JPH11503156A5 - - Google Patents
Info
- Publication number
- JPH11503156A5 JPH11503156A5 JP1996530356A JP53035696A JPH11503156A5 JP H11503156 A5 JPH11503156 A5 JP H11503156A5 JP 1996530356 A JP1996530356 A JP 1996530356A JP 53035696 A JP53035696 A JP 53035696A JP H11503156 A5 JPH11503156 A5 JP H11503156A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41964395A | 1995-04-07 | 1995-04-07 | |
| US08/419,643 | 1995-04-07 | ||
| PCT/US1996/004163 WO1996031513A1 (en) | 1995-04-07 | 1996-04-01 | Novel intermediates and process for the manufacture of camptothecin derivatives (cpt-11) and related compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007277903A Division JP2008069170A (ja) | 1995-04-07 | 2007-10-25 | カンプトテシン誘導体（ｃｐｔ−１１）および関連化合物を製造するための新規な中間体および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPH11503156A JPH11503156A (ja) | 1999-03-23 |
| JPH11503156A5 true JPH11503156A5 (2) | 2004-07-22 |
| JP4281075B2 JP4281075B2 (ja) | 2009-06-17 |
Family
ID=23663114
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53035696A Expired - Fee Related JP4281075B2 (ja) | 1995-04-07 | 1996-04-01 | カンプトテシン誘導体（ｃｐｔ−１１）および関連化合物を製造するための新規な中間体および方法 |
| JP2007277903A Pending JP2008069170A (ja) | 1995-04-07 | 2007-10-25 | カンプトテシン誘導体（ｃｐｔ−１１）および関連化合物を製造するための新規な中間体および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007277903A Pending JP2008069170A (ja) | 1995-04-07 | 2007-10-25 | カンプトテシン誘導体（ｃｐｔ−１１）および関連化合物を製造するための新規な中間体および方法 |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US6121451A (2) |
| EP (1) | EP0835257B1 (2) |
| JP (2) | JP4281075B2 (2) |
| KR (1) | KR100423627B1 (2) |
| CN (5) | CN1100058C (2) |
| AT (1) | ATE224899T1 (2) |
| AU (1) | AU717179B2 (2) |
| CA (1) | CA2214793C (2) |
| CZ (1) | CZ297862B6 (2) |
| DE (1) | DE69623960T2 (2) |
| DK (1) | DK0835257T3 (2) |
| ES (1) | ES2183943T3 (2) |
| HK (2) | HK1054234B (2) |
| HU (1) | HUP9801436A3 (2) |
| IL (1) | IL117684A (2) |
| MX (1) | MX9707706A (2) |
| NO (2) | NO320482B1 (2) |
| NZ (1) | NZ306664A (2) |
| PL (2) | PL186564B1 (2) |
| PT (1) | PT835257E (2) |
| RU (1) | RU2164917C2 (2) |
| SI (1) | SI0835257T1 (2) |
| TW (1) | TW438775B (2) |
| WO (1) | WO1996031513A1 (2) |
| ZA (1) | ZA962747B (2) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW464652B (en) | 1996-10-30 | 2001-11-21 | Tanabe Seiyaku Co | S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof |
| AU6004099A (en) * | 1998-10-07 | 2000-04-26 | Mitsubishi Chemical Corporation | Mixtures of optical isomers of 1,2-disubstituted-2,3-epoxypropanes, process for producing the same, pesticides containing the same as the active ingredient and intermediates thereof |
| FR2794123B1 (fr) | 1999-05-28 | 2001-07-27 | Aventis Pharma Sa | Preparation de derives de la camptothecine et de la nothapodytine |
| AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| US6855294B2 (en) * | 2000-11-22 | 2005-02-15 | Resonance, Inc. | Apparatus and methods for efficient generation of chlorine dioxide |
| AR035684A1 (es) * | 2001-02-21 | 2004-06-23 | Yakult Honsha Kk | Procedimiento para preparar 2'-amino-5'-hidroxipropiofenona, uso de la misma para la preparacion de analogos de camptotecina, procedimiento para prepararlos, compuestos intermediarios, procedimiento para preparar una cetona triciclica utilizada en la sintesis de analogos de camptotecina |
| US6723853B2 (en) * | 2001-08-27 | 2004-04-20 | University Of Pittsburgh | Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins |
| CA2482712A1 (en) | 2002-04-17 | 2003-10-30 | Pharmacia Corporation | Compounds useful in preparing camptothecin derivatives |
| WO2004100897A2 (en) | 2003-05-12 | 2004-11-25 | Scinopharm Taiwan, Ltd. | Process for the preparation of 7-alkyl-10-hydroxy-20(s)-camptothecin |
| CZ299329B6 (cs) | 2003-08-26 | 2008-06-18 | Pliva-Lachema A.S. | Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu |
