JPH10501218A - 迅速に消失するテクネチウム−９９ｍホスホネート骨格イメージング剤 - Google Patents

迅速に消失するテクネチウム−９９ｍホスホネート骨格イメージング剤

Info

Publication number
JPH10501218A
JPH10501218A JP8500791A JP50079194A JPH10501218A JP H10501218 A JPH10501218 A JP H10501218A JP 8500791 A JP8500791 A JP 8500791A JP 50079194 A JP50079194 A JP 50079194A JP H10501218 A JPH10501218 A JP H10501218A
Authority
JP
Japan
Prior art keywords
diagnostic
acid
mixture
skeletal
heated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8500791A
Other languages
English (en)
Japanese (ja)
Inventor
デロシュ，マーク・エイ
ドイチュ，エドワード・エイ
ドイチュ，カレン・エフ
Original Assignee
マリンクロッド・メディカル・インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by マリンクロッド・メディカル・インコーポレイテッド filed Critical マリンクロッド・メディカル・インコーポレイテッド
Publication of JPH10501218A publication Critical patent/JPH10501218A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP8500791A 1994-06-03 1994-06-03 迅速に消失するテクネチウム−９９ｍホスホネート骨格イメージング剤 Pending JPH10501218A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1994/006276 WO1995033757A1 (fr) 1994-06-03 1994-06-03 Phosphonate de technetium 99m rapidement evacue des parties molles lors d'une scintigraphie osseuse
BR9408590A BR9408590A (pt) 1994-06-03 1994-06-03 Agentes para imageamento ósseo rapidamente eliminaveis de fosfonato de tecnécio 99m

Publications (1)

Publication Number Publication Date
JPH10501218A true JPH10501218A (ja) 1998-02-03

Family

ID=4060358

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8500791A Pending JPH10501218A (ja) 1994-06-03 1994-06-03 迅速に消失するテクネチウム−９９ｍホスホネート骨格イメージング剤

Country Status (5)

Country Link
EP (1) EP0802919A4 (fr)
JP (1) JPH10501218A (fr)
AU (1) AU7312694A (fr)
BR (1) BR9408590A (fr)
WO (1) WO1995033757A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006522783A (ja) * 2003-04-11 2006-10-05 ジーイー・ヘルスケア・リミテッド 放射標識ガリウム錯体を合成するためのマイクロ波法

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7344702B2 (en) 2004-02-13 2008-03-18 Bristol-Myers Squibb Pharma Company Contrast agents for myocardial perfusion imaging
US7485283B2 (en) 2004-04-28 2009-02-03 Lantheus Medical Imaging Contrast agents for myocardial perfusion imaging
WO2009108376A2 (fr) 2008-02-29 2009-09-03 Lantheus Medical Imaging, Inc. Agents de contraste utilisés dans des applications notamment l’imagerie de perfusion
KR20160030589A (ko) 2009-04-15 2016-03-18 랜티우스 메디컬 이메징, 인크. 아스코르브산을 사용한 방사성 약제 조성물의 안정화
DK3323810T3 (da) 2010-02-08 2022-03-28 Lantheus Medical Imaging Inc Automatiseret reaktionssystem, kassette og indretning til syntese af billeddannelsesmidler
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
US10620171B2 (en) * 2017-08-31 2020-04-14 Agilent Technologies, Inc. Methods of liquid chromatography for anionic compounds
WO2024259346A1 (fr) 2023-06-16 2024-12-19 Progenics Pharmaceuticals, Inc Synthèse améliorée d'inhibiteur radiomarqué de l'antigène membranaire spécifique de la prostate (psma) [18f]dcfpyl

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5896031A (ja) * 1981-12-03 1983-06-07 Nippon Mejifuijitsukusu Kk 放射性診断剤およびその製造用組成物
US4504462A (en) * 1982-06-10 1985-03-12 Mallinckrodt, Inc. Process for making a lyophilized product for use in skeletal imaging
EP0111414A3 (fr) * 1982-12-08 1985-05-02 Mallinckrodt, Inc. (a Delaware corporation) Agents de visualisation radiographiques
US5089249A (en) * 1988-06-10 1992-02-18 Neorx Corporation Conjugates for bone imaging and bone cancer therapy
EP0538402B1 (fr) * 1990-07-06 2006-03-08 Mallinckrodt Inc. Procede de preparation d'une solution d'un complexe de rhenium radioactif

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006522783A (ja) * 2003-04-11 2006-10-05 ジーイー・ヘルスケア・リミテッド 放射標識ガリウム錯体を合成するためのマイクロ波法
JP4814785B2 (ja) * 2003-04-11 2011-11-16 ジーイー・ヘルスケア・リミテッド 放射標識ガリウム錯体を合成するためのマイクロ波法

Also Published As

Publication number Publication date
BR9408590A (pt) 1997-08-26
WO1995033757A1 (fr) 1995-12-14
EP0802919A4 (fr) 1999-08-18
AU7312694A (en) 1996-01-04
EP0802919A1 (fr) 1997-10-29

Similar Documents

Publication Publication Date Title
EP0004684B1 (fr) Agents stabilisés pour l'exploration radiographique et leur méthode de préparation
EP0006658B1 (fr) Agents de radiodiagnostic contenant hydroquinone comme stabilisant et leur procédé de préparation
AU657641B2 (en) Macrocyclic aminophosphonic acid complexes, their preparation, formulations and use
US3983227A (en) Dry mixture containing diphosphonates and a stannous salt useful in the preparation of Tc99M containing bone scanning agents
EP0006659B1 (fr) Compositions utilisables pour la production d'agents radiodiagnostic contenant un stabilisant, leur procédé de préparation et l'utilisation de gentisylated'étain comme agent stabilisant dans ces compositions
EP0096930B1 (fr) Agents de visualisation radiographique stables
JPS6133807B2 (fr)
IE43086B1 (en) Stable radiographic scannin agents
US4399817A (en) Boron containing polyphosphonates for the treatment of calcific tumors
CA2188133C (fr) Agents radiotherapeutiques contenant de l'etain 117m
US4497744A (en) Gentisic acid salts as radiographic scanning agent stabilizers
JPH10501218A (ja) 迅速に消失するテクネチウム−９９ｍホスホネート骨格イメージング剤
US4234562A (en) Radiographic scanning
Kothari et al. 186Re-1, 4, 8, 11-tetraaza cyclotetradecyl-1, 4, 8, 11-tetramethylene phosphonic acid: a novel agent for possible use in metastatic bone-pain palliation
JP3080984B2 (ja) レニウム ホスホネート薬剤の製造方法
Lungu et al. Radiolabeled phosphonates for bone metastases therapy
Datta et al. Synthesis of 99mTc-DOTMP and its preclinical evaluation as a multidentate imaging agent for skeletal metastases
JPH0662440B2 (ja) 石灰性腫瘍の治療のためのアミノカルボン酸錯体
EP0225409A1 (fr) Complexes d'acide organoaminophosphonique pour le traitement de tumeurs calciques
Radović et al. [161Tb] Tb-BPAMD as a High-Affinity Agent for Skeletal Targeting: Radiochemical and Biodistribution Insights
Fawzi Stabilized radiographic scanning agents
JPH07509226A (ja) 放射線撮影イメージング剤に有用な六座配位子類
Pauwels Tc99m Bone Seeking Phosphate Compounds: Studies on In Vivo and In Vitro Behaviour
MXPA99010058A (en) Radionuclide associated with nucleotide polyphosphate as tumor imaging agents
JPH06505268A (ja) 放射性医薬製剤の現場合成