JPH0653739B2 - ３位置換カルバセフエム化合物 - Google Patents

３位置換カルバセフエム化合物

Info

Publication number
JPH0653739B2
JPH0653739B2 JP59241380A JP24138084A JPH0653739B2 JP H0653739 B2 JPH0653739 B2 JP H0653739B2 JP 59241380 A JP59241380 A JP 59241380A JP 24138084 A JP24138084 A JP 24138084A JP H0653739 B2 JPH0653739 B2 JP H0653739B2
Authority
JP
Japan
Prior art keywords
added
syn
group
compound
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP59241380A
Other languages
English (en)
Japanese (ja)
Other versions
JPS61122285A (ja
Inventor
顕一 持田
剛裕 小笠
純一 島田
正 平田
清 佐藤
諒 岡地
Original Assignee
協和醗酵工業株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 協和醗酵工業株式会社 filed Critical 協和醗酵工業株式会社
Priority to JP59241380A priority Critical patent/JPH0653739B2/ja
Priority to EP85114501A priority patent/EP0182301B1/fr
Priority to DE8585114501T priority patent/DE3583214D1/de
Priority to US06/798,320 priority patent/US4760060A/en
Publication of JPS61122285A publication Critical patent/JPS61122285A/ja
Publication of JPH0653739B2 publication Critical patent/JPH0653739B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP59241380A 1984-11-15 1984-11-15 ３位置換カルバセフエム化合物 Expired - Lifetime JPH0653739B2 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP59241380A JPH0653739B2 (ja) 1984-11-15 1984-11-15 ３位置換カルバセフエム化合物
EP85114501A EP0182301B1 (fr) 1984-11-15 1985-11-14 Dérivés carbacéphem et céphem et leurs compositions pharmaceutiques
DE8585114501T DE3583214D1 (de) 1984-11-15 1985-11-14 3-substituierte carbacephem- und cephemverbindungen und ihre pharmazeutischen zusammensetzungen.
US06/798,320 US4760060A (en) 1984-11-15 1985-11-15 3-heteroaralkylthio carbacephem compounds and antibacterial pharmaceutical composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59241380A JPH0653739B2 (ja) 1984-11-15 1984-11-15 ３位置換カルバセフエム化合物

Publications (2)

Publication Number Publication Date
JPS61122285A JPS61122285A (ja) 1986-06-10
JPH0653739B2 true JPH0653739B2 (ja) 1994-07-20

Family

ID=17073421

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59241380A Expired - Lifetime JPH0653739B2 (ja) 1984-11-15 1984-11-15 ３位置換カルバセフエム化合物

Country Status (4)

Country Link
US (1) US4760060A (fr)
EP (1) EP0182301B1 (fr)
JP (1) JPH0653739B2 (fr)
DE (1) DE3583214D1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4812562A (en) * 1985-07-25 1989-03-14 Taisho Pharmaceutical Co., Ltd. Cephalosporin derivatives
FR2610630B2 (fr) * 1987-02-06 1989-05-26 Roussel Uclaf Nouveaux derives de l'acide 1-dethia 2-thia cephalosporanique, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
US4885291A (en) * 1988-01-14 1989-12-05 Eli Lilly And Company 1-carba(dethia)-3-cephem derivatives
DE3803169A1 (de) * 1988-02-03 1989-08-17 Bayer Ag Ss-lactam-antibiotika, verfahren zu ihrer herstellung und ihre verwendung als und in arzneimitteln
US4921953A (en) * 1988-02-18 1990-05-01 Taisho Pharmaceutical Co., Ltd. Cephalosporin derivatives
DE69028285T2 (de) * 1989-12-07 1997-03-20 Meiji Seika Kaisha Cephalosporinderivate, ihre Herstellung und Anwendungen
US5077287A (en) * 1991-01-18 1991-12-31 Eli Lilly And Company 3-thiazolylthio carbacephem antibacterial agents
IL100576A (en) * 1991-01-18 1995-11-27 Eli Lilley And Company Cephalosporin antibiotics
US5247073A (en) * 1991-01-18 1993-09-21 Eli Lilly And Company 7-(Amino or protected amino)-3-thioheterobicyclic cephalosporins
JP3238209B2 (ja) * 1992-09-30 2001-12-10 塩野義製薬株式会社 チオメチルチオカルバセファロスポリン誘導体
TW427993B (en) * 1993-09-09 2001-04-01 Fujisawa Pharmaceutical Co New cephem compounds
US5688786A (en) * 1994-04-01 1997-11-18 Microcide Pharmaceuticals, Inc. β-lactam antibiotics
US5593986A (en) * 1994-04-01 1997-01-14 Microcide Pharmaceuticals, Inc. Cephalosporin antibiotics
US5698547A (en) * 1994-04-01 1997-12-16 Microcide Pharmaceuticals, Inc. Cephalosporin antibiotics
EP1444237A1 (fr) * 2001-11-12 2004-08-11 Hans Rudolf Pfaendler Nouveaux derives acetal de formaldehyde c-3 s/o- et s/n de cephalosporines et leur utilisation en tant qu'antibiotiques
EA201070504A1 (ru) 2007-10-25 2010-12-30 Эйкеоджен, Инк. КАРБАЦЕФЕМ β-ЛАКТАМОВЫЕ АНТИБИОТИКИ

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226866A (en) * 1972-11-06 1980-10-07 Merck & Co., Inc. Novel antibiotic analogues of cephalosporins
CH605997A5 (fr) * 1974-08-30 1978-10-13 Ciba Geigy Ag
US4150156A (en) * 1975-11-21 1979-04-17 Merck & Co., Inc. 7-(Substituted methyl)-3-(substituted thio)-cephalosporins, derivatives and pharmaceutical compositions containing them
ZA766941B (en) * 1975-11-21 1978-06-28 Merck & Co Inc 3-(substituted thio)cephalosporins,derivatives and nuclear analogues thereof
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
JPS6058920B2 (ja) * 1978-12-26 1985-12-23 協和醗酵工業株式会社 セフアロスポリン類縁体
EP0025017A1 (fr) * 1979-08-28 1981-03-11 Ciba-Geigy Ag Composés polyazathia, procédé pour leur préparation, compositions pharmaceutiques les contenant et utilisation de ces dernières
FR2550200B1 (fr) * 1983-08-01 1988-04-08 Fujisawa Pharmaceutical Co Procede de preparation de composes de cephem a activite antimicrobienne et nouveaux produits ainsi obtenus
JPS6133190A (ja) * 1984-07-10 1986-02-17 Fujisawa Pharmaceut Co Ltd 新規セフエム化合物，その製造法およびその用途

Also Published As

Publication number Publication date
DE3583214D1 (de) 1991-07-18
US4760060A (en) 1988-07-26
EP0182301B1 (fr) 1991-06-12
JPS61122285A (ja) 1986-06-10
EP0182301A2 (fr) 1986-05-28
EP0182301A3 (en) 1987-07-22

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