JPS60255736A - ニフエジピン調製物 - Google Patents

ニフエジピン調製物

Info

Publication number: JPS60255736A
Authority: JP; Japan
Prior art keywords: nifedipine; weight; preparation according; water; granules
Prior art date: 1984-05-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP60106214A

Other languages

English (en)

Japanese (ja)

Inventor

ウイルリツヒ・ポザンスキイ

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer AG

Original Assignee

Bayer AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-05-23

Filing date

1985-05-20

Publication date

1985-12-17

1985-05-20 Application filed by Bayer AG filed Critical Bayer AG

1985-12-17 Publication of JPS60255736A publication Critical patent/JPS60255736A/ja

Status Pending legal-status Critical Current

Links

HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 title claims description 33
229960001597 nifedipine Drugs 0.000 title claims description 33
238000002360 preparation method Methods 0.000 title claims description 21
239000008187 granular material Substances 0.000 claims description 13
239000000945 filler Substances 0.000 claims description 10
238000000034 method Methods 0.000 claims description 9
239000001913 cellulose Substances 0.000 claims description 6
239000007787 solid Substances 0.000 claims description 6
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 5
229930195725 Mannitol Natural products 0.000 claims description 5
239000000594 mannitol Substances 0.000 claims description 5
235000010355 mannitol Nutrition 0.000 claims description 5
125000004432 carbon atom Chemical group C* 0.000 claims description 4
239000002552 dosage form Substances 0.000 claims description 4
-1 enamine compound Chemical class 0.000 claims description 4
239000004922 lacquer Substances 0.000 claims description 4
238000004519 manufacturing process Methods 0.000 claims description 4
239000002904 solvent Substances 0.000 claims description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
239000000546 pharmaceutical excipient Substances 0.000 claims description 3
229920002472 Starch Polymers 0.000 claims description 2
239000008107 starch Substances 0.000 claims description 2
235000019698 starch Nutrition 0.000 claims description 2
229920002678 cellulose Polymers 0.000 claims 1
238000005550 wet granulation Methods 0.000 claims 1
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 14
239000000203 mixture Substances 0.000 description 10
229920002261 Corn starch Polymers 0.000 description 8
239000008120 corn starch Substances 0.000 description 8
150000001875 compounds Chemical class 0.000 description 7
235000019359 magnesium stearate Nutrition 0.000 description 7
239000007864 aqueous solution Substances 0.000 description 6
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 5
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 5
239000008101 lactose Substances 0.000 description 5
235000019814 powdered cellulose Nutrition 0.000 description 5
229920003124 powdered cellulose Polymers 0.000 description 5
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
239000011248 coating agent Substances 0.000 description 4
238000000576 coating method Methods 0.000 description 4
239000003814 drug Substances 0.000 description 4
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
230000005540 biological transmission Effects 0.000 description 3
229940079593 drug Drugs 0.000 description 3
235000019333 sodium laurylsulphate Nutrition 0.000 description 3
239000000126 substance Substances 0.000 description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
239000002202 Polyethylene glycol Substances 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
239000002253 acid Substances 0.000 description 2
239000002671 adjuvant Substances 0.000 description 2
229910021529 ammonia Inorganic materials 0.000 description 2
239000002775 capsule Substances 0.000 description 2
239000000969 carrier Substances 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
230000000694 effects Effects 0.000 description 2
150000002148 esters Chemical class 0.000 description 2
238000009472 formulation Methods 0.000 description 2
238000003780 insertion Methods 0.000 description 2
230000037431 insertion Effects 0.000 description 2
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 2
239000001095 magnesium carbonate Substances 0.000 description 2
229910000021 magnesium carbonate Inorganic materials 0.000 description 2
238000002156 mixing Methods 0.000 description 2
239000002245 particle Substances 0.000 description 2
229920001223 polyethylene glycol Polymers 0.000 description 2
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
229920000053 polysorbate 80 Polymers 0.000 description 2
229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
239000001267 polyvinylpyrrolidone Substances 0.000 description 2
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
239000000047 product Substances 0.000 description 2
150000003839 salts Chemical group 0.000 description 2
239000004094 surface-active agent Substances 0.000 description 2
238000005303 weighing Methods 0.000 description 2
YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical compound C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
239000005715 Fructose Substances 0.000 description 1
229930091371 Fructose Natural products 0.000 description 1
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
230000009471 action Effects 0.000 description 1
239000002156 adsorbate Substances 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
150000003863 ammonium salts Chemical class 0.000 description 1
150000001450 anions Chemical class 0.000 description 1
238000010533 azeotropic distillation Methods 0.000 description 1
230000008901 benefit Effects 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
GUBGYTABKSRVRQ-QRZGKKJRSA-N beta-cellobiose Chemical compound OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QRZGKKJRSA-N 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
230000036772 blood pressure Effects 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
230000003197 catalytic effect Effects 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
239000008139 complexing agent Substances 0.000 description 1
238000007906 compression Methods 0.000 description 1
230000006835 compression Effects 0.000 description 1
239000013078 crystal Substances 0.000 description 1
238000000280 densification Methods 0.000 description 1
238000001035 drying Methods 0.000 description 1
235000013312 flour Nutrition 0.000 description 1
239000012530 fluid Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
239000007903 gelatin capsule Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000008103 glucose Substances 0.000 description 1
238000005469 granulation Methods 0.000 description 1
230000003179 granulation Effects 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
230000006872 improvement Effects 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
239000000049 pigment Substances 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229960003975 potassium Drugs 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000001508 potassium citrate Substances 0.000 description 1
229960002635 potassium citrate Drugs 0.000 description 1
QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
235000011082 potassium citrates Nutrition 0.000 description 1
239000000843 powder Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
230000008569 process Effects 0.000 description 1
239000011814 protection agent Substances 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
239000011241 protective layer Substances 0.000 description 1
239000000376 reactant Substances 0.000 description 1
230000009467 reduction Effects 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000007962 solid dispersion Substances 0.000 description 1
239000007909 solid dosage form Substances 0.000 description 1
239000000243 solution Substances 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000005846 sugar alcohols Chemical class 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
230000009747 swallowing Effects 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Hydrogenated Pyridines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

