JPS6353201B2 - - Google Patents
Info
- Publication number
- JPS6353201B2 JPS6353201B2 JP59258138A JP25813884A JPS6353201B2 JP S6353201 B2 JPS6353201 B2 JP S6353201B2 JP 59258138 A JP59258138 A JP 59258138A JP 25813884 A JP25813884 A JP 25813884A JP S6353201 B2 JPS6353201 B2 JP S6353201B2
- Authority
- JP
- Japan
- Prior art keywords
- polymer compound
- conjugate
- physiologically active
- dfo
- dialdehyde
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 claims description 66
- 229920000642 polymer Polymers 0.000 claims description 46
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 22
- UBQYURCVBFRUQT-UHFFFAOYSA-N N-benzoyl-Ferrioxamine B Chemical compound CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN UBQYURCVBFRUQT-UHFFFAOYSA-N 0.000 claims description 21
- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 claims description 14
- 229960000958 deferoxamine Drugs 0.000 claims description 13
- 229920000856 Amylose Polymers 0.000 claims description 9
- 229920002307 Dextran Polymers 0.000 claims description 4
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 3
- 150000004985 diamines Chemical class 0.000 claims description 2
- 239000013543 active substance Substances 0.000 description 26
- 239000000243 solution Substances 0.000 description 25
- 239000003446 ligand Substances 0.000 description 24
- 125000003277 amino group Chemical group 0.000 description 22
- 230000002285 radioactive effect Effects 0.000 description 18
- 230000001588 bifunctional effect Effects 0.000 description 15
- 150000004676 glycans Chemical class 0.000 description 15
- 229910052751 metal Inorganic materials 0.000 description 15
- 229920001282 polysaccharide Polymers 0.000 description 15
- 239000005017 polysaccharide Substances 0.000 description 15
- 239000002184 metal Substances 0.000 description 12
- 239000000126 substance Substances 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 102000008100 Human Serum Albumin Human genes 0.000 description 10
- 108091006905 Human Serum Albumin Proteins 0.000 description 10
- 238000009206 nuclear medicine Methods 0.000 description 10
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 9
- 238000006243 chemical reaction Methods 0.000 description 8
- 238000003745 diagnosis Methods 0.000 description 8
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 229940056501 technetium 99m Drugs 0.000 description 7
- GYHNNYVSQQEPJS-OIOBTWANSA-N Gallium-67 Chemical compound [67Ga] GYHNNYVSQQEPJS-OIOBTWANSA-N 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 6
- 239000003638 chemical reducing agent Substances 0.000 description 6
- 229940006110 gallium-67 Drugs 0.000 description 6
- 239000012217 radiopharmaceutical Substances 0.000 description 6
- 229940121896 radiopharmaceutical Drugs 0.000 description 6
- 230000002799 radiopharmaceutical effect Effects 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- PNDPGZBMCMUPRI-HVTJNCQCSA-N 10043-66-0 Chemical compound [131I][131I] PNDPGZBMCMUPRI-HVTJNCQCSA-N 0.000 description 5
- 150000001720 carbohydrates Chemical group 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 238000006722 reduction reaction Methods 0.000 description 5
- -1 san Chemical class 0.000 description 5
- 229920002085 Dialdehyde starch Polymers 0.000 description 4
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 4
- 238000000502 dialysis Methods 0.000 description 4
- 238000002372 labelling Methods 0.000 description 4
- 230000014759 maintenance of location Effects 0.000 description 4
- 229960003330 pentetic acid Drugs 0.000 description 4
- 239000008363 phosphate buffer Substances 0.000 description 4
- 239000012279 sodium borohydride Substances 0.000 description 4
- 229910000033 sodium borohydride Inorganic materials 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 102000008946 Fibrinogen Human genes 0.000 description 3
- 108010049003 Fibrinogen Proteins 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000012736 aqueous medium Substances 0.000 description 3
- 238000009833 condensation Methods 0.000 description 3
- 230000005494 condensation Effects 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229940012952 fibrinogen Drugs 0.000 description 3
- 238000004108 freeze drying Methods 0.000 description 3
- 238000005227 gel permeation chromatography Methods 0.000 description 3
- 238000002523 gelfiltration Methods 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 229940055742 indium-111 Drugs 0.000 description 3
- APFVFJFRJDLVQX-AHCXROLUSA-N indium-111 Chemical compound [111In] APFVFJFRJDLVQX-AHCXROLUSA-N 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 150000002739 metals Chemical class 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 239000007800 oxidant agent Substances 0.000 description 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 108010006654 Bleomycin Proteins 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 150000008065 acid anhydrides Chemical class 0.000 description 2
- 229940088623 biologically active substance Drugs 0.000 description 2
- 229960001561 bleomycin Drugs 0.000 description 2
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 2
- 150000004697 chelate complex Chemical class 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000004440 column chromatography Methods 0.000 description 2
- 238000006482 condensation reaction Methods 0.000 description 2
- 230000036425 denaturation Effects 0.000 description 2
- 238000004925 denaturation Methods 0.000 description 2
- 239000000032 diagnostic agent Substances 0.000 description 2
- 229940039227 diagnostic agent Drugs 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 description 2
- 229910052713 technetium Inorganic materials 0.000 description 2
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 2
- 150000003584 thiosemicarbazones Chemical class 0.000 description 2
- PMHQXRGRBMOZDU-UHFFFAOYSA-N 1,1-diaminoethanethiol Chemical compound CC(N)(N)S PMHQXRGRBMOZDU-UHFFFAOYSA-N 0.000 description 1
- CVVLIXMGSRDKLW-UHFFFAOYSA-N 2,7-diaminohept-1-en-1-one Chemical compound NCCCCCC(N)=C=O CVVLIXMGSRDKLW-UHFFFAOYSA-N 0.000 description 1
- GFIWSSUBVYLTRF-UHFFFAOYSA-N 2-[2-(2-hydroxyethylamino)ethylamino]ethanol Chemical compound OCCNCCNCCO GFIWSSUBVYLTRF-UHFFFAOYSA-N 0.000 description 1
- CQMNNMLVXSWLCH-UHFFFAOYSA-B 2-hydroxypropane-1,2,3-tricarboxylate;tin(4+) Chemical compound [Sn+4].[Sn+4].[Sn+4].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O CQMNNMLVXSWLCH-UHFFFAOYSA-B 0.000 description 1
- YOETUEMZNOLGDB-UHFFFAOYSA-N 2-methylpropyl carbonochloridate Chemical compound CC(C)COC(Cl)=O YOETUEMZNOLGDB-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 229920000945 Amylopectin Polymers 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 239000005973 Carvone Substances 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- GYHNNYVSQQEPJS-YPZZEJLDSA-N Gallium-68 Chemical compound [68Ga] GYHNNYVSQQEPJS-YPZZEJLDSA-N 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 1
- 229920001202 Inulin Polymers 0.000 description 1
- 229910021578 Iron(III) chloride Inorganic materials 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 102000003982 Parathyroid hormone Human genes 0.000 description 1
- 108090000445 Parathyroid hormone Proteins 0.000 description 1
- 229920002230 Pectic acid Polymers 0.000 description 1
- 229920001218 Pullulan Polymers 0.000 description 1
- 239000004373 Pullulan Substances 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 108010023197 Streptokinase Proteins 0.000 description 1
- 102000011923 Thyrotropin Human genes 0.000 description 1
- 108010061174 Thyrotropin Proteins 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical class [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 125000005263 alkylenediamine group Chemical group 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- UKLJMHXGZUJRTL-UHFFFAOYSA-L calcium;n-cyclohexylsulfamate Chemical compound [Ca+2].[O-]S(=O)(=O)NC1CCCCC1.[O-]S(=O)(=O)NC1CCCCC1 UKLJMHXGZUJRTL-UHFFFAOYSA-L 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 229910052733 gallium Inorganic materials 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 229940029339 inulin Drugs 0.000 description 1
