JPH11513021A - キノロン類およびその医療上の使用 - Google Patents

キノロン類およびその医療上の使用

Info

Publication number: JPH11513021A
Authority: JP; Japan
Prior art keywords: ethyl; dihydro; oxo; quinolinecarboxamide; trifluoromethyl
Prior art date: 1995-08-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

JP9507373A

Other languages

English (en)

Japanese (ja)

Other versions

JPH11513021A5 (2

Inventor

ビーズリー，スティーブン・コリン

モンタナ，ジョン・ゲイリー

ダイク，ヘイゼル・ジョーン

ホーガン，アラン・ファインドレイ

ランシー，カレン・アン

マナラック，デイビッド・トーマス

バックリー，ジョージ・マーティン

マキシー，ロバート・ジェイムズ

ケンドール，ハナ・ジェーン

バクスター，アンドリュー・ダグラス

Original Assignee

カイロサイエンス・リミテッド

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-08-02

Filing date

1996-08-02

Publication date

1999-11-09

1995-08-02 Priority claimed from GBGB9515811.9A external-priority patent/GB9515811D0/en

1995-12-22 Priority claimed from GBGB9526377.8A external-priority patent/GB9526377D0/en

1996-03-20 Priority claimed from GBGB9605868.0A external-priority patent/GB9605868D0/en

1996-06-07 Priority claimed from GBGB9611898.9A external-priority patent/GB9611898D0/en

1996-08-02 Application filed by カイロサイエンス・リミテッド filed Critical カイロサイエンス・リミテッド

1999-11-09 Publication of JPH11513021A publication Critical patent/JPH11513021A/ja

2004-09-09 Publication of JPH11513021A5 publication Critical patent/JPH11513021A5/ja

Status Ceased legal-status Critical Current

Links

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150000001875 compounds Chemical class 0.000 claims description 134
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 26
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 25
239000002253 acid Substances 0.000 claims description 24
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238000000034 method Methods 0.000 claims description 24
150000003839 salts Chemical class 0.000 claims description 22
239000000203 mixture Substances 0.000 claims description 20
125000000217 alkyl group Chemical group 0.000 claims description 17
-1 pyrindanyl Chemical group 0.000 claims description 17
125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 12
125000003118 aryl group Chemical group 0.000 claims description 12
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 12
150000002148 esters Chemical class 0.000 claims description 12
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 12
238000006243 chemical reaction Methods 0.000 claims description 11
229910052736 halogen Inorganic materials 0.000 claims description 9
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125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
MMCIXNVRVDTQSG-UHFFFAOYSA-N quinoline-7-carboxamide Chemical compound C1=CC=NC2=CC(C(=O)N)=CC=C21 MMCIXNVRVDTQSG-UHFFFAOYSA-N 0.000 claims description 7
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Pulmonology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Communicable Diseases (AREA)
Obesity (AREA)
Oncology (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
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Emergency Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)

JP9507373A 1995-08-02 1996-08-02 キノロン類およびその医療上の使用 Ceased JPH11513021A (ja)

Applications Claiming Priority (9)

Application Number	Priority Date	Filing Date	Title
GB9515811.9		1995-08-02
GBGB9515811.9A GB9515811D0 (en)	1995-08-02	1995-08-02	Novel compounds
GBGB9526377.8A GB9526377D0 (en)	1995-12-22	1995-12-22	Novel compounds
GB9526377.8		1995-12-22
GBGB9605868.0A GB9605868D0 (en)	1996-03-20	1996-03-20	Novel compounds
GB9605868.0		1996-03-20
GBGB9611898.9A GB9611898D0 (en)	1996-06-07	1996-06-07	Quinolones and their therapeutic use
GB9611898.9		1996-06-07
PCT/GB1996/001862 WO1997004779A1 (en)	1995-08-02	1996-08-02	Quinolones and their therapeutic use

Publications (2)

Publication Number	Publication Date
JPH11513021A true JPH11513021A (ja)	1999-11-09
JPH11513021A5 JPH11513021A5 (2)	2004-09-09

Family

ID=27451319

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP9507373A Ceased JPH11513021A (ja)	1995-08-02	1996-08-02	キノロン類およびその医療上の使用

