JPS60181052A - 安定なイソソルビド硝酸エステル組成物及びその製造法 - Google Patents

安定なイソソルビド硝酸エステル組成物及びその製造法

Info

Publication number: JPS60181052A
Authority: JP; Japan
Prior art keywords: nitrate; insorbide; producing; weight; same
Prior art date: 1984-02-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP3618084A

Other languages

English (en)

Japanese (ja)

Other versions

JPH0244460B2 (fr

Inventor

Takeshi Nara

奈良　武志

Hisashi Hayashi

林　久司

Kentarou Satou

佐藤　賢太朗

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Toa Eiyo Ltd

Original Assignee

Toa Eiyo Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-02-29

Filing date

1984-02-29

Publication date

1985-09-14

1984-02-29 Application filed by Toa Eiyo Ltd filed Critical Toa Eiyo Ltd

1984-02-29 Priority to JP3618084A priority Critical patent/JPS60181052A/ja

1985-09-14 Publication of JPS60181052A publication Critical patent/JPS60181052A/ja

1990-10-04 Publication of JPH0244460B2 publication Critical patent/JPH0244460B2/ja

Status Granted legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims description 22
YWXYYJSYQOXTPL-JGWLITMVSA-N [(3r,3ar,6s,6as)-3-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] nitrate Chemical compound [O-][N+](=O)O[C@H]1CO[C@@H]2[C@H](O)CO[C@@H]21 YWXYYJSYQOXTPL-JGWLITMVSA-N 0.000 title claims description 5
238000004519 manufacturing process Methods 0.000 title claims description 3
229910002651 NO3 Inorganic materials 0.000 claims description 20
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 13
-1 nitrate ester Chemical class 0.000 claims description 11
239000002904 solvent Substances 0.000 claims description 10
229920000609 methyl cellulose Polymers 0.000 claims description 8
239000001923 methylcellulose Substances 0.000 claims description 8
235000010981 methylcellulose Nutrition 0.000 claims description 8
239000001267 polyvinylpyrrolidone Substances 0.000 claims description 8
235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 8
229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 8
229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 7
239000001863 hydroxypropyl cellulose Substances 0.000 claims description 7
235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 7
239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 7
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 7
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 7
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 7
238000002156 mixing Methods 0.000 claims description 2
239000008187 granular material Substances 0.000 description 13
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
239000000546 pharmaceutical excipient Substances 0.000 description 8
238000009472 formulation Methods 0.000 description 6
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 5
230000015572 biosynthetic process Effects 0.000 description 5
239000013078 crystal Substances 0.000 description 5
239000008101 lactose Substances 0.000 description 5
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
238000000034 method Methods 0.000 description 4
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
239000011230 binding agent Substances 0.000 description 3
229940079593 drug Drugs 0.000 description 3
239000004615 ingredient Substances 0.000 description 3
230000007794 irritation Effects 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
239000000243 solution Substances 0.000 description 3
229920002678 cellulose Polymers 0.000 description 2
239000001913 cellulose Substances 0.000 description 2
239000003814 drug Substances 0.000 description 2
229960003827 isosorbide mononitrate Drugs 0.000 description 2
YWXYYJSYQOXTPL-SLPGGIOYSA-N isosorbide mononitrate Chemical compound [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 YWXYYJSYQOXTPL-SLPGGIOYSA-N 0.000 description 2
239000011812 mixed powder Substances 0.000 description 2
229920001592 potato starch Polymers 0.000 description 2
239000000843 powder Substances 0.000 description 2
239000007921 spray Substances 0.000 description 2
239000000829 suppository Substances 0.000 description 2
239000003826 tablet Substances 0.000 description 2
206010002383 Angina Pectoris Diseases 0.000 description 1
240000005979 Hordeum vulgare Species 0.000 description 1
235000007340 Hordeum vulgare Nutrition 0.000 description 1
KLDXJTOLSGUMSJ-JGWLITMVSA-N Isosorbide Chemical compound O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 KLDXJTOLSGUMSJ-JGWLITMVSA-N 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000000654 additive Substances 0.000 description 1
235000019658 bitter taste Nutrition 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
239000003086 colorant Substances 0.000 description 1
WGLUMOCWFMKWIL-UHFFFAOYSA-N dichloromethane;methanol Chemical compound OC.ClCCl WGLUMOCWFMKWIL-UHFFFAOYSA-N 0.000 description 1
RYPWQHONZWFXBN-UHFFFAOYSA-N dichloromethyl(methylidene)-$l^{3}-chlorane Chemical compound ClC(Cl)Cl=C RYPWQHONZWFXBN-UHFFFAOYSA-N 0.000 description 1
239000007884 disintegrant Substances 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000000945 filler Substances 0.000 description 1
239000004503 fine granule Substances 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
238000005469 granulation Methods 0.000 description 1
230000003179 granulation Effects 0.000 description 1
239000007902 hard capsule Substances 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
229960002479 isosorbide Drugs 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
239000011259 mixed solution Substances 0.000 description 1
229910017604 nitric acid Inorganic materials 0.000 description 1
239000002674 ointment Substances 0.000 description 1
239000007935 oral tablet Substances 0.000 description 1
229920006316 polyvinylpyrrolidine Polymers 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000005507 spraying Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
238000003756 stirring Methods 0.000 description 1
238000003860 storage Methods 0.000 description 1
239000006190 sub-lingual tablet Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000007939 sustained release tablet Substances 0.000 description 1
230000000304 vasodilatating effect Effects 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
238000005550 wet granulation Methods 0.000 description 1