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 1
- 239000007951 isotonicity adjuster Substances 0.000 description 1
- 229960000318 kanamycin Drugs 0.000 description 1
- 229930027917 kanamycin Natural products 0.000 description 1
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
- 229930182823 kanamycin A Natural products 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 229910052987 metal hydride Inorganic materials 0.000 description 1
- 150000004681 metal hydrides Chemical class 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- MQFDGLAHEPKSGL-UHFFFAOYSA-N n-(2-aminoethyl)-2,2-bis(sulfanyl)acetamide Chemical compound NCCNC(=O)C(S)S MQFDGLAHEPKSGL-UHFFFAOYSA-N 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 229960001319 parathyroid hormone Drugs 0.000 description 1
- 239000000199 parathyroid hormone Substances 0.000 description 1
- LCLHHZYHLXDRQG-ZNKJPWOQSA-N pectic acid Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)O[C@H](C(O)=O)[C@@H]1OC1[C@H](O)[C@@H](O)[C@@H](OC2[C@@H]([C@@H](O)[C@@H](O)[C@H](O2)C(O)=O)O)[C@@H](C(O)=O)O1 LCLHHZYHLXDRQG-ZNKJPWOQSA-N 0.000 description 1
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000010318 polygalacturonic acid Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 235000019423 pullulan Nutrition 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- SRWFBFUYENBCGF-UHFFFAOYSA-M sodium;chloride;hydrochloride Chemical compound [Na+].Cl.[Cl-] SRWFBFUYENBCGF-UHFFFAOYSA-M 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229960005202 streptokinase Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- BKVIYDNLLOSFOA-OIOBTWANSA-N thallium-201 Chemical compound [201Tl] BKVIYDNLLOSFOA-OIOBTWANSA-N 0.000 description 1
- FAKFSJNVVCGEEI-UHFFFAOYSA-J tin(4+);disulfate Chemical compound [Sn+4].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O FAKFSJNVVCGEEI-UHFFFAOYSA-J 0.000 description 1
- YJGJRYWNNHUESM-UHFFFAOYSA-J triacetyloxystannyl acetate Chemical compound [Sn+4].CC([O-])=O.CC([O-])=O.CC([O-])=O.CC([O-])=O YJGJRYWNNHUESM-UHFFFAOYSA-J 0.000 description 1
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
- YQMWDQQWGKVOSQ-UHFFFAOYSA-N trinitrooxystannyl nitrate Chemical compound [Sn+4].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O YQMWDQQWGKVOSQ-UHFFFAOYSA-N 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Description
æ¬çºæã¯å°ãªããšãïŒåã®éé¢ãã«ãã«åºãæ
ããé«ååååç©ãç¹ã«ãã«ãã«åºå«æããªãµã
ã«ã©ã€ãèªå°äœãšã¢ããåºå«æïŒå®èœé äœååå
ç©ãçµåããŠæããå°ãªããšãïŒåã®éé¢ãã«ã
ã«åºãæããé«ååååç©ã«é¢ããã æ¬çºæã®é«ååååç©ã¯æç®æªèŒã®æ°èŠç©è³ªã§
ãããç¹å®èåšã®æåºãåå®çŸæ£ã®æ€åºãçç掻
æ§ç©è³ªã®åæ æ€æ»ãçŸç ã®æ²»çãªã©ã®æ žå»åŠççš
éã«é©ãããå®å®ãªæŸå°æ§éå±å çŽ æšèã€ãæŸå°
æ§è¬åãæäŸããããšãåºæ¥ããã®ã§ããã ç¹å®èåšã®æåºãç¹å®çŸæ£ã®æ€åºãåæ æ€æ»ãª
ã©ãç®çãšããé䟵襲çæ žå»åŠèšºæã®ããã«ãåŸ
æ¥ãšãŒãâ131ã§æšèãããçç掻æ§ç©è³ªãæ±çš
ãããŠãããããšãã°ãè¡æ¶²åŸªç°ç³»ã®æåºãåæ
æ€æ»ã«çšãããããšãŒãâ131æšèããè¡æž ã¢ã«
ããã³ãè¡æ ã®æ€åºã«çšãããããšãŒãâ131æš
èãã€ããªããŒã²ã³ãªã©ãæãããããããããª
ããããšãŒãâ131ã¯åæžæãçŽïŒæ¥ãšé·ããã
ã€ãæ žå»åŠèšºæã«æçšãªã¬ã³ããŒç·ã®ä»ã«ãããŒ
ã¿ç·ãæŸåºããããã被æ€è ã«å€éã®æŸå°ç·è¢«æ
ãäžããæ¬ ç¹ãããã ããã§æ žå»åŠèšºæã«ããé©ããç©ççç¹æ§ãæ
ããæŸå°æ§éå±ããä»ã®æ¹æ³ã«ããçç掻æ§ç©è³ª
ã«å°å ¥ããæçšãªæŸå°æ§èšºæå€ãåŸãããšããè©Š
ã¿ãç¶ããããŠãããããšãã°ãçç掻æ§ç©è³ªã«
çŽæ¥ãæŸå°æ§éå±å¡©ãäœçšãããæšèæ³ã§åŸãã
ããã®ãšããŠããã¯ãããŠã â99ïœæšèããè¡æž
ã¢ã«ããã³ãã€ã³ãžãŠã â111æšèãã¬ãªãã€ã·
ã³ãªã©ãç¥ãããŠãããããã«ãžãšãã¬ã³ããªã¢
ãã³äºé ¢é žïŒDTPAïŒãïŒâãªããœããã©ãŒã«ã
ã¹ïŒïŒ®âã¡ãã«ããªã»ãã«ã«ããŸã³ïŒã«ã«ãã³
é žããããšãããµãã³ãªã©ã®ïŒå®èœé äœåååç©
ã®åçš®éå±ã«å¯Ÿãã匷ããã¬ãŒã圢æèœãšããã
ãã®ååç©æ«ç«¯ã®ã¢ããåºããã³ã«ã«ããã·ã«åº
ã®çš®ã ã®çç掻æ§ç©è³ªã«å¯Ÿããåå¿æ§ã«åºã¥ã
ãŠããããïŒå®èœé äœåååç©ãä»ããŠæŸå°æ§é
å±ããã³çç掻æ§ç©è³ªãçµåãããæ¹æ³ãææ¡ã
ããŠããã ãããã®æ¹æ³ã§åŸãããæšèååç©ã¯æ¯èŒçå®
å®ã§ããããããçç掻æ§ç©è³ªã®æŽ»æ§ãä¿æããŠ
ããã®ã§ãæ žå»åŠèšºæç®çã«éåžžã«èå³ããè¬å€
ã§ãããããããªããããããã®æ¹æ³ã«ãã€ãŠåŸ
ãããæŸå°æ§èšºæå€ã¯ãååéã®å€§ããçç掻æ§
ç©è³ªãããšãã°è¡æ 蚺æãã¬ã³èšºæã«äœ¿çšããã
ããããååéçŽ34äžã®ãã€ããªããŒã²ã³ãåå
éçŽ16äžã®IgGãçšããå Žåã蚺æã«å¿ èŠãªé«æ¯
æŸå°èœã®ãã®ãåŸãããªãæ¬ ç¹ãããã æ¬çºæè ãã¯ããã®æ¬ ç¹ã解決ãã¹ãçš®ã ç 究
ãéããçµæãå ã«ãžã¢ã«ããããã³ãã³ã«ã¢ã
ãåºå«æïŒå®èœé äœåååç©ãšã¢ããåºå«æçç
掻æ§ç©è³ªãçµåããé«ååååç©ãéçºããããš
ã«æåããïŒç¹éæ59â105002å·æ现æžããã³ç¹
éæ59â106425å·æ现æžåç §ïŒããã®é«åååå
ç©ã¯ãïŒåååœããå€æ°ã®é äœåããã€ãã®ã§ã
ãããã®ããšã¯ãšããçŽããïŒåååœããã«çµå
ããæŸå°æ§éå±ã€ãªã³ã®æ°ãåŸæ¥ã®ïŒå®èœé äœå
ååç©ã«æ¯ããŠæ Œæ®µã«å€ãããšãæå³ããããã
ãŠãã®é«ååååç©ã䜿çšããããšã«ãããçç
掻æ§ç©è³ªã®å€æ§ããã³æŽ»æ§äœäžãæ¥ãããšãªãé«
æ¯æŸå°èœã®æŸå°æ§èšºæå€ãåŸãããäºå®ãèŠåºã
ãããã äžèšã®ç¥èŠã«åºã¥ããŠæŽã«ç 究ãé²ããçµæã
ãžã¢ã«ããããã³ãã³ã«ä»£ããŠä»ã®ãã«ãã«åºå«
æããªãµãã«ã©ã€ãèªå°äœã䜿çšããŠãåæ§ã«ç
ç掻æ§ç©è³ªã®å€æ§ã掻æ§äœäžãèµ·ããããšãªãé«
æ¯æŸå°èœã®æŸå°æ§å»è¬åãåŸãããäºå®ãèŠåºã
ããããäžè¬ã«ãžã¢ã«ããããã³ãã³ã¯ååéå
åžãåºãã網ç¶æ§é ãæããã®ã§ããã®ç¹°ãè¿ã
æ§é ã®æ°ã»ã©ã«ã¯ïŒå®èœé äœåååç©ãå¹æçã«
çµåãã«ããåŸåãèªãããããããžã¢ã«ããã
ã¢ãããŒã¹ã®ããã«ååéååžãçããã€çŽéæ§
é ãæãããã®ã䜿çšããã°å€æ°ã®ïŒå®èœé äœå
ååç©ãå¹æçã«çµåããããšãåºæ¥ãã æ¬çºæã¯ä»¥äžã®ç¥èŠã«åºã¥ããŠå®æããããã®
ã§ãã€ãŠããã®èŠæšã¯ååäžã«å°ãªããšãïŒåã®
ãã«ãã«åºãæããããªãµãã«ã©ã€ãèªå°äœïŒã
ã ãããžã¢ã«ããããã³ãã³ãé€ããïŒïŒïŒãšã¢
ããåºå«æïŒå®èœé äœåååç©ïŒïŒãåè ïŒå
ååœããåŸè ãå°ãªããšãïŒååã®å²åã«ãããŠ
ã¡ãã¬ã³ã€ããçµåïŒâCHïŒïŒ®âïŒãŸãã¯ã¡ã
ã¬ã³ã¢ãã³çµåïŒâCH2NHâïŒãä»ããŠçµåã
ãŠæãå°ãªããšãïŒåã®éé¢ãã«ãã«åºãæãã
é«ååååç©ïŒïŒãç¹ã«(a)ããè¿ãåäœïŒã
1000ã®ãžã¢ã«ãããã¢ãããŒã¹ãŸãã¯ãžã¢ã«ãã
ãããã¹ãã©ã³ãš(b)ãããšãããµãã³ãŸãã¯ïŒâ
ãªããœããã©ãŒã«ãã¹ïŒïŒ®âã¡ãã«ããªã»ãã«ã«
ããŸã³ïŒã«ã«ãã³é žã»ãžã¢ãã³çž®åäœãåè ïŒå
ååœããåŸè å°ãªããšãïŒååã®å²åã«ãããŠã¡
ãã¬ã³ã€ãã³çµåïŒâCHïŒïŒ®âïŒãŸãã¯ã¡ãã¬
ã³ã¢ãã³çµåïŒâCH2NHâïŒãä»ããŠçµåããŠ
æãå°ãªããšãïŒåã®éé¢ãã«ãã«åºãæããé«
ååååç©ã«åããã æ¬çºæã®ç®çãšããäžèšé«ååååç©ïŒïŒã¯
ããªãµãã«ã©ã€ãèªå°äœïŒïŒãšïŒå®èœé äœåå
åç©ïŒïŒãçµåããŠæ§æããããã®ã§ããã ããªãµãã«ã©ã€ãèªå°äœïŒïŒã¯ååäžã«å°ãª
ããšãïŒåã®ãã«ãã«åºãæã€ããšãå¿ èŠã§ã
ãããã«ãã«åºã®æ°ãå€ãã»ã©å¥œãŸãããããã
ã®ãã«ãã«åºã®ãã¡å°ãªããšãïŒåã¯ïŒå®èœé äœ
åååç©ïŒïŒãšã®çµåã«åœ¹ç«ã€ãã®ã§ãããä»
ã®å°ãªããšãïŒåã¯é«ååååç©ïŒïŒã«ãããŠ
éé¢ã®ãŸãŸæ®çããåŸã«é«ååååç©ïŒïŒã«ç
ç掻æ§ç©è³ªïŒïŒãçµåãããã®ã«åœ¹ç«ã€ã ããªãµãã«ã©ã€ãèªå°äœïŒïŒãšããŠã¯ãããš
ãã°é©å®ã«çœ®æãããŠããããšãããããªãµãã«
ã©ã€ããé žåå€ïŒããšãã°éãšãŒãé žãããªãŠ
ã ïŒã§åŠçããŠåŸããããååãšããŠãµãã«ã©ã€
ãåäœæ¯ã«ïŒåãŸãã¯ïŒåã®ãã«ãã«åºãæãã
ãã®ã䜿çšãããããããªãµãã«ã©ã€ããšããŠ
ã¯ããªãªã³ãµãã«ã©ã€ãã§ãããããæ¬çºæã®ç®
çããç解ãããããã«ãã³ãâãµã³ããããœâ
ãµã³ãããªã°ã«ã³ãµãã³ãããªãŠãã³é žãã°ãªã³
ãµããã°ãªã«ã³ãã°ãªã³ãŠããã°ãªã«ã³ãããã
ãããœâãµã³ãªã©é«æ¬¡ã®ããªãµãã«ã©ã€ãã奜ãŸ
ãããå ·äœäŸãšããŠã¯ãã¢ãããŒã¹ãã¢ãããã¯
ãã³ãããã¹ãã©ã³ãã»ã«ããŒã¹ãã€ããªã³ãã
ã¯ãã³é žããã«ã©ã³ãªã©ãæãããããããã®æ··
åç©ãè±æ°Žçž®åç©ã§ãã€ãŠããããäžè¬ã«ãµãã«
ã©ã€ãåäœã3000以äžãç¹ã«1000以äžã®ãã®ãæ
ãŸããã ïŒå®èœé äœåååç©ïŒïŒãšããŠã¯ãæŸå°æ§é
å±å çŽ ïŒïŒã«å¯Ÿã匷åºãªãã¬ãŒãçµåã圢æ
ãããã€æ¯èŒçç·©åãªæ¡ä»¶äžã§ããªãµãã«ã©ã€ã
èªå°äœïŒïŒã®ãã«ãã«åºãšåå¿ãåŸãã¢ããåº
ãæãããã®ã䜿çšãããããã®ãããªïŒå®èœé
äœåååç©ïŒïŒã®å ·äœãšããŠã¯ãããšãããµã
ã³ïŒã¡ã«ã¯ã»ã€ã³ããã¯ã¹ã第ïŒçã374é
ïŒ1976幎ïŒïŒãåŒïŒ ïŒåŒäžãR1ããã³R2ããããæ°ŽçŽ ãC1ãC3ã¢ã«
ãã«ãŸãã¯ããšãã«ãè¡šããïŒã§è¡šãããïŒâã¢
ããã¡ãã¬ã³âïŒïŒïŒâãã³ã¿ã³ãžãªã³âãã¹
ïŒããªã»ãã«ã«ããŸã³ïŒèªå°äœïŒãšãŒãããç¹èš±
åºé¡ç¬¬54920å·æ现åºïŒãåŒïŒ ïŒåŒäžãR3ããã³R4ã¯ããããæ°ŽçŽ ãŸãã¯C1ã
C3ã¢ã«ãã«ãïœã¯ïŒãïŒã®æŽæ°ãè¡šããïŒã§è¡šã
ããïŒâïŒïœâã¢ããã¢ã«ãã«ïŒããšãã«ããã
ã³âïŒïŒïŒâãžãªã³âãã¹ïŒããªã»ãã«ã«ããŸ
ã³ïŒèªå°äœïŒãªãŒã¹ãã©ã€ã¢ç¹èš±ç¬¬533722å·æ现
æžïŒãªã©ãæããããã ãã®ãã®èªäœã¯ã¢ããåºãæããŠããªããŠã容
æã«ã¢ããåºãŸãã¯ã¢ããåºå«ææ§é ã圢æãåŸ
ãåºãŸãã¯æ§é ãæããŠããå Žåã¯ãæŸå°æ§éå±
å çŽ ãææããæ§è³ªãæããéãããã®ãã®ããŸ
ãã¢ããåºãŸãã¯ã¢ããåºå«ææ§é ã圢æããã
ãããã§ãïŒå®èœé äœåååç©ïŒïŒãšããŠäœ¿çš
ãåŸããããšãã°ãã«ã«ããã·ã«åºãæãããã®
ã¯ãããã«ã¢ã«ãã¬ã³ãžã¢ãã³ãåå¿ãããããš
ã«ãã€ãŠå®¹æã«ã¢ããåºãå°å ¥ããããšãåºæ¥ã
æ¬çºæã«ãããŠïŒå®èœé äœåååç©ïŒïŒã®ïŒçš®
ãšããŠäœ¿çšããããšãåºæ¥ãããã®ãããªïŒå®èœ
é äœåååç©ïŒïŒã®å ·äœäŸãšããŠã¯ããžãšãã¬
ã³ããªã¢ãã³äºé ¢é žïŒDTPAïŒããšãã¬ã³ãžã¢ã
ã³åé ¢é žïŒEDTAïŒããžã¡ã«ã«ããã¢ã»ãã«ãšã
ã¬ã³ãžã¢ãã³ïŒããªããããŒã¯ïŒFritzbergïŒ
ãïŒãžã€ãŒãã«ã»ãªãã»ãã¯ã¬ã¢ãŒã»ã¡ãã€ã¹ã³
ïŒJ.Nucl.Med.ïŒã23ã917ïŒ1982ïŒïŒããã³ãã¹ã¢
ãããšã¿ã³ããªãŒã«ïŒFritzbergãïŒJ.Nucl.
Med.ã25ã916ïŒ1984ïŒïŒã«ä»£è¡šãããN2S2ãªã¬
ã³ãããµã€ã¯ã©ã³ïŒã«ã€ãªã³ã°ïŒKeiringïŒãïŒ
ãžã€ãŒãã«ã»ãªãã»ãã¯ã¬ã¢ãŒã»ã¡ãã€ã¹ã³ïŒJ.
