JPH07508735A - 薬物送達デバイスおよびそのデバイスの製造方法 - Google Patents

薬物送達デバイスおよびそのデバイスの製造方法

Info

Publication number: JPH07508735A
Authority: JP; Japan
Prior art keywords: drug; delivery device; drug delivery; polymer; cross
Prior art date: 1992-07-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

JP6502843A

Other languages

English (en)

Japanese (ja)

Inventor

ブロンドステッド，ヘレ

ボブガード，ラルス

Original Assignee

アストラ　アクチボラゲット

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-07

Filing date

1993-07-06

Publication date

1995-09-28

1993-07-06 Application filed by アストラ　アクチボラゲット filed Critical アストラ　アクチボラゲット

1995-09-28 Publication of JPH07508735A publication Critical patent/JPH07508735A/ja

Status Expired - Lifetime legal-status Critical Current

Links

238000012377 drug delivery Methods 0.000 title claims description 24
238000000034 method Methods 0.000 title claims description 14
238000004519 manufacturing process Methods 0.000 title claims description 11
239000003814 drug Substances 0.000 claims description 70
229940079593 drug Drugs 0.000 claims description 66
239000000017 hydrogel Substances 0.000 claims description 45
239000011159 matrix material Substances 0.000 claims description 28
229920000642 polymer Polymers 0.000 claims description 20
229920002307 Dextran Polymers 0.000 claims description 17
239000003431 cross linking reagent Substances 0.000 claims description 16
229920006237 degradable polymer Polymers 0.000 claims description 14
238000004132 cross linking Methods 0.000 claims description 12
238000006243 chemical reaction Methods 0.000 claims description 8
239000005057 Hexamethylene diisocyanate Substances 0.000 claims description 5
239000003795 chemical substances by application Substances 0.000 claims description 3
RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical group O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 claims description 3
238000010521 absorption reaction Methods 0.000 claims description 2
125000005442 diisocyanate group Chemical group 0.000 claims description 2
239000007788 liquid Substances 0.000 claims description 2
239000000463 material Substances 0.000 claims description 2
239000000178 monomer Substances 0.000 claims description 2
239000002904 solvent Substances 0.000 claims description 2
125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 claims 1
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 24
239000000499 gel Substances 0.000 description 21
210000001072 colon Anatomy 0.000 description 19
230000008961 swelling Effects 0.000 description 16
239000000203 mixture Substances 0.000 description 15
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 14
210000002784 stomach Anatomy 0.000 description 12
108010001682 Dextranase Proteins 0.000 description 11
230000015556 catabolic process Effects 0.000 description 9
238000006731 degradation reaction Methods 0.000 description 9
210000000813 small intestine Anatomy 0.000 description 8
108090000790 Enzymes Proteins 0.000 description 7
102000004190 Enzymes Human genes 0.000 description 7
229940088598 enzyme Drugs 0.000 description 7
229960000890 hydrocortisone Drugs 0.000 description 7
239000013543 active substance Substances 0.000 description 6
239000000872 buffer Substances 0.000 description 6
239000000243 solution Substances 0.000 description 6
210000004534 cecum Anatomy 0.000 description 4
239000012530 fluid Substances 0.000 description 4
150000004676 glycans Chemical class 0.000 description 4
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
102000035195 Peptidases Human genes 0.000 description 3
108091005804 Peptidases Proteins 0.000 description 3
150000001768 cations Chemical class 0.000 description 3
230000007423 decrease Effects 0.000 description 3
230000001419 dependent effect Effects 0.000 description 3
230000000694 effects Effects 0.000 description 3
-1 hydrogen ions Chemical class 0.000 description 3
230000000968 intestinal effect Effects 0.000 description 3
229940126701 oral medication Drugs 0.000 description 3
229920001282 polysaccharide Polymers 0.000 description 3
239000005017 polysaccharide Substances 0.000 description 3
229940002612 prodrug Drugs 0.000 description 3
239000000651 prodrug Substances 0.000 description 3
102000004169 proteins and genes Human genes 0.000 description 3
108090000623 proteins and genes Proteins 0.000 description 3
229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 3
239000011541 reaction mixture Substances 0.000 description 3
235000021419 vinegar Nutrition 0.000 description 3
239000000052 vinegar Substances 0.000 description 3
229920002567 Chondroitin Polymers 0.000 description 2
241000700159 Rattus Species 0.000 description 2
239000008351 acetate buffer Substances 0.000 description 2
239000002253 acid Substances 0.000 description 2
230000002378 acidificating effect Effects 0.000 description 2
239000004480 active ingredient Substances 0.000 description 2
239000002738 chelating agent Substances 0.000 description 2
DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 description 2
230000000112 colonic effect Effects 0.000 description 2
238000012937 correction Methods 0.000 description 2
238000000354 decomposition reaction Methods 0.000 description 2
230000001079 digestive effect Effects 0.000 description 2
235000013399 edible fruits Nutrition 0.000 description 2
150000002148 esters Chemical class 0.000 description 2
229910052739 hydrogen Inorganic materials 0.000 description 2
239000001257 hydrogen Substances 0.000 description 2
210000000936 intestine Anatomy 0.000 description 2
