JPS6291190A - 発酵法によるｌ−アミノ酸の製造法 - Google Patents

発酵法によるｌ−アミノ酸の製造法

Info

Publication number: JPS6291190A
Authority: JP; Japan
Prior art keywords: oxygen; medium; culture; fermentation; aminoacid
Prior art date: 1985-10-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP23174085A

Other languages

English (en)

Japanese (ja)

Other versions

JPH0548117B2 (de

Inventor

Eiji Nakazawa

英次中沢

Hiroshi Sonoda

薗田　洋

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ajinomoto Co Inc

Original Assignee

Ajinomoto Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-10-17

Filing date

1985-10-17

Publication date

1987-04-25

1985-10-17 Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc

1985-10-17 Priority to JP23174085A priority Critical patent/JPS6291190A/ja

1987-04-25 Publication of JPS6291190A publication Critical patent/JPS6291190A/ja

1993-07-20 Publication of JPH0548117B2 publication Critical patent/JPH0548117B2/ja

Status Granted legal-status Critical Current

Links

238000000855 fermentation Methods 0.000 title claims abstract description 20
230000004151 fermentation Effects 0.000 title claims abstract description 20
238000004519 manufacturing process Methods 0.000 title claims abstract description 17
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 45
229910052760 oxygen Inorganic materials 0.000 claims abstract description 45
239000001301 oxygen Substances 0.000 claims abstract description 45
244000005700 microbiome Species 0.000 claims abstract description 7
150000008575 L-amino acids Chemical class 0.000 claims description 18
238000000034 method Methods 0.000 claims description 12
238000012258 culturing Methods 0.000 claims description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract description 34
239000002609 medium Substances 0.000 abstract description 20
238000011218 seed culture Methods 0.000 abstract description 18
239000004310 lactic acid Substances 0.000 abstract description 17
235000014655 lactic acid Nutrition 0.000 abstract description 17
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract description 10
229940024606 amino acid Drugs 0.000 abstract description 10
239000001963 growth medium Substances 0.000 abstract description 10
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract description 8
ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 abstract description 7
229930182816 L-glutamine Natural products 0.000 abstract description 6
229960002989 glutamic acid Drugs 0.000 abstract description 6
239000004473 Threonine Substances 0.000 abstract description 5
238000009825 accumulation Methods 0.000 abstract description 5
229960002898 threonine Drugs 0.000 abstract description 5
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract description 4
WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 abstract description 4
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract description 2
229930064664 L-arginine Natural products 0.000 abstract description 2
235000014852 L-arginine Nutrition 0.000 abstract description 2
229960005190 phenylalanine Drugs 0.000 abstract description 2
210000005056 cell body Anatomy 0.000 abstract 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 21
239000008103 glucose Substances 0.000 description 21
241000894006 Bacteria Species 0.000 description 17
230000001580 bacterial effect Effects 0.000 description 13
-1 and L-fulginine Chemical compound 0.000 description 9
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 8
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 8
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 8
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 8
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 8
239000007789 gas Substances 0.000 description 8
RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 description 7
235000001014 amino acid Nutrition 0.000 description 7
150000001413 amino acids Chemical class 0.000 description 7
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
241000186226 Corynebacterium glutamicum Species 0.000 description 6
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 6
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 6
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 5
239000002253 acid Substances 0.000 description 5
YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
239000004395 L-leucine Substances 0.000 description 4
235000019454 L-leucine Nutrition 0.000 description 4
229960002173 citrulline Drugs 0.000 description 4
229960002885 histidine Drugs 0.000 description 4
229960003136 leucine Drugs 0.000 description 4
OPMNROCQHKJDAQ-FKSUSPILSA-N loline Chemical compound C1C[C@@H]2O[C@H]3[C@H](NC)[C@@H]2N1C3 OPMNROCQHKJDAQ-FKSUSPILSA-N 0.000 description 4
229910052943 magnesium sulfate Inorganic materials 0.000 description 4
235000019341 magnesium sulphate Nutrition 0.000 description 4
150000007524 organic acids Chemical class 0.000 description 4