Nucl.Med.ïŒã23ã917ïŒ1982ïŒïŒã«ä»£è¡šãããN4
ãªã¬ã³ããïŒNâ²âãã¹ïŒïŒâããããã·ãšã
ã«ïŒãšãã¬ã³ãžã¢ãã³ïŒãã¯ããŒã»ãžãŠãã¢
ïŒWagnerJr.ïŒãïŒããã·ãŒãã€ã³ã°ã¹ã»ãªãã»
ã¶ã»ã€ã³ã¿ãŒãã·ãšãã«ã»ã·ã³ããžãŠã ã»ãªã³ã»
ãã¯ãããŠã ã»ã€ã³ã»ã±ãã¹ããªã€ã»ã¢ã³ãã»ã
ã¯ã¬ã¢ãŒã»ã¡ãã€ã¹ã³ãããããã€ã¿ãªã€
ïŒProceedings of the International Symposium
on Technetium in Chemistry and Nuclear
MedicineãPadovaãItaly.ïŒ161é ïŒ1982ïŒïŒã«
代衚ãããN2O2ãªã¬ã³ããåŒïŒ ïŒåŒäžãR5ãR6ãR7ãR8ããã³R9ã¯æ°ŽçŽ ãŸãã¯
C1ãC3ã¢ã«ãã«ïŒã§è¡šããããïŒâããããªã³
ã¢ã«ãããâãã¹ïŒããªã»ãã«ã«ããŸã³ïŒèªå°äœ
ïŒã¢ã¡ãªã«ç¹èš±ç¬¬4287362å·æ现æžïŒãªã©ãæãã
ããã é«ååååç©ïŒïŒã補é ããã«ã¯ãããšãã°
ããªãµãã«ã©ã€ãèªå°äœïŒïŒãšïŒå®èœé äœåå
åç©ïŒïŒãçž®åãããŠåè ã®ãã«ãã«åºãšåŸè
ã®ã¢ããåºã®éã§ã¡ãã¬ã³ã€ãã³çµåã圢æãã
ããå¿ èŠã«å¿ããã®ã¡ãã¬ã³ã€ãã³çµåãéå ã
ãŠã¡ãã¬ã³ã¢ãã³çµåã«å€æããã°ãããäžèšçž®
ååå¿ã¯ãã«ãã«åºãšã¢ããåºãçž®åããããã
ã«æ¡çšãããèªäœåžžå¥ã®æ段ã§è¡ãã°ãããäžèš
éå åå¿ãã¡ãã¬ã³ã€ãã³çµåãã¡ãã¬ã³ã¢ãã³
çµåã«å€æãããŠãã«æ¡çšãããŠããèªäœåžžå¥ã®
æ段ãããšãã°ãã¯æ°ŽçŽ åããŠçŽ ãããªãŠã ã®ã
ããªéå±æ°ŽçŽ åç©ã䜿çšããããšã«ããè¡ãªãã
ããäžèšéå åå¿ã«éãããµãã«ã©ã€ãåäœäžã®
ãã«ãã«åºãäžéšéå ãããååç©ãå¯çããã
ãšãããããããã«ãã€ãŠæ¬çºæã®ç®çã劚ãã
ããããšã¯ãªããåå¿è©Šå€ãåå¿æ¡ä»¶ãªã©ã®çžé
ã«ããããªãµãã«ã©ã€ãèªå°äœïŒïŒïŒååã«çµ
åããïŒå®èœé äœåååç©ïŒïŒã®ååæ°ã¯ç°ãª
ãããäžè¬ã«ã¯ïŒãŸãã¯ãã以äžãç¹ã«10ãŸãã¯
ãã以äžã奜ãŸããããã ãããã®åå¿ã§åŸãã
ãé«ååååç©ïŒïŒã®ããªãµãã«ã©ã€èªå°äœ
ïŒïŒéšåã«ãããå°ãªããšãïŒåã®ãã«ãã«åº
ã¯çç掻æ§ç©è³ªïŒïŒãšã®çµåã®ããéé¢ã®ãŸãŸ
æ®çãã¹ãã§ããã ããªãµãã«ã©ã€ãèªå°äœïŒïŒãšããŠã¢ãããŒ
ã¹ç±æ¥ã®ãã®ã䜿çšããå ŽåãäŸã«æããŠé«åå
ååç©ïŒïŒã®æ§é ãåŒã§ç€ºãã°æ¬¡ã®éãã§ã
ãïŒ ïŒåŒäžãã¯ïŒå®èœé äœåååç©ïŒïŒããã¢ã
ãåºãé€å»ããæ®åºãã¯âCHOãŸãã¯â
CH2OHãã¯ïŒã1000ã®æŽæ°ãïœãïœãïœãã
ã³ïœã¯ããããïŒã1000ã®æŽæ°ãè¡šãããã ãã
ïœïŒïœïŒïœïŒïœã¯ïŒã1000ã®æŽæ°ã§ãããïŒã ãªããäžåŒã«ãããŠãžã¢ã«ãããã¢ãããŒã¹
ïŒïœïŒã¯ã¢ãããŒã¹ãåæãšãããããéãšãŒ
ãé žã®ãããªé žåå€ã§éšåçãããã¯å šäœçã«é ž
åããããšã«ããåŸãããéç¶é«ååç©è³ªã§ãã€
ãŠãããèªäœåžè²©ãããŠããããã®ãµãã«ã©ã€ã
åäœã¯éåžžïŒã1000ã§ãããç¹ã«ïŒã500ã奜ãŸ
ããã ããã«çæããé«ååååç©ïŒïŒã¯ãå¿ èŠã«
å¿ããé«ååç©è³ªã«é©çšãããã«ã©ã ã¯ãããã°
ã©ãã€ãŒãã²ã«ãéæ³ãéææ³ãªã©ã®åžžå¥ã®ç²Ÿè£œ
æ³ã«ãã粟補ãããŠãããã æ¬çºæã®é«ååååç©ïŒïŒã¯ããã®ååäžã«
å°ãªããšãïŒåã®éé¢ãã«ãã«åºãååšããã
ãããã®ãã«ãã«åºãä»ããŠã¢ããåºãæããç
ç掻æ§ç©è³ªïŒïŒãšçµåããæŸå°æ§å»è¬å調補çš
ãã€ãªã€ãŒãæäŸããããšãåºæ¥ããããã§èšã
çç掻æ§ç©è³ªãšã¯ãé©åœãªåšå®ãŸãã¯çµç¹ããã
ã¯ç¹å®ã®ç å·£ã«èç©ããããç¹å®ã®ççç¶æ ã«å¯Ÿ
å¿ããŠç¹ç°ãªæåã瀺ãç©è³ªãæå³ããçäœå ã«
ããããã®ãããªç©è³ªã®æåã远跡ããããšã«ã
ã€ãŠèšºæäžæçšãªæ å ±ãåŸãããšãåºæ¥ããã®ã§
ãããçç掻æ§ç©è³ªã¯äžè¬ã«ããèªäœã§ã¢ããåº
ãæããŠãããã®ãå€ããããã®ãããªçç掻æ§
ç©è³ªã¯ããšãããããèªäœã§ã¯ã¢ããåºãæããŠ
ããªããã®ã§ãã€ãŠããããã«é©å®ã®æ¹æ³ã§ã¢ã
ãåºãŸãã¯ã¢ããåºå«ææ§é ãå°å ¥ãããã®ã䜿
çšããããšãåºæ¥ãããã«ãã«åºãšã¢ããåºã®é
ã®åå¿ã¯æ¯èŒçç·©åãªæ¡ä»¶äžã§é²è¡ãããããæ¬
çºæã«ãããŠæå©ã«å©çšããããšãåºæ¥ãã çç掻æ§ç©è³ªïŒïŒã®å ·äœäŸãšããŠã¯ãè¡æ¶²è
çœè³ªïŒããšãã°ããè¡æž ã¢ã«ããã³ããã€ããªã
ãŒã²ã³ïŒãé µçŽ ïŒããšãã°ãŠããããŒãŒãã¹ãã¬
ãããããŒãŒïŒããã«ã¢ã³ïŒããšãã°ç²ç¶è ºåºæ¿
ãã«ã¢ã³ãå¯ç²ç¶è ºãã«ã¢ã³ïŒãå ç«æäœïŒããš
ãã°IgGããã³ãã®æçã®ïŒŠïŒabïŒ2â²ãFabâ²ã
FabïŒãã¢ãã¯ããŒãã«æäœãæçç©è³ªïŒããšã
ã°ãã¬ãªãã€ã·ã³ãã«ããã€ã·ã³ïŒãç³é¡ãèèª
é žãã¢ããé žãªã©ãæããããã æ¬çºæã®é«ååååç©ïŒïŒã«å¯ŸããŠçç掻æ§
ç©è³ªïŒïŒãçµåããããã«ã¯ãããšãã°é«åå
ååç©ïŒïŒãšçç掻æ§ç©è³ªïŒïŒãçž®åãããŠ
åè ã®ãã«ãã«åºãšåŸè ã®ã¢ããåºã®éã§ã¡ãã¬
ã³ã€ãã³çµåã圢æããããå¿ èŠã«å¿ããã®ã¡ã
ã¬ã³ã€ãã³çµåãéå ããŠã¡ãã¬ã³ã¢ãã³çµåã«
å€æããã°ãããäžèšçž®ååå¿ãéå åå¿ãå ±ã«
èªäœåžžå¥ã®æ¹æ³ã§è¡ãã°ãããé«ååååç©
ïŒïŒã®ïŒåååœããå°å ¥ãããçç掻æ§ç©è³ªã®
ååæ°ã¯ãåå¿è©Šå€ãåå¿æ¡ä»¶ãªã©ã«ãã€ãŠç°ãª
ãããéåžžã¯10ãŸãã¯ãã以äžãç¹ã«ïŒãŸãã¯ã
ã以äžã奜ãŸããã ããã«çæããé«ååååç©ïŒïŒãšçç掻æ§
ç©è³ªïŒïŒã®çµåäœã¯å¿ èŠã«å¿ãé«ååç©è³ªé©çš
ãããã«ã©ã ã¯ãããã°ã©ãã€ãŒãã²ã«ãéæ³ã
éææ³ãªã©ã®åžžå¥ã®ç²Ÿè£œæ³ã«ãã粟補ãããŠãã
ãã ãã®é«ååååç©ïŒïŒâçç掻æ§ç©è³ªïŒïŒ
çµåäœã¯ãåèšã®ããã«æŸå°æ§å»è¬å調補çšãã€
ãªã€ãŒãšããŠæçšãªãã®ã§ãããããªãã¡ã該çµ
åäœã«ã¯é«ååååç©ïŒïŒã®éšåã«ïŒå®èœé äœ
åååç©ïŒïŒãè€æ°åååšããŠãããããã«ã
ã€ãŠè€æ°åã®æŸå°æ§éå±å çŽ ïŒïŒãææããã
ãšãå¯èœã§ããããã®ããã«è€æ°åã®æŸå°æ§éå±
å çŽ ïŒïŒãææããããçµåäœã¯ããèªäœæŸå°
æ§å»è¬åãšããŠäœ¿çšããããã ããã«æŸå°æ§éå±å çŽ ïŒïŒãšããŠã¯ãæŸå°èœ
ãæããéå±å çŽ ã§ãã€ãŠãæ žå»åŠç蚺æãæ²»ç
ã«é©ããç©ççãŸãã¯ååŠçç¹æ§ãæããããã
ïŒå®èœé äœåååç©ïŒïŒã®é äœåæ§é ã«ãã容
æã«ææãããããã®ã䜿çšãããããã®å ·äœäŸ
ãšããŠã¯ãã¬ãªãŠã â67ãã¬ãªãŠã â68ãã¿ãªãŠ
ã â201ãã€ã³ãžãŠã â111ããã¯ãããŠã â99ïœ
ãªã©ãããããããã¯éåžžãå¡©ãç¹ã«æ°Žæº¶æ§å¡©ã®
圢ã§äœ¿çšãããæ°Žæ§åªäœäžã«ãããŠé«ååååç©
ïŒïŒâçç掻æ§ç©è³ªïŒïŒçµåäœãšæ¥è§ŠããããŠ
ãã®æšèåãè¡ãããã ããæŸå°æ§éå±å çŽ
ïŒïŒãå®å®ãªãã¬ãŒãé¯äœã圢æãããåå䟡
ç¶æ ã«ããå Žåã«ã¯ïŒããšãã°ã«ãªãŠã â67ãã€
ã³ãžãŠã â111ïŒãåå¿ç³»ã«ä»ã®è©Šå€ãååšããã
ãå¿ èŠã¯ãªãããå®å®ãªãã¬ãŒãé¯äœã圢æãã
ããã«åå䟡ç¶æ ãå€åããããå¿ èŠãããå Žå
ã«ã¯ïŒããšãã°ãã¯ãããŠã â99mïŒãåå¿ç³»ã«
éå å€ãŸãã¯é žåå€ãååšããããå¿ èŠããã
ããéå å€ãšããŠã¯ãïŒäŸ¡ã®ã¹ãºå¡©ïŒããšãã°ã
ãã²ã³åã¹ãºãç¡«é žã¹ãºãç¡é žã¹ãºãé ¢é žã¹ãºã
ã¯ãšã³é žã¹ãºïŒãæããããã ããšãã°ãæŸå°æ§éå±å çŽ ïŒïŒãšããŠãã¯ã
ããŠã â99mã䜿çšããå Žåãé«ååååç©
ïŒïŒâçç掻æ§ç©è³ªïŒïŒçµåäœãæ°Žæ§åªäœäžé
å å€ãšããŠã®ç¬¬ïŒã¹ãºå¡©ã®ååšäžããŒãã¯ãããŒ
ãã®åœ¢ã®ãã¯ãããŠã â99mãšåŠçããããšã«ã
ã€ãŠãã¯ãããŠã â99mæšèé«ååååç©ïŒïŒ
âçç掻æ§ç©è³ªïŒïŒçµåäœã調補ããããšãã§
ãããäžèšèª¿è£œã«éããåè©Šå€ã®æ··åé åºã«ã€ã
ãŠæ Œå¥ã®å¶éã¯ãªãããéåžžãæ°Žæ§åªè³ªäžã§æå
ã«ç¬¬ïŒã¹ãºå¡©ãšããŒãã¯ãããŒããæ··åããããš
ã¯é¿ããæ¹ãæãŸããã第ïŒã¹ãºå¡©ã¯ããŒãã¯ã
ããŒããå åã«éå åºæ¥ãéã§äœ¿çšããã®ã奜ãŸ
ããã ãã®ããã«ããŠåŸãããæšèé«ååååç©
ïŒïŒâçç掻æ§ç©è³ªïŒïŒçµåäœãæŸå°æ§èšºæå€
ãšããŠæçšã§ããããã«ã¯ã蚺æãå¯èœãšããå
åãªæŸå°èœãšæŸå°èœæ¿åºŠãæããããšãå¿ èŠã§ã
ããããšãã°æŸå°æ§éå±å çŽ ãšããŠãã¯ãããŠã
â99mã䜿çšããå Žåãæäžæã«çŽ0.5ã5.0mlåœ
ãã0.1ã50mCiã®æŸå°èœæ¿åºŠãæããããšãæ
ãŸããããŸãããã®ãããªæšèé«ååååç©
ïŒïŒâçç掻æ§ç©è³ªïŒïŒçµåäœã¯èª¿è£œåŸçŽã¡ã«
æäžãããŠããããã奜ãŸããã¯èª¿è£œåŸé©åœæé
ä¿åã«èãããçšåºŠã®å®å®æ§ãæããããšãæãŸ
ããããªããŸããæšèé«ååååç©ïŒïŒâçç
掻æ§ç©è³ªïŒïŒçµåäœã«ã¯ãå¿ èŠã«å¿ãPH調ç¯å€
ïŒããšãã°é žãå¡©åºãç·©è¡å€ïŒãå®å®å€ïŒããšãã°
ã¢ã¹ã³ã«ãã³é žïŒãç匵å€ïŒããšãã°å¡©åãããª
ãŠã ïŒãªã©ãé åãããŠãããã æ¬çºæé«ååååç©ïŒïŒãçšããŠåŸãããæŸ
å°æ§å»è¬åã®äžäŸãããªãµãã«ã©ã€ãèªå°äœ
ïŒïŒãšããŠãžã¢ã«ãããã¢ãããŒã¹ãïŒå®èœé
äœåååç©ïŒïŒãšããŠãããšãããµã·ã³ãçç
掻æ§ç©è³ªïŒïŒãšããŠããè¡æž ã¢ã«ããã³ãæŸå°
æ§éå±å çŽ ïŒïŒãšããŠã¬ãªãŠã â67ã䜿çšãã
å Žåã«ã€ã説æããã°æ¬¡ã®éãã§ããã ãŸãããžã¢ã«ãããã¢ãããŒã¹ããããšãããµ
ãã³ãšçž®åãããåŸãå¿ èŠã«å¿ããŠéå ããããš
ã«ãããžã¢ã«ãããã¢ãããŒã¹âãããšãããµã
ã³çµåäœã調補ãããã®çµåäœã«ããè¡æž ã¢ã«ã
ãã³ãçž®åãããåŸãå¿ èŠã«å¿ããŠéå ããããš
ã«ããããè¡æž ã¢ã«ããã³âãžã¢ã«ãããã¢ãã
ãŒã¹âãããšãããµãã³çµåäœãåŸãããã®çµå