210000002429 large intestine Anatomy 0.000 description 2
239000002609 medium Substances 0.000 description 2
239000012528 membrane Substances 0.000 description 2
230000000813 microbial effect Effects 0.000 description 2
230000003204 osmotic effect Effects 0.000 description 2
LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
FZWBNHMXJMCXLU-UHFFFAOYSA-N 2,3,4,5-tetrahydroxy-6-[3,4,5-trihydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxyhexanal Chemical compound OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OCC(O)C(O)C(O)C(O)C=O)O1 FZWBNHMXJMCXLU-UHFFFAOYSA-N 0.000 description 1
235000001674 Agaricus brunnescens Nutrition 0.000 description 1
239000004382 Amylase Substances 0.000 description 1
108010065511 Amylases Proteins 0.000 description 1
102000013142 Amylases Human genes 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
229920001353 Dextrin Polymers 0.000 description 1
239000004375 Dextrin Substances 0.000 description 1
229920002491 Diethylaminoethyl-dextran Polymers 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
LFVLUOAHQIVABZ-UHFFFAOYSA-N Iodofenphos Chemical compound COP(=S)(OC)OC1=CC(Cl)=C(I)C=C1Cl LFVLUOAHQIVABZ-UHFFFAOYSA-N 0.000 description 1
241000211181 Manta Species 0.000 description 1
241000287462 Phalacrocorax carbo Species 0.000 description 1
102100026827 Protein associated with UVRAG as autophagy enhancer Human genes 0.000 description 1
101710102978 Protein associated with UVRAG as autophagy enhancer Proteins 0.000 description 1
239000004809 Teflon Substances 0.000 description 1
229920006362 Teflon® Polymers 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
239000000654 additive Substances 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
235000019418 amylase Nutrition 0.000 description 1
229940124599 anti-inflammatory drug Drugs 0.000 description 1
239000002246 antineoplastic agent Substances 0.000 description 1
229940041181 antineoplastic drug Drugs 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
239000002775 capsule Substances 0.000 description 1
238000003776 cleavage reaction Methods 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
229940000425 combination drug Drugs 0.000 description 1
239000007891 compressed tablet Substances 0.000 description 1
238000013270 controlled release Methods 0.000 description 1
239000012059 conventional drug carrier Substances 0.000 description 1
238000001816 cooling Methods 0.000 description 1
230000008878 coupling Effects 0.000 description 1
238000010168 coupling process Methods 0.000 description 1
238000005859 coupling reaction Methods 0.000 description 1
229920006037 cross link polymer Polymers 0.000 description 1
229940041984 dextran 1 Drugs 0.000 description 1
229940119743 dextran 70 Drugs 0.000 description 1
235000019425 dextrin Nutrition 0.000 description 1
238000010586 diagram Methods 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
235000013305 food Nutrition 0.000 description 1
239000012737 fresh medium Substances 0.000 description 1
125000000524 functional group Chemical group 0.000 description 1
210000004211 gastric acid Anatomy 0.000 description 1
230000002496 gastric effect Effects 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
239000007903 gelatin capsule Substances 0.000 description 1
239000011521 glass Substances 0.000 description 1
239000008103 glucose Substances 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
238000002513 implantation Methods 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000005342 ion exchange Methods 0.000 description 1
238000005259 measurement Methods 0.000 description 1
238000002483 medication Methods 0.000 description 1
NFGXHKASABOEEW-LDRANXPESA-N methoprene Chemical compound COC(C)(C)CCCC(C)C\C=C\C(\C)=C\C(=O)OC(C)C NFGXHKASABOEEW-LDRANXPESA-N 0.000 description 1
239000004005 microsphere Substances 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
231100000404 nontoxic agent Toxicity 0.000 description 1
229940124583 pain medication Drugs 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
150000004804 polysaccharides Polymers 0.000 description 1
229910000160 potassium phosphate Inorganic materials 0.000 description 1
235000011009 potassium phosphates Nutrition 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
230000007017 scission Effects 0.000 description 1
241000894007 species Species 0.000 description 1
230000003335 steric effect Effects 0.000 description 1
150000003431 steroids Chemical class 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
230000002522 swelling effect Effects 0.000 description 1
239000003826 tablet Substances 0.000 description 1
230000036962 time dependent Effects 0.000 description 1
230000005919 time-dependent effect Effects 0.000 description 1
230000001131 transforming effect Effects 0.000 description 1
238000013519 translation Methods 0.000 description 1
238000000825 ultraviolet detection Methods 0.000 description 1
150000003673 urethanes Chemical class 0.000 description 1
229960005486 vaccine Drugs 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
230000002747 voluntary effect Effects 0.000 description 1
238000005406 washing Methods 0.000 description 1
229920003169 water-soluble polymer Polymers 0.000 description 1
238000005303 weighing Methods 0.000 description 1
230000004580 weight loss Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Inorganic Chemistry (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Retarders (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

