JPH1045562A - Antimicrobial and low-irritant cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prepare a cosmetic having synergistically enhanced antimicrobial actions without not only manifesting the primary irritation and sensitizing properties to the skin but also imparting an unpleasant feeling such as a sharply stabbing pain, a tingling pain or a prickling pain thereto when using the cosmetic. SOLUTION: This antimicrobial and low-irritant cosmetic comprises one or more of antimicrobial metal-supporting ceramics and one or more plant extracts having antimicrobial actions used in combination. Silver, copper and zinc are preferred as the antimicrobial metal to be supported. A calcium compound, zinc oxide, zirconium oxide, titanium oxide, magnesium oxide, aluminum oxide, silicon oxide, talc and zeolite are preferred as the ceramics. The respective amounts of the blended ingredients are sufficiently about 0.1-10.0wt.% antimicrobial metal-supporting ceramics and about 0.01-20.0wt.% plant extract having the antimicrobial actions.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic having excellent antibacterial properties, stable and less irritating to the skin, which is not contaminated by microorganisms such as bacteria and fungi. More specifically, 1 of antibacterial metal-supported ceramics
The present invention relates to a low anti-irritant cosmetic having high antibacterial activity, comprising one or more plant extracts having an antibacterial action with one or more species.

[0002]

2. Description of the Related Art Conventionally, cosmetics containing water, such as lotions, emulsions, creams, etc., have various antiseptic and antifungal agents in order to prevent deterioration due to the incorporation of microorganisms such as bacteria and mold during production and use. Agents have been used. Examples of such preservatives include phenols such as isopropylmethylphenol, paraoxybenzoate, phenoxyethanol and hinokitiol; benzoic acid and its salts; salicylic acid and its salts; dehydroacetic acid and its salts; sorbic acid and its salts; Quaternary ammoniums such as benzalkonium, benzethonium chloride and alkyltrimethylammonium chloride, amphoteric surfactants such as alkylaminoethylglycine hydrochloride and sodium stearylhydroxyethylbetaine chloride, and photosensitizers are used.

However, many of the above-mentioned preservatives and fungicides have been reported to have primary irritation, sensitization or photosensitization to the skin, and the amount of the preservative and fungicide is regulated based on the standard of cosmetic raw materials from the viewpoint of safety. In many cases, it is not possible to add an amount that actually shows effective antibacterial activity. Furthermore, it is known that even if the skin does not show a stimulating or sensitizing reaction such as redness, rash, or edema, it may cause discomfort such as stinging, tingling or tingling when using the cosmetic. Have been. Further, due to the interaction with the base of the cosmetic or other compounding components, there may be a case where sufficient antibacterial activity is not exhibited.

[0004] For example, oil-soluble preservatives and fungicides such as isopropylmethylphenol, paraoxybenzoate, and sorbic acid, when incorporated into cosmetics containing polymer thickeners and powders, have reduced antibacterial activity due to adsorption and the like. To do. Also,
In cosmetics containing a surfactant, the antibacterial activity is also decreased due to incorporation into the surfactant micelle. However, if a large amount is blended in the expectation of sufficient antibacterial activity, problems such as crystal precipitation at low temperatures and stability of the product will occur.

[0005] Water-soluble preservatives and fungicides such as benzoate, salicylate and dehydroacetate are not effective unless the pH of the cosmetic is weakly acidic. As the acidity increases, the solubility in water decreases, and crystals may precipitate.

Further, regarding quaternary ammonium compounds and amphoteric surfactants, skin irritation and eye mucous membrane irritation are recognized, foaming is likely to occur, and antibacterial activity decreases on the acidic side.
There is a problem in practical use such as interaction with an anionic substance.

In addition to the above-mentioned organic antibacterial agents, ceramics carrying an antibacterial metal have been studied as inorganic antibacterial compositions, and their application to oral compositions such as toothpastes and mouthwashes has been studied. An application for the treatment of atopic dermatitis (JP-A-6-285131) and an antibacterial cosmetic containing the same (JP-A-7-101821) have been disclosed for a long time. However, the antibacterial metal-carrying ceramic alone could not obtain a sufficient antibacterial and fungicidal action even in a complex prescription system, even when about 10% by weight was added.

[0008]

Accordingly, in the present invention, an effective antibacterial action is exhibited without deteriorating the antibacterial activity by a cosmetic base or other compounding components, and a preservative or fungicide is added as much as possible. To obtain a cosmetic that reduces the amount and does not cause primary irritation or sensitization to the skin, and does not cause discomfort such as stinging, tingling, or tingling when using the cosmetic. Aimed at.

[0009]

In order to solve the above problems, as a result of examining antiseptic and fungicide systems having high stability and low irritation to the skin, one or more antibacterial metal-supported ceramics were obtained, and By containing one or two or more plant extracts having an antibacterial action in combination, it is found that not only the antibacterial activity is synergistically improved, but also that irritation and discomfort to the skin are significantly reduced, The present invention has been completed.

