JPH0729941B2 - 眼の組織中に目薬を保持するための薬剤 - Google Patents

眼の組織中に目薬を保持するための薬剤

Info

Publication number
JPH0729941B2
JPH0729941B2 JP3040134A JP4013491A JPH0729941B2 JP H0729941 B2 JPH0729941 B2 JP H0729941B2 JP 3040134 A JP3040134 A JP 3040134A JP 4013491 A JP4013491 A JP 4013491A JP H0729941 B2 JPH0729941 B2 JP H0729941B2
Authority
JP
Japan
Prior art keywords
sulfate
drug
glucan
cyclodextrin
complex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP3040134A
Other languages
English (en)
Japanese (ja)
Other versions
JPH04211615A (ja
Inventor
フォークマン ジューダ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Childrens Hospital
Original Assignee
Boston Childrens Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Childrens Hospital filed Critical Boston Childrens Hospital
Publication of JPH04211615A publication Critical patent/JPH04211615A/ja
Publication of JPH0729941B2 publication Critical patent/JPH0729941B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Prostheses (AREA)
JP3040134A 1990-03-07 1991-03-06 眼の組織中に目薬を保持するための薬剤 Expired - Lifetime JPH0729941B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/489680 1990-03-07
US07/489,680 US5227372A (en) 1990-03-07 1990-03-07 Method for retaining ophthalmological agents in ocular tissues

Publications (2)

Publication Number Publication Date
JPH04211615A JPH04211615A (ja) 1992-08-03
JPH0729941B2 true JPH0729941B2 (ja) 1995-04-05

Family

ID=23944834

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3040134A Expired - Lifetime JPH0729941B2 (ja) 1990-03-07 1991-03-06 眼の組織中に目薬を保持するための薬剤

Country Status (10)

Country Link
US (1) US5227372A (de)
EP (1) EP0447351B1 (de)
JP (1) JPH0729941B2 (de)
KR (1) KR910016315A (de)
AT (1) ATE132741T1 (de)
AU (1) AU636451B2 (de)
CA (1) CA2037624A1 (de)
DE (1) DE69116186D1 (de)
IE (1) IE910658A1 (de)
NZ (1) NZ237165A (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605938A (en) * 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
US5705178A (en) * 1991-05-31 1998-01-06 Gliatech, Inc. Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers
WO1993005777A1 (fr) * 1991-09-18 1993-04-01 Fujisawa Pharmaceutical Co., Ltd. Preparation transoculaire
ATE205092T1 (de) * 1992-01-30 2001-09-15 Takeda Chemical Industries Ltd Verfahren zur herstellung hoch-wasserlöslicher zyklodextrinkomplexe
TW251236B (de) * 1992-09-10 1995-07-11 Ciba Vision Ag
US5328930A (en) * 1993-03-01 1994-07-12 Emory University Treatment of microsporidial and acanthamoeba keratoconjunctivitis with topical fumagillin
US5662919A (en) * 1994-11-21 1997-09-02 Alcon Laboratories, Inc. Sulfated polyvinyl alcohol polymers to stabilize pharmaceutical drug compounds
US5710148A (en) * 1995-03-06 1998-01-20 Senju Pharmaceuticals Co., Ltd. Corneal opacification inhibitory composition
US5744154A (en) * 1995-09-06 1998-04-28 Laboratoire Chauvin S.A. Ready-to-use indomethacin-based eye lotion
US5686095A (en) * 1995-10-23 1997-11-11 Price, Jr.; Francis W. Method of treating canker sores
DE19539532C2 (de) * 1995-10-24 1999-02-25 Mann Gerhard Chem Pharm Fab Ophthalmisches Cromoglicat-Gelpräparat
JP2001524097A (ja) * 1997-04-23 2001-11-27 ユニバーシティ オブ オタゴ 眼用組成物の制御放出
US20040152664A1 (en) * 1998-09-02 2004-08-05 Allergan, Inc. Prednisolone compositions
WO2000012137A1 (en) 1998-09-02 2000-03-09 Allergan Sales, Inc. Preserved cyclodextrin-containing compositions
DE60008234T2 (de) * 1999-04-29 2004-12-30 Alza Corp., Mountain View Liposomenzusammensetzungen zur verbesserten wirkstoffzurückhaltung
JP2001158750A (ja) * 1999-12-02 2001-06-12 Lion Corp 眼科用組成物及び抗アレルギー薬の持続性向上方法
US6265435B1 (en) 2000-03-07 2001-07-24 Hans Rosenkoetter Method for enhancing corneal penetration by water soluble ophthalmic drugs
RU2177801C1 (ru) * 2001-01-25 2002-01-10 Санкт-Петербургская Общественная Организация "Санкт-Петербургский Институт Биорегуляции И Геронтологии Сзо Рамн" Средство, ингибирующее ангиогенез при заболеваниях органа зрения
US20040009953A1 (en) * 2002-01-10 2004-01-15 Comper Wayne D. Antimicrobial charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and method of use thereof
US20030181416A1 (en) * 2002-01-10 2003-09-25 Comper Wayne D. Antimicrobial charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and method of use thereof
MXPA04008171A (es) * 2002-02-22 2004-11-26 Pharmacia Corp Formulacion oftalmica con sistema de goma.
CA2481306A1 (en) * 2002-04-09 2003-10-23 Greenville Hospital System Metastasis modulating activity of highly sulfated oligosaccharides
US20050085446A1 (en) * 2003-04-14 2005-04-21 Babu M.K. M. Fluoroquinolone formulations and methods of making and using the same
US20050009782A1 (en) * 2003-07-09 2005-01-13 Comper Wayne D. Antiviral charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and methods of use thereof
US20050234018A1 (en) * 2004-04-15 2005-10-20 Allergan, Inc. Drug delivery to the back of the eye
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
ES2667945T3 (es) 2007-10-08 2018-05-16 Aurinia Pharmaceuticals Inc. Composiciones oftálmicas que comprenden inhibidores de calcineurina o Inhibidores de mTOR
MY156662A (en) * 2007-11-01 2016-03-15 Acucela Inc Amine derivative compounds for treating ophthalmic diseases and disorders
JP5890182B2 (ja) * 2009-02-12 2016-03-22 インセプト エルエルシー ヒドロゲルプラグによる薬物送達
EP2440185B1 (de) * 2009-06-09 2015-04-08 Aurinia Pharmaceuticals Inc. Topische arzneimittelabgabesysteme zur ophthalmischen verwendung
AU2011233663B2 (en) 2010-04-03 2016-04-14 Praful Doshi Medical devices including medicaments and methods of making and using same
US10413506B2 (en) 2010-04-03 2019-09-17 Praful Doshi Medical devices including medicaments and methods of making and using same including enhancing comfort, enhancing drug penetration, and treatment of myopia
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
JP6199883B2 (ja) 2011-12-05 2017-09-20 インセプト・リミテッド・ライアビリティ・カンパニーＩｎｃｅｐｔ，Ｌｌｃ 医療用オルガノゲルプロセス及び組成物
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis
ES2777836T3 (es) 2017-05-17 2020-08-06 Tx Medic Ab Tratamiento del glaucoma
EP3810659A1 (de) * 2018-06-20 2021-04-28 DuPont Industrial Biosciences USA, LLC Polysaccharidderivate und zusammensetzungen damit