235000005985 organic acids Nutrition 0.000 description 4
229960001153 serine Drugs 0.000 description 4
229960003495 thiamine Drugs 0.000 description 4
229960004441 tyrosine Drugs 0.000 description 4
241000186216 Corynebacterium Species 0.000 description 3
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 3
108010073771 Soybean Proteins Proteins 0.000 description 3
JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 3
238000005273 aeration Methods 0.000 description 3
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 3
229910052921 ammonium sulfate Inorganic materials 0.000 description 3
235000011130 ammonium sulphate Nutrition 0.000 description 3
239000004202 carbamide Substances 0.000 description 3
229910052757 nitrogen Inorganic materials 0.000 description 3
235000019710 soybean protein Nutrition 0.000 description 3
235000019157 thiamine Nutrition 0.000 description 3
239000011721 thiamine Substances 0.000 description 3
KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 3
DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 3
229960004295 valine Drugs 0.000 description 3
238000009423 ventilation Methods 0.000 description 3
QDGAVODICPCDMU-UHFFFAOYSA-N 2-amino-3-[3-[bis(2-chloroethyl)amino]phenyl]propanoic acid Chemical compound OC(=O)C(N)CC1=CC=CC(N(CCCl)CCCl)=C1 QDGAVODICPCDMU-UHFFFAOYSA-N 0.000 description 2
239000004475 Arginine Substances 0.000 description 2
AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 2
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 2
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 2
241000319304 [Brevibacterium] flavum Species 0.000 description 2
229910000147 aluminium phosphate Inorganic materials 0.000 description 2
229960003121 arginine Drugs 0.000 description 2
229960002685 biotin Drugs 0.000 description 2
235000020958 biotin Nutrition 0.000 description 2
239000011616 biotin Substances 0.000 description 2
238000007796 conventional method Methods 0.000 description 2
230000007423 decrease Effects 0.000 description 2
OPMNROCQHKJDAQ-UHFFFAOYSA-N festucine Natural products C1CC2OC3C(NC)C2N1C3 OPMNROCQHKJDAQ-UHFFFAOYSA-N 0.000 description 2
BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 2
229910000359 iron(II) sulfate Inorganic materials 0.000 description 2
239000007788 liquid Substances 0.000 description 2
239000013028 medium composition Substances 0.000 description 2
239000000203 mixture Substances 0.000 description 2
235000015097 nutrients Nutrition 0.000 description 2
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
YBJHBAHKTGYVGT-ZXFLCMHBSA-N 5-[(3ar,4r,6as)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoic acid Chemical compound N1C(=O)N[C@H]2[C@@H](CCCCC(=O)O)SC[C@H]21 YBJHBAHKTGYVGT-ZXFLCMHBSA-N 0.000 description 1
241000186146 Brevibacterium Species 0.000 description 1
235000002568 Capsicum frutescens Nutrition 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
235000019766 L-Lysine Nutrition 0.000 description 1
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
229930182844 L-isoleucine Natural products 0.000 description 1
229930182821 L-proline Natural products 0.000 description 1
239000004472 Lysine Substances 0.000 description 1
101100444073 Mus musculus Dtna gene Proteins 0.000 description 1
RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 description 1
AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
235000009697 arginine Nutrition 0.000 description 1
241000573739 bacterium V Species 0.000 description 1
KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
235000013477 citrulline Nutrition 0.000 description 1
ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 1
235000021403 cultural food Nutrition 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000004220 glutamic acid Substances 0.000 description 1
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
239000010931 gold Substances 0.000 description 1
229910052737 gold Inorganic materials 0.000 description 1
229960000310 isoleucine Drugs 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
239000012528 membrane Substances 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
229960003104 ornithine Drugs 0.000 description 1
229910052698 phosphorus Inorganic materials 0.000 description 1
239000013587 production medium Substances 0.000 description 1
229960002429 proline Drugs 0.000 description 1
IFGCUJZIWBUILZ-UHFFFAOYSA-N sodium 2-[[2-[[hydroxy-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical compound [Na+].C=1NC2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C(CC(C)C)NP(O)(=O)OC1OC(C)C(O)C(O)C1O IFGCUJZIWBUILZ-UHFFFAOYSA-N 0.000 description 1
238000003756 stirring Methods 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
239000013589 supplement Substances 0.000 description 1
229960000344 thiamine hydrochloride Drugs 0.000 description 1
235000019190 thiamine hydrochloride Nutrition 0.000 description 1
239000011747 thiamine hydrochloride Substances 0.000 description 1