| ES2629696T3 (es) * | 2003-09-17 | 2017-08-14 | Nektar Therapeutics | Profármacos poliméricos multibrazo |
| US8394365B2 (en) | 2003-09-17 | 2013-03-12 | Nektar Therapeutics | Multi-arm polymer prodrugs |
| CZ299593B6 (cs) | 2003-12-16 | 2008-09-10 | Pliva-Lachema A. S. | Zpusob výroby 7-ethyl-10-hydroxykamptothecinu |
| US20050197355A1 (en) * | 2004-03-02 | 2005-09-08 | Henegar Kevin E. | Compounds useful in preparing camptothecin derivatives |
| US20050267141A1 (en) * | 2004-05-28 | 2005-12-01 | Phytogen Life Sciences Inc. | Process to prepare camptothecin derivatives |
| US20050272757A1 (en) * | 2004-06-04 | 2005-12-08 | Phytogen Life Sciences Inc. | Process to prepare camptothecin derivatives and novel intermediate and compounds thereof |
| US20080182990A1 (en) * | 2004-08-09 | 2008-07-31 | Shilpa Medicare Limited | Process for the Preparation of Irinotecan Hydrochloride Trihydrate |
| US20060046993A1 (en) * | 2004-09-01 | 2006-03-02 | Pharmacia Italia S.P.A. | Crystalline polymorphic form of irinotecan hydrochloride |
| ATE446299T1 (de) * | 2005-02-07 | 2009-11-15 | Fermion Oy | Verfahren zur herstellung von 7-ethyl-10- hydroxycamptothecin |
| US7767813B2 (en) | 2005-02-08 | 2010-08-03 | Fermion Oy | Preparation method |
| JP5133703B2 (ja) | 2005-02-08 | 2013-01-30 | フェルミオン オサケ ユキチュア | ［１，４’］ビピペリジニル−１’−カルボニルクロリドまたはその塩酸塩の製造方法 |
| TWI375678B (en) * | 2005-06-09 | 2012-11-01 | Yakult Honsha Kk | A method of preparation of a tricyclic ketone |
| EP1803725A1 (en) * | 2005-12-13 | 2007-07-04 | W.C. Heraeus GmbH | Methods for preparing irinotecan |
| US7462627B2 (en) * | 2006-02-09 | 2008-12-09 | Enzon Pharmaceuticals, Inc. | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
| US7671067B2 (en) * | 2006-02-09 | 2010-03-02 | Enzon Pharmaceuticals, Inc. | Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin |
| CN101583380B (zh) | 2006-11-30 | 2013-07-10 | 尼克塔治疗公司 | 用于制备聚合物轭合物的方法 |
| WO2008098178A2 (en) * | 2007-02-09 | 2008-08-14 | Enzon Pharmaceuticals, Inc. | Treatment of resistant or refractory cancers with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin |
| EP2351780B1 (en) * | 2008-07-31 | 2018-10-10 | The Lubrizol Corporation | Novel copolymers and lubricating compositions thereof |
| KR101671537B1 (ko) | 2008-08-11 | 2016-11-01 | 넥타르 테라퓨틱스 | 다분지형 중합체 알카노에이트 컨쥬게이트 |
| TW201010732A (en) * | 2008-08-29 | 2010-03-16 | Enzon Pharmaceuticals Inc | Method of treating RAS associated cancer |
| HUE047352T2 (hu) | 2008-09-23 | 2020-04-28 | Nektar Therapeutics | Eljárás ütemezett beadásra kamptotecin elõgyógyszerekkel (például PEG-ironotekánnal) |
| CA2738807A1 (en) * | 2008-10-21 | 2010-04-29 | Enzon Pharmaceuticals, Inc. | Treatment of neuroblastoma with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin |
| WO2012032531A1 (en) * | 2010-09-06 | 2012-03-15 | Avra Laboratories Pvt. Ltd. | Process for the manufacture of irinotecan hydrochloride by total synthesis |
| WO2012088422A1 (en) | 2010-12-22 | 2012-06-28 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
| US10894087B2 (en) | 2010-12-22 | 2021-01-19 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
| JO3283B1 (ar) | 2011-04-26 | 2018-09-16 | Sanofi Sa | تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI) |
| KR102486321B1 (ko) | 2014-07-18 | 2023-01-09 | 사노피 | 암을 앓고 있는 것으로 의심되는 환자를 아플리베르셉트로 치료한 결과를 예측하는 방법 |
| JP6550538B2 (ja) | 2015-10-27 | 2019-07-24 | カリフォルニア パシフィック メディカル センター | ポドフィロトキシン誘導体およびそれらの使用 |
| US10087194B2 (en) * | 2015-10-27 | 2018-10-02 | California Pacific Medical Center | Podophyllotoxin derivatives and their use |
| ES3057783T3 (en) | 2016-03-15 | 2026-03-04 | Oryzon Genomics Sa | Combinations of lsd1 inhibitors for use in the treatment of neoplastic diseases |
| CN105965710B (zh) * | 2016-06-28 | 2019-03-22 | 常州大学 | 一种硅棒金钢线切割树脂板的制备方法及应用 |
| EP3911660B1 (en) | 2019-01-15 | 2023-05-10 | Laurus Labs Limited | Process for preparation of 2-amino-5-hydroxy propiophenone |