Country Status (12)

Country	Link
US (1)	US5891878A (2)
EP (1)	EP0841929B1 (2)
JP (1)	JPH11513021A (2)
AT (1)	ATE239477T1 (2)
AU (1)	AU696390B2 (2)
CA (1)	CA2225552A1 (2)
DE (1)	DE69628019T2 (2)
DK (1)	DK0841929T3 (2)
ES (1)	ES2193252T3 (2)
MX (1)	MX9800922A (2)
PT (1)	PT841929E (2)
WO (1)	WO1997004779A1 (2)

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JP2004518722A (ja) *	2001-02-13	2004-06-24	アベンティス・ファーマ・ドイチユラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング	アシル化１，２，３，４−テトラヒドロナフチルアミンおよび医薬としてのその使用
JP2008504291A (ja) *	2004-06-24	2008-02-14	バーテックス　ファーマシューティカルズ　インコーポレイテッド	Ａｔｐ結合カセットトランスポーターのモジュレーター
JP2009530292A (ja) *	2006-03-13	2009-08-27	アクティヴィックスバイオサイエンシーズインコーポレイテッド	Ｇｓｋ−３インヒビターとしてのアミノキノロン
US9670163B2 (en)	2005-12-28	2017-06-06	Vertex Pharmaceuticals Incorporated	Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
US9701639B2 (en)	2014-10-07	2017-07-11	Vertex Pharmaceuticals Incorporated	Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator
US9751839B2 (en)	2009-03-20	2017-09-05	Vertex Pharmaceuticals Incorporated	Process for making modulators of cystic fibrosis transmembrane conductance regulator
US10272046B2 (en)	2012-02-27	2019-04-30	Vertex Pharmaceuticals Incorporated	Pharmaceutical composition and administrations thereof
US10646481B2 (en)	2008-08-13	2020-05-12	Vertex Pharmaceuticals Incorporated	Pharmaceutical composition and administrations thereof
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US6248736B1 (en)	1999-01-08	2001-06-19	Pharmacia & Upjohn Company	4-oxo-1,4-dihydro-3-quinolinecarboxamides as antiviral agents
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JP2003531195A (ja)	2000-03-21	2003-10-21	ファルマシア・アンド・アップジョン・カンパニー	抗ウイルス剤としての４−ヒドロキシシンノリン−３−カルボキサミド
NZ521522A (en)	2000-03-21	2004-08-27	Upjohn Co	4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxamides useful as antiviral agents
CA2399991A1 (en)	2000-03-21	2001-09-27	Pharmacia & Upjohn Company	4-hydroxy-1,8-naphthyridine-3-carboxamides as antiviral agents
JP2003528087A (ja)	2000-03-21	2003-09-24	ファルマシア・アンド・アップジョン・カンパニー	抗ウイルス剤としての４−オキソ−１，４−ジヒドロ−３−シンノリンカルボキサミド
PE20011349A1 (es)	2000-06-16	2002-01-19	Upjohn Co	1-aril-4-oxo-1,4-dihidro-3-quinolincarboxamidas como agentes antivirales
US6559145B2 (en)	2000-07-12	2003-05-06	Pharmacia & Upjohn Company	Heterocycle carboxamides as antiviral agents
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US20070213310A1 (en) *	2002-04-01	2007-09-13	Laszlo Prokai	Prodrugs for Use as Ophthalmic Agents
US7186707B2 (en)	2002-04-01	2007-03-06	University Of Florida	Prodrugs for use as ophthalmic agents
EP1569648A4 (en) *	2002-12-09	2006-10-04	Univ Florida	PRODRUGS FOR OPHTHALMIKA
MXPA05010373A (es)	2003-04-01	2005-12-05	Applied Research Systems	Inhibidores de fosfodiesterasas en infertilidad.
WO2005009971A1 (ja)	2003-07-24	2005-02-03	Astellas Pharma Inc.	キノロン誘導体又はその塩
US7470706B2 (en) *	2004-01-31	2008-12-30	Sanofi-Aventis Deutschland Gmbh	Cycloalkyl-substituted 7-amino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments
DE102004004971B3 (de) *	2004-01-31	2005-09-15	Aventis Pharma Deutschland Gmbh	Cycloalkyl substituierte 7-Amino-4-chinolon-3-carbonsäure-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arnzeimittel
JP4775259B2 (ja)	2004-03-31	2011-09-21	味の素株式会社	アニリン誘導体
EP2502914A3 (en) *	2004-06-24	2013-12-04	Vertex Pharmaceuticals Incorporated	Modulators of ATP-binding cassette transporters
RU2556984C2 (ru) *	2004-06-24	2015-07-20	Вертекс Фармасьютикалз Инкорпорейтед	Модуляторы транспортеров атф-связывающей кассеты
US8354427B2 (en)	2004-06-24	2013-01-15	Vertex Pharmaceutical Incorporated	Modulators of ATP-binding cassette transporters
DE102004035203A1 (de) *	2004-07-21	2006-02-16	Bayer Healthcare Ag	Substituierte Chinolone
DE102005030524A1 (de)	2005-06-30	2007-01-18	Aicuris Gmbh & Co. Kg	Substituierte Chinolone II
EP1979367A2 (en) *	2005-12-24	2008-10-15	Vertex Pharmaceuticals Incorporated	Quinolin-4-one derivatives as modulators of abc transporters
AU2006331565A1 (en) *	2005-12-27	2007-07-05	Vertex Pharmaceuticals Incorporated	Compounds useful in CFTR assays and methods therewith
DE102006005861A1 (de)	2006-02-09	2007-08-23	Aicuris Gmbh & Co. Kg	Substituierte Chinolone III
EP2349263B1 (en)	2008-10-23	2014-04-23	Vertex Pharmaceuticals Inc.	Modulators of cystic fibrosis transmembrane conductance regulator
US8802700B2 (en)	2010-12-10	2014-08-12	Vertex Pharmaceuticals Incorporated	Modulators of ATP-Binding Cassette transporters
GB201409044D0 (en)	2014-05-21	2014-07-02	Ucl Business Plc	New compounds
CN107998131B (zh) *	2017-12-27	2019-09-24	湖北工业大学	芳香酯类化合物用于制备抗adv-7病毒药物
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FR2564832B1 (fr) *	1984-05-23	1987-05-15	Panmedica Sa	Nouveaux n-acyl derives d'amino-acides et leurs esters, leur procede de preparation et medicaments les contenant
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1996
- 1996-08-02 AU AU66263/96A patent/AU696390B2/en not_active Ceased
- 1996-08-02 AT AT96925905T patent/ATE239477T1/de not_active IP Right Cessation
- 1996-08-02 JP JP9507373A patent/JPH11513021A/ja not_active Ceased
- 1996-08-02 WO PCT/GB1996/001862 patent/WO1997004779A1/en not_active Ceased
- 1996-08-02 ES ES96925905T patent/ES2193252T3/es not_active Expired - Lifetime
- 1996-08-02 EP EP96925905A patent/EP0841929B1/en not_active Expired - Lifetime
- 1996-08-02 CA CA002225552A patent/CA2225552A1/en not_active Abandoned
- 1996-08-02 DK DK96925905T patent/DK0841929T3/da active
- 1996-08-02 DE DE69628019T patent/DE69628019T2/de not_active Expired - Fee Related
- 1996-08-02 MX MX9800922A patent/MX9800922A/es not_active IP Right Cessation
- 1996-08-02 US US08/691,338 patent/US5891878A/en not_active Expired - Fee Related
- 1996-08-02 PT PT96925905T patent/PT841929E/pt unknown

