219421A/xx unknown
- 1987-02-26 LU LU86792A patent/LU86792A1/fr unknown
- 1987-02-26 FR FR878702541A patent/FR2594849B1/fr not_active Expired - Lifetime
- 1987-02-26 IT IT19501/87A patent/IT1202581B/it active
- 1987-02-26 SE SE8700821A patent/SE468816B/sv not_active IP Right Cessation
- 1987-02-26 ES ES08700776A patent/ES2061411A6/es not_active Expired - Fee Related
- 1987-02-26 IE IE49687A patent/IE66904B1/en not_active IP Right Cessation
- 1987-02-26 CA CA000530691A patent/CA1287558C/en not_active Expired - Lifetime
- 1987-02-26 KR KR870001680A patent/KR870008033A/ko not_active Withdrawn
- 1987-02-26 CH CH756/87A patent/CH675593A5/de not_active IP Right Cessation
- 1987-02-26 IS IS3197A patent/IS3197A7/is unknown
- 1987-02-26 ZA ZA871401A patent/ZA871401B/xx unknown
- 1987-02-26 NL NL8700483A patent/NL195097C/nl not_active IP Right Cessation
- 1987-02-26 HU HU87750A patent/HU201808B/hu unknown
- 1987-02-26 DE DE19873706285 patent/DE3706285A1/de active Granted
- 1987-02-26 PT PT84368A patent/PT84368B/pt unknown
- 1987-02-26 DK DK198700993A patent/DK174784B1/da not_active IP Right Cessation
- 1987-02-26 BE BE8700177A patent/BE1001168A4/fr not_active IP Right Cessation
- 1987-02-26 GB GB8704517A patent/GB2187283B/en not_active Expired - Lifetime
- 1987-02-26 AT AT431/87A patent/AT393511B/de not_active IP Right Cessation
- 1987-02-26 AU AU69275/87A patent/AU603562B2/en not_active Expired
- 1987-02-26 NO NO870794A patent/NO175380C/no unknown
- 1987-02-27 IL IL81695A patent/IL81695A/xx not_active IP Right Cessation
- 1987-02-27 DD DD87300286A patent/DD270383A5/de unknown

Also Published As

Publication number	Publication date
IE870496L (en)	1987-08-27
HU201808B (en)	1990-12-28
IL81695A (en)	1991-04-15
IT8719501A0 (it)	1987-02-26
PT84368B (pt)	1989-10-04
NL8700483A (nl)	1987-09-16
SE468816B (sv)	1993-03-22
NO870794D0 (no)	1987-02-26
DK99387A (da)	1987-08-28
GB8704517D0 (en)	1987-04-01
SE8700821D0 (sv)	1987-02-26
FR2594849A1 (fr)	1987-08-28
GB2187283A (en)	1987-09-03
DK99387D0 (da)	1987-02-26
DD270383A5 (de)	1989-07-26
AT393511B (de)	1991-11-11
FI860836L (fi)	1987-08-28
CH675593A5 (de)	1990-10-15
NO175380B (no)	1994-06-27
AU6927587A (en)	1987-09-03
AU603562B2 (en)	1990-11-22
IS3197A7 (is)	1987-08-28
NO870794L (no)	1987-08-28
FI76119C (fi)	1988-09-09
CA1287558C (en)	1991-08-13
ATA43187A (de)	1991-04-15
NO175380C (no)	1994-10-05
GB2187283B (en)	1990-05-30
DE3706285A1 (de)	1987-11-12
HUT43647A (en)	1987-11-30
NZ219421A (en)	1988-11-29
FI860836A0 (fi)	1986-02-27
ES2061411A6 (es)	1994-12-01
SE8700821L (sv)	1987-08-28
IL81695A0 (en)	1987-09-16
PT84368A (en)	1987-03-01
ZA871401B (en)	1987-10-28
DK174784B1 (da)	2003-11-10
LU86792A1 (fr)	1987-07-24
FI76119B (fi)	1988-05-31
FR2594849B1 (fr)	1990-04-20
NL195097C (nl)	2004-03-17
DE3706285C2 (de)	1993-02-04
JPS62205800A (ja)	1987-09-10
IE66904B1 (en)	1996-02-07
KR870008033A (ko)	1987-09-23
BE1001168A4 (fr)	1989-08-08
IT1202581B (it)	1989-02-09

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