JPH11322730A5 - - Google Patents

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Publication number
JPH11322730A5
JPH11322730A5 JP1999059696A JP5969699A JPH11322730A5 JP H11322730 A5 JPH11322730 A5 JP H11322730A5 JP 1999059696 A JP1999059696 A JP 1999059696A JP 5969699 A JP5969699 A JP 5969699A JP H11322730 A5 JPH11322730 A5 JP H11322730A5
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JP
Japan
Prior art keywords
cyclopentyloxy
methoxyphenyl
mixture
ice cooling
dry tetrahydrofuran
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1999059696A
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English (en)
Other versions
JP4518587B2 (ja
JPH11322730A (ja
Filing date
Publication date
Application filed filed Critical
Priority to JP05969699A priority Critical patent/JP4518587B2/ja
Priority claimed from JP05969699A external-priority patent/JP4518587B2/ja
Publication of JPH11322730A publication Critical patent/JPH11322730A/ja
Publication of JPH11322730A5 publication Critical patent/JPH11322730A5/ja
Application granted granted Critical
Publication of JP4518587B2 publication Critical patent/JP4518587B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Description

＜実施例９＞
２−（３−シクロペンチルオキシ−４−メトキシフェニル）−４−（４−ピリジルメトキシカルボニル）モルホリン(表４の化合物Ｎo．９)の合成
４−ピリジンメタノール３５ｍｇ（０．３２ｍＭ）の乾燥テトラヒドロフラン０．５ｍｌ溶液を、氷冷下、６０％水素化ナトリウム２５ｍｇ（０．６５ｍＭ）の乾燥テトラヒドロフラン０．３ｍｌ溶液に滴下し、室温で３０分攪拌する。次いで、４−クロロカルボニル−２−（３−シクロペンチルオキシ−４−メトキシフェニル）モルホリン１００ｍｇ（０．２９ｍＭ）の乾燥テトラヒドロフラン０．５ｍｌ溶液を、氷冷下、反応溶液に滴下し、徐々に室温に戻し３時間攪拌する。氷冷下、反応溶液に水を加え、塩化メチレンで抽出する。得られた抽出液を無水硫酸マグネシウムで乾燥し、減圧下溶媒を留去して無色油状の粗生成物を得る。この粗生成物をフラッシュカラムクロマトグラフィー（ＳｉＯ2；４％メタノール／ジクロロメタン）で精製し、淡黄色油状の標記化合物１２１ｍｇ（収率１００％）を得る。
＜実施例２２＞
２−（３−シクロペンチルオキシ−４−メトキシフェニル）−４−ニコチノイルモルホリン（表４の化合物Ｎo．２２）の合成
実施例１と同様の手法を用い、クロロギ酸メチルのかわりにニコチノイルクロライド塩酸塩を使用し、無色油状の標記化合物（収率１１．９％）を得る。

JP05969699A 1998-03-09 1999-03-08 ２−フェニルモルホリン誘導体 Expired - Fee Related JP4518587B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP05969699A JP4518587B2 (ja) 1998-03-09 1999-03-08 ２−フェニルモルホリン誘導体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP10-73059 1998-03-09
JP7305998 1998-03-09
JP05969699A JP4518587B2 (ja) 1998-03-09 1999-03-08 ２−フェニルモルホリン誘導体

Publications (3)

Publication Number Publication Date
JPH11322730A JPH11322730A (ja) 1999-11-24
JPH11322730A5 true JPH11322730A5 (ja) 2006-03-09
JP4518587B2 JP4518587B2 (ja) 2010-08-04

Family

ID=26400770

Family Applications (1)

Application Number Title Priority Date Filing Date
JP05969699A Expired - Fee Related JP4518587B2 (ja) 1998-03-09 1999-03-08 ２−フェニルモルホリン誘導体

Country Status (1)

Country Link
JP (1) JP4518587B2 (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006316079B2 (en) * 2005-11-15 2012-03-29 Otsuka Pharmaceutical Co., Ltd. Oxazole compound and pharmaceutical composition
TW201206893A (en) * 2010-07-09 2012-02-16 Abbott Healthcare Products Bv Bisaryl (thio) morpholine derivatives as S1P modulators
EP4554595A4 (en) * 2022-07-11 2026-04-01 Univ Rutgers GALPHA12 INHIBITORS AND THEIR METHODS OF USE

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9222253D0 (en) * 1992-10-23 1992-12-09 Celltech Ltd Chemical compounds
BR9307570A (pt) * 1992-12-02 1999-05-25 Pfizer Diéteres de catecol como inibidores seletivos de pdeiv
US6300372B1 (en) * 1993-07-30 2001-10-09 Smithkline Beecham Corporation 3-Cyano-3-(3,4-disubstituted) phenylcyclohexyl-1-carboxylates
US5665754A (en) * 1993-09-20 1997-09-09 Glaxo Wellcome Inc. Substituted pyrrolidines
JPH07300455A (ja) * 1994-03-08 1995-11-14 Mitsubishi Chem Corp ３−フェニルピロリジン誘導体
US6265402B1 (en) * 1996-08-27 2001-07-24 Nikken Chemicals Co., Ltd. Use of 2-phenylmorpholin-5-one derivatives

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