As the antibacterial metal-supporting ceramics used in the present invention, one or more of silver, copper and zinc are calcium compounds, zinc oxide, zirconium oxide, titanium oxide, magnesium oxide, aluminum oxide, silicon oxide, Those supported on ceramics such as talc and zeolite are preferred, and those supported on calcium compounds such as calcium phosphate, hydroxyapatite and calcium carbonate are particularly preferred. These can be obtained by supporting a salt of an antibacterial metal selected from silver, copper and zinc on ceramics, and then firing at a temperature equal to or higher than the melting point of the antibacterial metal. A low concentration of about 0.1 to 10.0% by weight is sufficient as the amount to be added to cosmetics.

In the present invention, the plant extract having an antibacterial activity used in combination with the antibacterial metal-supporting ceramics includes:
One or more extracts of the plants shown below are used.
The whole plant may be used for extraction. However, if it is clear that the plant contains a particularly strong antibacterial component such as flowers, stems, roots, seeds, fruits, bark, etc. It is preferable to select and use. Further, the plant may be extracted as it is, or the extraction operation may be performed after processing such as shredding, drying, and pulverization.

As the extraction solvent, in addition to water, methanol,
Ethanol, propanol, isopropanol, butanol, ethylene glycol, propylene glycol, 1,
Highly polar organic solvents such as 3-butylene glycol, diethylene glycol, dipropylene glycol, isoprene glycol, hexylene glycol, glycerin, methyl acetate, ethyl acetate, isopropyl acetate, ethyl ether, isopropyl ether, and acetone can be used. One of these is used alone, or two or more are used in combination.

Ginkgo biloba L. ( Ginkgo biloba L.) and Sasa albo-marginata Makino et Shibata ( S. veit)
chii ), a base plant of the herbal medicine " saishin " in the family Echinacea , Asiasarum sieboldii F. M.
aekawa) and Keirin Saishin ( A. heterotropoides va
r. mandshuricum F. Maekawa), its is closely plant Kurofune Herba Asari (A. dimidiatum F. Maekawa), Ok Ezo asiasarum (A. heterotropoides F. Maekawa), Usugesaishin (A. heterotropoides var. seoulense F. M
aekawa).

[0014] Then, of hypericaceae plant St. John's wort (Hypericum erectum Thunb.) And Tomoesou (H. A
scyron L.), a birch birch ( Betula pl
atyphylla Sukatchev var. japonica Hara).

In the Asteraceae plant, Arnica monta
na L.), chamomile ( Matricaria ch amomilla L.), and wormwood ( Ar ), which is the basic plant of the herb "Inchinko".
temisia capillaris Thunb.) and mugwort ( A. scop)
aria Waldstein, Burdock ( Arctium lappa L.), Calendula officinalis L., Calendula ( C. arvensis L.), Cornflower ( Centaurea cyanus )
L.) and Roman chamomile ( Anthemis nobilis L.) are used.

[0016] In the Ranunculaceae plant, spinach ( Coptis)
is a japonica Makino) and its congeners plant Kikubaouren (C. japonica var. japonica Satake ), Seribaouren (C. japonica var. dissecta Nakai ), Koseribaouren (C. japonica var. major Satake ), Coptis trifolia (C. trifolia Salib. ), Baikaouren ( C. quinguefolia Miq.) Is used.

The bay camphor tree ( Larus n)
obilis L.), mulberry plants ( Morus bombycis Koidz) and magwa ( M. alba L.), which are the base plants of the herbal medicine "Sohakuhoku", and hop ( Hum ), also a plant of the mulberry family
ulus lupulus L.) can also be used.

[0018] In the mint family plants, is a MotoHara plant of herbal "Enmeisou" cause (Isodonjaponicus Hara) and Kurobanahikiokoshi (I. Trichocarpus Kudo), a MotoHara plant of herbal "Golden" Scutellaria (Scutellari
a baicalensis Georg.), Salvia officinal
is L.), perilla ( Perilla frutescens Britton var. acut)
a Kudo.), a variant of P. frutes
cens Britton var. crispa Decne.) , and a closely related plant Perilla (P. frutescens viridis), Katamejiso (P. frutescens f. discolor) , Thymus vulgaris (time, Tymusvulgaris L.), peppermint (Ment
ha piperita L.) and its variants, mint ( M. arvensis)
L. var. Piperascens Malin.), Green mint ( M. vir)
idis L.), Mannenrou (Rosemary, Rosmarinus)
officinalis L.) and lavender ( Lavandula vera D)
C.) is used.

