JPS54130552A - 2-azetidinone derivative and its preparation - Google Patents

2-azetidinone derivative and its preparation

Info

Publication number
JPS54130552A
JPS54130552A JP2001078A JP2001078A JPS54130552A JP S54130552 A JPS54130552 A JP S54130552A JP 2001078 A JP2001078 A JP 2001078A JP 2001078 A JP2001078 A JP 2001078A JP S54130552 A JPS54130552 A JP S54130552A
Authority
JP
Japan
Prior art keywords
aralkyl
alkyl
aryl
compound
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001078A
Other languages
Japanese (ja)
Inventor
Tadashi Hirata
Akira Sato
Yoshihiro Nakamizo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP2001078A priority Critical patent/JPS54130552A/en
Priority to DE19782842466 priority patent/DE2842466A1/en
Priority to GB7838626A priority patent/GB2006195B/en
Priority to CA000312398A priority patent/CA1145347A/en
Priority to FR7827889A priority patent/FR2404632A1/en
Publication of JPS54130552A publication Critical patent/JPS54130552A/en
Priority to US06/142,542 priority patent/US4322345A/en
Pending legal-status Critical Current

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The compound of formula I (R1 is H, OH, alkoxy, aralkyloxy, amino, etc.; R2 is alkyl, aralkyl; R3 is alkyl, aryl, aralkyl, heterocyclic group, etc.; R4 is alkyl, alkenyl, aryl, aralkyl).
EXAMPLE: (4S)-t-Butyl-α-(4-benzyloxycarbonyl-2-oxoazetidin-1-yl)-α-(acetyl)aceta mide.
USE: Antibacterial agent having β-lactamase inhibiting activity, and expected to be useful as a remedy of infections diseases. Also important as an intermediate of bicyclic β-lactam antibiotic.
PROCESS: The compound I is prepared by the condensation reaction of an aspartic acid derivative II with an aldehyde III and an isonitrile IV in a proper solvent.
COPYRIGHT: (C)1979,JPO&Japio
JP2001078A 1977-09-30 1978-02-23 2-azetidinone derivative and its preparation Pending JPS54130552A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2001078A JPS54130552A (en) 1978-02-23 1978-02-23 2-azetidinone derivative and its preparation
DE19782842466 DE2842466A1 (en) 1977-09-30 1978-09-29 2-AZETIDINONE DERIVATIVES AND PROCESS FOR THEIR PRODUCTION
GB7838626A GB2006195B (en) 1977-09-30 1978-09-29 2-azetidinone derivatives
CA000312398A CA1145347A (en) 1977-09-30 1978-09-29 2-azetidinone derivatives
FR7827889A FR2404632A1 (en) 1977-09-30 1978-09-29 NEW AZETIDINONE DERIVATIVES AND THEIR MANUFACTURING PROCEDURES
US06/142,542 US4322345A (en) 1977-09-30 1980-04-21 2-Azetidinone 4-carboxy derivatives and a process for producing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2001078A JPS54130552A (en) 1978-02-23 1978-02-23 2-azetidinone derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS54130552A true JPS54130552A (en) 1979-10-09

Family

ID=12015136

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001078A Pending JPS54130552A (en) 1977-09-30 1978-02-23 2-azetidinone derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS54130552A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2572727A1 (en) * 1984-11-02 1986-05-09 Roussel Uclaf NOVEL PROCESS FOR PREPARING OPTICALLY ACTIVE 2-AZETIDINONES, INTERMEDIATE PRODUCTS THEREOF AND FINAL PRODUCTS OBTAINED BY THE PROCESS

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2572727A1 (en) * 1984-11-02 1986-05-09 Roussel Uclaf NOVEL PROCESS FOR PREPARING OPTICALLY ACTIVE 2-AZETIDINONES, INTERMEDIATE PRODUCTS THEREOF AND FINAL PRODUCTS OBTAINED BY THE PROCESS

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