äœãšïŒäŸ¡ã®ã¬ãªãŠã ã€ãªã³ã®åœ¢ã§ã¬ãªãŠã â67ã
å«ã氎溶液ãæ¥è§Šãããããšã«ãããå®å®ã§é«æ¯
æŸå°èœã®ã¬ãªãŠã â67æšèããè¡æž ã¢ã«ããã³â
ãžã¢ã«ãããã¢ãããŒã¹âãããšãããµãã³çµå
äœãåŸãã ãã®æšèçµåäœã®é»æ°æ³³åçæåã¯ãããè¡æž
ã¢ã«ããã³ã®æåãšå šãåãã§ããããŸãããã®
æšèçµåäœã®ã©ããäœå ååžã¯åŸæ¥ã®ãšãŒãâ
131æšèããè¡æž ã¢ã«ããã³ãšã»ãŒåãã§ããã
è¡äžæ¿åºŠã®åæžæã¯çŽ30æéã§ããšãŒãâ131æš
èããè¡æž ã¢ã«ããã³ã®è¡äžæ¿åºŠã®åæžæïŒ5.7
æéïŒãããå åé·ããããªãã¡ãæ¬çºæã«ãã
æšèçµåäœã¯ãå¿ããŒã«åã®æåºã«æçšã§ããã
ãšãç解åºæ¥ãã æ¬çºæã«ããäžèšããè¡æž ã¢ã«ããã³âãžã¢ã«
ããããã¢ãããŒã¹âãããšãããµãã³çµåäœ
ïŒè©ŠæïŒïŒãšåŸæ¥æ³ã«ããããè¡æž ã¢ã«ããã³ãš
ãããšãããµã³ãçŽæ¥çµåããããã®ïŒè©ŠæïŒïŒ
ãšã®ã¬ãªãŠã â67ã1mCiã«å¯Ÿããæšèèœãæ¯èŒ
ãããšããã次ã®ãããªçµæãåŸãããã
ããé«ååååç©ãç¹ã«ãã«ãã«åºå«æããªãµã
ã«ã©ã€ãèªå°äœãšã¢ããåºå«æïŒå®èœé äœååå
ç©ãçµåããŠæããå°ãªããšãïŒåã®éé¢ãã«ã
ã«åºãæããé«ååååç©ã«é¢ããã æ¬çºæã®é«ååååç©ã¯æç®æªèŒã®æ°èŠç©è³ªã§
ãããç¹å®èåšã®æåºãåå®çŸæ£ã®æ€åºãçç掻
æ§ç©è³ªã®åæ æ€æ»ãçŸç ã®æ²»çãªã©ã®æ žå»åŠççš
éã«é©ãããå®å®ãªæŸå°æ§éå±å çŽ æšèã€ãæŸå°
æ§è¬åãæäŸããããšãåºæ¥ããã®ã§ããã ç¹å®èåšã®æåºãç¹å®çŸæ£ã®æ€åºãåæ æ€æ»ãª
ã©ãç®çãšããé䟵襲çæ žå»åŠèšºæã®ããã«ãåŸ
æ¥ãšãŒãâ131ã§æšèãããçç掻æ§ç©è³ªãæ±çš
ãããŠãããããšãã°ãè¡æ¶²åŸªç°ç³»ã®æåºãåæ
æ€æ»ã«çšãããããšãŒãâ131æšèããè¡æž ã¢ã«
ããã³ãè¡æ ã®æ€åºã«çšãããããšãŒãâ131æš
èãã€ããªããŒã²ã³ãªã©ãæãããããããããª
ããããšãŒãâ131ã¯åæžæãçŽïŒæ¥ãšé·ããã
ã€ãæ žå»åŠèšºæã«æçšãªã¬ã³ããŒç·ã®ä»ã«ãããŒ
ã¿ç·ãæŸåºããããã被æ€è ã«å€éã®æŸå°ç·è¢«æ
ãäžããæ¬ ç¹ãããã ããã§æ žå»åŠèšºæã«ããé©ããç©ççç¹æ§ãæ
ããæŸå°æ§éå±ããä»ã®æ¹æ³ã«ããçç掻æ§ç©è³ª
ã«å°å ¥ããæçšãªæŸå°æ§èšºæå€ãåŸãããšããè©Š
ã¿ãç¶ããããŠãããããšãã°ãçç掻æ§ç©è³ªã«
çŽæ¥ãæŸå°æ§éå±å¡©ãäœçšãããæšèæ³ã§åŸãã
ããã®ãšããŠããã¯ãããŠã â99ïœæšèããè¡æž
ã¢ã«ããã³ãã€ã³ãžãŠã â111æšèãã¬ãªãã€ã·
ã³ãªã©ãç¥ãããŠãããããã«ãžãšãã¬ã³ããªã¢
ãã³äºé ¢é žïŒDTPAïŒãïŒâãªããœããã©ãŒã«ã
ã¹ïŒïŒ®âã¡ãã«ããªã»ãã«ã«ããŸã³ïŒã«ã«ãã³
é žããããšãããµãã³ãªã©ã®ïŒå®èœé äœåååç©
ã®åçš®éå±ã«å¯Ÿãã匷ããã¬ãŒã圢æèœãšããã
ãã®ååç©æ«ç«¯ã®ã¢ããåºããã³ã«ã«ããã·ã«åº
ã®çš®ã ã®çç掻æ§ç©è³ªã«å¯Ÿããåå¿æ§ã«åºã¥ã
ãŠããããïŒå®èœé äœåååç©ãä»ããŠæŸå°æ§é
å±ããã³çç掻æ§ç©è³ªãçµåãããæ¹æ³ãææ¡ã
ããŠããã ãããã®æ¹æ³ã§åŸãããæšèååç©ã¯æ¯èŒçå®
å®ã§ããããããçç掻æ§ç©è³ªã®æŽ»æ§ãä¿æããŠ
ããã®ã§ãæ žå»åŠèšºæç®çã«éåžžã«èå³ããè¬å€
ã§ãããããããªããããããã®æ¹æ³ã«ãã€ãŠåŸ
ãããæŸå°æ§èšºæå€ã¯ãååéã®å€§ããçç掻æ§
ç©è³ªãããšãã°è¡æ 蚺æãã¬ã³èšºæã«äœ¿çšããã
ããããååéçŽ34äžã®ãã€ããªããŒã²ã³ãåå
éçŽ16äžã®IgGãçšããå Žåã蚺æã«å¿ èŠãªé«æ¯
æŸå°èœã®ãã®ãåŸãããªãæ¬ ç¹ãããã æ¬çºæè ãã¯ããã®æ¬ ç¹ã解決ãã¹ãçš®ã ç 究
ãéããçµæãå ã«ãžã¢ã«ããããã³ãã³ã«ã¢ã
ãåºå«æïŒå®èœé äœåååç©ãšã¢ããåºå«æçç
掻æ§ç©è³ªãçµåããé«ååååç©ãéçºããããš
ã«æåããïŒç¹éæ59â105002å·æ现æžããã³ç¹
éæ59â106425å·æ现æžåç §ïŒããã®é«åååå
ç©ã¯ãïŒåååœããå€æ°ã®é äœåããã€ãã®ã§ã
ãããã®ããšã¯ãšããçŽããïŒåååœããã«çµå
ããæŸå°æ§éå±ã€ãªã³ã®æ°ãåŸæ¥ã®ïŒå®èœé äœå
ååç©ã«æ¯ããŠæ Œæ®µã«å€ãããšãæå³ããããã
ãŠãã®é«ååååç©ã䜿çšããããšã«ãããçç
掻æ§ç©è³ªã®å€æ§ããã³æŽ»æ§äœäžãæ¥ãããšãªãé«
æ¯æŸå°èœã®æŸå°æ§èšºæå€ãåŸãããäºå®ãèŠåºã
ãããã äžèšã®ç¥èŠã«åºã¥ããŠæŽã«ç 究ãé²ããçµæã
ãžã¢ã«ããããã³ãã³ã«ä»£ããŠä»ã®ãã«ãã«åºå«
æããªãµãã«ã©ã€ãèªå°äœã䜿çšããŠãåæ§ã«ç
ç掻æ§ç©è³ªã®å€æ§ã掻æ§äœäžãèµ·ããããšãªãé«
æ¯æŸå°èœã®æŸå°æ§å»è¬åãåŸãããäºå®ãèŠåºã
ããããäžè¬ã«ãžã¢ã«ããããã³ãã³ã¯ååéå
åžãåºãã網ç¶æ§é ãæããã®ã§ããã®ç¹°ãè¿ã
æ§é ã®æ°ã»ã©ã«ã¯ïŒå®èœé äœåååç©ãå¹æçã«
çµåãã«ããåŸåãèªãããããããžã¢ã«ããã
ã¢ãããŒã¹ã®ããã«ååéååžãçããã€çŽéæ§
é ãæãããã®ã䜿çšããã°å€æ°ã®ïŒå®èœé äœå
ååç©ãå¹æçã«çµåããããšãåºæ¥ãã æ¬çºæã¯ä»¥äžã®ç¥èŠã«åºã¥ããŠå®æããããã®
ã§ãã€ãŠããã®èŠæšã¯ååäžã«å°ãªããšãïŒåã®
ãã«ãã«åºãæããããªãµãã«ã©ã€ãèªå°äœïŒã
ã ãããžã¢ã«ããããã³ãã³ãé€ããïŒïŒïŒãšã¢
ããåºå«æïŒå®èœé äœåååç©ïŒïŒãåè ïŒå
ååœããåŸè ãå°ãªããšãïŒååã®å²åã«ãããŠ
ã¡ãã¬ã³ã€ããçµåïŒâCHïŒïŒ®âïŒãŸãã¯ã¡ã
ã¬ã³ã¢ãã³çµåïŒâCH2NHâïŒãä»ããŠçµåã
ãŠæãå°ãªããšãïŒåã®éé¢ãã«ãã«åºãæãã
é«ååååç©ïŒïŒãç¹ã«(a)ããè¿ãåäœïŒã
1000ã®ãžã¢ã«ãããã¢ãããŒã¹ãŸãã¯ãžã¢ã«ãã
ãããã¹ãã©ã³ãš(b)ãããšãããµãã³ãŸãã¯ïŒâ
ãªããœããã©ãŒã«ãã¹ïŒïŒ®âã¡ãã«ããªã»ãã«ã«
ããŸã³ïŒã«ã«ãã³é žã»ãžã¢ãã³çž®åäœãåè ïŒå
ååœããåŸè å°ãªããšãïŒååã®å²åã«ãããŠã¡
ãã¬ã³ã€ãã³çµåïŒâCHïŒïŒ®âïŒãŸãã¯ã¡ãã¬
ã³ã¢ãã³çµåïŒâCH2NHâïŒãä»ããŠçµåããŠ
æãå°ãªããšãïŒåã®éé¢ãã«ãã«åºãæããé«
ååååç©ã«åããã æ¬çºæã®ç®çãšããäžèšé«ååååç©ïŒïŒã¯
ããªãµãã«ã©ã€ãèªå°äœïŒïŒãšïŒå®èœé äœåå
åç©ïŒïŒãçµåããŠæ§æããããã®ã§ããã ããªãµãã«ã©ã€ãèªå°äœïŒïŒã¯ååäžã«å°ãª
ããšãïŒåã®ãã«ãã«åºãæã€ããšãå¿ èŠã§ã
ãããã«ãã«åºã®æ°ãå€ãã»ã©å¥œãŸãããããã
ã®ãã«ãã«åºã®ãã¡å°ãªããšãïŒåã¯ïŒå®èœé äœ
åååç©ïŒïŒãšã®çµåã«åœ¹ç«ã€ãã®ã§ãããä»
ã®å°ãªããšãïŒåã¯é«ååååç©ïŒïŒã«ãããŠ
éé¢ã®ãŸãŸæ®çããåŸã«é«ååååç©ïŒïŒã«ç
ç掻æ§ç©è³ªïŒïŒãçµåãããã®ã«åœ¹ç«ã€ã ããªãµãã«ã©ã€ãèªå°äœïŒïŒãšããŠã¯ãããš
ãã°é©å®ã«çœ®æãããŠããããšãããããªãµãã«
ã©ã€ããé žåå€ïŒããšãã°éãšãŒãé žãããªãŠ
ã ïŒã§åŠçããŠåŸããããååãšããŠãµãã«ã©ã€
ãåäœæ¯ã«ïŒåãŸãã¯ïŒåã®ãã«ãã«åºãæãã
ãã®ã䜿çšãããããããªãµãã«ã©ã€ããšããŠ
ã¯ããªãªã³ãµãã«ã©ã€ãã§ãããããæ¬çºæã®ç®
çããç解ãããããã«ãã³ãâãµã³ããããœâ
ãµã³ãããªã°ã«ã³ãµãã³ãããªãŠãã³é žãã°ãªã³
ãµããã°ãªã«ã³ãã°ãªã³ãŠããã°ãªã«ã³ãããã
ãããœâãµã³ãªã©é«æ¬¡ã®ããªãµãã«ã©ã€ãã奜ãŸ
ãããå ·äœäŸãšããŠã¯ãã¢ãããŒã¹ãã¢ãããã¯
ãã³ãããã¹ãã©ã³ãã»ã«ããŒã¹ãã€ããªã³ãã
ã¯ãã³é žããã«ã©ã³ãªã©ãæãããããããã®æ··
åç©ãè±æ°Žçž®åç©ã§ãã€ãŠããããäžè¬ã«ãµãã«
ã©ã€ãåäœã3000以äžãç¹ã«1000以äžã®ãã®ãæ
ãŸããã ïŒå®èœé äœåååç©ïŒïŒãšããŠã¯ãæŸå°æ§é
å±å çŽ ïŒïŒã«å¯Ÿã匷åºãªãã¬ãŒãçµåã圢æ
ãããã€æ¯èŒçç·©åãªæ¡ä»¶äžã§ããªãµãã«ã©ã€ã
èªå°äœïŒïŒã®ãã«ãã«åºãšåå¿ãåŸãã¢ããåº
ãæãããã®ã䜿çšãããããã®ãããªïŒå®èœé
äœåååç©ïŒïŒã®å ·äœãšããŠã¯ãããšãããµã
ã³ïŒã¡ã«ã¯ã»ã€ã³ããã¯ã¹ã第ïŒçã374é
ïŒ1976幎ïŒïŒãåŒïŒ ïŒåŒäžãR1ããã³R2ããããæ°ŽçŽ ãC1ãC3ã¢ã«
ãã«ãŸãã¯ããšãã«ãè¡šããïŒã§è¡šãããïŒâã¢
ããã¡ãã¬ã³âïŒïŒïŒâãã³ã¿ã³ãžãªã³âãã¹
ïŒããªã»ãã«ã«ããŸã³ïŒèªå°äœïŒãšãŒãããç¹èš±
åºé¡ç¬¬54920å·æ现åºïŒãåŒïŒ ïŒåŒäžãR3ããã³R4ã¯ããããæ°ŽçŽ ãŸãã¯C1ã
C3ã¢ã«ãã«ãïœã¯ïŒãïŒã®æŽæ°ãè¡šããïŒã§è¡šã
ããïŒâïŒïœâã¢ããã¢ã«ãã«ïŒããšãã«ããã
ã³âïŒïŒïŒâãžãªã³âãã¹ïŒããªã»ãã«ã«ããŸ
ã³ïŒèªå°äœïŒãªãŒã¹ãã©ã€ã¢ç¹èš±ç¬¬533722å·æ现
æžïŒãªã©ãæããããã ãã®ãã®èªäœã¯ã¢ããåºãæããŠããªããŠã容
æã«ã¢ããåºãŸãã¯ã¢ããåºå«ææ§é ã圢æãåŸ
ãåºãŸãã¯æ§é ãæããŠããå Žåã¯ãæŸå°æ§éå±
å çŽ ãææããæ§è³ªãæããéãããã®ãã®ããŸ
ãã¢ããåºãŸãã¯ã¢ããåºå«ææ§é ã圢æããã
ãããã§ãïŒå®èœé äœåååç©ïŒïŒãšããŠäœ¿çš
ãåŸããããšãã°ãã«ã«ããã·ã«åºãæãããã®
ã¯ãããã«ã¢ã«ãã¬ã³ãžã¢ãã³ãåå¿ãããããš
ã«ãã€ãŠå®¹æã«ã¢ããåºãå°å ¥ããããšãåºæ¥ã
æ¬çºæã«ãããŠïŒå®èœé äœåååç©ïŒïŒã®ïŒçš®
ãšããŠäœ¿çšããããšãåºæ¥ãããã®ãããªïŒå®èœ
é äœåååç©ïŒïŒã®å ·äœäŸãšããŠã¯ããžãšãã¬
ã³ããªã¢ãã³äºé ¢é žïŒDTPAïŒããšãã¬ã³ãžã¢ã
ã³åé ¢é žïŒEDTAïŒããžã¡ã«ã«ããã¢ã»ãã«ãšã
ã¬ã³ãžã¢ãã³ïŒããªããããŒã¯ïŒFritzbergïŒ
ãïŒãžã€ãŒãã«ã»ãªãã»ãã¯ã¬ã¢ãŒã»ã¡ãã€ã¹ã³
ïŒJ.Nucl.Med.ïŒã23ã917ïŒ1982ïŒïŒããã³ãã¹ã¢
ãããšã¿ã³ããªãŒã«ïŒFritzbergãïŒJ.Nucl.