[0019] of the honeysuckle family plant honeysuckle (caulis lonicerae, Lonicera japonica Thunb.), Of the Umbelliferae plant fennel (Foeniculum vulgare Mill.), Sinensis (Cnid
ium officinale Makino), Camellia ( Thea)
sinensis L.) and its congener plant, tocha ( T.
sinensis L. var. macrophylla Sieb.) , Assam tea (T. sinensis L. var. assamica Pierre), oolong tea (T. sinensis L.var. viridis Szkzyl .), Benibanacha (T. sinensis L. var. rosea Makino ), Houttuynia cordata Thunb., Which is the base plant of the herbal medicine "Juyaku" in the family Asteraceae , Aesculus hippocastanum
L.) and horse chestnut ( A. turbinata Blume) may also be used.

In the Rosaceae plants, peaches ( Prunus persica B
atsch.), peach ( P. persica Batsch. var. davidian)
a Maxim.), Rosa acicularis Lind
l.), Takanebara ( R. acicularis Lindl. var. nippon
ensis Koehne), Mokkoubara ( R. banksiae Aito
n), Kaninabara (R. canina L.), Sentinel Folia Roses (R. centifolia L.), Kokebara (R. centifolia
L. var. Mucosa Seringe), Ko Simbara ( R. chinens
is Jacq.), Damask Rose (R. damascena Mill.), Foetidabara (R. foetida Herrm.), Garikabara (R. gallica L.), Giganteabara (R. gigantea Col
lett et Hemsl.), Salamander ( R. hirtula Naka)
i), Mosukatabara (R. moschata Herrm.), Odorata Roses (R. odorata Sweet.), R. multiflora (R. multif
lora Thunb.), Yamaibara ( R. sambucina Koidz.),
Terihanoibara ( R. wichuraiana Crep.) And the wild plant “ Sanguisorba of
ficinalis L.) is used.

[0021] Geranium thu ( Geranium thu ), which is a base plant of the herbaceous plant "Gennoshoko"
nbergii Sieb. et Zucc.) and its cognate plants American Furo ( G. carodinianum L.), Ibukifuuro ( G. dahuricum DC. var. lobutatum Nakai), Gunnifuro ( G. onoei Franch. et Savat.), Iyofuro ( G. shikokianum Matsumura), Haksan Fuuro ( G. ye
sonse Franch. et Savat. var. nipponicum Nakai),
Tachifuuro (G. Japonicum Franch. Et Savat .), Ichigefuuro (G. Sibiricum L.) and, of Myrtaceae plant clove (Syzygium aromaticum Merrill et Perry, Euge
nia caryophyllata Thunb.) can also be used.

Among legumes, licorice ( Glycyrrhizaglabra L. var. Glan), which is the base plant of the herbal medicine "liquorice", is used.
dulifera Regel et Herder), Chinese elephant ( G. echin
ata L.), Spanish liquorice ( G. glabra L.), Ural liquorice ( G. uralensis Fisch. et DC.), and Clara ( Sophora flavesce) which is the base plant of crude drug "Kudin"
ns Aiton).

Hamamelis ( Hammelis)
virginiana L.) may also be used. In addition, yellowfin ( Phellodendro) , a citrus plant and the base plant of the herbal medicine “Obaku”
n amurense Rupr.), P. amurense va
r. japonica Ohwi), Miyaki Hada ( P. amurense var.
lavallei Sprag.), Hirohakihada ( P. amurense var.)
sachalinense Fr. Schmidt.), yellow skin ( P. chinense
Schneid.), And also a citrus plant salamander ( Za)
nthoxylum piperitum DC.) and its congener, Asakusan- san ( Z. piperitum DC. f. inerme Makin)
o), Yamasakurazan Show ( Z. piperitum DC. f. b
revispinosum Makino) is also used.

[0025] Lithospermum erythrorhizon Siebo, which is the base plant of the herb medicine "Sikon"
ld et Zuccarini), of the Oleaceae plant forsythia (For
sythia suspensa Vahl.), Chinese Forsythia ( F. viridi
ssima Lindl.), Korean Forsythia ( F. koreana N)
akai) can also be used.

Examples of Liliaceae include plants belonging to the genus Aloe. As a plant belonging to the genus Aloe, Aloe ferox Mill., A. african , which is a base plant of the herbal medicine "Aloe"
a Mill., A. spicata Baker, A. arborescens Mill.,
A. succotrina Lam., A. plicatilis Mill., A. ba
inesii Th. Dyer., A. perryi Baker, A. vera L., etc. are used. Also, A. arborescens Mil
l. var. natalensis Berg.) can also be used. In addition, Narco Lily ( Po
lygonatum falcatum A. Gray), Oonarukoyuri (P. m
acranthum Koidzumi), and related plants, Kagyurubananakoyuri ( P. sibricum Red.), Kurumabanarukoyuri ( P. stenopyllum Maxim.) can also be used.

