JPS5368796A - Syn-isomer of 3,7-disubstd.-3-cephem-4-carboxylic acids, and their preventingor treating agents containing their salts as active constituent againstdiseases caused by bacterial infection - Google Patents

Syn-isomer of 3,7-disubstd.-3-cephem-4-carboxylic acids, and their preventingor treating agents containing their salts as active constituent againstdiseases caused by bacterial infection

Info

Publication number: JPS5368796A
Authority: JP; Japan
Prior art keywords: cephem; disubstd; syn; isomer; salts
Prior art date: 1976-04-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP8249077A

Other languages

English (en)

Other versions

JPS6137250B2 (ja

Inventor

Takao Takatani

Takashi Masugi

Hisashi Takasugi

Hiromu Kawachi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Fujisawa Pharmaceutical Co Ltd

Original Assignee

Fujisawa Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-04-12

Filing date

1977-07-08

Publication date

1978-06-19

1977-07-08 Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd

1978-06-19 Publication of JPS5368796A publication Critical patent/JPS5368796A/ja

1986-08-22 Publication of JPS6137250B2 publication Critical patent/JPS6137250B2/ja

Status Granted legal-status Critical Current

Links

150000003839 salts Chemical class 0.000 title abstract 2
208000035143 Bacterial infection Diseases 0.000 title 1
208000022362 bacterial infectious disease Diseases 0.000 title 1
239000003795 chemical substances by application Substances 0.000 title 1
239000000470 constituent Substances 0.000 title 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
HJJDBAOLQAWBMH-WCRCJTMVSA-N (6R)-7-[[2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound NC=1SC=C(N=1)C(C(=O)NC1[C@@H]2N(C(=C(CS2)CSC2=NN=NN2C)C(=O)O)C1=O)=NOC HJJDBAOLQAWBMH-WCRCJTMVSA-N 0.000 abstract 1
125000005042 acyloxymethyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
-1 amino, protected amino Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000001841 imino group Chemical group [H]N=* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

JP8249077A 1976-04-12 1977-07-08 Syn-isomer of 3,7-disubstd.-3-cephem-4-carboxylic acids, and their preventingor treating agents containing their salts as active constituent againstdiseases caused by bacterial infection Granted JPS5368796A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB14916/76A GB1576625A (en)	1976-04-12	1976-04-12	Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof
GB2349076		1976-06-07

Related Parent Applications (1)

Application Number	Title	Priority Date	Filing Date
JP51125826A Division JPS5941995B2 (ja)	1976-04-02	1976-10-19	３，７−ジ置換−３−セフエム−４−カルボン酸化合物およびその塩類およびそれらの製造方法

Publications (2)

Publication Number	Publication Date
JPS5368796A true JPS5368796A (en)	1978-06-19
JPS6137250B2 JPS6137250B2 (ja)	1986-08-22

Family

ID=26250890

Family Applications (6)

Application Number	Title	Priority Date	Filing Date
JP51125826A Expired JPS5941995B2 (ja)	1976-04-02	1976-10-19	３，７−ジ置換−３−セフエム−４−カルボン酸化合物およびその塩類およびそれらの製造方法
JP8248977A Pending JPS5368795A (en)	1976-04-12	1977-07-08	Syn-isomer of 7-substd.-3-methyl-3-cephem-4-carboxylic acids, their salts,and their preparation
JP8249077A Granted JPS5368796A (en)	1976-04-12	1977-07-08	Syn-isomer of 3,7-disubstd.-3-cephem-4-carboxylic acids, and their preventingor treating agents containing their salts as active constituent againstdiseases caused by bacterial infection
JP15697479A Granted JPS5598189A (en)	1976-04-12	1979-12-03	Syn-isomer of 3, 7-di-substituted-3-cephem-4-carboxylic acid compound, its salt, and their preparation
JP58128676A Granted JPS5962597A (ja)	1976-04-12	1983-07-13	３，７−ジ置換−３−セフエム−４−カルボン酸化合物のシン異性体およびその塩類およびそれらを製造する方法
JP2261173A Expired - Lifetime JPH0684338B2 (ja)	1976-04-12	1990-09-28	置換酢酸誘導体

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
JP51125826A Expired JPS5941995B2 (ja)	1976-04-02	1976-10-19	３，７−ジ置換−３−セフエム−４−カルボン酸化合物およびその塩類およびそれらの製造方法
JP8248977A Pending JPS5368795A (en)	1976-04-12	1977-07-08	Syn-isomer of 7-substd.-3-methyl-3-cephem-4-carboxylic acids, their salts,and their preparation

Family Applications After (3)