Med.ã25ã916ïŒ1984ïŒïŒã«ä»£è¡šãããN2S2ãªã¬
ã³ãããµã€ã¯ã©ã³ïŒã«ã€ãªã³ã°ïŒKeiringïŒãïŒ
ãžã€ãŒãã«ã»ãªãã»ãã¯ã¬ã¢ãŒã»ã¡ãã€ã¹ã³ïŒJ.
Nucl.Med.ïŒã23ã917ïŒ1982ïŒïŒã«ä»£è¡šãããN4
ãªã¬ã³ããïŒNâ²âãã¹ïŒïŒâããããã·ãšã
ã«ïŒãšãã¬ã³ãžã¢ãã³ïŒãã¯ããŒã»ãžãŠãã¢
ïŒWagnerJr.ïŒãïŒããã·ãŒãã€ã³ã°ã¹ã»ãªãã»
ã¶ã»ã€ã³ã¿ãŒãã·ãšãã«ã»ã·ã³ããžãŠã ã»ãªã³ã»
ãã¯ãããŠã ã»ã€ã³ã»ã±ãã¹ããªã€ã»ã¢ã³ãã»ã
ã¯ã¬ã¢ãŒã»ã¡ãã€ã¹ã³ãããããã€ã¿ãªã€
ïŒProceedings of the International Symposium
on Technetium in Chemistry and Nuclear
MedicineãPadovaãItaly.ïŒ161é ïŒ1982ïŒïŒã«
代衚ãããN2O2ãªã¬ã³ããåŒïŒ ïŒåŒäžãR5ãR6ãR7ãR8ããã³R9ã¯æ°ŽçŽ ãŸãã¯
C1ãC3ã¢ã«ãã«ïŒã§è¡šããããïŒâããããªã³
ã¢ã«ãããâãã¹ïŒããªã»ãã«ã«ããŸã³ïŒèªå°äœ
ïŒã¢ã¡ãªã«ç¹èš±ç¬¬4287362å·æ现æžïŒãªã©ãæãã
ããã é«ååååç©ïŒïŒã補é ããã«ã¯ãããšãã°
ããªãµãã«ã©ã€ãèªå°äœïŒïŒãšïŒå®èœé äœåå
åç©ïŒïŒãçž®åãããŠåè ã®ãã«ãã«åºãšåŸè
ã®ã¢ããåºã®éã§ã¡ãã¬ã³ã€ãã³çµåã圢æãã
ããå¿ èŠã«å¿ããã®ã¡ãã¬ã³ã€ãã³çµåãéå ã
ãŠã¡ãã¬ã³ã¢ãã³çµåã«å€æããã°ãããäžèšçž®
ååå¿ã¯ãã«ãã«åºãšã¢ããåºãçž®åããããã
ã«æ¡çšãããèªäœåžžå¥ã®æ段ã§è¡ãã°ãããäžèš
éå åå¿ãã¡ãã¬ã³ã€ãã³çµåãã¡ãã¬ã³ã¢ãã³
çµåã«å€æãããŠãã«æ¡çšãããŠããèªäœåžžå¥ã®
æ段ãããšãã°ãã¯æ°ŽçŽ åããŠçŽ ãããªãŠã ã®ã
ããªéå±æ°ŽçŽ åç©ã䜿çšããããšã«ããè¡ãªãã
ããäžèšéå åå¿ã«éãããµãã«ã©ã€ãåäœäžã®
ãã«ãã«åºãäžéšéå ãããååç©ãå¯çããã
ãšãããããããã«ãã€ãŠæ¬çºæã®ç®çã劚ãã
ããããšã¯ãªããåå¿è©Šå€ãåå¿æ¡ä»¶ãªã©ã®çžé
ã«ããããªãµãã«ã©ã€ãèªå°äœïŒïŒïŒååã«çµ
åããïŒå®èœé äœåååç©ïŒïŒã®ååæ°ã¯ç°ãª
ãããäžè¬ã«ã¯ïŒãŸãã¯ãã以äžãç¹ã«10ãŸãã¯
ãã以äžã奜ãŸããããã ãããã®åå¿ã§åŸãã
ãé«ååååç©ïŒïŒã®ããªãµãã«ã©ã€èªå°äœ
ïŒïŒéšåã«ãããå°ãªããšãïŒåã®ãã«ãã«åº
ã¯çç掻æ§ç©è³ªïŒïŒãšã®çµåã®ããéé¢ã®ãŸãŸ
æ®çãã¹ãã§ããã ããªãµãã«ã©ã€ãèªå°äœïŒïŒãšããŠã¢ãããŒ
ã¹ç±æ¥ã®ãã®ã䜿çšããå ŽåãäŸã«æããŠé«åå
ååç©ïŒïŒã®æ§é ãåŒã§ç€ºãã°æ¬¡ã®éãã§ã
ãïŒ ïŒåŒäžãã¯ïŒå®èœé äœåååç©ïŒïŒããã¢ã
ãåºãé€å»ããæ®åºãã¯âCHOãŸãã¯â
CH2OHãã¯ïŒã1000ã®æŽæ°ãïœãïœãïœãã
ã³ïœã¯ããããïŒã1000ã®æŽæ°ãè¡šãããã ãã
ïœïŒïœïŒïœïŒïœã¯ïŒã1000ã®æŽæ°ã§ãããïŒã ãªããäžåŒã«ãããŠãžã¢ã«ãããã¢ãããŒã¹
ïŒïœïŒã¯ã¢ãããŒã¹ãåæãšãããããéãšãŒ
ãé žã®ãããªé žåå€ã§éšåçãããã¯å šäœçã«é ž
åããããšã«ããåŸãããéç¶é«ååç©è³ªã§ãã€
ãŠãããèªäœåžè²©ãããŠããããã®ãµãã«ã©ã€ã
åäœã¯éåžžïŒã1000ã§ãããç¹ã«ïŒã500ã奜ãŸ
ããã ããã«çæããé«ååååç©ïŒïŒã¯ãå¿ èŠã«
å¿ããé«ååç©è³ªã«é©çšãããã«ã©ã ã¯ãããã°
ã©ãã€ãŒãã²ã«ãéæ³ãéææ³ãªã©ã®åžžå¥ã®ç²Ÿè£œ
æ³ã«ãã粟補ãããŠãããã æ¬çºæã®é«ååååç©ïŒïŒã¯ããã®ååäžã«
å°ãªããšãïŒåã®éé¢ãã«ãã«åºãååšããã
ãããã®ãã«ãã«åºãä»ããŠã¢ããåºãæããç
ç掻æ§ç©è³ªïŒïŒãšçµåããæŸå°æ§å»è¬å調補çš
ãã€ãªã€ãŒãæäŸããããšãåºæ¥ããããã§èšã
çç掻æ§ç©è³ªãšã¯ãé©åœãªåšå®ãŸãã¯çµç¹ããã
ã¯ç¹å®ã®ç å·£ã«èç©ããããç¹å®ã®ççç¶æ ã«å¯Ÿ
å¿ããŠç¹ç°ãªæåã瀺ãç©è³ªãæå³ããçäœå ã«
ããããã®ãããªç©è³ªã®æåã远跡ããããšã«ã
ã€ãŠèšºæäžæçšãªæ å ±ãåŸãããšãåºæ¥ããã®ã§
ãããçç掻æ§ç©è³ªã¯äžè¬ã«ããèªäœã§ã¢ããåº
ãæããŠãããã®ãå€ããããã®ãããªçç掻æ§
ç©è³ªã¯ããšãããããèªäœã§ã¯ã¢ããåºãæããŠ
ããªããã®ã§ãã€ãŠããããã«é©å®ã®æ¹æ³ã§ã¢ã
ãåºãŸãã¯ã¢ããåºå«ææ§é ãå°å ¥ãããã®ã䜿
çšããããšãåºæ¥ãããã«ãã«åºãšã¢ããåºã®é
ã®åå¿ã¯æ¯èŒçç·©åãªæ¡ä»¶äžã§é²è¡ãããããæ¬
çºæã«ãããŠæå©ã«å©çšããããšãåºæ¥ãã çç掻æ§ç©è³ªïŒïŒã®å ·äœäŸãšããŠã¯ãè¡æ¶²è
çœè³ªïŒããšãã°ããè¡æž ã¢ã«ããã³ããã€ããªã
ãŒã²ã³ïŒãé µçŽ ïŒããšãã°ãŠããããŒãŒãã¹ãã¬
ãããããŒãŒïŒããã«ã¢ã³ïŒããšãã°ç²ç¶è ºåºæ¿
ãã«ã¢ã³ãå¯ç²ç¶è ºãã«ã¢ã³ïŒãå ç«æäœïŒããš
ãã°IgGããã³ãã®æçã®ïŒŠïŒabïŒ2â²ãFabâ²ã
FabïŒãã¢ãã¯ããŒãã«æäœãæçç©è³ªïŒããšã
ã°ãã¬ãªãã€ã·ã³ãã«ããã€ã·ã³ïŒãç³é¡ãèèª
é žãã¢ããé žãªã©ãæããããã æ¬çºæã®é«ååååç©ïŒïŒã«å¯ŸããŠçç掻æ§
ç©è³ªïŒïŒãçµåããããã«ã¯ãããšãã°é«åå
ååç©ïŒïŒãšçç掻æ§ç©è³ªïŒïŒãçž®åãããŠ
åè ã®ãã«ãã«åºãšåŸè ã®ã¢ããåºã®éã§ã¡ãã¬
ã³ã€ãã³çµåã圢æããããå¿ èŠã«å¿ããã®ã¡ã
ã¬ã³ã€ãã³çµåãéå ããŠã¡ãã¬ã³ã¢ãã³çµåã«
å€æããã°ãããäžèšçž®ååå¿ãéå åå¿ãå ±ã«
èªäœåžžå¥ã®æ¹æ³ã§è¡ãã°ãããé«ååååç©
ïŒïŒã®ïŒåååœããå°å ¥ãããçç掻æ§ç©è³ªã®
ååæ°ã¯ãåå¿è©Šå€ãåå¿æ¡ä»¶ãªã©ã«ãã€ãŠç°ãª
ãããéåžžã¯10ãŸãã¯ãã以äžãç¹ã«ïŒãŸãã¯ã
ã以äžã奜ãŸããã ããã«çæããé«ååååç©ïŒïŒãšçç掻æ§
ç©è³ªïŒïŒã®çµåäœã¯å¿ èŠã«å¿ãé«ååç©è³ªé©çš
ãããã«ã©ã ã¯ãããã°ã©ãã€ãŒãã²ã«ãéæ³ã
éææ³ãªã©ã®åžžå¥ã®ç²Ÿè£œæ³ã«ãã粟補ãããŠãã
ãã ãã®é«ååååç©ïŒïŒâçç掻æ§ç©è³ªïŒïŒ
çµåäœã¯ãåèšã®ããã«æŸå°æ§å»è¬å調補çšãã€
ãªã€ãŒãšããŠæçšãªãã®ã§ãããããªãã¡ã該çµ
åäœã«ã¯é«ååååç©ïŒïŒã®éšåã«ïŒå®èœé äœ
åååç©ïŒïŒãè€æ°åååšããŠãããããã«ã
ã€ãŠè€æ°åã®æŸå°æ§éå±å çŽ ïŒïŒãææããã
ãšãå¯èœã§ããããã®ããã«è€æ°åã®æŸå°æ§éå±
å çŽ ïŒïŒãææããããçµåäœã¯ããèªäœæŸå°
æ§å»è¬åãšããŠäœ¿çšããããã ããã«æŸå°æ§éå±å çŽ ïŒïŒãšããŠã¯ãæŸå°èœ
ãæããéå±å çŽ ã§ãã€ãŠãæ žå»åŠç蚺æãæ²»ç
ã«é©ããç©ççãŸãã¯ååŠçç¹æ§ãæããããã
ïŒå®èœé äœåååç©ïŒïŒã®é äœåæ§é ã«ãã容
æã«ææãããããã®ã䜿çšãããããã®å ·äœäŸ
ãšããŠã¯ãã¬ãªãŠã â67ãã¬ãªãŠã â68ãã¿ãªãŠ
ã â201ãã€ã³ãžãŠã â111ããã¯ãããŠã â99ïœ
ãªã©ãããããããã¯éåžžãå¡©ãç¹ã«æ°Žæº¶æ§å¡©ã®
圢ã§äœ¿çšãããæ°Žæ§åªäœäžã«ãããŠé«ååååç©
ïŒïŒâçç掻æ§ç©è³ªïŒïŒçµåäœãšæ¥è§ŠããããŠ
ãã®æšèåãè¡ãããã ããæŸå°æ§éå±å çŽ
ïŒïŒãå®å®ãªãã¬ãŒãé¯äœã圢æãããåå䟡
ç¶æ ã«ããå Žåã«ã¯ïŒããšãã°ã«ãªãŠã â67ãã€
ã³ãžãŠã â111ïŒãåå¿ç³»ã«ä»ã®è©Šå€ãååšããã
ãå¿ èŠã¯ãªãããå®å®ãªãã¬ãŒãé¯äœã圢æãã
ããã«åå䟡ç¶æ ãå€åããããå¿ èŠãããå Žå
ã«ã¯ïŒããšãã°ãã¯ãããŠã â99mïŒãåå¿ç³»ã«
éå å€ãŸãã¯é žåå€ãååšããããå¿ èŠããã
ããéå å€ãšããŠã¯ãïŒäŸ¡ã®ã¹ãºå¡©ïŒããšãã°ã
ãã²ã³åã¹ãºãç¡«é žã¹ãºãç¡é žã¹ãºãé ¢é žã¹ãºã
ã¯ãšã³é žã¹ãºïŒãæããããã ããšãã°ãæŸå°æ§éå±å çŽ ïŒïŒãšããŠãã¯ã
ããŠã â99mã䜿çšããå Žåãé«ååååç©
ïŒïŒâçç掻æ§ç©è³ªïŒïŒçµåäœãæ°Žæ§åªäœäžé
å å€ãšããŠã®ç¬¬ïŒã¹ãºå¡©ã®ååšäžããŒãã¯ãããŒ
ãã®åœ¢ã®ãã¯ãããŠã â99mãšåŠçããããšã«ã
ã€ãŠãã¯ãããŠã â99mæšèé«ååååç©ïŒïŒ
âçç掻æ§ç©è³ªïŒïŒçµåäœã調補ããããšãã§
ãããäžèšèª¿è£œã«éããåè©Šå€ã®æ··åé åºã«ã€ã
ãŠæ Œå¥ã®å¶éã¯ãªãããéåžžãæ°Žæ§åªè³ªäžã§æå
ã«ç¬¬ïŒã¹ãºå¡©ãšããŒãã¯ãããŒããæ··åããããš
ã¯é¿ããæ¹ãæãŸããã第ïŒã¹ãºå¡©ã¯ããŒãã¯ã
ããŒããå åã«éå åºæ¥ãéã§äœ¿çšããã®ã奜ãŸ
ããã ãã®ããã«ããŠåŸãããæšèé«ååååç©
ïŒïŒâçç掻æ§ç©è³ªïŒïŒçµåäœãæŸå°æ§èšºæå€
ãšããŠæçšã§ããããã«ã¯ã蚺æãå¯èœãšããå
åãªæŸå°èœãšæŸå°èœæ¿åºŠãæããããšãå¿ èŠã§ã
ããããšãã°æŸå°æ§éå±å çŽ ãšããŠãã¯ãããŠã
â99mã䜿çšããå Žåãæäžæã«çŽ0.5ã5.0mlåœ
ãã0.1ã50mCiã®æŸå°èœæ¿åºŠãæããããšãæ
ãŸããããŸãããã®ãããªæšèé«ååååç©
ïŒïŒâçç掻æ§ç©è³ªïŒïŒçµåäœã¯èª¿è£œåŸçŽã¡ã«