The above-mentioned plant extract can be added to the cosmetics as it is, or can be blended after adding purification operations such as deodorization and decolorization to the extent that the antibacterial action is not lost. Further, the extraction solvent may be evaporated and dried from the extract, and re-dissolved in a solvent such as water, ethanol, propylene glycol, 1,3-butylene glycol, or glycerin, and added. A proper amount of the compound is 0.01 to 20.0% by weight.

[0027]

The antimicrobial metal-carrying ceramic alone could not obtain a sufficient antimicrobial activity when incorporated into a cosmetic composition, even at 10.0% by weight. However, in the present invention, synergistic enhancement of the antibacterial action is observed when used in combination with the plant extract, and therefore 0.1 to 1
A sufficient antibacterial and fungicidal action can be obtained by the antimicrobial metal-carrying ceramic of about 0.0% by weight. In addition, in the present invention, since a small amount of the antimicrobial metal-supported ceramic and the plant extract exert an antimicrobial activity, irritation and discomfort to the skin and eyes can be reduced.

[0028]

BEST MODE FOR CARRYING OUT THE INVENTION The invention according to the present invention is particularly useful for a system containing a large amount of water and an O / W type emulsion system in which the external phase is a water phase, and is useful for skin such as lotions, emulsions and creams. Cosmetics,
Makeup cosmetics such as makeup base lotion or cream, milky or creamy foundation, emulsified eye color or cheek color, aqueous suspension type eyeliner, emulsified eyeliner or mascara, cleansing lotion, cleansing gel, It can be provided as a washing cosmetic such as liquid soap, and a hair cosmetic such as shampoo and hair rinse.

[0029]

EXAMPLES Further, the features of the present invention will be described in detail with reference to examples. First, the formulations of Examples 1 to 3 are shown in Table 1 as the lotion according to the present invention. These are shown in Table 1.
Medium (1) ~ (7) each component is added to (8) sequentially, and mixed uniformly,
Prepare by dispersing.

[Table 1]

Next, as an emulsion according to the present invention, Example 4
Table 2 shows the formulations of Examples to 6. These are prepared as follows. First, the oil phase components (1) to (6) in Table 2 are mixed, heated and melted, and maintained at 75 ° C. On the other hand, the aqueous phase components (7) to (10) are mixed and dissolved by heating. After dispersing (11), the mixture is heated to 75 ° C., and the oil phase is added thereto with stirring to emulsify.
After cooling, (12) and (13) are added and mixed at 40 ° C.

[Table 2]

Next, the formulations of Examples 7 to 9 which are creams according to the present invention are shown in Table 3. These are prepared as follows. The oil phase components (1) to (7) are mixed and heated to 75 ° C. On the other hand, the aqueous phase components (8) to (9) are mixed, heated and dissolved, and (10) is dispersed and brought to 75 ° C., and the oil phase is added to this to emulsify, followed by cooling at 40 ° C. Add 11) and (12).

[Table 3]

[Example 10] Makeup base cream (1) Stearic acid 12.0 (% by weight) (2) Cetanol 2.0 (3) Self-emulsifying glyceryl monostearate 2.0 (4) Propylene glycol 10.0 (5) Potassium hydroxide 0.3 (6) Purified water 64.6 (7) Peach leaf water extract 1.5 (8) Fragrance 0.1 (9) Zinc-loaded hydroxyapatite 6.0 ( 10) Titanium dioxide 1.0 (11) Bengala 0.1 (12) Yellow iron oxide 0.4 Production method: (9) to (12) are kneaded with (4), and this is mixed with water of (5) and (6). Add to the phase components, mix and heat to 70 ° C. On the other hand, (1) to (3)
The oil phase component (1) is mixed and heated to 70 ° C., and this is added to the aqueous phase with stirring to emulsify. Cool after emulsification 4
At 0 ° C, add (7) and (8).

Example 11 Emulsion foundation (1) Stearic acid 2.4 (% by weight) (2) Propylene glycol monostearate 2.0 (3) Cetostearyl alcohol 0.2 (4) Liquid lanolin 0 (5) Liquid paraffin 3.0 (6) Isopropyl myristate 8.5 (7) Sodium carboxymethyl cellulose 0.2 (8) Bentonite 0.5 (9) Propylene glycol 4.0 (10) Triethanolamine 1. 1 (11) Purified water 55.3 (12) Yellowfin 50% by weight propylene glycol 2.5 Extract (13) Perfume 0.1 (14) Silver supported titanium oxide 4.5 (15) Titanium oxide 3.7 (16) Talc 4.0 (17) Bengala 3.0 (18) Yellow iron oxide 2.5 (19) Black iron oxide 0.5 Production method: After mixing the pigments of (14) to (19), Smash. (11) is heated to 70 ° C., (8) is added to swell it well, and (7) is dispersed in (9) in advance, and (10) is further added and dissolved. The oil phase components (1) to (6) are mixed, heated and melted to 80 ° C. The pigment is added to the aqueous phase with stirring and passed through a colloid mill for 75 minutes.
The oil phase was added with stirring to emulsify, and after cooling, (12) and (13) were added at 40 ° C.