| CN112300184B (zh) * | 2019-08-02 | 2022-12-06 | 华东师范大学 | 一种三元环化合物的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5217499A (en) * | 1975-07-31 | 1977-02-09 | Nippon Chemiphar Co Ltd | Preparation of mappicine |
| EP0220601B1 (en) * | 1985-10-21 | 1991-12-11 | Daiichi Seiyaku Co., Ltd. | Pyranoindolizine derivatives and preparation process thereof |
| US4981968A (en) * | 1987-03-31 | 1991-01-01 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
| US5053512A (en) * | 1987-04-14 | 1991-10-01 | Research Triangle Institute | Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives |
| US4894456A (en) * | 1987-03-31 | 1990-01-16 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
| US5883255A (en) * | 1990-10-31 | 1999-03-16 | Smithkline Beecham Corporation | Substituted indolizino 1,2-b!quinolinones |
| US5405963A (en) * | 1993-06-10 | 1995-04-11 | Smithkline Beecham Corporation | Process for asymmetric total synthesis of camptothecin analogues |
| GB9316352D0 (en) * | 1993-08-06 | 1993-09-22 | Erba Carlo Spa | Process for the preparation of 9-amino camptothecin |
| GB9319944D0 (en) * | 1993-09-28 | 1993-11-17 | Erba Carlo Spa | Process for the preparation of 9-amino camptothecin |
-
1996
- 1996-03-27 TW TW085103680A patent/TW438775B/zh not_active IP Right Cessation
- 1996-03-27 IL IL11768496A patent/IL117684A/en not_active IP Right Cessation
- 1996-04-01 CN CN96193138A patent/CN1100058C/zh not_active Expired - Fee Related
- 1996-04-01 DE DE69623960T patent/DE69623960T2/de not_active Expired - Lifetime
- 1996-04-01 ES ES96912468T patent/ES2183943T3/es not_active Expired - Lifetime
- 1996-04-01 EP EP96912468A patent/EP0835257B1/en not_active Expired - Lifetime
- 1996-04-01 DK DK96912468T patent/DK0835257T3/da active
- 1996-04-01 US US09/230,245 patent/US6121451A/en not_active Expired - Fee Related
- 1996-04-01 PT PT96912468T patent/PT835257E/pt unknown
- 1996-04-01 JP JP53035696A patent/JP4281075B2/ja not_active Expired - Fee Related
- 1996-04-01 WO PCT/US1996/004163 patent/WO1996031513A1/en not_active Ceased
- 1996-04-01 PL PL96355318A patent/PL186564B1/pl not_active IP Right Cessation
- 1996-04-01 MX MX9707706A patent/MX9707706A/es not_active IP Right Cessation
- 1996-04-01 AU AU55278/96A patent/AU717179B2/en not_active Ceased
- 1996-04-01 CA CA002214793A patent/CA2214793C/en not_active Expired - Fee Related
- 1996-04-01 SI SI9630551T patent/SI0835257T1/xx unknown
- 1996-04-01 CN CN03103098XA patent/CN1434043B/zh not_active Expired - Fee Related
- 1996-04-01 KR KR1019970707091A patent/KR100423627B1/ko not_active Expired - Fee Related
- 1996-04-01 HU HU9801436A patent/HUP9801436A3/hu unknown
- 1996-04-01 NZ NZ306664A patent/NZ306664A/xx not_active IP Right Cessation
- 1996-04-01 PL PL96322651A patent/PL186446B1/pl not_active IP Right Cessation
- 1996-04-01 CN CNB031030971A patent/CN100396682C/zh not_active Expired - Fee Related
- 1996-04-01 CZ CZ0311097A patent/CZ297862B6/cs not_active IP Right Cessation
- 1996-04-01 RU RU97118673/04A patent/RU2164917C2/ru not_active IP Right Cessation
- 1996-04-01 AT AT96912468T patent/ATE224899T1/de active
- 1996-04-01 CN CNB031030998A patent/CN1241926C/zh not_active Expired - Fee Related
- 1996-04-01 CN CNB031031005A patent/CN100537538C/zh not_active Expired - Fee Related
- 1996-04-04 ZA ZA9602747A patent/ZA962747B/xx unknown
-
1997
- 1997-10-06 NO NO19974608A patent/NO320482B1/no not_active IP Right Cessation
-
2000
- 2000-02-22 US US09/511,006 patent/US6235907B1/en not_active Expired - Fee Related
- 2000-10-13 US US09/687,227 patent/US6444820B1/en not_active Expired - Fee Related
-
2003
- 2003-09-11 HK HK03106488.3A patent/HK1054234B/zh not_active IP Right Cessation
- 2003-09-11 HK HK03106509.8A patent/HK1054236B/zh not_active IP Right Cessation
-
2005
- 2005-01-25 NO NO20050408A patent/NO329776B1/no not_active IP Right Cessation
-
2007
- 2007-10-25 JP JP2007277903A patent/JP2008069170A/ja active Pending