JPS604719B2 - β‐ラクタマーゼ阻害活性を有する抗生物質ＰＳ―５の製造方法 - Google Patents

β‐ラクタマーゼ阻害活性を有する抗生物質ＰＳ―５の製造方法

Info

Publication number
JPS604719B2
JPS604719B2 JP52035375A JP3537577A JPS604719B2 JP S604719 B2 JPS604719 B2 JP S604719B2 JP 52035375 A JP52035375 A JP 52035375A JP 3537577 A JP3537577 A JP 3537577A JP S604719 B2 JPS604719 B2 JP S604719B2
Authority
JP
Japan
Prior art keywords
antibiotic
solution
culture
lactamase
trityl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP52035375A
Other languages
English (en)
Japanese (ja)
Other versions
JPS53121702A (en
Inventor
和彦 岡村
尚司 平田
康 奥村
泰男 深川
康隆 島内
知之 石倉
景明 河野
ジヨセフ・リ−ン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Panlabs Inc Japan
Original Assignee
Panlabs Inc Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Panlabs Inc Japan filed Critical Panlabs Inc Japan
Priority to JP52035375A priority Critical patent/JPS604719B2/ja
Priority to GR55463A priority patent/GR62185B/el
Priority to ZA00780915A priority patent/ZA78915B/xx
Priority to IL54118A priority patent/IL54118A/xx
Priority to FI780671A priority patent/FI59813C/fi
Priority to US05/882,730 priority patent/US4318916A/en
Priority to GB9338/78A priority patent/GB1598062A/en
Priority to NL7802976A priority patent/NL7802976A/xx
Priority to AR271592A priority patent/AR219738A1/es
Priority to NO781076A priority patent/NO781076L/no
Priority to AU34592/78A priority patent/AU518781B2/en
Priority to IT21748/78A priority patent/IT1113066B/it
Priority to IE638/78A priority patent/IE46369B1/en
Priority to PT67848A priority patent/PT67848B/pt
Priority to CH340678A priority patent/CH643262A5/de
Priority to NZ186830A priority patent/NZ186830A/xx
Priority to CA300,097A priority patent/CA1123767A/fr
Priority to AT224578A priority patent/AT362059B/de
Priority to SE7803623A priority patent/SE7803623L/xx
Priority to BE186475A priority patent/BE865578A/fr
Priority to ES468418A priority patent/ES468418A1/es
Priority to DE19782813922 priority patent/DE2813922A1/de
Priority to SU782596895A priority patent/SU738517A3/ru
Priority to LU79351A priority patent/LU79351A1/fr
Priority to FR7809644A priority patent/FR2408608B1/fr
Priority to DK143678A priority patent/DK144098C/da
Publication of JPS53121702A publication Critical patent/JPS53121702A/ja
Priority to AT18980A priority patent/AT362506B/de
Priority to FI801352A priority patent/FI801352A7/fi
Publication of JPS604719B2 publication Critical patent/JPS604719B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
JP52035375A 1977-03-31 1977-03-31 β‐ラクタマーゼ阻害活性を有する抗生物質ＰＳ―５の製造方法 Expired JPS604719B2 (ja)

Priority Applications (28)