[Example 12] Creamy foundation (1) Stearic acid 5.0 (% by weight) (2) Lipophilic glyceryl monostearate 2.5 (3) Propylene glycol monolaurate 3.0 (4) Cetostearyl alcohol 1.0 (5) Liquid paraffin 7.0 (6) Isopropyl myristate 8.0 (7) Sorbitol 3.0 (8) Triethanolamine 1.2 (9) Purified water 42.7 (10) 50% by weight of horse chestnut and forsythia 3.0 Glycerin extract (11) Fragrance 0.1 (12) Zinc oxide supported on copper 2.5 (13) Titanium oxide 8.0 (14) Kaolin 5.0 (15) Talc 2 0.0 (16) Bentonite 1.0 (17) Red iron oxide 2.6 (18) Yellow iron oxide 2.1 (19) Black iron oxide 0.3 Manufacturing method: After mixing the pigments of (12) to (19), pulverizing Pulverize with a machine. Mix (7) to (9), dissolve, and heat. The oil phase components (1) to (6) are mixed, heated and melted to 80 ° C. The pigment is added to the aqueous phase with stirring, the temperature is raised to 75 ° C. through a colloid mill, the oil phase is added with stirring to emulsify, and after cooling, (10) and (11) are added at 40 ° C.

Example 13 Emulsifying Eye Color (1) Stearic acid 8.00 (% by weight) (2) White petrolatum 15.00 (3) Isopropyl palmitate 5.00 (4) Lanolin 5.00 (5 ) 1,3-butylene glycol 5.00 (6) Triethanolamine 2.00 (7) Purified water 53.83 (8) Murasaki water extract 1.25 (9) Lavender ethanol extract 1.25 (10) Perfume 0.15 (11) Zirconium oxide supporting zinc 2.00 (12) Red No. 221 0.02 (13) Gunjo 1.50 Manufacturing method: Mix and dissolve the water phase components (5) to (7) and heat. Then, (11) to (13) previously mixed and pulverized are added thereto, dispersed, and heated to 75 ° C. Add (1) to (4), which was mixed and heated to make it uniform, with stirring to emulsify,
After cooling, add (8) to (10) and mix.

Example 14 Emulsion type teak color (1) Beeswax 3.00 (% by weight) (2) Stearic acid 2.00 (3) Cetanol 3.00 (4) Lanolin 3.00 (5) Liquid paraffin 15.00 (6) Isopropyl myristate 7.00 (7) Polyoxyethylene (20 E.O.) sorbitan 4.20 Monostearate (8) Sorbitan monostearate 1.80 (9) Glyceryl monostearate Ester 2.00 (10) Propylene glycol 5.00 (11) Triethanolamine 0.60 (12) Purified water 45.45 (13) 50% by weight ethanol extract of damask rose 1.75 (14) Narco lily 50 Weight% Dipropylene 1.75 Glycol extract (15) Perfume 0.15 (16) Zinc-supporting talc 2.00 (17) Red No. 202 0.05 (18) Yellow iron oxide 2.25 Manufacturing method: (10) to (12) water phase Minute mixing, dissolved by heating to,
The (16) to (18) previously mixed and pulverized are added thereto, dispersed, and heated to 75 ° C. To this are added (1) to (9), which have been mixed and heated to homogenize with stirring, to emulsify, and after cooling, (13) to (15) are added and mixed.

[Example 15] Emulsion type eyeliner (1) Stearic acid 3.5 (wt%) (2) Beeswax 2.0 (3) Carnauba wax 0.5 (4) Microcrystalline wax 5.0 (5) 1,3-butylene glycol 7.0 (6) triethanolamine 1.5 (7) purified water 38.9 (8) chamomile water extract 10.0 (9) fragrance 0.1 (10) 3.0 weight % Bentonite dispersion 20.0 (11) Silver-supported silicon oxide 1.5 (12) Copper-supported titanium oxide 1.5 (13) Titanium oxide 6.5 (14) Carbon black 2.0 Production method: (1)-( Mix and heat the oil phase components of 4) to dissolve. The aqueous phase components (5) to (7) are mixed with this, heated, and added with stirring to emulsify. Next, (10) to (1)
4) was added, dispersed through a colloid mill and then cooled,
Add (8) and (9) at 40 ° C.

