JPS5629519A - Preparation of active antitumor agent - Google Patents

Preparation of active antitumor agent

Info

Publication number
JPS5629519A
JPS5629519A JP10468379A JP10468379A JPS5629519A JP S5629519 A JPS5629519 A JP S5629519A JP 10468379 A JP10468379 A JP 10468379A JP 10468379 A JP10468379 A JP 10468379A JP S5629519 A JPS5629519 A JP S5629519A
Authority
JP
Japan
Prior art keywords
solution
water
organic solvent
added
rice bran
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10468379A
Other languages
Japanese (ja)
Other versions
JPS591690B2 (en
Inventor
Kimitoshi Kawai
Kunio Sugawara
Takeshi Morinaga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daicel Corp
Sapporo Breweries Ltd
Original Assignee
Daicel Corp
Sapporo Breweries Ltd
Daicel Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daicel Corp, Sapporo Breweries Ltd, Daicel Chemical Industries Ltd filed Critical Daicel Corp
Priority to JP54104683A priority Critical patent/JPS591690B2/en
Priority to KR1019800003223A priority patent/KR840001511B1/en
Priority to DE8080104847T priority patent/DE3064701D1/en
Priority to EP80104847A priority patent/EP0027514B1/en
Publication of JPS5629519A publication Critical patent/JPS5629519A/en
Priority to US06/377,490 priority patent/US4457863A/en
Publication of JPS591690B2 publication Critical patent/JPS591690B2/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: To obtain the titled agent having preventing action on a solid cancer without troublesome purification through dialysis, by treating an extracted solution of rice bran through an alkaline aqueous solution with a water-soluble organic solvent so that harmful impurities are precipitated and removed, followed by neutralization.
CONSTITUTION: For example, rice bran is boiled in 5W20wt. times water to remove hot water-soluble ingredients, e.g., polysaccharides. A basic aqueous solution, e.g., 5wt% aqueous solution of caustic soda is added to the rice bran, which is preferably extracted at 50°C for 10W20hr. An organic solvent miscible with water, e.g., ethanol, etc., is added to the prepared extracted solution in such a way that the solution has 40wt% ethanol concentration so that harmful impurities are precipitated and removed. An acid, e.g., hydrochloric acid, etc. is added to the solution and neutralized to form the desired agent as a precipitate. The prepared product consists of a polar organic solvent-soluble ingredient and an insoluble ingredient, and the former had extremely controlling effect against mouce ascites tumor and the latter has one against mouce solid cancer respectively.
COPYRIGHT: (C)1981,JPO&Japio
JP54104683A 1979-08-17 1979-08-17 Method for producing antitumor active substances Expired JPS591690B2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP54104683A JPS591690B2 (en) 1979-08-17 1979-08-17 Method for producing antitumor active substances
KR1019800003223A KR840001511B1 (en) 1979-08-17 1980-08-14 Process for preparing antitumor substance
DE8080104847T DE3064701D1 (en) 1979-08-17 1980-08-14 Antitumor substance and its production
EP80104847A EP0027514B1 (en) 1979-08-17 1980-08-14 Antitumor substance and its production
US06/377,490 US4457863A (en) 1979-08-17 1982-05-12 Antitumor substance

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP54104683A JPS591690B2 (en) 1979-08-17 1979-08-17 Method for producing antitumor active substances

Publications (2)

Publication Number Publication Date
JPS5629519A true JPS5629519A (en) 1981-03-24
JPS591690B2 JPS591690B2 (en) 1984-01-13

Family

ID=14387261

Family Applications (1)

Application Number Title Priority Date Filing Date
JP54104683A Expired JPS591690B2 (en) 1979-08-17 1979-08-17 Method for producing antitumor active substances

Country Status (2)

Country Link
JP (1) JPS591690B2 (en)
KR (1) KR840001511B1 (en)

Also Published As

Publication number Publication date
JPS591690B2 (en) 1984-01-13
KR830003211A (en) 1983-06-18
KR840001511B1 (en) 1984-09-29

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