Application Number	Title	Priority Date	Filing Date
JP15697479A Granted JPS5598189A (en)	1976-04-12	1979-12-03	Syn-isomer of 3, 7-di-substituted-3-cephem-4-carboxylic acid compound, its salt, and their preparation
JP58128676A Granted JPS5962597A (ja)	1976-04-12	1983-07-13	３，７−ジ置換−３−セフエム−４−カルボン酸化合物のシン異性体およびその塩類およびそれらを製造する方法
JP2261173A Expired - Lifetime JPH0684338B2 (ja)	1976-04-12	1990-09-28	置換酢酸誘導体

Country Status (3)

Country	Link
JP (6)	JPS5941995B2 (ja)
GB (1)	GB1576625A (ja)
HU (1)	HU183009B (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS549296A (en) *	1977-04-02	1979-01-24	Hoechst Ag	Cephem derivative and its preparation
JPS5585594A (en) *	1978-11-13	1980-06-27	Fujisawa Pharmaceut Co Ltd	Cephem compound and their preparation
JPS5692291A (en) *	1979-12-07	1981-07-25	Erba Carlo Spa	Nnsubstituted thiazolyl derivative of oxyimino substituted cephalosporin
JPS57154175A (en) *	1981-03-16	1982-09-22	Mitsui Toatsu Chem Inc	2-thiazoleamine derivative, its preparation, and drug composition comprising it