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JP2004518722A (ja) *	2001-02-13	2004-06-24	アベンティス・ファーマ・ドイチユラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング	アシル化１，２，３，４−テトラヒドロナフチルアミンおよび医薬としてのその使用
JP2008504291A (ja) *	2004-06-24	2008-02-14	バーテックス　ファーマシューティカルズ　インコーポレイテッド	Ａｔｐ結合カセットトランスポーターのモジュレーター
US10662192B2 (en)	2004-06-24	2020-05-26	Vertex Pharmaceuticals Incorporated	Modulators of ATP-binding cassette transporters
JP2012056963A (ja) *	2004-06-24	2012-03-22	Vertex Pharmaceuticals Inc	Ａｔｐ結合カセットトランスポーターのモジュレーター
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JP2012107069A (ja) *	2004-06-24	2012-06-07	Vertex Pharmaceuticals Inc	Ａｔｐ結合カセットトランスポーターのモジュレーター
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US11291662B2 (en)	2005-12-28	2022-04-05	Vertex Pharmaceuticals Incorporated	Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
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JP2009530292A (ja) *	2006-03-13	2009-08-27	アクティヴィックスバイオサイエンシーズインコーポレイテッド	Ｇｓｋ−３インヒビターとしてのアミノキノロン
US11564916B2 (en)	2008-08-13	2023-01-31	Vertex Pharmaceuticals Incorporated	Pharmaceutical composition and administrations thereof
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Also Published As