æäžãããŠããããã奜ãŸããã¯èª¿è£œåŸé©åœæé
ä¿åã«èãããçšåºŠã®å®å®æ§ãæããããšãæãŸ
ããããªããŸããæšèé«ååååç©ïŒïŒâçç
掻æ§ç©è³ªïŒïŒçµåäœã«ã¯ãå¿ èŠã«å¿ãPH調ç¯å€
ïŒããšãã°é žãå¡©åºãç·©è¡å€ïŒãå®å®å€ïŒããšãã°
ã¢ã¹ã³ã«ãã³é žïŒãç匵å€ïŒããšãã°å¡©åãããª
ãŠã ïŒãªã©ãé åãããŠãããã æ¬çºæé«ååååç©ïŒïŒãçšããŠåŸãããæŸ
å°æ§å»è¬åã®äžäŸãããªãµãã«ã©ã€ãèªå°äœ
ïŒïŒãšããŠãžã¢ã«ãããã¢ãããŒã¹ãïŒå®èœé
äœåååç©ïŒïŒãšããŠãããšãããµã·ã³ãçç
掻æ§ç©è³ªïŒïŒãšããŠããè¡æž ã¢ã«ããã³ãæŸå°
æ§éå±å çŽ ïŒïŒãšããŠã¬ãªãŠã â67ã䜿çšãã
å Žåã«ã€ã説æããã°æ¬¡ã®éãã§ããã ãŸãããžã¢ã«ãããã¢ãããŒã¹ããããšãããµ
ãã³ãšçž®åãããåŸãå¿ èŠã«å¿ããŠéå ããããš
ã«ãããžã¢ã«ãããã¢ãããŒã¹âãããšãããµã
ã³çµåäœã調補ãããã®çµåäœã«ããè¡æž ã¢ã«ã
ãã³ãçž®åãããåŸãå¿ èŠã«å¿ããŠéå ããããš
ã«ããããè¡æž ã¢ã«ããã³âãžã¢ã«ãããã¢ãã
ãŒã¹âãããšãããµãã³çµåäœãåŸãããã®çµå
äœãšïŒäŸ¡ã®ã¬ãªãŠã ã€ãªã³ã®åœ¢ã§ã¬ãªãŠã â67ã
å«ã氎溶液ãæ¥è§Šãããããšã«ãããå®å®ã§é«æ¯
æŸå°èœã®ã¬ãªãŠã â67æšèããè¡æž ã¢ã«ããã³â
ãžã¢ã«ãããã¢ãããŒã¹âãããšãããµãã³çµå
äœãåŸãã ãã®æšèçµåäœã®é»æ°æ³³åçæåã¯ãããè¡æž
ã¢ã«ããã³ã®æåãšå šãåãã§ããããŸãããã®
æšèçµåäœã®ã©ããäœå ååžã¯åŸæ¥ã®ãšãŒãâ
131æšèããè¡æž ã¢ã«ããã³ãšã»ãŒåãã§ããã
è¡äžæ¿åºŠã®åæžæã¯çŽ30æéã§ããšãŒãâ131æš
èããè¡æž ã¢ã«ããã³ã®è¡äžæ¿åºŠã®åæžæïŒ5.7
æéïŒãããå åé·ããããªãã¡ãæ¬çºæã«ãã
æšèçµåäœã¯ãå¿ããŒã«åã®æåºã«æçšã§ããã
ãšãç解åºæ¥ãã æ¬çºæã«ããäžèšããè¡æž ã¢ã«ããã³âãžã¢ã«
ããããã¢ãããŒã¹âãããšãããµãã³çµåäœ
ïŒè©ŠæïŒïŒãšåŸæ¥æ³ã«ããããè¡æž ã¢ã«ããã³ãš
ãããšãããµã³ãçŽæ¥çµåããããã®ïŒè©ŠæïŒïŒ
ãšã®ã¬ãªãŠã â67ã1mCiã«å¯Ÿããæšèèœãæ¯èŒ
ãããšããã次ã®ãããªçµæãåŸãããã
ãè¡šã
è¡šïŒã«ç€ºãããšããæ¬çºæã«ãã調補ãããã
ã€ãªã€ãŒïŒè©ŠæïŒïŒã¯ãããè¡æž ã¢ã«ããã³0.52
mgã䜿çšããå Žåãå®çšçãªæšèæéã§ããïŒæ
éã«ãããŠã1mCiã®ã¬ãªãŠã â67ã100ïŒ æšèã
ããã®ã«å¯ŸããåŸæ¥æ³ã«ããéæŸå°æ§ãã€ãªã€ãŒ
ã¯åæ§ã®æ¡ä»¶äžã§15ïŒ ããæšèã§ããã100ïŒ ã®
æšèçãåŸãã«ã¯3.5mgãå¿ èŠãšããã 以äžã®çµæããæãããªããã«ãæ¬çºæé«åå
ååç©ïŒïŒã䜿çšããããšã«ãããé«æ¯æŸå°èœ
ã®æŸå°æ§å»è¬åã調補ããããšãå¯èœã§ããã 以äžã«å®æœäŸã瀺ããæ¬çºæãæŽã«å ·äœçã«èª¬
æããã å®æœäŸ ïŒ ãžã¢ã«ãããã¢ãããŒã¹âãããšãããµãã³çµ
åäœïŒçž®åäœïŒã®è£œé ïŒâ å¹³åååé2900ã®ãžã¢ã«ãããã¢ãããŒã¹ïŒä»¥
äžãDAAãšç¥ããïŒïŒ10mgïŒãæ°ŽïŒ0.4mlïŒã«æº¶è§£
ããããã®æº¶æ¶²ã液ãšãããå¥ã«ãããšãããµ
ãã³ïŒä»¥äžãDFOãšç¥ããïŒïŒ34mgïŒãæ°ŽïŒ0.6mlïŒ
ã«æº¶è§£ãããã®æº¶æ¶²ã«çã¢ã«éïŒ5.5mgïŒã®ããª
ãšãã«ã¢ãã³ãå ããããã®æº¶æ¶²ã液ãšããã
液ã宀枩ã«ãŠ10åéæ¹æåŸã液ã«å ãã30å
é宀枩ã«ãŠæ¹æãããçæããDAAâDFOçµå
äœã粟補ããããäžèšã®ã²ã«ã¯ãããã°ã©ãã€ãŒ
ãå®æœããã æ äœïŒã»ãã¢ããã¯ã¹ïŒ§â50 溶 åªïŒ0.03Mãªã³é žç·©è¡æ¶²ãPH7.0 ã«ã©ã ãµã€ãºïŒçŽåŸ2.2cmãé«ã30cm æµ éïŒ47mlïŒhr DAAâDFOçµåäœã¯ã70ã100mlã«æº¶åºããã
æªåå¿DFOã¯110ã130mlã«æº¶åºããããDAAâ
DFOçµåäœãå«ã70ã100mlã®æº¶åºæ¶²ãåçµä¹Ÿç¥
ããããšã«ããç®çã®é«ååååç©ãåŸãããšã
åºæ¥ãããã®é«ååååç©ãäžèšã®æ¡ä»¶ã§é«é液
äœã¯ãããã°ã©ãã€ãŒã«ããåæãè¡ããšä¿æäœ
ç©ã¯24.7mlã§ãã€ãããªãéé¢ã®DFOã¯æ€åºãã
ãªãã€ãïŒãã®ç³»ã§ã®DFOã®ä¿æäœç©ã¯29.2mlã§
ããïŒã ã«ã©ã ïŒTSKâ3000SW 溶 åªïŒ0.2Mãªã³é žç·©è¡æ¶²ãPH7.0 å§ åïŒ380psi æµ éïŒ0.75mlïŒmin åžå æ³¢é·ïŒ280nïœ å®æœäŸ ïŒ ãžã¢ã«ãããã¢ãããŒã¹âãããšãããµãã³çµ
åäœïŒçž®åéå äœïŒã®è£œé ïŒâ å¹³åååé2900ã®DAAïŒ10mgïŒãæ°ŽïŒ0.4mlïŒ
ã«æº¶è§£ããããã®æº¶æ¶²ã液ãšãããå¥ã«DFO
ïŒ38mgïŒãæ°ŽïŒ0.6mlïŒã«æº¶è§£ãããã®æº¶æ¶²ã«çã¢
ã«éïŒ5.5mgïŒã®ããªãšãã«ã¢ãã³ãå ãããã
ã®æº¶æ¶²ã液ãšããã液ã宀枩ã«ãŠ10åéæ¹æ
åŸã液ã«å ãã30åé宀枩ã«ãŠæ¹æããããã
ã«æ°ŽçŽ åããŠçŽ ãããªãŠã ïŒ2.4mgïŒãå ããçŽ
ïŒæé宀枩ã§æ¹æããªããéå ãããçæãã
DAAâDFOçµåäœã粟補ããããäžèšã®ã²ã«ã¯
ãããã°ã©ãã€ãŒãå®æœããã æ äœïŒã»ãã¢ããã¯ã¹ïŒ§â50 溶 åªïŒ0.03Mãªã³é žç·©è¡æ¶²ãPH7.0 ã«ã©ã ãµã€ãºïŒçŽåŸ2.2cmãé«ã30cm æµ éïŒ47mlïŒhr DAAâDFOçµåäœã¯ã75ã100mlã«æº¶åºããã
æªåå¿ã®DFOã¯110ã130mlã«æº¶åºããããDAA
âDFOçµåäœãå«ã75ã100mlã®æº¶åºæ¶²ãåçµä¹Ÿ
ç¥ããããšã«ããç®çã®é«ååååç©ãåŸãããš
ãåºæ¥ãããã®é«ååååç©ãäžèšã®æ¡ä»¶ã§é«é
液äœã¯ãããã°ã©ãã€ãŒã«ããåæãè¡ããšä¿æ
äœç©ã¯25.5mlã§ãã€ãããªããéé¢ã®DFOã¯æ€åº
ãããªãã€ãïŒãã®ç³»ã§ã®DFOã®ä¿æäœç©ã¯30.4
mlã§ããïŒã ã«ã©ã ïŒTSKâ3000SW 溶 åªïŒ0.2Mãªã³é žç·©è¡æ¶²ãPH7.0 å§ åïŒ380psi æµ éïŒ0.75mlïŒmin åžå æ³¢é·ïŒ280nïœ FeïŒïŒãšDFOã¯ïŒïŒïŒé¯äœã圢æãã420nïœ
ã«æ¥µå€§åžåãæãããFeïŒïŒâDFCé¯äœã®420n
ïœã«ãããEmaxã¯2.63Ã103ã§ãã€ããäžèšé«å
åååç©ã®æ¢ç¥éãæ°Žã«æº¶è§£ããDFOãšFeïŒïŒ
ãïŒïŒïŒé¯äœã圢æããã®ã«å åãªå¡©å第ïŒé溶
液ãå ããïŒæéé眮ããåŸã420nïœã«ããã
åžå 床ã枬å®ããããã®çµæãäžèšé«ååååç©
äžã«ãããŠDAA1åååœããDFO11.5åãçµåã
ãŠããããšã確èªããããåŸã€ãŠãäžèšé«ååå
åç©ã®å¹³åååéã¯çŽ10000ãšèšç®ãããã å®æœäŸ ïŒ ãžã¢ã«ãããã¢ãããŒã¹âïŒâãªããœããã©ãŒ
ã«ãã¹ïŒïŒ®âã¡ãã«ããªã»ãã«ã«ããŸã³ïŒã«ã«
ãã³é žã¢ãã³èªå°äœã®çµåäœïŒçž®åéå äœïŒã®
補é ïŒâ ïŒâãªããœããã©ãŒã«ãã¹ïŒïŒ®âã¡ãã«ããªã»
ãã«ã«ããŸã³ïŒã«ã«ãã³é žïŒä»¥äžãKTSãšç¥
ããïŒïŒ132mgïŒãç¡æ°Žãžãªããµã³ïŒïŒmlïŒã«æº¶è§£
ãã10âä»è¿ã«å·åŽããã®ã¡ãããªâïœâããã«
ã¢ãã³ïŒ0.12mlïŒãæŽã«ã€ãœããã«ã¯ãããã«ã¡
ã€ãïŒ64ÎŒïŒãå ããå枩床ã§çŽ50åéæ¹æã
ãŠãæ··åé žç¡æ°Žç©ãåŸãã å¥ã«ïŒ®âtertâããã«ãªãã·ã«ã«ããã«âïŒïŒ
ïŒâãããµã³ãžã¢ãã³ïŒ104mgïŒãç¡æ°Žãžãªããµ
ã³ïŒïŒmlïŒã«æº¶è§£ãã溶液ã調補ãããã®æº¶æ¶²ã
æ··åé žç¡æ°Žç©æº¶æ¶²ã«å ãã10âä»è¿ã§çŽ15æéæ¹
æããKTSââtertâããã«ãªãã·ã«ã«ããã«
âïŒïŒïŒâãããµã³ãžã¢ãã³çž®åäœãåŸãããã®
çž®åäœæº¶æ¶²ã«æ¿å¡©é žïŒïŒãïŒæ»ŽïŒãå ããŠPHïŒã«
äžããããšã«ããâtertâããã«ãªãã·ã«ã«ã
ãã«åºãé¢è±ããããKTSâãããµã³ãžã¢ãã³
çž®åäœã®æº¶æ¶²ãåŸãããããDAAïŒ83mgïŒã®ãžã¡
ãã«ã¹ã«ããã·ãïŒïŒmlïŒæº¶æ¶²ã«å ããåŸãæ°ŽçŽ
åããŠçŽ ãããªãŠã ïŒ17.2mgïŒãå ãã宀枩ã§çŽ
ïŒæéåå¿ãããDAAâãããµã³ãžã¢ãã³â
KTSçµåäœã®æº¶æ¶²ãåŸãã äžèšæº¶æ¶²ãéåžžã®éæããŠãŒãã«å ¥ããåžžæ³ã«
ãã30æééæããããšã«ãããæªåå¿è©Šè¬ãé€
å»ããããã«åçµä¹Ÿç¥ããããšã«ãããç®çãšã
ãé«ååååç©ãåŸãã ãããµã³ãžã¢ãã³âKTSçµåäœã®æ倧åžåã¯ã
æ³¢é·334nïœã«ååšãããã®Emaxã¯4.37Ã104ã§ã
ãããšã確èªãããäžèšé«ååååç©ãæ°Žã«æº¶è§£
ããŠïŒmgïŒmlã®æ¿åºŠãšããæ°Žãå¯Ÿç §ãšããŠ334n
ïœã§åžå 床ã枬å®ããããã®çµæãDAA1ååã
ããKTS10.5åãçµåããŠããããšã確èªãã
ããåŸã€ãŠãäžèšé«ååååç©ã®å¹³åååéã¯çŽ
7000ãšç®åºãããã å®æœäŸ ïŒ ãžã¢ã«ãããããã¹ãã©ã³âãããšãããµãã³
çµåäœïŒçž®åéå äœïŒã®è£œé ïŒâ DFOïŒ2.8ïœïŒãæ°ŽïŒ30mlïŒã«æº¶è§£ãããã®æº¶æ¶²
ã«çã¢ã«éïŒ432mgïŒã®ããªãšãã«ã¢ãã³ãå ãã
宀枩ã«ãŠ10åéæ¹æãããããããžã¢ã«ãããã
ãã¹ãã©ã³ïŒä»¥äžãDADãšç¥ããïŒïŒïŒïœïŒãã«