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE878514A (fr) *	1978-09-04	1980-02-29	Fujisawa Pharmaceutical Co	Procede de preparation de composes d'acide 3-cephem-4-carboxylique a disubstitution en positions 3 et 7, nouveaux produits ainsi obtenus et leur utilisation pour leur activite antibacterienne
BE878433A (fr) *	1978-08-31	1980-02-25	Fujisawa Pharmaceutical Co	Procede de preparation de derives d'acide 3-cephem-4-carboxylique 3,7-disubstitue, nouveaux produits ainsi obtenus et leur utilisation pour leur activite antibacterienne
SE439312B (sv) *	1977-03-25	1985-06-10	Roussel Uclaf	Sett att framstella nya oximderivat av 3-acetoximetyl-7-aminotiazolylacetamido cefalosporansyra
NL7805715A (nl) *	1977-06-03	1978-12-05	Hoffmann La Roche	Werkwijze voor het bereiden van acylderivaten.
FR2410655A1 (fr) *	1977-12-05	1979-06-29	Roussel Uclaf	Nouvelles oximes derivees de l'acide 3-substitue 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
JPS5498795A (en) *	1978-01-13	1979-08-03	Takeda Chem Ind Ltd	Cephalosporin derivative and its preparation
JPS54128594A (en) *	1978-03-27	1979-10-05	Fujisawa Pharmaceut Co Ltd	3,7-disubstituted-3-cephem-4-carboxylic acid derivative
FR2432521A1 (fr) *	1978-03-31	1980-02-29	Roussel Uclaf	Nouvelles oximes o-substituees derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2421907A1 (fr) *	1978-04-07	1979-11-02	Roussel Uclaf	Nouvelles cephalosporines derivees de l'acide 7-/2-(2-amino 4-thiazolyl)2-(carboxymethoxyimino/acetamido 3-substitue cephalosporanique, leur procede de preparation et leur application comme medicaments
GB1604723A (en) *	1978-05-26	1981-12-16	Glaxo Operations Ltd	7-(2-aminothiazol-4-yl)-2-oxyimino-acetamido)-cephem derivatives
GB1604722A (en) *	1978-05-26	1981-12-16	Glaxo Operations Ltd	7-(2-(2-amino-4-thiozolyl)-2-oxymino-acetamido)-cephem derivatives
EP0059486B1 (en) *	1978-07-17	1985-10-02	Fujisawa Pharmaceutical Co., Ltd.	New starting compounds for preparing cephem compounds and processes for their preparation
US4703046A (en) *	1978-09-08	1987-10-27	Fujisawa Pharmaceutical Co., Ltd.	Cephem compounds and processes for preparation thereof
BE878637A (fr) *	1978-09-11	1980-03-06	Fujisawa Pharmaceutical Co	Procede de preparation de composes d'acide 3-cephem-4-carboxylique 3,7-disubstitue et de leurs sels pharmaceutiquement acceptables, nouveaux produits ainsi obtenus et leur utilisation pour leurs activites antimicrobiennes
JPH02111750A (ja) *	1978-09-12	1990-04-24	Fujisawa Pharmaceut Co Ltd	酪酸誘導体
JPS5579393A (en) *	1978-12-11	1980-06-14	Takeda Chem Ind Ltd	Cephalosporin derivative and its preparation
JPS5616490A (en) *	1979-07-18	1981-02-17	Hoechst Ag	Cephem compound manufacture
DE3165922D1 (en) *	1980-03-28	1984-10-18	Biochemie Gmbh	New process for the production of cephalosporin antibiotics, and novel intermediates used in such process and their production
IL63207A (en) *	1980-07-24	1985-09-29	Lonza Ag	Process for the preparation of 2-(2-aminothiazole-4-yl)-2-(syn)-methoxyiminoacetic acid esters
JPS57157594U (ja) *	1981-03-31	1982-10-04
WO1984004305A1 (fr) *	1983-05-02	1984-11-08	Takeda Chemical Industries Ltd	Procede de preparation de derives d'acide aminothiazolacetique
WO1984002703A1 (fr) *	1983-01-07	1984-07-19	Takeda Chemical Industries Ltd	Procede de preparation de derives d'acide aminothiazolylacetique
EP0115770B2 (en) *	1983-01-07	1996-06-19	Takeda Chemical Industries, Ltd.	Thiazole Derivatives
GB8318846D0 (en) *	1983-07-12	1983-08-10	Fujisawa Pharmaceutical Co	Prophylactic/therapeutic agent against fish diseases
JPS60142987A (ja) *	1983-12-29	1985-07-29	Mochida Pharmaceut Co Ltd	セフアロスポリン誘導体
DE3485860T2 (de) *	1983-12-29	1993-01-14	Mochida Pharm Co Ltd	Cephalosporinverbindungen, verfahren zu ihrer herstellung und pharmazeutishe praeparate.
JPS60178891A (ja) *	1984-02-24	1985-09-12	Kureha Chem Ind Co Ltd	セファロスポリン誘導体及び該誘導体を含有する医薬
JPS60155167A (ja) *	1984-07-31	1985-08-15	Fujisawa Pharmaceut Co Ltd	置換イミノ酢酸誘導体およびその塩類
US4840945A (en) *	1985-04-01	1989-06-20	Mochida Pharmaceutical Co., Ltd.	Cephalosporin derivatives
AU579469B2 (en) *	1985-05-30	1988-11-24	Shionogi & Co., Ltd.	A process for preparing hydroxymethylcephem compounds
JPS6236386A (ja) *	1985-08-09	1987-02-17	Kureha Chem Ind Co Ltd	セフアロスポリン誘導体、その製造方法及び該誘導体を含有する医薬
JPS6332235A (ja) *	1986-07-25	1988-02-10	アトラス・エア・（オ−ストラリア）・ピ−テイ−ワイ・リミテツド	区域空調方法及びその装置
US4880798A (en) *	1986-11-25	1989-11-14	Mochida Pharmaceutical Co., Ltd.	Cephalosporin derivatives
JPS63132893A (ja) *	1986-11-25	1988-06-04	Mochida Pharmaceut Co Ltd	新規セフアロスポリン誘導体、その製法およびそれらを有効成分とする抗菌剤
US5189157A (en) *	1987-06-16	1993-02-23	Hoffmann La Roche Inc.	Antibacterial cephalosporin compounds
CA2216259A1 (en) *	1996-09-25	1998-03-25	Eisai Chemical Co., Ltd.	Production process of cephem compound
CN112480024A (zh) *	2020-12-11	2021-03-12	山东金城医药化工有限公司	生产氨噻肟酸反式异构体的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1445979A (en) *	1972-10-25	1976-08-11	Glaxo Lab Ltd	Cephalosporin derivatives
GB1453049A (en) *	1973-08-21	1976-10-20	Glaxo Lab Ltd	Cephalosporing antibiotics
JPS4849789A (ja) *	1971-10-25	1973-07-13
JPS50111093A (ja) *	1974-02-20	1975-09-01
GB1536281A (en) *	1975-06-09	1978-12-20	Takeda Chemical Industries Ltd	Cephem compounds
SE440655B (sv) *	1976-01-23	1985-08-12	Roussel Uclaf	Sett att framstella nya oximderivat av 7-amino-tiazolyl-acetamido-cefalosporansyra
FR2345153A1 (fr) *	1976-03-25	1977-10-21	Roussel Uclaf	Nouvelles alcoyloximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments

1976
- 1976-04-12 GB GB14916/76A patent/GB1576625A/en not_active Expired
- 1976-10-19 JP JP51125826A patent/JPS5941995B2/ja not_active Expired
1977
- 1977-02-28 HU HU77FU362A patent/HU183009B/hu unknown
- 1977-07-08 JP JP8248977A patent/JPS5368795A/ja active Pending
- 1977-07-08 JP JP8249077A patent/JPS5368796A/ja active Granted
1979
- 1979-12-03 JP JP15697479A patent/JPS5598189A/ja active Granted
1983
- 1983-07-13 JP JP58128676A patent/JPS5962597A/ja active Granted
1990
- 1990-09-28 JP JP2261173A patent/JPH0684338B2/ja not_active Expired - Lifetime

