JPS56156283A - 8-substituted pyrrolitidine and its quaternary ammonium salt - Google Patents

8-substituted pyrrolitidine and its quaternary ammonium salt

Info

Publication number
JPS56156283A
JPS56156283A JP6109580A JP6109580A JPS56156283A JP S56156283 A JPS56156283 A JP S56156283A JP 6109580 A JP6109580 A JP 6109580A JP 6109580 A JP6109580 A JP 6109580A JP S56156283 A JPS56156283 A JP S56156283A
Authority
JP
Japan
Prior art keywords
substituted
alkyl
pyrrolitidine
formula
quaternary ammonium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP6109580A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0338272B2 (2
Inventor
Seiji Miyano
Kunihiro Sumoto
Minoru Morita
Fumio Sato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suntory Ltd
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Priority to JP6109580A priority Critical patent/JPS56156283A/ja
Priority to EP81103448A priority patent/EP0039903B1/en
Priority to DE8181103448T priority patent/DE3174295D1/de
Publication of JPS56156283A publication Critical patent/JPS56156283A/ja
Priority to US06/574,932 priority patent/US4617401A/en
Publication of JPH0338272B2 publication Critical patent/JPH0338272B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP6109580A 1980-05-07 1980-05-07 8-substituted pyrrolitidine and its quaternary ammonium salt Granted JPS56156283A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP6109580A JPS56156283A (en) 1980-05-07 1980-05-07 8-substituted pyrrolitidine and its quaternary ammonium salt
EP81103448A EP0039903B1 (en) 1980-05-07 1981-05-06 8-substituted pyrrolizidines and quaternary ammonium salts thereof
DE8181103448T DE3174295D1 (en) 1980-05-07 1981-05-06 8-substituted pyrrolizidines and quaternary ammonium salts thereof
US06/574,932 US4617401A (en) 1980-05-07 1984-01-27 8-substituted pyrrolizidine and quaternary ammonium salts thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6109580A JPS56156283A (en) 1980-05-07 1980-05-07 8-substituted pyrrolitidine and its quaternary ammonium salt

Publications (2)

Publication Number Publication Date
JPS56156283A true JPS56156283A (en) 1981-12-02
JPH0338272B2 JPH0338272B2 (2) 1991-06-10

Family

ID=13161173

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6109580A Granted JPS56156283A (en) 1980-05-07 1980-05-07 8-substituted pyrrolitidine and its quaternary ammonium salt

Country Status (4)

Country Link
US (1) US4617401A (2)
EP (1) EP0039903B1 (2)
JP (1) JPS56156283A (2)
DE (1) DE3174295D1 (2)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5885888A (ja) * 1981-11-18 1983-05-23 Suntory Ltd ８−アシルオキシエチルピロリチジンおよび第４級アンモニウム塩
JPS58159493A (ja) * 1982-03-16 1983-09-21 Suntory Ltd ８−置換ピロリチジン誘導体およびその用途
JPS59184178A (ja) * 1983-03-31 1984-10-19 Suntory Ltd ピロリチジン誘導体
EP0213713A2 (en) 1985-07-23 1987-03-11 Sanwa Kagaku Kenkyusho Co., Ltd. 2-Oxopyrrolidine pharmaceutical compounds, salts thereof, and the preparation thereof
US5530138A (en) * 1993-10-06 1996-06-25 Sanwa Kagaku Kenkyusho Co., Ltd. Compounds and use thereof

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4581462A (en) * 1983-08-25 1986-04-08 The Upjohn Company Pyrrolizidine-3-ones
JPS60184079A (ja) * 1984-02-29 1985-09-19 Suntory Ltd ピロリチジン誘導体
JPS6122084A (ja) * 1984-07-06 1986-01-30 Suntory Ltd ピロリチジン化合物、その製造法およびその用途
JPS6256489A (ja) * 1985-09-04 1987-03-12 Sanwa Kagaku Kenkyusho:Kk 新規なピロリチジン化合物及びその塩、これらの製法並びにこれらを有効成分とする消化性潰瘍治療剤
ATE133415T1 (de) * 1987-04-15 1996-02-15 Beecham Group Plc Am brückenkopf substituierte azabicyclenderivate
JP2692760B2 (ja) * 1988-06-07 1997-12-17 株式会社三和化学研究所 ピロリジン誘導体及び製法
JP2714396B2 (ja) * 1988-06-07 1998-02-16 株式会社三和化学研究所 ピロリジン誘導体の製法
WO1992015590A1 (en) * 1991-03-07 1992-09-17 G.D. Searle & Co. New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents
US5516782A (en) * 1991-03-07 1996-05-14 G. D. Searle & Co. New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents
WO1993005040A1 (en) * 1991-09-12 1993-03-18 Smithkline Beecham Plc Azabicyclic compounds as 5-ht4 receptor antagonists
JPH0820586A (ja) * 1994-07-05 1996-01-23 Sanwa Kagaku Kenkyusho Co Ltd １−アザビシクロ［３．３．０］オクタン誘導体、その塩及び製法並びに用途
JPH0841065A (ja) * 1994-07-29 1996-02-13 Sanwa Kagaku Kenkyusho Co Ltd １−アザビシクロ［３．３．０］オクタン誘導体の製法
US5733912A (en) * 1997-02-19 1998-03-31 Abbott Laboratories 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
AU2003213337A1 (en) * 2002-03-14 2003-09-22 Daiichi Suntory Pharma Co., Ltd. Tablet containing pilsicainide hydrochloride (wet)
KR20040091135A (ko) * 2002-03-14 2004-10-27 다이이찌 산토리 파마 가부시키가이샤 염산 필지카이니드 함유 정제(건식)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3544590A (en) * 1967-04-28 1970-12-01 Exxon Research Engineering Co Cyclic amines and the process for their formation

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5885888A (ja) * 1981-11-18 1983-05-23 Suntory Ltd ８−アシルオキシエチルピロリチジンおよび第４級アンモニウム塩
JPS58159493A (ja) * 1982-03-16 1983-09-21 Suntory Ltd ８−置換ピロリチジン誘導体およびその用途
JPS59184178A (ja) * 1983-03-31 1984-10-19 Suntory Ltd ピロリチジン誘導体
EP0213713A2 (en) 1985-07-23 1987-03-11 Sanwa Kagaku Kenkyusho Co., Ltd. 2-Oxopyrrolidine pharmaceutical compounds, salts thereof, and the preparation thereof
US5530138A (en) * 1993-10-06 1996-06-25 Sanwa Kagaku Kenkyusho Co., Ltd. Compounds and use thereof

Also Published As

Publication number Publication date
EP0039903A3 (en) 1982-06-16
JPH0338272B2 (2) 1991-06-10
EP0039903A2 (en) 1981-11-18
US4617401A (en) 1986-10-14
EP0039903B1 (en) 1986-04-09
DE3174295D1 (en) 1986-05-15

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