|
US5843937A
(en)
*
|
1996-05-23 |
1998-12-01 |
Panorama Research, Inc. |
DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents
|
|
NZ334344A
(en)
*
|
1996-09-12 |
2000-08-25 |
Cancer Res Campaign Tech |
benzo[e]indole and pyrrolo[3,2-e]indole compounds and their use as prodrugs
|
|
US6130237A
(en)
*
|
1996-09-12 |
2000-10-10 |
Cancer Research Campaign Technology Limited |
Condensed N-aclyindoles as antitumor agents
|
|
JP4862120B2
(ja)
*
|
2001-02-22 |
2012-01-25 |
ユニヴァーシティ オブ ブラッドフォード |
腫瘍治療のためのプロドラッグとしてのベンズ−インドールおよびベンゾ−キノリン誘導体
|
|
DE10121217A1
(de)
|
2001-04-30 |
2002-10-31 |
Merck Patent Gmbh |
6H-Oxazolo[4,5-e]indol-Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden
|
|
DE10121215A1
(de)
*
|
2001-04-30 |
2002-10-31 |
Merck Patent Gmbh |
Dihydro-imidazo[4,5-e]indol- und 7H-Pyrrolo[3,2-f]chinoxalin Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden
|
|
EP1392359B2
(en)
|
2001-05-11 |
2013-03-13 |
Ludwig Institute for Cancer Research Ltd. |
Specific binding proteins and uses thereof
|
|
US20100056762A1
(en)
|
2001-05-11 |
2010-03-04 |
Old Lloyd J |
Specific binding proteins and uses thereof
|
|
US7129261B2
(en)
|
2001-05-31 |
2006-10-31 |
Medarex, Inc. |
Cytotoxic agents
|
|
WO2003022274A2
(en)
*
|
2001-09-13 |
2003-03-20 |
Synta Pharmaceuticals Corp. |
2-aroylimidazole compounds for treating cancer
|
|
US6756397B2
(en)
*
|
2002-04-05 |
2004-06-29 |
Immunogen, Inc. |
Prodrugs of CC-1065 analogs
|
|
JP4806680B2
(ja)
*
|
2004-05-19 |
2011-11-02 |
メダレックス インコーポレイテッド |
自己犠牲リンカー及び薬剤複合体
|
|
RU2402548C2
(ru)
*
|
2004-05-19 |
2010-10-27 |
Медарекс, Инк. |
Химические линкеры и их конъюгаты
|
|
US7393665B2
(en)
*
|
2005-02-10 |
2008-07-01 |
Population Genetics Technologies Ltd |
Methods and compositions for tagging and identifying polynucleotides
|
|
NZ556661A
(en)
*
|
2005-02-18 |
2010-10-29 |
Medarex Inc |
Human monoclonal antibodies to prostate specific membrance antigen (PSMA)
|
|
US7714016B2
(en)
*
|
2005-04-08 |
2010-05-11 |
Medarex, Inc. |
Cytotoxic compounds and conjugates with cleavable substrates
|
|
BRPI0617546A2
(pt)
*
|
2005-09-26 |
2011-07-26 |
Medarex Inc |
conjugado de fÁrmaco-anticorpo, formulaÇço farmacÊutica, mÉtodo para matar uma cÉlula de tumor, mÉtodo para retardar ou interromper o crescimento de um tumor em um sujeito mamÍfero e composto
|
|
CA2623236A1
(en)
|
2005-09-26 |
2007-04-05 |
Medarex, Inc. |
Human monoclonal antibodies to cd70
|
|
SI1940789T1
(sl)
*
|
2005-10-26 |
2012-03-30 |
Medarex Inc |
Postopki in spojine za pripravo cc analogov
|
|
CA2627190A1
(en)
|
2005-11-10 |
2007-05-24 |
Medarex, Inc. |
Duocarmycin derivatives as novel cytotoxic compounds and conjugates
|
|
US8383118B2
(en)
|
2005-12-08 |
2013-02-26 |
Medarex, Inc. |
Human monoclonal antibodies to fucosyl-GM1 and methods for using anti-fucosyl-GM1
|
|
EA017812B1
(ru)
|
2005-12-08 |
2013-03-29 |
Медарекс, Инк. |
Выделенное моноклональное антитело или его антигенсвязывающий участок, которые связываются с протеинтирозинкиназой 7 ( ptk7) человека, и их применение
|
|
ES2396569T3
(es)
|
2006-01-17 |
2013-02-22 |
Medarex, Inc. |
Anticuerpos monoclonales contra CD30 que carecen de restos fucosilo y xilosilo
|
|
MX2009002418A
(es)
|
2006-09-05 |
2009-04-23 |
Medarex Inc |
Anticuerpos para las proteinas morfogenicas oseas y receptores de estas y metodos para su uso.