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS549296A (en) *	1977-04-02	1979-01-24	Hoechst Ag	Cephem derivative and its preparation
JPS5716887A (en) *	1977-04-02	1982-01-28	Hoechst Ag	Cephem derivative and manufacture
JPS5585594A (en) *	1978-11-13	1980-06-27	Fujisawa Pharmaceut Co Ltd	Cephem compound and their preparation
JPS5692291A (en) *	1979-12-07	1981-07-25	Erba Carlo Spa	Nnsubstituted thiazolyl derivative of oxyimino substituted cephalosporin
JPS57154175A (en) *	1981-03-16	1982-09-22	Mitsui Toatsu Chem Inc	2-thiazoleamine derivative, its preparation, and drug composition comprising it

Also Published As

Publication number	Publication date
JPS5962597A (ja)	1984-04-10
JPH03135946A (ja)	1991-06-10
JPS52125190A (en)	1977-10-20
GB1576625A (en)	1980-10-08
JPS6141516B2 (ja)	1986-09-16
JPS5368795A (en)	1978-06-19
JPH0373553B2 (ja)	1991-11-22
JPS5941995B2 (ja)	1984-10-11
JPH0684338B2 (ja)	1994-10-26
JPS5598189A (en)	1980-07-25
JPS6137250B2 (ja)	1986-08-22
HU183009B (en)	1984-04-28

Publication	Publication Date	Title
JPS5598189A (en)	1980-07-25	Syn-isomer of 3, 7-di-substituted-3-cephem-4-carboxylic acid compound, its salt, and their preparation
JPS5353691A (en)	1978-05-16	3,7-di-substituted-3-cephem-4 carboxylic acid derivatives, their salts andtheir preparation
JPS5686188A (en)	1981-07-13	7-acylamino-3-substituted cephalosporanic acid derivative and its preparation
JPS5492987A (en)	1979-07-23	Cephalosporanic acid derivative, its salt, or their preparation, and preventives and remedies for microbisms consisting mainly of them
JPS54132592A (en)	1979-10-15	3,7-di-substituted-3-cephem-4-carboxylic acid derivative, its salt, and their preparation
JPS55105689A (en)	1980-08-13	Novel cephem and cepham compounds, their preparation and preventive and remedy for microbism
JPS5519267A (en)	1980-02-09	3,7-disubstituted-3-cephem-4-carboxylic acid, its salts, their preparation, and preventive and remedy for microbism comprising them as active constituents
JPS5798288A (en)	1982-06-18	Novel cephem compound or its salt, their preparation, and preventive and remedy for bacteriosis containing said compound as active component
JPS5547688A (en)	1980-04-04	Novel cephem compound and its preparation
JPS5334795A (en)	1978-03-31	Cephalosporin derivatives and their preparation
JPS5535096A (en)	1980-03-11	3-cephem compound, its salt, their preparation, and preventive and remedy for microbism comprising thema active constituent
JPS5533500A (en)	1980-03-08	3,7-disubstituted-3-cephem-4-carboxylic acid, its salt, their preparation, and preventive and remedy for microbism
JPS6485A (en)	1989-01-05	Novel cephalosporin derivative
JPS5246093A (en)	1977-04-12	2-alkyl-7-substituted-2, or 3-cephem-4-carboxylic compounds, their sal ts, and preparation thereof
JPS5444695A (en)	1979-04-09	3,7-disubstituted-3-cephem-4-carboxylic acid and its salt and their preparation
JPS54117493A (en)	1979-09-12	3,7-disubstituted-3-cephem-4-carboxylic acid compound, its salt, its preparation, and preventives and remedies for microbism consisting mainly of them
JPS53101393A (en)	1978-09-04	Cephalosporin derivatives and process for their preparation
JPS54117494A (en)	1979-09-12	Cephalosporin compound and its preparation
JPS5515454A (en)	1980-02-02	Novel cephalosporin derivative
JPS52122389A (en)	1977-10-14	Cephalosporin derivatives and their preparation
JPS5673088A (en)	1981-06-17	Novel cephalosporin
JPS5547690A (en)	1980-04-04	Cephem compound, its salt, their preparation, and preventives and remedies for microbism comprising them as active constituents
JPS55149295A (en)	1980-11-20	Novel cephalosporin compound and its preparation
JPS56161395A (en)	1981-12-11	7-substituted ureido-3-cephem-4-carboxylic acid derivative, its preparation and preventing agent and remedy for microbism containing the same as active constituent
JPS57163386A (en)	1982-10-07	Cephalosporin derivative and its production