ãã«åºå«é5.1ÎŒmolïŒmgïŒã®æ°ŽïŒ40mlïŒæº¶æ¶²ã«å
ãã15åé宀枩ã«ãŠæ¹æãããããã«æ°ŽçŽ åããŠ
çŽ ãããªãŠã ïŒ167mgïŒãå ããçŽïŒæé宀枩ã§
æ¹æããªããéå ãããçæããDADâDFOçµ
åäœã粟補ãããããéæããŠãŒãã«å°å ¥ããæ°Ž
ã«å¯ŸããŠïŒæ¥ééæããåŸãäžèšã®ã²ã«ã¯ããã
ã°ã©ãã€ãŒãå®æœããã æ äœïŒã»ãã¢ããã¯ã¹ïŒ§â50 溶 åªïŒæ°Ž ã«ã©ã ãµã€ãºïŒçŽåŸ4.5cmãé«ã50cm æµ éïŒ2.5mlïŒmin DADâDFOçµåäœã¯ã300ã450mlã«æº¶åºã
ããæªåå¿DFOã¯550ã600mlã«æº¶åºãããã
DAOâDFOçµåäœãå«ã溶åºæ¶²ãåçµä¹Ÿç¥ãã
ããšã«ããç®çã®é«ååååç©ãåŸãããšãåºæ¥
ãããã®é«ååååç©ãäžèšã®æ¡ä»¶ã§é«é液äœã¯
ãããã°ã©ãã€ãŒã«ããåæãè¡ããšä¿æäœç©ã¯
27.3mlã§ãã€ãããªããéé¢ã®DFOã¯æ€åºãããª
ãã€ãïŒãã®ç³»ã§ã®DFOã®ä¿æäœç©ã¯32.8mlã§ã
ãïŒã ã«ã©ã ïŒTSKâ3000SW 溶 åªïŒ0.05Mããªã¹â0.15Må¡©åãããªãŠã â
å¡©é žç·©è¡æ¶²ãPH7.4 å§ åïŒ100KgïŒcm2 æµ éïŒ1.0mlïŒmin åžå æ³¢é·ïŒ280nïœ ä»¥äžã®å®æœäŸã¯æ¬çºæãäŸç€ºããããã«æå³ã
ãããã®ã§ããããã®ç¯å²ããªããå¶éãããã®
ã§ãªãã
ã€ãªã€ãŒïŒè©ŠæïŒïŒã¯ãããè¡æž ã¢ã«ããã³0.52
mgã䜿çšããå Žåãå®çšçãªæšèæéã§ããïŒæ
éã«ãããŠã1mCiã®ã¬ãªãŠã â67ã100ïŒ æšèã
ããã®ã«å¯ŸããåŸæ¥æ³ã«ããéæŸå°æ§ãã€ãªã€ãŒ
ã¯åæ§ã®æ¡ä»¶äžã§15ïŒ ããæšèã§ããã100ïŒ ã®
æšèçãåŸãã«ã¯3.5mgãå¿ èŠãšããã 以äžã®çµæããæãããªããã«ãæ¬çºæé«åå
ååç©ïŒïŒã䜿çšããããšã«ãããé«æ¯æŸå°èœ
ã®æŸå°æ§å»è¬åã調補ããããšãå¯èœã§ããã 以äžã«å®æœäŸã瀺ããæ¬çºæãæŽã«å ·äœçã«èª¬
æããã å®æœäŸ ïŒ ãžã¢ã«ãããã¢ãããŒã¹âãããšãããµãã³çµ
åäœïŒçž®åäœïŒã®è£œé ïŒâ å¹³åååé2900ã®ãžã¢ã«ãããã¢ãããŒã¹ïŒä»¥
äžãDAAãšç¥ããïŒïŒ10mgïŒãæ°ŽïŒ0.4mlïŒã«æº¶è§£
ããããã®æº¶æ¶²ã液ãšãããå¥ã«ãããšãããµ
ãã³ïŒä»¥äžãDFOãšç¥ããïŒïŒ34mgïŒãæ°ŽïŒ0.6mlïŒ
ã«æº¶è§£ãããã®æº¶æ¶²ã«çã¢ã«éïŒ5.5mgïŒã®ããª
ãšãã«ã¢ãã³ãå ããããã®æº¶æ¶²ã液ãšããã
液ã宀枩ã«ãŠ10åéæ¹æåŸã液ã«å ãã30å
é宀枩ã«ãŠæ¹æãããçæããDAAâDFOçµå
äœã粟補ããããäžèšã®ã²ã«ã¯ãããã°ã©ãã€ãŒ
ãå®æœããã æ äœïŒã»ãã¢ããã¯ã¹ïŒ§â50 溶 åªïŒ0.03Mãªã³é žç·©è¡æ¶²ãPH7.0 ã«ã©ã ãµã€ãºïŒçŽåŸ2.2cmãé«ã30cm æµ éïŒ47mlïŒhr DAAâDFOçµåäœã¯ã70ã100mlã«æº¶åºããã
æªåå¿DFOã¯110ã130mlã«æº¶åºããããDAAâ
DFOçµåäœãå«ã70ã100mlã®æº¶åºæ¶²ãåçµä¹Ÿç¥
ããããšã«ããç®çã®é«ååååç©ãåŸãããšã
åºæ¥ãããã®é«ååååç©ãäžèšã®æ¡ä»¶ã§é«é液
äœã¯ãããã°ã©ãã€ãŒã«ããåæãè¡ããšä¿æäœ
ç©ã¯24.7mlã§ãã€ãããªãéé¢ã®DFOã¯æ€åºãã
ãªãã€ãïŒãã®ç³»ã§ã®DFOã®ä¿æäœç©ã¯29.2mlã§
ããïŒã ã«ã©ã ïŒTSKâ3000SW 溶 åªïŒ0.2Mãªã³é žç·©è¡æ¶²ãPH7.0 å§ åïŒ380psi æµ éïŒ0.75mlïŒmin åžå æ³¢é·ïŒ280nïœ å®æœäŸ ïŒ ãžã¢ã«ãããã¢ãããŒã¹âãããšãããµãã³çµ
åäœïŒçž®åéå äœïŒã®è£œé ïŒâ å¹³åååé2900ã®DAAïŒ10mgïŒãæ°ŽïŒ0.4mlïŒ
ã«æº¶è§£ããããã®æº¶æ¶²ã液ãšãããå¥ã«DFO
ïŒ38mgïŒãæ°ŽïŒ0.6mlïŒã«æº¶è§£ãããã®æº¶æ¶²ã«çã¢
ã«éïŒ5.5mgïŒã®ããªãšãã«ã¢ãã³ãå ãããã
ã®æº¶æ¶²ã液ãšããã液ã宀枩ã«ãŠ10åéæ¹æ
åŸã液ã«å ãã30åé宀枩ã«ãŠæ¹æããããã
ã«æ°ŽçŽ åããŠçŽ ãããªãŠã ïŒ2.4mgïŒãå ããçŽ
ïŒæé宀枩ã§æ¹æããªããéå ãããçæãã
DAAâDFOçµåäœã粟補ããããäžèšã®ã²ã«ã¯
ãããã°ã©ãã€ãŒãå®æœããã æ äœïŒã»ãã¢ããã¯ã¹ïŒ§â50 溶 åªïŒ0.03Mãªã³é žç·©è¡æ¶²ãPH7.0 ã«ã©ã ãµã€ãºïŒçŽåŸ2.2cmãé«ã30cm æµ éïŒ47mlïŒhr DAAâDFOçµåäœã¯ã75ã100mlã«æº¶åºããã
æªåå¿ã®DFOã¯110ã130mlã«æº¶åºããããDAA
âDFOçµåäœãå«ã75ã100mlã®æº¶åºæ¶²ãåçµä¹Ÿ
ç¥ããããšã«ããç®çã®é«ååååç©ãåŸãããš
ãåºæ¥ãããã®é«ååååç©ãäžèšã®æ¡ä»¶ã§é«é
液äœã¯ãããã°ã©ãã€ãŒã«ããåæãè¡ããšä¿æ
äœç©ã¯25.5mlã§ãã€ãããªããéé¢ã®DFOã¯æ€åº
ãããªãã€ãïŒãã®ç³»ã§ã®DFOã®ä¿æäœç©ã¯30.4
mlã§ããïŒã ã«ã©ã ïŒTSKâ3000SW 溶 åªïŒ0.2Mãªã³é žç·©è¡æ¶²ãPH7.0 å§ åïŒ380psi æµ éïŒ0.75mlïŒmin åžå æ³¢é·ïŒ280nïœ FeïŒïŒãšDFOã¯ïŒïŒïŒé¯äœã圢æãã420nïœ
ã«æ¥µå€§åžåãæãããFeïŒïŒâDFCé¯äœã®420n
ïœã«ãããEmaxã¯2.63Ã103ã§ãã€ããäžèšé«å
åååç©ã®æ¢ç¥éãæ°Žã«æº¶è§£ããDFOãšFeïŒïŒ
ãïŒïŒïŒé¯äœã圢æããã®ã«å åãªå¡©å第ïŒé溶
液ãå ããïŒæéé眮ããåŸã420nïœã«ããã
åžå 床ã枬å®ããããã®çµæãäžèšé«ååååç©
äžã«ãããŠDAA1åååœããDFO11.5åãçµåã
ãŠããããšã確èªããããåŸã€ãŠãäžèšé«ååå
åç©ã®å¹³åååéã¯çŽ10000ãšèšç®ãããã å®æœäŸ ïŒ ãžã¢ã«ãããã¢ãããŒã¹âïŒâãªããœããã©ãŒ
ã«ãã¹ïŒïŒ®âã¡ãã«ããªã»ãã«ã«ããŸã³ïŒã«ã«
ãã³é žã¢ãã³èªå°äœã®çµåäœïŒçž®åéå äœïŒã®
補é ïŒâ ïŒâãªããœããã©ãŒã«ãã¹ïŒïŒ®âã¡ãã«ããªã»
ãã«ã«ããŸã³ïŒã«ã«ãã³é žïŒä»¥äžãKTSãšç¥
ããïŒïŒ132mgïŒãç¡æ°Žãžãªããµã³ïŒïŒmlïŒã«æº¶è§£
ãã10âä»è¿ã«å·åŽããã®ã¡ãããªâïœâããã«
ã¢ãã³ïŒ0.12mlïŒãæŽã«ã€ãœããã«ã¯ãããã«ã¡
ã€ãïŒ64ÎŒïŒãå ããå枩床ã§çŽ50åéæ¹æã
ãŠãæ··åé žç¡æ°Žç©ãåŸãã å¥ã«ïŒ®âtertâããã«ãªãã·ã«ã«ããã«âïŒïŒ
ïŒâãããµã³ãžã¢ãã³ïŒ104mgïŒãç¡æ°Žãžãªããµ
ã³ïŒïŒmlïŒã«æº¶è§£ãã溶液ã調補ãããã®æº¶æ¶²ã
æ··åé žç¡æ°Žç©æº¶æ¶²ã«å ãã10âä»è¿ã§çŽ15æéæ¹
æããKTSââtertâããã«ãªãã·ã«ã«ããã«
âïŒïŒïŒâãããµã³ãžã¢ãã³çž®åäœãåŸãããã®
çž®åäœæº¶æ¶²ã«æ¿å¡©é žïŒïŒãïŒæ»ŽïŒãå ããŠPHïŒã«
äžããããšã«ããâtertâããã«ãªãã·ã«ã«ã
ãã«åºãé¢è±ããããKTSâãããµã³ãžã¢ãã³
çž®åäœã®æº¶æ¶²ãåŸãããããDAAïŒ83mgïŒã®ãžã¡
ãã«ã¹ã«ããã·ãïŒïŒmlïŒæº¶æ¶²ã«å ããåŸãæ°ŽçŽ
åããŠçŽ ãããªãŠã ïŒ17.2mgïŒãå ãã宀枩ã§çŽ
ïŒæéåå¿ãããDAAâãããµã³ãžã¢ãã³â
KTSçµåäœã®æº¶æ¶²ãåŸãã äžèšæº¶æ¶²ãéåžžã®éæããŠãŒãã«å ¥ããåžžæ³ã«
ãã30æééæããããšã«ãããæªåå¿è©Šè¬ãé€
å»ããããã«åçµä¹Ÿç¥ããããšã«ãããç®çãšã
ãé«ååååç©ãåŸãã ãããµã³ãžã¢ãã³âKTSçµåäœã®æ倧åžåã¯ã
æ³¢é·334nïœã«ååšãããã®Emaxã¯4.37Ã104ã§ã
ãããšã確èªãããäžèšé«ååååç©ãæ°Žã«æº¶è§£
ããŠïŒmgïŒmlã®æ¿åºŠãšããæ°Žãå¯Ÿç §ãšããŠ334n
ïœã§åžå 床ã枬å®ããããã®çµæãDAA1ååã
ããKTS10.5åãçµåããŠããããšã確èªãã
ããåŸã€ãŠãäžèšé«ååååç©ã®å¹³åååéã¯çŽ
7000ãšç®åºãããã å®æœäŸ ïŒ ãžã¢ã«ãããããã¹ãã©ã³âãããšãããµãã³
çµåäœïŒçž®åéå äœïŒã®è£œé ïŒâ DFOïŒ2.8ïœïŒãæ°ŽïŒ30mlïŒã«æº¶è§£ãããã®æº¶æ¶²
ã«çã¢ã«éïŒ432mgïŒã®ããªãšãã«ã¢ãã³ãå ãã
宀枩ã«ãŠ10åéæ¹æãããããããžã¢ã«ãããã
ãã¹ãã©ã³ïŒä»¥äžãDADãšç¥ããïŒïŒïŒïœïŒãã«
ãã«åºå«é5.1ÎŒmolïŒmgïŒã®æ°ŽïŒ40mlïŒæº¶æ¶²ã«å
ãã15åé宀枩ã«ãŠæ¹æãããããã«æ°ŽçŽ åããŠ
çŽ ãããªãŠã ïŒ167mgïŒãå ããçŽïŒæé宀枩ã§
æ¹æããªããéå ãããçæããDADâDFOçµ
åäœã粟補ãããããéæããŠãŒãã«å°å ¥ããæ°Ž
ã«å¯ŸããŠïŒæ¥ééæããåŸãäžèšã®ã²ã«ã¯ããã
ã°ã©ãã€ãŒãå®æœããã æ äœïŒã»ãã¢ããã¯ã¹ïŒ§â50 溶 åªïŒæ°Ž ã«ã©ã ãµã€ãºïŒçŽåŸ4.5cmãé«ã50cm æµ éïŒ2.5mlïŒmin DADâDFOçµåäœã¯ã300ã450mlã«æº¶åºã
ããæªåå¿DFOã¯550ã600mlã«æº¶åºãããã
DAOâDFOçµåäœãå«ã溶åºæ¶²ãåçµä¹Ÿç¥ãã
ããšã«ããç®çã®é«ååååç©ãåŸãããšãåºæ¥
ãããã®é«ååååç©ãäžèšã®æ¡ä»¶ã§é«é液äœã¯
ãããã°ã©ãã€ãŒã«ããåæãè¡ããšä¿æäœç©ã¯
27.3mlã§ãã€ãããªããéé¢ã®DFOã¯æ€åºãããª
ãã€ãïŒãã®ç³»ã§ã®DFOã®ä¿æäœç©ã¯32.8mlã§ã
ãïŒã ã«ã©ã ïŒTSKâ3000SW 溶 åªïŒ0.05Mããªã¹â0.15Må¡©åãããªãŠã â