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Preparation Of Compounds By Using Micro-Organisms (AREA)

JP23174085A 1985-10-17 1985-10-17 発酵法によるｌ−アミノ酸の製造法 Granted JPS6291190A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP23174085A JPS6291190A (ja)	1985-10-17	1985-10-17	発酵法によるｌ−アミノ酸の製造法

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP23174085A JPS6291190A (ja)	1985-10-17	1985-10-17	発酵法によるｌ−アミノ酸の製造法

Publications (2)

Publication Number	Publication Date
JPS6291190A true JPS6291190A (ja)	1987-04-25
JPH0548117B2 JPH0548117B2 (de)	1993-07-20

Family

ID=16928294

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP23174085A Granted JPS6291190A (ja)	1985-10-17	1985-10-17	発酵法によるｌ−アミノ酸の製造法

Country Status (1)

Country	Link
JP (1)	JPS6291190A (de)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2009112205A (ja) *	2007-11-02	2009-05-28	Snow Brand Milk Prod Co Ltd	Ｌ−オルニチン含有物の製造方法
JP6087476B1 (ja) *	2015-07-30	2017-03-01	三菱化学エンジニアリング株式会社	酸素富化マイクロナノバブルを用いた生物反応装置及びこの生物反応装置を用いた生物反応方法
JP2018117578A (ja) *	2017-01-25	2018-08-02	三菱ケミカルエンジニアリング株式会社	マイクロナノバブルを用いた生物反応装置およびこの生物反応装置を用いた生物反応方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5134914A (de) *	1974-07-24	1976-03-25	Jenaer Glaswerk Schott & Gen
JPS57798A (en) *	1980-05-30	1982-01-05	Mitsubishi Electric Corp	Optical measuring device
JPS60133892A (ja) *	1983-10-31	1985-07-17	ジエネツクス・コ−ポレイシヨン	Ｌ−フエニルアラニンの製造方法

1985
- 1985-10-17 JP JP23174085A patent/JPS6291190A/ja active Granted

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5134914A (de) *	1974-07-24	1976-03-25	Jenaer Glaswerk Schott & Gen
JPS57798A (en) *	1980-05-30	1982-01-05	Mitsubishi Electric Corp	Optical measuring device
JPS60133892A (ja) *	1983-10-31	1985-07-17	ジエネツクス・コ−ポレイシヨン	Ｌ−フエニルアラニンの製造方法

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2009112205A (ja) *	2007-11-02	2009-05-28	Snow Brand Milk Prod Co Ltd	Ｌ−オルニチン含有物の製造方法
JP6087476B1 (ja) *	2015-07-30	2017-03-01	三菱化学エンジニアリング株式会社	酸素富化マイクロナノバブルを用いた生物反応装置及びこの生物反応装置を用いた生物反応方法
JP2018117578A (ja) *	2017-01-25	2018-08-02	三菱ケミカルエンジニアリング株式会社	マイクロナノバブルを用いた生物反応装置およびこの生物反応装置を用いた生物反応方法

Also Published As

Publication number	Publication date
JPH0548117B2 (de)	1993-07-20

Legal Events

Date	Code	Title	Description
2005-07-20	LAPS	Cancellation because of no payment of annual fees

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JPS6291190A - 発酵法によるｌ−アミノ酸の製造法 - Google Patents

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Links

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Priority Applications (1)

Applications Claiming Priority (1)

Publications (2)

Family

ID=16928294

Family Applications (1)

Country Status (1)

Cited By (3)

Citations (3)

Patent Citations (3)

Cited By (3)

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