|
|
KR101552735B1
(ko)
|
2006-12-01 |
2015-09-14 |
메다렉스, 엘.엘.시. |
씨디22에 결합하는 인간 항체 및 이의 용도
|
|
CL2007003622A1
(es)
|
2006-12-13 |
2009-08-07 |
Medarex Inc |
Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales.
|
|
KR20090088946A
(ko)
|
2006-12-14 |
2009-08-20 |
메다렉스, 인코포레이티드 |
씨디70에 결합하는 인간 항체 및 이의 용도
|
|
TWI412367B
(zh)
|
2006-12-28 |
2013-10-21 |
梅達雷克斯有限責任公司 |
化學鏈接劑與可裂解基質以及其之綴合物
|
|
US9090693B2
(en)
|
2007-01-25 |
2015-07-28 |
Dana-Farber Cancer Institute |
Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease
|
|
CA2678514A1
(en)
|
2007-02-21 |
2008-08-28 |
Medarex, Inc. |
Chemical linkers with single amino acids and conjugates thereof
|
|
ES2542152T3
(es)
*
|
2007-03-15 |
2015-07-31 |
Ludwig Institute For Cancer Research Ltd. |
Método de tratamiento que emplea anticuerpos de EGFR e inhibidores de Src y formulaciones relacionadas
|
|
US9901567B2
(en)
|
2007-08-01 |
2018-02-27 |
Syntarga B.V. |
Substituted CC-1065 analogs and their conjugates
|
|
CN108424454B
(zh)
|
2007-08-14 |
2022-05-31 |
路德维格癌症研究所有限公司 |
靶向egf受体的单克隆抗体175及其衍生物和用途
|
|
US8377981B2
(en)
*
|
2007-11-13 |
2013-02-19 |
The Scripps Research Institute |
CBI derivatives subject to reductive activation
|
|
AU2009320481C1
(en)
|
2008-11-03 |
2016-12-08 |
Syntarga B.V. |
Novel CC-1065 analogs and their conjugates
|
|
US8420084B2
(en)
|
2009-03-05 |
2013-04-16 |
Medarex, Inc. |
Fully human antibodies specific to CADM1
|
|
DK2421898T3
(en)
|
2009-04-20 |
2016-05-30 |
Oxford Biotherapeutics Ltd |
Cadherin-17 SPECIFIC ANTIBODIES
|
|
US20110076232A1
(en)
*
|
2009-09-29 |
2011-03-31 |
Ludwig Institute For Cancer Research |
Specific binding proteins and uses thereof
|
|
EP2470569A1
(en)
|
2009-10-13 |
2012-07-04 |
Oxford Biotherapeutics Ltd. |
Antibodies against epha10
|
|
DE102009051438A1
(de)
|
2009-10-30 |
2011-05-05 |
Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts |
Fluoreszenzfarbstoffe
|
|
AU2011243294C1
(en)
|
2010-04-21 |
2015-12-03 |
Syntarga B.V. |
Novel conjugates of CC-1065 analogs and bifunctional linkers
|
|
WO2012171020A1
(en)
|
2011-06-10 |
2012-12-13 |
Mersana Therapeutics, Inc. |
Protein-polymer-drug conjugates
|
|
UA114478C2
(uk)
|
2011-06-28 |
2017-06-26 |
Берлін-Хемі Аг |
Антитіло, яке специфічно зв'язується з bst1
|
|
US10131682B2
(en)
|
2012-11-24 |
2018-11-20 |
Hangzhou Dac Biotech Co., Ltd. |
Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
|
|
CA2892863C
(en)
|
2012-12-10 |
2022-03-15 |
Mersana Therapeutics, Inc. |
Polymeric scaffold based on phf for targeted drug delivery
|
|
WO2014093640A1
(en)
|
2012-12-12 |
2014-06-19 |
Mersana Therapeutics,Inc. |
Hydroxy-polmer-drug-protein conjugates
|
|
RU2015129800A
(ru)
|
2012-12-21 |
2017-01-30 |
Биоэллаенс К. В. |
Гидрофильные саморазрушающиеся линкеры и их конъюгаты
|
|
JP6173559B2
(ja)
*
|
2013-03-28 |
2017-08-02 |
ザ スクリプス リサーチ インスティテュート |
環状n−アシルo−アミノフェノールcbi誘導体
|
|
WO2015050959A1
(en)
|
2013-10-01 |
2015-04-09 |
