JPS6434976A - Gamma-lactonecarboxylic acid derivative and production thereof - Google Patents
Gamma-lactonecarboxylic acid derivative and production thereofInfo
- Publication number
- JPS6434976A JPS6434976A JP62270605A JP27060587A JPS6434976A JP S6434976 A JPS6434976 A JP S6434976A JP 62270605 A JP62270605 A JP 62270605A JP 27060587 A JP27060587 A JP 27060587A JP S6434976 A JPS6434976 A JP S6434976A
- Authority
- JP
- Japan
- Prior art keywords
- group
- formula
- compound expressed
- lactonecarboxylic
- gamma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002253 acid Substances 0.000 title 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- CZOWRZAJBCNLLX-UHFFFAOYSA-N (4-nitrophenyl)methyl 5-oxo-2-phenoxyoxolane-2-carboxylate Chemical compound C1=CC([N+](=O)[O-])=CC=C1COC(=O)C1(OC=2C=CC=CC=2)OC(=O)CC1 CZOWRZAJBCNLLX-UHFFFAOYSA-N 0.000 abstract 1
- 230000009435 amidation Effects 0.000 abstract 1
- 238000007112 amidation reaction Methods 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound expressed by formula I (R<1> represents organic residue bonding through carbon atom; R<2> represents carboxyl group which may be esterified or amidated; X represents O or S which may be oxidized) or salt thereof. EXAMPLE:4-Nitrobenzyl 2-phenoxy-5-oxo-2-tetrahydrofurancarboxylate. USE:An antibacterial agent. PREPARATION:A compound expressed by formula II (R<2>' represents esterified carboxy group; Z<1> represents leaving group) is condensed with a compound expressed by the formula R<1>'-X'-Z<2> (R<1>' is same as R<1>; X' represents O or S; Z<2> represents leaving group) and, as necessary, the group R<1>' is converted into the other R<1>. S is treated with an oxidizing agent and converted into oxidized S or the esterified carboxy group is subjected to hydrolysis, amidation or salt- forming reaction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62270605A JPH0791283B2 (en) | 1986-10-29 | 1987-10-27 | γ-Lactonecarboxylic acid derivative and method for producing the same |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25762986 | 1986-10-29 | ||
| JP8447787 | 1987-04-06 | ||
| JP62-84477 | 1987-04-06 | ||
| JP61-257629 | 1987-04-06 | ||
| JP62270605A JPH0791283B2 (en) | 1986-10-29 | 1987-10-27 | γ-Lactonecarboxylic acid derivative and method for producing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6434976A true JPS6434976A (en) | 1989-02-06 |
| JPH0791283B2 JPH0791283B2 (en) | 1995-10-04 |
Family
ID=27304557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62270605A Expired - Lifetime JPH0791283B2 (en) | 1986-10-29 | 1987-10-27 | γ-Lactonecarboxylic acid derivative and method for producing the same |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0791283B2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1950563A2 (en) | 2002-09-11 | 2008-07-30 | Michio Ishibashi | Method for screening for a substance for promoting regeneration of macrophages |
| JP2015172015A (en) * | 2014-03-11 | 2015-10-01 | 国立大学法人東北大学 | Derivatives of thiophene compounds, thiophene compounds and methods for producing them |
-
1987
- 1987-10-27 JP JP62270605A patent/JPH0791283B2/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1950563A2 (en) | 2002-09-11 | 2008-07-30 | Michio Ishibashi | Method for screening for a substance for promoting regeneration of macrophages |
| JP2015172015A (en) * | 2014-03-11 | 2015-10-01 | 国立大学法人東北大学 | Derivatives of thiophene compounds, thiophene compounds and methods for producing them |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0791283B2 (en) | 1995-10-04 |
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