Example 16 Emulsion resin type mascara (1) 50.0% by weight vinyl acetate emulsion 30.0 (% by weight) (2) Sodium carboxymethyl cellulose 1.0 (3) 1,3-butylene glycol 0 (4) Tea 1,3-butylene glycol extract 8.0 (5) Silver-supported magnesium oxide 0.5 (6) Zinc-supported aluminum oxide 0.5 (7) Copper-supported hydroxyapatite 1.0 (8) Titanium oxide 8.0 (9) Carbon black 1.6 (10) Red iron oxide 0.4 (11) Purified water 46.0 Manufacturing method: (2) to (4) are added to (11) and dissolved, and then ( Five)
Add (10) and disperse through a colloid mill. Add (1) to this and disperse uniformly.

Example 17 Shampoo (1) Sodium alkyl ether sulfate 18.000 (% by weight) (2) Palm oil fatty acid diethanolamide 2.000 (3) Ginkgo biloba water extract 5.000 (4) Yellow 4 No. 0.001 (5) Silver-supported zeolite 2.500 (6) Fragrance 0.200 (7) Purified water 72.299 Production method: (1) to (6) were sequentially added to (7) and mixed uniformly. Dissolve and disperse.

[Example 18] Hair rinse (1) Cetanol 2,000 (% by weight) (2) Stearyl trimethyl ammonium chloride 2.000 (3) Silicone oil 3.000 (4) Polyoxyethylene (10E.O. ) Oleyl 1.000 Ether (5) Glycerin 3.000 (6) 30% by weight of Pleurotus cornucopiae 1,3-butylene 3.000 Glycol extract (7) Green No. 3 0.002 (8) Zinc-supported calcium phosphate 1. 000 (9) Fragrance 0.150 (10) Purified water 84.848 Production method: (5), (7) and (8) are added to (10) and heated to 70 ° C. On the other hand, (1) to (4) are mixed, dissolved and heated to 70 ° C. This oil phase is gradually added to the previously prepared aqueous phase with stirring, pre-emulsified, homogenized by a homomixer, cooled, and (6) and (9) are added at 40 ° C.

Example 19 Cleansing Gel (1) Glycerin 15.00 (% by weight) (2) 1,3-butylene glycol 10.00 (3) Silicic anhydride 7.00 (4) Polyoxyethylene (20E) .O.) Lauryl ether 5.00 (5) Polyoxyethylene (50E.O.) hydrogenated castor oil 2.50 (6) Silver and zinc supported hydroxyapatite 5.00 (7) Carboxyvinyl polymer 0.50 (8 ) Potassium hydroxide 0.45 (9) Hop 30% by weight 1,3-butylene glycol 2.00 Extract (10) Perfume 0.10 (11) Purified water 52.45 Manufacturing method: (3), (7) After adding to (11) to homogenize, (6) is dispersed, (4) and (5) are dissolved and added to (1) and (2).
Heat to 0 ° C. to dissolve uniformly. Then cool to 40
Add (9) and (10) at ℃, and finally add (8) to neutralize.

Next, the above examples were evaluated for antibacterial activity, skin irritation and discomfort during use. As the samples, Examples 1, 4 and 7 and Examples 10 to 1 were used.
9 was used. At the same time, the comparative examples shown in Table 4 were similarly evaluated.

[Table 4]

(1) Evaluation of antibacterial activity As bacteria, Escherichia coli , Staphylococc
us aureus ), Pseudomonas aeruginosa ( Pseudomonas aeruginosa ), and Propionibacterium acnes ) as fungi as Candida albicans and Aspergillu
s niger ) and dandruff ( Pityrosporum ovale )
10 ⁶ bacteria and 10 ⁵ fungi were inoculated per 1 g of the sample, cultured at 37 ° C. and 25 ° C., respectively, and the number of viable cells was measured after 2 weeks. The antibacterial activity is as follows: when bacteria are killed after 2 weeks, the number of viable bacteria is 1 /
When it is 1000 or less, it is judged to be sufficient.
The evaluation results are shown in Table 5.

[Table 5]

As is clear from Table 5, in Examples of the present invention, sufficient antibacterial activity against both bacteria and fungi was observed. On the other hand, in Comparative Examples 1, 2, 4, 6, 7 and 8 containing only one of the antimicrobial metal-supported ceramics and the plant extract, sufficient antimicrobial activity was not recognized. Comparative Example 5 in which 0.2% by weight of methyl paraoxybenzoate was blended did not pass Pseudomonas aeruginosa, and Comparative Example 9 in which the hair rinse also contained 0.3% by weight of methyl paraoxybenzoate. Also did not meet the acceptance criteria for green bacterium, black mold and dandruff.

(2) Evaluation of skin irritation For each sample,
A 48-hour occlusion patch test was performed using 30 male panelists, and evaluated according to the criteria shown in Table 6 to obtain the average value of the skin irritation index of 30 persons. In addition, about Example 17-Example 19 and Comparative Example 8-Comparative Example 10, 1.0 wt%
The aqueous solution was used for the test.