Landscapes

Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

JP3618084A 1984-02-29 1984-02-29 安定なイソソルビド硝酸エステル組成物及びその製造法 Granted JPS60181052A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP3618084A JPS60181052A (ja)	1984-02-29	1984-02-29	安定なイソソルビド硝酸エステル組成物及びその製造法

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP3618084A JPS60181052A (ja)	1984-02-29	1984-02-29	安定なイソソルビド硝酸エステル組成物及びその製造法

Publications (2)

Publication Number	Publication Date
JPS60181052A true JPS60181052A (ja)	1985-09-14
JPH0244460B2 JPH0244460B2 (fr)	1990-10-04

Family

ID=12462533

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP3618084A Granted JPS60181052A (ja)	1984-02-29	1984-02-29	安定なイソソルビド硝酸エステル組成物及びその製造法

Country Status (1)

Country	Link
JP (1)	JPS60181052A (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS62123114A (ja) *	1985-10-15	1987-06-04	ユーランド　インターナショナル　ソチエタ　ペル　アツィオニ	安定化されたイソソルビド−５−モノニトレ−ト錠剤及びその製造方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5593235A (en) *	1979-01-05	1980-07-15	Nec Corp	Integrated circuit

1984
- 1984-02-29 JP JP3618084A patent/JPS60181052A/ja active Granted

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5593235A (en) *	1979-01-05	1980-07-15	Nec Corp	Integrated circuit

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS62123114A (ja) *	1985-10-15	1987-06-04	ユーランド　インターナショナル　ソチエタ　ペル　アツィオニ	安定化されたイソソルビド−５−モノニトレ−ト錠剤及びその製造方法

Also Published As

Publication number	Publication date
JPH0244460B2 (fr)	1990-10-04

Legal Events

Date	Code	Title	Description
2004-02-29	EXPY	Cancellation because of completion of term

Publication	Publication Date	Title
US3965256A (en)	1976-06-22	Slow release pharmaceutical compositions
US4254099A (en)	1981-03-03	Pharmaceutical tablet composition
US5543099A (en)	1996-08-06	Process to manufacture micronized nifedipine granules for sustained release medicaments
US3085942A (en)	1963-04-16	Antitussive compositions and preparation
JPS58403B2 (ja)	1983-01-06	Ｌ− アスコルビンサンセイザイノセイゾウホウ
JPH0524888B2 (fr)	1993-04-09
KR920006909B1 (ko)	1992-08-22	니트렌디핀을 함유하는 고상 약제의 제조 방법
KR0177493B1 (ko)	1999-03-20	단사정계 결정구조를 갖고 감열, 감광 및 감습성이 있는 활성성분을 함유하는 정제의 제조방법
JPS5810513A (ja)	1983-01-21	新規なベンドロフルメチアジド配合物およびその調整方法
KR920006908B1 (ko)	1992-08-22	디히드로피리딘을 함유하는 고상 약제의 제조 방법
JPH10203985A (ja)	1998-08-04	抗菌活性キノロン誘導体の味覚掩蔽製剤の製造
KR0170380B1 (ko)	1999-02-18	고상 투여형용 안정화계
JPS60255737A (ja)	1985-12-17	ジヒドロピリジン調製物
JPH029007B2 (fr)	1990-02-28
RU2106145C1 (ru)	1998-03-10	Фармацевтическая композиция и способ ее получения (варианты)
JPS60181052A (ja)	1985-09-14	安定なイソソルビド硝酸エステル組成物及びその製造法
JPS58189109A (ja)	1983-11-04	医薬組成物
JPS62228017A (ja)	1987-10-06	ジヒドロピリジンを含有する固体の迅速放出性薬剤調製物の製造方法
JP2003116966A (ja)	2003-04-22	直接錠剤化用調合物および補助剤の調合方法
JPH0328404B2 (fr)	1991-04-19
JPH031288B2 (fr)	1991-01-10
JP4591726B2 (ja)	2010-12-01	メキタジン含有内服固形製剤
JPH08325142A (ja)	1996-12-10	ヨウ化イソプロパミド含有製剤
JP3713722B2 (ja)	2005-11-09	グアイフェネシン配合製剤
JPH06329556A (ja)	1994-11-29	粉体及び固形剤における配合不適防止方法

JPS60181052A - 安定なイソソルビド硝酸エステル組成物及びその製造法 - Google Patents

Info

Links

Landscapes

Priority Applications (1)

Applications Claiming Priority (1)

Publications (2)

Family

ID=12462533

Family Applications (1)

Country Status (1)

Cited By (1)

Citations (1)

Patent Citations (1)

Cited By (1)

Also Published As

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