Application Number Priority Date Filing Date Title
JP52035375A JPS604719B2 (ja) 1977-03-31 1977-03-31 β‐ラクタマーゼ阻害活性を有する抗生物質ＰＳ―５の製造方法
GR55463A GR62185B (en) 1977-03-31 1978-02-15 Preparation process of an antibiotic ps-5 and its derivatives with inhibitory activity of b-lactamase
ZA00780915A ZA78915B (en) 1977-03-31 1978-02-16 Antibiotic ps-5 and derivatives having betalactamase inhibitory activity and production thereof
IL54118A IL54118A (en) 1977-03-31 1978-02-23 Antibiotic ps-5 and derivatives having -lactamase inhibitory activity,production tehreof and antibiotic compositions containing them
FI780671A FI59813C (fi) 1977-03-31 1978-02-28 Foerfarande foer framstaellning av antibiotikumet ps-5 och salter daerav med en beta-laktamas inhiberande aktivitet
US05/882,730 US4318916A (en) 1977-03-31 1978-03-02 Antibiotic PS-5 and derivatives having β-lactamase inhibitory activity and production thereof
GB9338/78A GB1598062A (en) 1977-03-31 1978-03-09 Antibiotic and its antibacterial derivatives
NL7802976A NL7802976A (nl) 1977-03-31 1978-03-20 Antibioticum ps-5 en derivaten daarvan met (beta)-lactamase-remwerking en werkwijze ter be- reiding daarvan.
AR271592A AR219738A1 (es) 1977-03-31 1978-03-29 Procedimiento para la obtencion de acido 3-(2-acetilamino etiltio)-6-etil-7-oxo-1-azabiciclo (3. 2. 0.) hept-2- en-2-carboxilico y derivados que tienen actividad antibiotica e inhibitoria de beta-lactamasa
NO781076A NO781076L (no) 1977-03-31 1978-03-29 Antibiotikum ps-5 og derivater av dette med beta-laktamasehemmende aktivitet samt fremgangsmaate for dets fremstilling
NZ186830A NZ186830A (en) 1977-03-31 1978-03-30 Antibiotic ps-5 and derivatives(2-carboxy-6-ethyl-3-substituted-1-azabicyclo (3,2,0) hept-2-en-7-ones) and pharmaceutical compostions
IT21748/78A IT1113066B (it) 1977-03-31 1978-03-30 Antibiotico ps-5 e suoi derivati aventi attivita' inibitoria della beta-lattamasi e loro produzione
IE638/78A IE46369B1 (en) 1977-03-31 1978-03-30 Novel antiobitoic and its antibacterial derivatives
PT67848A PT67848B (en) 1977-03-31 1978-03-30 Process for preparing a novel antibiotic and its derivatives having beta-lactamase inihbitory activity
CH340678A CH643262A5 (de) 1977-03-31 1978-03-30 Antibioticum mit betalactamasehemmender wirksamkeit sowie verfahren zu ihrer herstellung.
AU34592/78A AU518781B2 (en) 1977-03-31 1978-03-30 7-OXO-l-AZABICYCLO 3. 2. 0 HEPT-2-ENE-2-CARBOXYLIC ACID DERIVATIVES
CA300,097A CA1123767A (fr) 1977-03-31 1978-03-30 Ps-5 antibiotique et derives inhibiteurs de la beta-lactamase et production dudit antibiotique
AT224578A AT362059B (de) 1977-03-31 1978-03-30 Verfahren zur herstellung eines neuen antibiotikums und seiner derivate
SE7803623A SE7803623L (sv) 1977-03-31 1978-03-30 Antibiotikum ps-5 och derivat derav samt forfarande for framstellning derav
DE19782813922 DE2813922A1 (de) 1977-03-31 1978-03-31 Antibiotikum ps-5-verbindungen, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung von bakteriellen infektionen
ES468418A ES468418A1 (es) 1977-03-31 1978-03-31 Procedimiento para preparar un nuevo antibiotico con activi-dad inhibidora de beta-lactamasa
BE186475A BE865578A (fr) 1977-03-31 1978-03-31 Antibiotique rs-5 et ses derives, ainsi que leur production
SU782596895A SU738517A3 (ru) 1977-03-31 1978-03-31 Способ получени антибиотика
LU79351A LU79351A1 (fr) 1977-03-31 1978-03-31 Procede de preparation d'un nouvel antibiotique et de ses derives
FR7809644A FR2408608B1 (fr) 1977-03-31 1978-03-31 Nouvel antibiotique denomme ps-5 et ses derives doues d'activite inhibitrice de la b-lactamase et leur procede de preparation
DK143678A DK144098C (da) 1977-03-31 1978-03-31 Fremgangsmaade til fremstilling af antibiotikum ps-5 eller salte eller estere deraf
AT18980A AT362506B (de) 1977-03-31 1980-01-15 Verfahren zur herstellung von neuen ester- derivaten eines antibiotikums
FI801352A FI801352A7 (fi) 1977-03-31 1980-04-28 Foerfarande foer framstaellning av estrar av antibioten ps-5

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP52035375A JPS604719B2 (ja) 1977-03-31 1977-03-31 β‐ラクタマーゼ阻害活性を有する抗生物質ＰＳ―５の製造方法

Publications (2)

Publication Number Publication Date
JPS53121702A JPS53121702A (en) 1978-10-24
JPS604719B2 true JPS604719B2 (ja) 1985-02-06

Family

ID=12440142

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52035375A Expired JPS604719B2 (ja) 1977-03-31 1977-03-31 β‐ラクタマーゼ阻害活性を有する抗生物質ＰＳ―５の製造方法

Country Status (5)

Country Link
JP (1) JPS604719B2 (fr)
BE (1) BE865578A (fr)
ES (1) ES468418A1 (fr)
SU (1) SU738517A3 (fr)
ZA (1) ZA78915B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH16708A (en) 1978-07-24 1984-01-20 Merck & Co Inc Z-2-acylamino-3-monosubstituted propenoates

Also Published As

Publication number Publication date
SU738517A3 (ru) 1980-05-30
JPS53121702A (en) 1978-10-24
ZA78915B (en) 1979-02-28
ES468418A1 (es) 1979-10-01
BE865578A (fr) 1978-10-02

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