Publication number	Publication date
DE69628019D1 (de)	2003-06-12
AU6626396A (en)	1997-02-26
EP0841929A1 (en)	1998-05-20
DE69628019T2 (de)	2004-01-22
MX9800922A (es)	1998-05-31
US5891878A (en)	1999-04-06
CA2225552A1 (en)	1997-02-13
PT841929E (pt)	2003-09-30
WO1997004779A1 (en)	1997-02-13
ATE239477T1 (de)	2003-05-15
ES2193252T3 (es)	2003-11-01
AU696390B2 (en)	1998-09-10
EP0841929B1 (en)	2003-05-07
DK0841929T3 (da)	2003-09-01

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2007-04-17

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Effective date: 20070417

2007-09-27

A313

Final decision of rejection without a dissenting response from the applicant

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2007-11-06

A02

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Effective date: 20071106

Publication	Publication Date	Title
JPH11513021A (ja)	1999-11-09	キノロン類およびその医療上の使用
JPH11510156A (ja)	1999-09-07	キノロン類およびその医療上の使用
RU2170730C2 (ru)	2001-07-20	Хинолиновые карбоксамиды и фармацевтическая композиция на их основе
US5728712A (en)	1998-03-17	3,4-disubstituted-phenylsulphonamides and their therapeutic use
RU2285002C2 (ru)	2006-10-10	Производное пиридина и фармацевтическая композиция на его основе
US6069151A (en)	2000-05-30	Quinolines and their therapeutic use
EP0946541B1 (en)	2003-07-30	Quinolines and their therapeutic use
AU710825B2 (en)	1999-09-30	Quinolones and their therapeutic use
AU710876B2 (en)	1999-09-30	Quinolones and their therapeutic use
JP2002516325A (ja)	2002-06-04	新規な置換イミダゾール化合物
CZ371998A3 (cs)	1999-03-17	Benzofuranové karboxamidy a jejich terapeutické použití
JP2001526222A (ja)	2001-12-18	アリールおよびヘテロアリール置換複素環尿素を使用するｐ３８キナーゼ活性の阻害
HU230787B1 (en)	2018-05-02	Quinolinone derivatives as tyrosine kinase inhibitors
JP2001506230A (ja)	2001-05-15	新規ピペラジン含有化合物
JP2017537947A (ja)	2017-12-21	抗生物質増強剤としての複素環化合物
HUP9903797A2 (hu)	2001-04-28	Benzofurán-karboxamidok és -szulfonamidok, alkalmazásuk gyógyszerkészítmények előállítására és ezek a gyógyszerkészítmények
JP2001504479A (ja)	2001-04-03	二環式アリールカルボキシアミド及びその治療的使用
KR100729289B1 (ko)	2007-06-18	신규한 1,8-나프티리딘-2(1ｈ)-온 유도체
JP2002504925A (ja)	2002-02-12	Ｐｄｅｉｖおよび／又はｔｎｆインヒビターとしてのキノリン誘導体
US5792774A (en)	1998-08-11	Quinolones and their therapeutic use
JP2002528541A (ja)	2002-09-03	Ｔｎｆおよびｐｄｅ−ｉｖ阻害活性を有する複素環式化合物のｎ−オキシド
JP2002502851A (ja)	2002-01-29	ベンゾフラン−４−カルボキサミドとその治療的使用