[Table 6]

(3) Evaluation of discomfort during use Twenty female panelists were divided into one group, and each group was allowed to use each sample.
Stinging pain felt between 30 seconds and 1 minute after application,
They were asked to evaluate discomfort such as tingling and tingling. The evaluation results were "very strong; 5 points", "somewhat strong; 4 points", "feeling; 3 points", "slightly feeling; 2 points", "subtle feeling; 1 point", and "not feeling". ; 0
The score was evaluated as “point”, and indicated by the average value of 20 persons. Also in this case, Examples 17 to 19 and Comparative Examples 8 to 1
For 0, the test was performed with a 1.0% by weight aqueous solution. The above results are summarized in Table 7.

[0047]

[Table 7] In Table 7, the skin irritation was not observed in any of the examples of the present invention, and the discomfort during use was only slightly felt. On the other hand, Comparative Example 3 which is a cream containing 0.5% by weight of 2-phenoxyethanol and Comparative Example 10 which is a cleansing gel.
On the other hand, some skin irritation was observed, and significant discomfort during use was observed. Also, in Comparative Examples 5 and 9 containing 0.2% by weight of methyl paraoxybenzoate, slight erythema and edema and clear discomfort were recognized.

[0048]

As described in detail above, the present invention synergistically enhances the antibacterial action, and not only the skin irritation but also the unpleasant sensation such as stinging pain, tingling sensation and tingling sensation during use. An unfeelable antibacterial cosmetic was obtained.

Claims (6)