å¡©é žç·©è¡æ¶²ãPH7.4 å§ åïŒ100KgïŒcm2 æµ éïŒ1.0mlïŒmin åžå æ³¢é·ïŒ280nïœ ä»¥äžã®å®æœäŸã¯æ¬çºæãäŸç€ºããããã«æå³ã
ãããã®ã§ããããã®ç¯å²ããªããå¶éãããã®
ã§ãªãã
Claims (1)
- ïŒ (a)ããè¿ãåäœïŒã1000ã®ãžã¢ã«ãããã¢ã
ããŒã¹ãŸãã¯ãžã¢ã«ãããããã¹ãã©ã³ãš(b)ãã
ãšãããµãã³ãŸãã¯ïŒâãªããœããã©ãŒã«ãã¹
ïŒïŒ®âã¡ãã«ããªã»ãã«ã«ããŸã³ïŒã«ã«ãã³é žã»
ãžã¢ãã³çž®åäœãåè ïŒåååœããåŸè å°ãªããš
ãïŒååã®å²åã«ãããŠã¡ãã¬ã³ã€ãã³çµåïŒâ
CHïŒïŒ®âïŒãŸãã¯ã¡ãã¬ã³ã¢ãã³çµåïŒâ
CH2NHâïŒãä»ããŠçµåããŠæãå°ãªããšãïŒ
åã®éé¢ãã«ãã«åºãæããé«ååååç©ã
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US558333 | 1983-12-05 | ||
| US06/558,333 US4666697A (en) | 1982-12-08 | 1983-12-05 | Radioactive diagnostic agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60192703A JPS60192703A (ja) | 1985-10-01 |
| JPS6353201B2 true JPS6353201B2 (ja) | 1988-10-21 |
Family
ID=24229141
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59258138A Granted JPS60192703A (ja) | 1983-12-05 | 1984-12-05 | å°ãªããšãïŒåã®éé¢ãã«ãã«åºãæããé«ååååç© |
| JP59258139A Granted JPS60186502A (ja) | 1983-12-05 | 1984-12-05 | æŸå°æ§å»è¬åãšãã®èª¿è£œçšé«ååååç© |
| JP62268981A Granted JPS63225601A (ja) | 1983-12-05 | 1987-10-24 | æŸå°æ§å»è¬å調補çšé«ååååç© |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59258139A Granted JPS60186502A (ja) | 1983-12-05 | 1984-12-05 | æŸå°æ§å»è¬åãšãã®èª¿è£œçšé«ååååç© |
| JP62268981A Granted JPS63225601A (ja) | 1983-12-05 | 1987-10-24 | æŸå°æ§å»è¬å調補çšé«ååååç© |
Country Status (1)
| Country | Link |
|---|---|
| JP (3) | JPS60192703A (ja) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5672334A (en) * | 1991-01-16 | 1997-09-30 | Access Pharmaceuticals, Inc. | Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans |
| US5707604A (en) * | 1986-11-18 | 1998-01-13 | Access Pharmaceuticals, Inc. | Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles |
| US6106866A (en) * | 1995-07-31 | 2000-08-22 | Access Pharmaceuticals, Inc. | In vivo agents comprising cationic drugs, peptides and metal chelators with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles, including tumor sites |
| US11352325B2 (en) | 2011-09-28 | 2022-06-07 | Waters Technologies Corporation | Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals |
| EP3974412A1 (en) | 2011-09-28 | 2022-03-30 | Waters Technologies Corporation | Rapid fluorescence tagging of glycans and other biomolecules with enhanced ms signals |
| US10436790B2 (en) | 2011-09-28 | 2019-10-08 | Waters Technologies Corporation | Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals |
| JP6099055B2 (ja) * | 2014-05-09 | 2017-03-22 | ã¢ã³ã¹ãã£ã㥠ãã·ã§ãã« ã㥠㩠ãµã³ã ãš ã㥠㩠ã«ã·ã§ã«ã·ã¥ ã¡ãã£ã«ã« | å€æ§ç å€ã®èšºæã®ããã®ãªã¬ã³ããšããŠã®ãã³ã€ãã³ |
| CN115753702A (zh) | 2014-10-30 | 2023-03-07 | æ²ç¹äžç§æå ¬åž | å¿«éå¶å€æ è®°çè¡ç³åºèºååæç产æè¿°æ è®°çè¡ç³åºèºçç³åºåçç©ååçæ¹æ³ |
| US10502720B2 (en) | 2014-11-13 | 2019-12-10 | Waters Technologies Corporation | Methods for liquid chromatography calibration for rapid labeled N-glycans |
| WO2017222955A1 (en) | 2016-06-21 | 2017-12-28 | Waters Technologies Corporation | Methods of electrospray ionization of glycans modified with amphipathic, strongly basic moieties |
| US11061023B2 (en) | 2016-06-21 | 2021-07-13 | Waters Technologies Corporation | Fluorescence tagging of glycans and other biomolecules through reductive amination for enhanced MS signals |
| EP3479103B1 (en) | 2016-07-01 | 2022-04-20 | Waters Technologies Corporation | Methods for the rapid preparation of labeled glycosylamines from complex matrices using molecular weight cut off filtration and on-filter deglycosylation |
-
1984
- 1984-12-05 JP JP59258138A patent/JPS60192703A/ja active Granted
- 1984-12-05 JP JP59258139A patent/JPS60186502A/ja active Granted
-
1987
- 1987-10-24 JP JP62268981A patent/JPS63225601A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS60192703A (ja) | 1985-10-01 |
| JPS63225601A (ja) | 1988-09-20 |
| JPH0548761B2 (ja) | 1993-07-22 |
| JPS60186502A (ja) | 1985-09-24 |
| JPS641449B2 (ja) | 1989-01-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0233619B1 (en) | High molecular compounds having amino groups, and their utilization | |
| JP2752355B2 (ja) | æŸå°ç·æšèåãã¬ãŒã | |
| KR860000843B1 (ko) | ë°©ì¬ì± ì§ëšì ë° ê·žë¥Œ ìí ë¹ ë°©ì¬ì± ëŽì²Žì ì ì¡°ë°©ë² | |
| US5032678A (en) | Radio labeled high molecular compound comprising unit of asialoglycoprotein acceptor-directing compound and unit of chelate forming compound chemically bonded thereto | |
| US5130118A (en) | Methods and materials for the preparation of metal labelled antibody solutions | |
| JPS6353201B2 (ja) | ||
| JP2792871B2 (ja) | éå±ã€ãªã³ã®é€å»æ¹æ³ããã³ããã«çšãã溶液 | |
| US4431626A (en) | Tc-99m Labeled carrier for imaging | |
| JP2564459B2 (ja) | æŸå°æ§å»è¬å調補çšãã£ãªã€ãŒ | |
| JP2548711B2 (ja) | ã¢ããåºãšïŒå®èœæ§é äœåãæããåå¿æ§é«ååååç©ãšãã®å©çš | |
| JPH0421682B2 (ja) | ||
| JP2001507345A (ja) | å€ç³ããããèªå°äœ | |
| JPH0414084B2 (ja) | ||
| CA1258851A (en) | Chemical product useful as a non-radioactive carrier | |
| JPH0345723B2 (ja) | ||
| JPS59106425A (ja) | é«ååååç©å«ææŸå°æ§èšºæå€ | |
| JPS63170399A (ja) | æŸå°æ§å»è¬åãšãã®èª¿è£œçšé«ååååç© | |
| JPH0759524B2 (ja) | æŸå°æ§å»è¬åãšãã®èª¿è£œçšé«ååååç© | |
| JPH08253581A (ja) | çç掻æ§ç©è³ªçµåé«ååååç©ããã³åœè©²ååç©ãå«ãæŸå°æ§å»è¬å調補çšãã£ãªã¢ãŒ | |
| JPH01176000A (ja) | æŸå°æ§å»è¬åãšãã®èª¿è£œçšé«ååååç© | |
| JPH08259692A (ja) | æŸå°æ§éå±å çŽ çµåé«ååååç©ããã³åœè©²ååç©ãå«ãæŸå°æ§å»è¬å |