JP60106214A 1984-05-23 1985-05-20 ニフエジピン調製物 Pending JPS60255736A (ja)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3419129.1		1984-05-23
DE19843419129 DE3419129A1 (de)	1984-05-23	1984-05-23	Nifedipinpraeparate und verfahren zu ihrer herstellung

Publications (1)

Publication Number	Publication Date
JPS60255736A true JPS60255736A (ja)	1985-12-17

Family

ID=6236595

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP60106214A Pending JPS60255736A (ja)	1984-05-23	1985-05-20	ニフエジピン調製物

Country Status (14)

Country	Link
EP (1)	EP0164587A3 (2)
JP (1)	JPS60255736A (2)
KR (1)	KR850008280A (2)
CN (1)	CN85101689A (2)
AU (1)	AU4280885A (2)
DD (1)	DD236453A5 (2)
DE (1)	DE3419129A1 (2)
DK (1)	DK228185A (2)
ES (1)	ES8607016A1 (2)
GR (1)	GR851246B (2)
HU (1)	HUT38253A (2)
IL (1)	IL75241A0 (2)
PT (1)	PT80499B (2)
ZA (1)	ZA853875B (2)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993015724A1 (fr) *	1992-02-18	1993-08-19	Nippon Shinyaku Co., Ltd.	Comprime a solubilite acceleree
JPH09208458A (ja) *	1996-02-02	1997-08-12	Ss Pharmaceut Co Ltd	不快な味がマスキングされた製剤

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3419131A1 (de) *	1984-05-23	1985-11-28	Bayer Ag, 5090 Leverkusen	Dihydropyridinkombinationspraeparate und verfahren zu ihrer herstellung
SE457326B (sv) *	1986-02-14	1988-12-19	Lejus Medical Ab	Foerfarande foer framstaellning av en snabbt soenderfallande kaerna innehaallande bl a mikrokristallin cellulosa
DE3639073A1 (de) *	1986-11-14	1988-05-26	Klinge Co Chem Pharm Fab	Feste arzneizubereitungen und verfahren zu ihrer herstellung
US6440457B1 (en)	1993-05-27	2002-08-27	Alza Corporation	Method of administering antidepressant dosage form

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1670827C3 (de) *	1967-03-20	1974-10-24	Bayer Ag, 5090 Leverkusen	4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin
SU432703A3 (2) *	1971-08-24	1974-06-15	Фридрих Боссерт, Вульф Фатер, Курт Бауер
DE2400819C2 (de) *	1974-01-09	1982-04-22	Bayer Ag, 5090 Leverkusen	Verfahren zur Herstellung fester Zubereitungen von schwerlöslichen Arzneimittelwirkstoffen in feinster Verteilung
GB1579818A (en) *	1977-06-07	1980-11-26	Yamanouchi Pharma Co Ltd	Nifedipine-containing solid preparation composition
EP0001247A1 (en) *	1977-09-14	1979-04-04	Kanebo, Ltd.	Pharmaceutical preparation containing nifedipine and a method for producing the same.
FI72874B (fi) *	1983-04-12	1987-04-30	Orion Yhtymae Oy	Foerfarande foer framstaellning av laett absorberbar oral doseringsform av laekemedel av nifedipin.