Yale University |
Anti-kit antibodies and methods of use thereof
|
|
EA032231B1
(ru)
|
2013-10-11 |
2019-04-30 |
Мерсана Терапьютикс, Инк. |
Конъюгаты белок-полимер-лекарственное средство
|
|
CA2927022C
(en)
|
2013-10-11 |
2018-08-21 |
Asana Biosciences, Llc |
Protein-polymer-drug conjugates
|
|
AU2015205574B2
(en)
|
2014-01-10 |
2019-08-15 |
Byondis B.V. |
Method for purifying Cys-linked antibody-drug conjugates
|
|
CA2938919C
(en)
|
2014-02-28 |
2020-12-29 |
Hangzhou Dac Biotech Co., Ltd |
Charged linkers and their uses for conjugation
|
|
CN106795214B
(zh)
|
2014-03-20 |
2022-09-02 |
百时美施贵宝公司 |
稳定化的基于纤连蛋白的支架分子
|
|
SG11201610620UA
(en)
|
2014-06-20 |
2017-01-27 |
Bioalliance Cv |
Anti-folate receptor aplha (fra) antibody-drug conjugates and methods of using thereof
|
|
JP6668345B2
(ja)
|
2014-11-21 |
2020-03-18 |
ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company |
修飾された重鎖定常領域を含む抗体
|
|
MY189836A
(en)
|
2014-11-21 |
2022-03-11 |
Bristol Myers Squibb Co |
Antibodies against cd73 and uses thereof
|
|
ES2981335T3
(es)
|
2014-11-25 |
2024-10-08 |
Bristol Myers Squibb Co |
Novedosos polipéptidos de unión a PD-L1 para obtención de imágenes
|
|
CN107406496A
(zh)
|
2015-03-10 |
2017-11-28 |
百时美施贵宝公司 |
可通过转谷氨酰胺酶缀合的抗体和由其制备的缀合物
|
|
TN2019000101A1
(en)
|
2015-05-29 |
2020-07-15 |
Bristol Myers Squibb Co |
Antibodies against ox40 and uses thereof.
|
|
FI3319936T3
(fi)
|
2015-07-12 |
2026-03-12 |
Hangzhou Dac Biotech Co Ltd |
Silloituslinkkereitä soluun sitoutuvien molekyylien konjugoimiseksi
|
|
US9839687B2
(en)
|
2015-07-15 |
2017-12-12 |
Suzhou M-Conj Biotech Co., Ltd. |
Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
|
|
CN104961645A
(zh)
*
|
2015-07-22 |
2015-10-07 |
中国药科大学 |
苯氧乙酸类衍生物、其制备方法及其作为药物的用途
|
|
AU2016377371A1
(en)
|
2015-12-21 |
2018-08-09 |
Bristol-Myers Squibb Company |
Variant antibodies for site-specific conjugation
|
|
SG11201805557SA
(en)
|
2016-01-08 |
2018-07-30 |
Bioalliance Cv |
Tetravalent anti-psgl-1 antibodies and uses thereof
|
|
KR20230038311A
(ko)
|
2016-03-04 |
2023-03-17 |
브리스톨-마이어스 스큅 컴퍼니 |
항-cd73 항체와의 조합 요법
|
|
US11617799B2
(en)
|
2016-06-27 |
2023-04-04 |
Tagworks Pharmaceuticals B.V. |
Cleavable tetrazine used in bio-orthogonal drug activation
|
|
CN109641911B
(zh)
|
2016-08-19 |
2023-02-21 |
百时美施贵宝公司 |
seco-环丙吡咯并吲哚化合物和其抗体-药物缀合物以及制备和使用方法
|
|
WO2018048975A1
(en)
|
2016-09-09 |
2018-03-15 |
Bristol-Myers Squibb Company |
Use of an anti-pd-1 antibody in combination with an anti-mesothelin antibody in cancer treatment
|
|
CA3042442C
(en)
|
2016-11-14 |
2024-01-02 |
Hangzhou Dac Biotech Co., Ltd |
Conjugation linkers, cell binding molecule-drug conjugates containing the linkers, methods of making and uses of such conjugates with the linkers
|
|
US11135307B2
(en)
|
2016-11-23 |
2021-10-05 |
Mersana Therapeutics, Inc. |
Peptide-containing linkers for antibody-drug conjugates
|
|
IL270596B2
(en)
|
2017-05-25 |
2026-01-01 |
