JPS5791998A - Novel 5'-o-acylnucleoside derivative and its preparation - Google Patents

Novel 5'-o-acylnucleoside derivative and its preparation

Info

Publication number: JPS5791998A
Authority: JP; Japan
Prior art keywords: derivative; expressed; acyl group; formula; aminocarboxylic acid
Prior art date: 1980-11-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP56080231A

Other languages

English (en)

Inventor

Takeshi Endo

Katsumi Sakai

Kiyoaki Cho

Yoshitaka Inamoto

Haruhiko Teshigahara

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Fuji Chemical Industries Co Ltd

Original Assignee

Fuji Chemical Industries Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-11-26

Filing date

1981-05-28

Publication date

1982-06-08

1980-11-26 Priority claimed from US06/210,796 external-priority patent/US4340728A/en

1981-05-28 Application filed by Fuji Chemical Industries Co Ltd filed Critical Fuji Chemical Industries Co Ltd

1982-06-08 Publication of JPS5791998A publication Critical patent/JPS5791998A/ja

Status Pending legal-status Critical Current

Links

KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 abstract 3
125000002252 acyl group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
150000007933 aliphatic carboxylic acids Chemical class 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000003277 amino group Chemical group 0.000 abstract 2
150000003833 nucleoside derivatives Chemical class 0.000 abstract 2
-1 5'-O-[N-(2,3-Dihydroxypropoxyacetyl)-alanyl]-5-fluorouridine Chemical compound 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
230000009876 antimalignant effect Effects 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
230000001900 immune effect Effects 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
239000002777 nucleoside Substances 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

JP56080231A 1980-11-26 1981-05-28 Novel 5'-o-acylnucleoside derivative and its preparation Pending JPS5791998A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/210,796 US4340728A (en)	1979-11-28	1980-11-26	Nucleoside derivatives and process for preparing same

Publications (1)

Publication Number	Publication Date
JPS5791998A true JPS5791998A (en)	1982-06-08

Family

ID=22784293

Family Applications (5)

Application Number	Title	Priority Date	Filing Date
JP56079434A Pending JPS5791994A (en)	1980-11-26	1981-05-27	5'-o-(n-alkylcarbamoylalanyl)-5-fluorouridine and its preparation
JP56080231A Pending JPS5791998A (en)	1980-11-26	1981-05-28	Novel 5'-o-acylnucleoside derivative and its preparation
JP56080230A Granted JPS5791997A (en)	1980-11-26	1981-05-28	5'-o-acylnucleoside and its preparation
JP56080229A Granted JPS5791996A (en)	1980-11-26	1981-05-28	Novel nucleoside derivative and its preparation
JP56080228A Pending JPS5791995A (en)	1980-11-26	1981-05-28	Nucleoside-5'-o-morpholinoacyl ester and its preparation

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
JP56079434A Pending JPS5791994A (en)	1980-11-26	1981-05-27	5'-o-(n-alkylcarbamoylalanyl)-5-fluorouridine and its preparation

Family Applications After (3)

Application Number	Title	Priority Date	Filing Date
JP56080230A Granted JPS5791997A (en)	1980-11-26	1981-05-28	5'-o-acylnucleoside and its preparation
JP56080229A Granted JPS5791996A (en)	1980-11-26	1981-05-28	Novel nucleoside derivative and its preparation
JP56080228A Pending JPS5791995A (en)	1980-11-26	1981-05-28	Nucleoside-5'-o-morpholinoacyl ester and its preparation

Country Status (1)

Country	Link
JP (5)	JPS5791994A (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4892939A (en) *	1986-05-30	1990-01-09	Fuji Kagaku Kogyo Kabushiki Kaisha	Oligopeptidyl-5-fluorouridine compounds and process for preparing the same
US4946951A (en) *	1987-07-31	1990-08-07	Taiho Pharmaceutical Co., Ltd.	2'-deoxy-5-fluorouridine derivatives
US5783689A (en) *	1996-11-12	1998-07-21	University Of Notre Dame	Antibacterial and antifungal nucleosides
US5808049A (en) *	1994-05-20	1998-09-15	Director-General Of Agency Of Industrial Science And Technology	Stereospecific 5-fu esters and methods for preparing same

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5925327A (ja) *	1982-07-31	1984-02-09	Hidematsu Hirai	抗腫瘍性複合体の製造方法
JPS61134397A (ja) *	1984-12-01	1986-06-21	Fuji Kagaku Kogyo Kk	５’−０−オリゴペプチジル−５−フルオロウリジン及びその製造方法
JP2575372B2 (ja) *	1987-02-12	1997-01-22	三井東圧化学株式会社	制ガン剤
US6020322A (en)	1993-11-09	2000-02-01	Pro-Neuron, Inc.	Acyl deoxyribonucleoside derivatives and uses thereof
EP0339075B1 (en) *	1987-10-28	1993-08-18	Pro-Neuron, Inc.	Acylated uridine and cytidine and uses thereof
US5470838A (en) *	1987-10-28	1995-11-28	Pro-Neuron, Inc.	Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine
EP0355131B1 (en) *	1987-10-28	1996-09-04	Pro-Neuron, Inc.	Acyl deoxyribonucleoside derivatives and uses thereof
JP2631227B2 (ja) *	1988-07-11	1997-07-16	大鵬薬品工業株式会社	５´−ベンジル−５−フルオロウリジン誘導体及びその中間体
US7169765B1 (en)	1988-10-27	2007-01-30	Wellstat Therapeutics Corporation	Acyl deoxyribonucleoside derivatives and uses thereof
WO1991012259A1 (fr) *	1990-02-08	1991-08-22	Sankyo Company, Limited	Derive de 5-fu

1981
- 1981-05-27 JP JP56079434A patent/JPS5791994A/ja active Pending
- 1981-05-28 JP JP56080231A patent/JPS5791998A/ja active Pending
- 1981-05-28 JP JP56080230A patent/JPS5791997A/ja active Granted
- 1981-05-28 JP JP56080229A patent/JPS5791996A/ja active Granted
- 1981-05-28 JP JP56080228A patent/JPS5791995A/ja active Pending

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4892939A (en) *	1986-05-30	1990-01-09	Fuji Kagaku Kogyo Kabushiki Kaisha	Oligopeptidyl-5-fluorouridine compounds and process for preparing the same
US4946951A (en) *	1987-07-31	1990-08-07	Taiho Pharmaceutical Co., Ltd.	2'-deoxy-5-fluorouridine derivatives
US5808049A (en) *	1994-05-20	1998-09-15	Director-General Of Agency Of Industrial Science And Technology	Stereospecific 5-fu esters and methods for preparing same
US5783689A (en) *	1996-11-12	1998-07-21	University Of Notre Dame	Antibacterial and antifungal nucleosides

Also Published As

Publication number	Publication date
JPS6247196B2 (ja)	1987-10-06
JPS5791996A (en)	1982-06-08
JPS5791995A (en)	1982-06-08
JPS5791994A (en)	1982-06-08
JPS5791997A (en)	1982-06-08
JPS6247198B2 (ja)	1987-10-06

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