JPS5791997A - 5'-o-acylnucleoside and its preparation - Google Patents
5'-o-acylnucleoside and its preparationInfo
- Publication number
- JPS5791997A JPS5791997A JP56080230A JP8023081A JPS5791997A JP S5791997 A JPS5791997 A JP S5791997A JP 56080230 A JP56080230 A JP 56080230A JP 8023081 A JP8023081 A JP 8023081A JP S5791997 A JPS5791997 A JP S5791997A
- Authority
- JP
- Japan
- Prior art keywords
- expressed
- formula
- aminocarboxylic acid
- compound
- formulai
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- FHIDNBAQOFJWCA-UAKXSSHOSA-N 5-fluorouridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(F)=C1 FHIDNBAQOFJWCA-UAKXSSHOSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000009876 antimalignant effect Effects 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/210,796 US4340728A (en) | 1979-11-28 | 1980-11-26 | Nucleoside derivatives and process for preparing same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5791997A true JPS5791997A (en) | 1982-06-08 |
| JPS6247196B2 JPS6247196B2 (ja) | 1987-10-06 |
Family
ID=22784293
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56079434A Pending JPS5791994A (en) | 1980-11-26 | 1981-05-27 | 5'-o-(n-alkylcarbamoylalanyl)-5-fluorouridine and its preparation |
| JP56080231A Pending JPS5791998A (en) | 1980-11-26 | 1981-05-28 | Novel 5'-o-acylnucleoside derivative and its preparation |
| JP56080229A Granted JPS5791996A (en) | 1980-11-26 | 1981-05-28 | Novel nucleoside derivative and its preparation |
| JP56080230A Granted JPS5791997A (en) | 1980-11-26 | 1981-05-28 | 5'-o-acylnucleoside and its preparation |
| JP56080228A Pending JPS5791995A (en) | 1980-11-26 | 1981-05-28 | Nucleoside-5'-o-morpholinoacyl ester and its preparation |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56079434A Pending JPS5791994A (en) | 1980-11-26 | 1981-05-27 | 5'-o-(n-alkylcarbamoylalanyl)-5-fluorouridine and its preparation |
| JP56080231A Pending JPS5791998A (en) | 1980-11-26 | 1981-05-28 | Novel 5'-o-acylnucleoside derivative and its preparation |
| JP56080229A Granted JPS5791996A (en) | 1980-11-26 | 1981-05-28 | Novel nucleoside derivative and its preparation |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56080228A Pending JPS5791995A (en) | 1980-11-26 | 1981-05-28 | Nucleoside-5'-o-morpholinoacyl ester and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (5) | JPS5791994A (ja) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61134397A (ja) * | 1984-12-01 | 1986-06-21 | Fuji Kagaku Kogyo Kk | ５’−０−オリゴペプチジル−５−フルオロウリジン及びその製造方法 |
| US4892939A (en) * | 1986-05-30 | 1990-01-09 | Fuji Kagaku Kogyo Kabushiki Kaisha | Oligopeptidyl-5-fluorouridine compounds and process for preparing the same |
| JPH0222291A (ja) * | 1988-07-11 | 1990-01-25 | Taiho Yakuhin Kogyo Kk | ５´−ベンジル−５−フルオロウリジン誘導体及びその中間体 |
| US4946951A (en) * | 1987-07-31 | 1990-08-07 | Taiho Pharmaceutical Co., Ltd. | 2'-deoxy-5-fluorouridine derivatives |
| WO1991012259A1 (fr) * | 1990-02-08 | 1991-08-22 | Sankyo Company, Limited | Derive de 5-fu |
| US5783689A (en) * | 1996-11-12 | 1998-07-21 | University Of Notre Dame | Antibacterial and antifungal nucleosides |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5925327A (ja) * | 1982-07-31 | 1984-02-09 | Hidematsu Hirai | 抗腫瘍性複合体の製造方法 |
| JP2575372B2 (ja) * | 1987-02-12 | 1997-01-22 | 三井東圧化学株式会社 | 制ガン剤 |
| US5470838A (en) * | 1987-10-28 | 1995-11-28 | Pro-Neuron, Inc. | Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine |
| DE3856557T2 (de) * | 1987-10-28 | 2004-06-03 | Wellstat Therapeutics Corp. | Acyldeoxyribonukleosid-Derivate und Verwendungen davon |
| JP2894610B2 (ja) * | 1987-10-28 | 1999-05-24 | プロ−ニューロン，インコーポレーテッド | アシル化ウリジンおよびシチジンならびにその使用 |
| US6020322A (en) * | 1993-11-09 | 2000-02-01 | Pro-Neuron, Inc. | Acyl deoxyribonucleoside derivatives and uses thereof |
| US7169765B1 (en) | 1988-10-27 | 2007-01-30 | Wellstat Therapeutics Corporation | Acyl deoxyribonucleoside derivatives and uses thereof |
| JP2526414B2 (ja) * | 1994-05-20 | 1996-08-21 | 工業技術院長 | 制ガン剤エステル化合物及びその製造方法 |
-
1981
- 1981-05-27 JP JP56079434A patent/JPS5791994A/ja active Pending
- 1981-05-28 JP JP56080231A patent/JPS5791998A/ja active Pending
- 1981-05-28 JP JP56080229A patent/JPS5791996A/ja active Granted
- 1981-05-28 JP JP56080230A patent/JPS5791997A/ja active Granted
- 1981-05-28 JP JP56080228A patent/JPS5791995A/ja active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61134397A (ja) * | 1984-12-01 | 1986-06-21 | Fuji Kagaku Kogyo Kk | ５’−０−オリゴペプチジル−５−フルオロウリジン及びその製造方法 |
| US4892939A (en) * | 1986-05-30 | 1990-01-09 | Fuji Kagaku Kogyo Kabushiki Kaisha | Oligopeptidyl-5-fluorouridine compounds and process for preparing the same |
| US4946951A (en) * | 1987-07-31 | 1990-08-07 | Taiho Pharmaceutical Co., Ltd. | 2'-deoxy-5-fluorouridine derivatives |
| JPH0222291A (ja) * | 1988-07-11 | 1990-01-25 | Taiho Yakuhin Kogyo Kk | ５´−ベンジル−５−フルオロウリジン誘導体及びその中間体 |
| WO1991012259A1 (fr) * | 1990-02-08 | 1991-08-22 | Sankyo Company, Limited | Derive de 5-fu |
| US5783689A (en) * | 1996-11-12 | 1998-07-21 | University Of Notre Dame | Antibacterial and antifungal nucleosides |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6247198B2 (ja) | 1987-10-06 |
| JPS5791994A (en) | 1982-06-08 |
| JPS5791996A (en) | 1982-06-08 |
| JPS5791998A (en) | 1982-06-08 |
| JPS6247196B2 (ja) | 1987-10-06 |
| JPS5791995A (en) | 1982-06-08 |
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