[Claims] 1. An antibacterial metal-carrying ceramic and / or two or more kinds of plant extracts having an antibacterial action.
An antibacterial hypoallergenic cosmetic comprising at least one species. 2. The antibacterial metal-supported ceramic is silver,
The antibacterial hypoallergenic cosmetics according to claim 1, which carry one or more selected from copper and zinc. 3. The ceramic material is one or more selected from a calcium compound, zinc oxide, zirconium oxide, titanium oxide, magnesium oxide, aluminum oxide, silicon oxide, talc and zeolite. The antibacterial hypoallergenic cosmetic composition according to claim 1 or 2. 4. The calcium compound is calcium phosphate,
4. A material selected from one or more selected from hydroxyapatite and calcium carbonate.
2. The antibacterial and hypoallergenic cosmetic according to item 1. 5. One or more kinds of plant extracts having an antibacterial action are Ginkgo biloba ( Ginkgo biloba).
L.), Sasa albo-marginata Makino
et Shibata, S. veitchii ), Usbasaicin ( Asia)
sarum sieboldii F. Maekawa) and Keirin saicin ( A. heterotropoides var. mandshuricum F. Maekaw)
a), its related plant, Kurofunesaishin ( A. dimidi)
atum F. Maekawa), ochezocysin ( A. heterotrope)
oides F. Maekawa), Usugesaishin ( A. heterotropo
ides var. seoulense F. Maekawa), Hypericumerectum Thunb. and Hypericumerectum T. ( H. ascyron L.), Birch birch ( Betula platyphylla Sukatchev var. japonica H)
ara), Arnica montana (Asteraceae)
L.), chamomile ( Matricaria chamomilla L.), Artemisia japonicus ( Arte)
misia capillaris Thunb.) and a mugwort ( A. scopar)
ia Waldstein), Burdock ( Arctium lappa L.), Calendula officinalis ( C. arvensis L.), Calendula ( C. arvensis L.), Cornflower ( Centaurea cyanus )
L.), Roman chamomile ( Anthemis nobilis L.), and crimson ( Ranumaceae ) plant, Coptis japonica Makin
o) and its cognate plant Kikubaouren ( C. japo
nica var. japonica Satake), Ceriobauren ( C. ja
ponica var. dissecta Nakai), Coseliba Ouren ( C.
japonica var. major Satake) and honey beetle ( C.
trifolia Salib.), baikauren ( C. quinguefolia
Miq.), Camphor tree Laurus nobi
lis L.), mulberry ( Morusbombycis Koidz) and magwa ( M.
alba L.), hops ( Humulus lupulus L.), Lamiaceae plants, which are the base plants of the herb medicine "Emnesou", Isodon japonicus Hara, and I. trichocarpus Kudo, the origin of the herb medicine "Ougon". The plant Scutellaria baicalensis Geor
g.), Salvia ( Salvia officinalis L.), Perilla ( Per )
illa frutescens Britton var. acuta Kudo.), a variant of it, P. frutescens Britton var.
crispa Decne.) and a related plant, Aodiso ( P. f .
rutescens viridis ), catamejizo ( P. frutescens f.
discolor ), Tachimus vulgaris (thyme, Tymus vulgar)
is L.), Mentha ( Mentha piperita L.) and its variants, Mentha ( M. arvensis L. var. piperascens)
Malin.), Green mint ( M. viridis L.), Mannen wax (Rosemary, Rosmarinus officinalis L.),
And lavender ( Lavandula vera DC.), A honeysuckle family (Honeysuckle, Lonicera japonica Thun)
b.), Apiaceae plant Fennel ( Foeniculum vulgare M
ill.), Senkyu ( Cnidium officinale Makino),
The camellia plant tea ( Thea sinensis L.) and its cognate plant toucha ( T. sinensis L. var. Macrophy
lla Sieb.), Assamcha ( T. sinensis L. var. ass)
amica Pierre), Oolongcha ( T. sinensis L. var.)
viridis Szkzyl.), safflower ( T. sinensis L. va
r. rosea Makino), a herbal medicine "Juyaku"
Houttuynia cordata Thun
b.), Aesculus hippocastanum (horse chestnut,
Aesculus hippocastanum L.) and horse chestnut ( A. turbin
ata Blume), a peach ( Prunus persica)
Batsch.), Nomomo ( P. persica Batsch. Var. Davidia
na Maxim.), Rosa acicularis Lind
l.), Takanebara ( R. acicularis Lindl. var. nippon
ensis Koehne), Mokkobara ( R. banksiae Aito)
n), Kaninabara (R. canina L.), Sentinel Folia Roses (R. centifolia L.), Kokebara (R. centifolia
L. var. Mucosa Seringe), Koushinbara ( R. chinens)
is Jacq.), Damask Rose ( R. damascena Mill.), Fouetet Dabara ( R. foetida Herrm.), Garikabara ( R. gallica L.), Gigante Abara ( R. gigantea Col.
lett et Hemsl.), salamander ( R. hirtula Naka
i), Mosukatabara (R. moschata Herrm.), Odorata Roses (R. odorata Sweet.), R. multiflora (R. multif
lora Thunb.), Yamaibara ( R. sambucina Koidz.),
R. wichuraiana Crep., And Sanguisorba of Sanguisorba of the base plant of crude drug "Chiyu"
ficinalis L.), is a MotoHara plant of herbal "cranesbill" in geraniaceae plant, cranesbill (Geranium t
hunbergii Sieb. et Zucc. and its congeners, American uro ( G. carodinianum L.), Ibuki uro ( G. dahuricum DC. var. lobutatum Nakai), Gunn knife uro ( G. onoei Franch. et Savat.), ( G. shikokianum Matsumura), Hakusan fuuro ( G. y
esonse Franch. et Savat. var. nipponicum Nakai),
Tachifuuro (G. Japonicum Franch. Et Savat .), Ichigefuuro (G. Sibiricum L.), of the Myrtaceae plant clove (Syzygium aromaticum Merrill et Perry, Eugeni
a caryophyllata Thunb.), a leguminous plant, which is the base plant of the herbal medicine "liquorice" ( Glycyrrhiza glabra)
L. var. Glandulifera Regel et Herder) , Shinakanzou (G. Echinata L.), Spain licorice (G. Glabr
a L.), G. uralensis Fisch. et D
C.) and Clara ( So
phora flavescens Aiton), Hamamelis virginiana L., a rhododendron plant, and a rhododendron plant, which is the base plant of the herb "Oubaku", Phellodendron
amurense Rupr.), P. amurense var.
japonica Ohwi), Miyaki Hada ( P. amurense var. la)
vallei Sprag.), Hirohakihada ( P. amurense var. sa)
chalinense Fr. Schmidt.), yellow skin ( P. chinense Sch
neid.), salamander ( Zanthoxylum piperitum DC.) and its congener, Asakurazansho ( Z. piperit)
um DC. f. inerme Makino), Z. piperitum DC. f. brevispinosum Makino, and murasaki ( Lithospermum erythrorhizon Siebold et Zuccarin), which is a plant of the purple family and the base plant of the crude drug "Sicon"
i) Forsythia suspens, Forsythia suspens
a Vahl.), Chinese Forsythia ( F. viridissima Lind
l.), Datura ( F. koreana Nakai), a plant belonging to the genus Aloe of the lily family, and a lily family plant, the base plant of the crude drug "Ousei" Narco lily ( Polygonatum falcat)
um A. Gray), Onalco lily ( P. macranthum Koidzu)
mi), and a related plant, Kagi Kurumabanarukoyuri ( P.
sibricum Red.), car banarco lily ( P. stenopyll)
um Maxim.), which is an extract of one or more plants selected from the group consisting of: 6. The compounding amount of the antibacterial metal-supporting ceramics is 0.1 to 10.0% by weight, and the compounding amount of the plant extract having an antibacterial action is 0.01 to 20.0% by weight. The antibacterial and hypoallergenic cosmetic according to any one of claims 1 to 5.