JP6502843A 1992-07-07 1993-07-06 薬物送達デバイスおよびそのデバイスの製造方法 Expired - Lifetime JPH07508735A (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK92895A DK89592D0 (da)	1992-07-07	1992-07-07	Laegemiddelafgivelsesindretning samt fremgangsmaade til fremstilling deraf
DK0895/92		1992-07-07
PCT/DK1993/000227 WO1994001136A1 (en)	1992-07-07	1993-07-06	A drug delivery device and a method of making such device

Related Child Applications (2)

Application Number	Title	Priority Date	Filing Date
JP30355097A Division JP2883062B2 (ja)	1997-10-17	1997-10-17	差動歯車装置
JP30355197A Division JP2883063B2 (ja)	1997-10-17	1997-10-17	差動歯車装置

Publications (1)

Publication Number	Publication Date
JPH07508735A true JPH07508735A (ja)	1995-09-28

Family

ID=8098759

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP6502843A Expired - Lifetime JPH07508735A (ja)	1992-07-07	1993-07-06	薬物送達デバイスおよびそのデバイスの製造方法

Country Status (15)

Country	Link
EP (1)	EP0648129A1 (cs)
JP (1)	JPH07508735A (cs)
KR (1)	KR950702437A (cs)
AU (1)	AU671651B2 (cs)
BR (1)	BR9306700A (cs)
CA (1)	CA2139747A1 (cs)
CZ (1)	CZ3895A3 (cs)
DK (1)	DK89592D0 (cs)
FI (1)	FI950065A7 (cs)
HU (1)	HUT75665A (cs)
NZ (1)	NZ253678A (cs)
PL (1)	PL172724B1 (cs)
RU (1)	RU2139093C1 (cs)
SK (1)	SK1795A3 (cs)
WO (1)	WO1994001136A1 (cs)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2013523748A (ja) *	2010-03-29	2013-06-17	サーモディクス，インコーポレイテッド	注射用薬物送達製剤
JP2015502957A (ja) *	2011-12-05	2015-01-29	インセプト・リミテッド・ライアビリティ・カンパニーＩｎｃｅｐｔ，Ｌｌｃ	医療用オルガノゲルプロセス及び組成物

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5783214A (en) *	1994-06-13	1998-07-21	Buford Biomedical, Inc.	Bio-erodible matrix for the controlled release of medicinals
ES2198579T3 (es) *	1996-07-01	2004-02-01	Universiteit Utrecht	Hidrogeles hidrolizables para liberacion controlada.
CN1402629A (zh)	1999-12-23	2003-03-12	辉瑞产品公司	提供提高的药物浓度的药物组合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2550750A (en) *	1947-09-22	1951-05-01	Arthur C Abelt	Differential for automobiles
JPS5997346A (ja) *	1982-11-24	1984-06-05	Komatsu Ltd	車両のデイフアレンシヤル装置

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4024073A (en) *	1972-01-08	1977-05-17	Toray Industries, Inc.	Hydrogel and production thereof
JPS57500432A (cs) *	1980-03-20	1982-03-11
IT1131833B (it) *	1980-06-20	1986-06-25	Crinos Industria Farmaco	Eccipienti per sostanze spermicide
US4925677A (en) *	1988-08-31	1990-05-15	Theratech, Inc.	Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
SE9002339L (sv) *	1990-07-04	1992-01-05	Kabi Pharmacia Ab	Terapeutisk komposition och foerfarande foer dess framstaellning