1984
- 1984-05-23 DE DE19843419129 patent/DE3419129A1/de not_active Withdrawn
1985
- 1985-04-01 CN CN198585101689A patent/CN85101689A/zh active Pending
- 1985-05-11 EP EP85105797A patent/EP0164587A3/de not_active Withdrawn
- 1985-05-20 JP JP60106214A patent/JPS60255736A/ja active Pending
- 1985-05-20 IL IL75241A patent/IL75241A0/xx unknown
- 1985-05-21 PT PT80499A patent/PT80499B/pt unknown
- 1985-05-21 DD DD85276558A patent/DD236453A5/de unknown
- 1985-05-21 ES ES543350A patent/ES8607016A1/es not_active Expired
- 1985-05-21 GR GR851246A patent/GR851246B/el unknown
- 1985-05-22 ZA ZA853875A patent/ZA853875B/xx unknown
- 1985-05-22 KR KR1019850003502A patent/KR850008280A/ko not_active Abandoned
- 1985-05-22 DK DK228185A patent/DK228185A/da not_active Application Discontinuation
- 1985-05-23 AU AU42808/85A patent/AU4280885A/en not_active Abandoned
- 1985-05-23 HU HU851959A patent/HUT38253A/hu unknown

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993015724A1 (fr) *	1992-02-18	1993-08-19	Nippon Shinyaku Co., Ltd.	Comprime a solubilite acceleree
JPH09208458A (ja) *	1996-02-02	1997-08-12	Ss Pharmaceut Co Ltd	不快な味がマスキングされた製剤

Also Published As

Publication number	Publication date
ZA853875B (en)	1986-01-29
DK228185D0 (da)	1985-05-22
PT80499B (en)	1987-04-21
DD236453A5 (de)	1986-06-11
DK228185A (da)	1985-11-24
HUT38253A (en)	1986-05-28
PT80499A (en)	1985-06-01
CN85101689A (zh)	1987-01-24
KR850008280A (ko)	1985-12-16
EP0164587A2 (de)	1985-12-18
ES8607016A1 (es)	1986-06-01
EP0164587A3 (de)	1986-03-19
AU4280885A (en)	1985-11-28
IL75241A0 (en)	1985-09-29
ES543350A0 (es)	1986-06-01
DE3419129A1 (de)	1985-11-28
GR851246B (2)	1985-11-25

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JP4129995B2 (ja)	2008-08-06	水性媒体に迅速に懸濁する医薬組成物
EP1622586B1 (en)	2009-08-05	Process for preparing tannate tablet capsule or other solid dosage forms
PL155652B1 (en)	1991-12-31	Method for manufacturing ion exchange resins containing derivatives of quinolon carboxylic acid
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JPS60255737A (ja)	1985-12-17	ジヒドロピリジン調製物
JPH0774153B2 (ja)	1995-08-09	ロキソプロフェン・ナトリウム含有製剤
JPS60255725A (ja)	1985-12-17	ジヒドロピリジン配合調製物
JPH029007B2 (2)	1990-02-28
JPS59148789A (ja)	1984-08-25	高度に結晶性のナトリウムセフオペラゾンの製法
US4532253A (en)	1985-07-30	Oxaprozin calcium salt pharmaceutical compositions
JPH0328404B2 (2)	1991-04-19
US2721827A (en)	1955-10-25	Composition containing polyamine resin having adsorbed thereon an anion of para-aminosalicylic acid
JPS60255724A (ja)	1985-12-17	ニフエジピン配合調製物
CN85101689A (zh)	1987-01-24	硝苯吡啶制剂及其制备方法
JPH0737383B2 (ja)	1995-04-26	胃酸分泌抑制剤含有固型製剤
JPS61200942A (ja)	1986-09-05	ビタミンＫ↓２−ジメチル−β−シクロデキストリン包接化合物
JPH05139974A (ja)	1993-06-08	ジヒドロピリジンａ物質含有易溶性固体分散体の製造法
JPH05139973A (ja)	1993-06-08	ニフエジピン含有固形製剤の製造方法
WO1999020277A1 (en)	1999-04-29	Rapidly soluble drug composition
JPH0549649B2 (2)	1993-07-26
JPS589082B2 (ja)	1983-02-18	小粒剤の製造法
JPS6216416A (ja)	1987-01-24	ニフエジピン含有製剤
JPH0528689B2 (2)	1993-04-27

JPS60255736A - ニフエジピン調製物 - Google Patents

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