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2923704A (en) * 1957-05-15 1960-02-02 Hoffmann La Roche Cycloamylose sulfates and derivatives thereof
US3754925A (en) * 1970-03-24 1973-08-28 Takeda Chemical Industries Ltd New thermo gelable polysaccharide containing foodstuffs
DK135268A (de) * 1973-02-09
JPS5036422A (de) * 1973-08-07 1975-04-05
JPS5366442A (en) * 1976-11-18 1978-06-13 Takuma Sasaki Antitumors
JPS5583798A (en) * 1978-12-19 1980-06-24 Takuma Sasaki (1,3)-beta-d-glucan derivative
EP0244178A3 (de) * 1986-04-28 1989-02-08 Iolab, Inc Intraokuläre Mittel und Verfahren zu deren Verwendung
EP0261719A3 (de) * 1986-09-23 1990-10-10 Akzo N.V. Thermochemischlumineszierende Komplexe von Cyclodextrinen
JP2577049B2 (ja) * 1987-06-04 1997-01-29 三共株式会社 シクロスポリン製剤
US4877778A (en) * 1987-07-01 1989-10-31 The Children's Medical Center Corporation Method of enhancing lipophile transport using cyclodextrin derivatives
US4877774A (en) * 1987-09-09 1989-10-31 The United States Of America As Represented By The Department Of Health And Human Services Administration of steroid hormones
NZ226171A (en) * 1987-09-18 1990-06-26 Ethicon Inc Gel formulation containing polypeptide growth factor
DE3740838A1 (de) * 1987-11-27 1989-06-08 Schering Ag Cyclodextrinclathrate von 5-cyano-prostacyclinderivaten und ihre verwendung als arzneimittel
ES2059571T3 (es) * 1988-01-19 1994-11-16 Takeda Chemical Industries Ltd Fumagilina como agente angiostatico.
KR900700114A (ko) * 1988-01-19 1990-08-11 모세 쥬다 포크만 성장억제 작용제 및 그 사용법
US5019562A (en) * 1988-01-19 1991-05-28 The Trustees Of The University Of Pennsylvania/Childrens Hospital Corporation Growth inhibiting agent and the use thereof
US5007967A (en) * 1988-08-15 1991-04-16 American Maize-Products Company Separation and purification of branched beta cyclodextrins

Also Published As

Publication number Publication date
DE69116186D1 (de) 1996-02-22
EP0447351B1 (de) 1996-01-10
IE910658A1 (en) 1991-09-11
EP0447351A1 (de) 1991-09-18
KR910016315A (ko) 1991-11-05
AU7139691A (en) 1991-09-12
US5227372A (en) 1993-07-13
AU636451B2 (en) 1993-04-29
CA2037624A1 (en) 1991-09-08
JPH04211615A (ja) 1992-08-03
NZ237165A (en) 1992-10-28
ATE132741T1 (de) 1996-01-15

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Legal Events

Date Code Title Description
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 19950912