Bristol Myers Squibb Co |
Antibodies containing heavy constant regions are adapted for use in cancer therapy
|
|
JP7320458B2
(ja)
|
2017-06-22 |
2023-08-03 |
メルサナ セラピューティクス インコーポレイテッド |
薬物担持ポリマースキャフォールドおよびタンパク質-ポリマー-薬物コンジュゲートを製造する方法
|
|
ES2975330T3
(es)
|
2018-05-04 |
2024-07-04 |
Tagworks Pharmaceuticals B V |
Compuestos que comprenden un enlazador para aumentar la estabilidad del trans-cicloocteno
|
|
EP3787691A1
(en)
|
2018-05-04 |
2021-03-10 |
Tagworks Pharmaceuticals B.V. |
Tetrazines for high click conjugation yield in vivo and high click release yield
|
|
AU2019369340A1
(en)
|
2018-10-29 |
2021-05-20 |
Mersana Therapeutics, Inc. |
Cysteine engineered antibody-drug conjugates with peptide-containing linkers
|
|
EP4382129A3
(en)
|
2019-06-17 |
2024-07-03 |
Tagworks Pharmaceuticals B.V. |
Compounds for fast and efficient click release
|
|
IL289094A
(en)
|
2019-06-17 |
2022-02-01 |
Tagworks Pharmaceuticals B V |
Tetrazines for increasing the speed and yield of the "click release" reaction
|
|
JP2024532537A
(ja)
|
2021-09-06 |
2024-09-05 |
ヴェラクサ バイオテック ゲーエムベーハー |
真核生物における遺伝暗号の拡張のための新規アミノアシルtRNA合成酵素変異体
|
|
CN117980327A
(zh)
|
2021-11-03 |
2024-05-03 |
杭州多禧生物科技有限公司 |
抗体的特异性偶联
|
|
CA3238627A1
(en)
|
2021-11-25 |
2023-06-01 |
Christine Kohler |
Improved antibody-payload conjugates (apcs) prepared by site-specific conjugation utilizing genetic code expansion
|
|
ES3039688T3
(en)
|
2021-11-25 |
2025-10-23 |
Veraxa Biotech Gmbh |
Improved antibody-payload conjugates (apcs) prepared by site-specific conjugation utilizing genetic code expansion
|
|
KR20240119102A
(ko)
|
2021-12-08 |
2024-08-06 |
유럽피안 몰레큘러 바이올로지 래보러토리 |
표적화 접합체의 제조를 위한 친수성 테트라진-관능화 페이로드
|
|
EP4372000A3
(en)
|
2022-02-15 |
2024-07-17 |
Tagworks Pharmaceuticals B.V. |
Masked il12 protein
|
|
JP2025524728A
(ja)
|
2022-07-15 |
2025-07-30 |
フィアン セラピューティクス エルティーディー |
抗体-薬物複合体
|
|
IL320221A
(en)
|
2022-10-12 |
2025-06-01 |
Tagworks Pharmaceuticals B V |
Strained bicyclo-nonanes
|
|
CN120569216A
(zh)
|
2023-01-20 |
2025-08-29 |
巴斯夫欧洲公司 |
稳定型生物聚合物组合物、其制造和用途
|
|
KR20250169530A
(ko)
|
2023-03-10 |
2025-12-03 |
태그웍스 파마슈티컬스 비.브이. |
개선된 t-링커를 갖는 트랜스-사이클로옥텐
|
|
AU2024300552A1
(en)
|
2023-07-27 |
2026-01-29 |
Veraxa Biotech Gmbh |
Hydrophilic trans-cyclooctene (hytco) compounds, constructs and conjugates containing the same
|
|
WO2025056807A1
(en)
|
2023-09-15 |
2025-03-20 |
Basf Se |
Stabilized biopolymer composition, their manufacture and use
|
|
WO2025149667A1
(en)
|
2024-01-12 |
2025-07-17 |
Pheon Therapeutics Ltd |
Antibody drug conjugates and uses thereof
|
|
WO2025174248A1
(en)
|
2024-02-16 |
2025-08-21 |
Tagworks Pharmaceuticals B.V. |
Trans-cyclooctenes with "or gate" release
|
|
WO2026043376A1
(en)
|
2024-08-22 |
2026-02-26 |
Tagworks Pharmaceuticals B.V. |
Trans-cyclooctene formulations
|
|
WO2026078060A1
(en)
|
2024-10-08 |
2026-04-16 |
Basf Se |
Tocopherol alkoxylates for biopolymer stabilization
|