JPH0564128B2 - - Google Patents

Info

Publication number
JPH0564128B2
JPH0564128B2 JP59174351A JP17435184A JPH0564128B2 JP H0564128 B2 JPH0564128 B2 JP H0564128B2 JP 59174351 A JP59174351 A JP 59174351A JP 17435184 A JP17435184 A JP 17435184A JP H0564128 B2 JPH0564128 B2 JP H0564128B2
Authority
JP
Japan
Prior art keywords
hemoglobin
polyalkylene glycol
acid
molecular weight
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP59174351A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6153223A (ja
Inventor
Takaharu Iwasaki
Juji Iwashita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Fujirebio Inc
Original Assignee
Ajinomoto Co Inc
Fujirebio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc, Fujirebio Inc filed Critical Ajinomoto Co Inc
Priority to JP59174351A priority Critical patent/JPS6153223A/ja
Publication of JPS6153223A publication Critical patent/JPS6153223A/ja
Publication of JPH0564128B2 publication Critical patent/JPH0564128B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP59174351A 1984-08-22 1984-08-22 ヘモグロビン−ポリアルキレングリコ−ル結合体の製造方法 Granted JPS6153223A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP59174351A JPS6153223A (ja) 1984-08-22 1984-08-22 ヘモグロビン−ポリアルキレングリコ−ル結合体の製造方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59174351A JPS6153223A (ja) 1984-08-22 1984-08-22 ヘモグロビン−ポリアルキレングリコ−ル結合体の製造方法

Publications (2)

Publication Number Publication Date
JPS6153223A JPS6153223A (ja) 1986-03-17
JPH0564128B2 true JPH0564128B2 (de) 1993-09-14

Family

ID=15977118

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59174351A Granted JPS6153223A (ja) 1984-08-22 1984-08-22 ヘモグロビン−ポリアルキレングリコ−ル結合体の製造方法

Country Status (1)

Country Link
JP (1) JPS6153223A (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6667292B1 (en) 1999-02-08 2003-12-23 Hokkaido University Nitric monoxide metabolite-polyoxyalkylene-hemoglobin complex

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100316154B1 (ko) * 1999-03-26 2001-12-12 노광 폴리에틸렌글리콜－헤모글로빈 결합체

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6023084B2 (ja) * 1979-07-11 1985-06-05 味の素株式会社 代用血液
JPS57206622A (en) * 1981-06-10 1982-12-18 Ajinomoto Co Inc Blood substitute
JPS5989629A (ja) * 1982-11-15 1984-05-23 Ajinomoto Co Inc 代用血液
JPS59104323A (ja) * 1982-12-07 1984-06-16 Ajinomoto Co Inc 代用血液

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6667292B1 (en) 1999-02-08 2003-12-23 Hokkaido University Nitric monoxide metabolite-polyoxyalkylene-hemoglobin complex

Also Published As

Publication number Publication date
JPS6153223A (ja) 1986-03-17

Similar Documents

Publication Publication Date Title
US4670417A (en) Hemoglobin combined with a poly(alkylene oxide)
US4301144A (en) Blood substitute containing modified hemoglobin
EP0200467B1 (de) Mit einem Poly(alkylenoxid) kombinierte Superoxid-Dismutase
US5110909A (en) Macromolecular conjugates of hemoglobin, a procedure for their preparation and their uses
US6017943A (en) Hemoglobin crosslinkers
JPH026337B2 (de)
JP2000514434A (ja) ヘモグロビン―ヒドロキシエチルスターチ結合体含有酸素運搬剤、その製造方法及びその血液代用剤等としての使用
JPH07506123A (ja) 酸化開環サッカライドによるヘモグロビンの選択的架橋
JP2018150335A (ja) スクシンイミド活性化されたニトロキシル化合物およびタンパク質のニトロキシル化のためのその使用のための方法
CA2101361A1 (en) Low diol polyalkylene oxide biologically active proteinaceous substances
RU1776275C (ru) Способ получени водорастворимого коньюгата С @ , Z @ -зависимой пероксид-дисмутазы
US20040023851A1 (en) Method for the porduction of artificial oxygen carriers from covalently cross linking haemoglobin with improved functional properties of haemoglobin by cross- linking in the presence of chemically non- reacting effectors of the oxygen affinity of the haemoglobin
CA1266550A (en) Polymer resins with amino acid containing pendants for sorption of bile pigments and bile acids
KR20150132235A (ko) 폴리알킬렌 산화물 발레르산염 헤모글로빈 접합체
ES2395894T3 (es) Hemoglobinas de mamífero compatibles con plasma sanguíneo, reticuladas y conjugadas con poli(óxidos de alquileno) como portadores de oxígeno médicos artificiales, su preparación y su uso
JPH0564128B2 (de)
WO2011106396A1 (en) Methods for preparing peg-hemoglobin conjugates using reduced reactant ratios
JP2000230000A (ja) 一酸化窒素代謝物−ポリオキシアルキレン−ヘモグロビン結合体
JPS63208523A (ja) 酸素運搬剤
US20100075379A1 (en) Method for making polyalkylene oxide modified hemoglobin
JP2501543B2 (ja) ヘモグロビン−ポリオキシアルキレン結合体凍結乾燥製剤
JPS59104323A (ja) 代用血液
CN120737352B (zh) 一种化学修饰剂及其制备胃蛋白酶的方法
Pietta et al. Comparison of the Properties of Human Hemoglobin Covalently Bound to Carboxyl Dextrans with Free and Polymerized Hemoglobin
US6326178B1 (en) Method for synthesizing a composite of a conductive macromolecule and a protein

Legal Events

Date Code Title Description
EXPY Cancellation because of completion of term