1992
- 1992-07-07 DK DK92895A patent/DK89592D0/da not_active Application Discontinuation
1993
- 1993-07-06 CA CA002139747A patent/CA2139747A1/en not_active Abandoned
- 1993-07-06 EP EP93914649A patent/EP0648129A1/en not_active Withdrawn
- 1993-07-06 WO PCT/DK1993/000227 patent/WO1994001136A1/en not_active Ceased
- 1993-07-06 AU AU44178/93A patent/AU671651B2/en not_active Ceased
- 1993-07-06 HU HU9500042A patent/HUT75665A/hu unknown
- 1993-07-06 CZ CZ9538A patent/CZ3895A3/cs unknown
- 1993-07-06 NZ NZ253678A patent/NZ253678A/en unknown
- 1993-07-06 PL PL93307050A patent/PL172724B1/pl unknown
- 1993-07-06 JP JP6502843A patent/JPH07508735A/ja not_active Expired - Lifetime
- 1993-07-06 SK SK17-95A patent/SK1795A3/sk unknown
- 1993-07-06 RU RU95105519A patent/RU2139093C1/ru active
- 1993-07-06 BR BR9306700A patent/BR9306700A/pt not_active Application Discontinuation
- 1993-07-06 KR KR1019950700048A patent/KR950702437A/ko not_active Ceased
1995
- 1995-01-05 FI FI950065A patent/FI950065A7/fi unknown

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2550750A (en) *	1947-09-22	1951-05-01	Arthur C Abelt	Differential for automobiles
JPS5997346A (ja) *	1982-11-24	1984-06-05	Komatsu Ltd	車両のデイフアレンシヤル装置

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2013523748A (ja) *	2010-03-29	2013-06-17	サーモディクス，インコーポレイテッド	注射用薬物送達製剤
JP2015502957A (ja) *	2011-12-05	2015-01-29	インセプト・リミテッド・ライアビリティ・カンパニーＩｎｃｅｐｔ，Ｌｌｃ	医療用オルガノゲルプロセス及び組成物

Also Published As

Publication number	Publication date
PL307050A1 (en)	1995-05-02
DK89592D0 (da)	1992-07-07
PL172724B1 (pl)	1997-11-28
FI950065A0 (fi)	1995-01-05
HUT75665A (en)	1997-05-28
FI950065A7 (fi)	1995-03-02
WO1994001136A1 (en)	1994-01-20
NZ253678A (en)	1996-07-26
BR9306700A (pt)	1998-12-08
CA2139747A1 (en)	1994-01-20
EP0648129A1 (en)	1995-04-19
SK1795A3 (en)	1995-09-13
HU9500042D0 (en)	1995-03-28
CZ3895A3 (en)	1995-09-13
KR950702437A (ko)	1995-07-29
AU4417893A (en)	1994-01-31
AU671651B2 (en)	1996-09-05
RU2139093C1 (ru)	1999-10-10

Legal Events

Date	Code	Title	Description
2006-10-04	S111	Request for change of ownership or part of ownership	Free format text: JAPANESE INTERMEDIATE CODE: R313111
2006-10-13	R350	Written notification of registration of transfer	Free format text: JAPANESE INTERMEDIATE CODE: R350
2007-09-25	FPAY	Renewal fee payment (event date is renewal date of database)	Free format text: PAYMENT UNTIL: 20080918 Year of fee payment: 10
2008-09-09	FPAY	Renewal fee payment (event date is renewal date of database)	Free format text: PAYMENT UNTIL: 20090918 Year of fee payment: 11
2009-09-08	FPAY	Renewal fee payment (event date is renewal date of database)	Free format text: PAYMENT UNTIL: 20100918 Year of fee payment: 12
2010-08-31	FPAY	Renewal fee payment (event date is renewal date of database)	Free format text: PAYMENT UNTIL: 20110918 Year of fee payment: 13
2011-08-09	FPAY	Renewal fee payment (event date is renewal date of database)	Free format text: PAYMENT UNTIL: 20120918 Year of fee payment: 14
2012-07-06	EXPY	Cancellation because of completion of term

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JPH08502036A (ja)	1996-03-05	酵素的に制御された薬剤放出のための架橋されたポリヒドロキシ材料
JPH07508735A (ja)	1995-09-28	薬物送達デバイスおよびそのデバイスの製造方法
García-Couce et al.	2019	Dexamethasone‐Loaded Chitosan Beads Coated with a pH‐Dependent Interpolymer Complex for Colon‐Specific Drug Delivery
Karnaki et al.	2024	Thermoresponsive hydrogels: current status and future perspectives
Rojas	2015	Improved polymer functionality by cross-linking with glutaraldehyde to achieve controlled drug release
Puri et al.	2024	A prospective utilization of biodegradable polymers for controlled drug-delivery applications
WO2001028918A1 (en)	2001-04-26	Controlled release of doxorubicin
Raul et al.	2024	Polymer paradigm: revolutionizing drug delivery
Jameela	1997	Crosslinked chitosan as a carrier for controlled drug delivery.

JPH07508735A - 薬物送達デバイスおよびそのデバイスの製造方法 - Google Patents

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