KR900000074A - 초미세 리포좀 형태의 양쪽친화성 지질의 분산 콜로이드계를 제조하는 방법 - Google Patents

초미세 리포좀 형태의 양쪽친화성 지질의 분산 콜로이드계를 제조하는 방법 Download PDF

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KR900000074A
KR900000074A KR1019890009023A KR890009023A KR900000074A KR 900000074 A KR900000074 A KR 900000074A KR 1019890009023 A KR1019890009023 A KR 1019890009023A KR 890009023 A KR890009023 A KR 890009023A KR 900000074 A KR900000074 A KR 900000074A
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solvent
liposomes
substance
liquid phase
preparing
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KR960014869B1 (ko
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스뗑메쓰 세르주
패씨 아땅
드비싸게 쟝-필립
쀠시외 프랑스
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원본미기재
쌍트르 나시오날 드 라 르쉐르슈 씨앙띠피끄
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Cosmetics (AREA)

Abstract

내용 없음

Description

초미세 리포좀 형태의 양쪽친화성 지질의 분산 콜로이드계를 제조하는 방법.
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. (1)필수적으로, 용매 또는 용매 혼합물중의 양쪽친화성 지질 및 임의로는 물질 A의 용액으로 이루어지며, 또한 용액중에 물질 B를 함유할 수 있는 제1액상을 제조하고, (2)필수적으로 물 또는 물질 B의 수용액으로 이루어진 제2액상을 제조하고, (3)리포좀의 콜로이드 현탁액이 형성되도록 적절히 교반하면서 제1액상을 제2액상에 가한후, (4)경우에 따라, 목적하는 농도의 리포좀 콜로이드 현탁액이 형성되도록 용매 또는 용매 혼합물 및 물을 완전히 또는 부분적으로 제거시킴을 특징으로하여, 양쪽친화성지질 및 임의로는 물질 A로 이루어진 벽, 및 물 또는 임의로는 물질 B를 함유하는 수용액으로 이루어진 내부를 갖는, 초미세 크기의 올리고라멜라 리포좀 형태의 양쪽친화성 지질의 분산 콜로이드계를 제조하는 방법.
  2. 제1항에 있어서, 양쪽친화성 지질이 인지질인 방법.
  3. 제1항 또는 제2항에 있어서, 용매가 물과 모든 비율로 혼합될 수 있는 알코올인 방법.
  4. 제1항 내지 제3항중 어느 한항에 있어서, 알코올이 에탄올인 방법.
  5. 제1항 내지 제4항중 어느 한항에 있어서, 용매중 지질의 농도가 0.1내지 10중량%인 방법.
  6. 제5항에 있어서, 용매중 지질의 농도가 1내지 5중량%인 방법.
  7. 제1항 내지 제6항중 어느 한항에 있어서, 제1액상의 옹매의 용적이 제2수성상의 용적의 5내지 100%인 방법.
  8. 제1항 내지 제7항중 어느 한항에 있어서, 물질A가 콜레스테롤인 방법.
  9. 제1항 내지 제7항중 어느 한항에 있어서, 물질 B가 수용성 약제인 방법.
  10. 제1항 내지 제9항중 어느 한항에 있어서, 리포좀의 크기가 약100내지 300㎜인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890009023A 1988-06-30 1989-06-29 서브미크론 크기의 리포좀 형태의 양쪽친화성 지질의 분산성 콜로이드계를 제조하는 방법 Expired - Fee Related KR960014869B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8808874 1988-06-30
FR8808874A FR2634375B3 (fr) 1988-06-30 1988-06-30 Procede de preparation de systemes colloidaux dispersibles de lipide amphiphiles sous forme de liposomes submicroniques

Publications (2)

Publication Number Publication Date
KR900000074A true KR900000074A (ko) 1990-01-30
KR960014869B1 KR960014869B1 (ko) 1996-10-21

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ID=9367941

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KR1019890009023A Expired - Fee Related KR960014869B1 (ko) 1988-06-30 1989-06-29 서브미크론 크기의 리포좀 형태의 양쪽친화성 지질의 분산성 콜로이드계를 제조하는 방법

Country Status (8)

Country Link
EP (1) EP0349429B2 (ko)
JP (1) JPH0824840B2 (ko)
KR (1) KR960014869B1 (ko)
AT (1) ATE85888T1 (ko)
DE (1) DE68904999T3 (ko)
ES (1) ES2054053T5 (ko)
FR (1) FR2634375B3 (ko)
GR (2) GR3007265T3 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101405417B1 (ko) * 2007-07-19 2014-06-12 (주)아모레퍼시픽 라이소인지질 콜로이드의 상거동을 이용하여 경피흡수도가조절된 피부 외용제의 제조방법

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US20020150539A1 (en) 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
DE4013580A1 (de) * 1990-04-24 1991-10-31 Schering Ag Verfahren zur herstellung von wirkstoffhaltigen waessrigen liposomensuspensionen
ES2071081T3 (es) * 1990-06-11 1995-06-16 Idi Farmaceutici Spa Liposomas fosfolipidicos que contienen principios activos y un procedimiento para su obtencion.
FR2668063A1 (fr) * 1990-10-17 1992-04-24 Fabre Pierre Cosmetique Liposomes d'eaux thermales stabilises dans un gel d'adn.
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
EP0713387B1 (en) * 1993-08-06 1998-03-04 Opperbas Holding B.V. A method for preparation of vesicles loaded with biological structures, biopolymers and/or oligomers
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
AU2006200015B8 (en) * 1998-01-14 2008-02-21 Dupont Pharmaceuticals Company Preparation of a lipid blend and a phospholipid suspension containing a lipid blend, and contrast agents based on these
JP4758915B2 (ja) * 2004-08-06 2011-08-31 バイオスペクトラム，インコーポレイテッド 多重層リポソームおよびその製造方法
EP3138556B1 (en) 2014-04-30 2022-03-02 FUJIFILM Corporation Method for producing liposomes
IL296875A (en) 2014-12-31 2022-12-01 Lantheus Medical Imaging Inc Fat-wrapped gas microsphere preparations and related methods
CN109641068B (zh) 2016-05-04 2022-09-30 蓝瑟斯医学影像公司 用于制备超声波造影剂的方法及装置
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
IT201900004877A1 (it) 2019-04-01 2020-10-01 Res Pharma Ind S R L Processo di preparazione di sistemi colloidali concentrati

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CH621479A5 (ko) * 1977-08-05 1981-02-13 Battelle Memorial Institute
GR77320B (ko) * 1980-12-22 1984-09-11 Procter & Gamble
EP0069307B1 (de) * 1981-07-02 1986-03-05 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur Herstellung von Liposomenlösungen
JPS607932A (ja) * 1983-06-29 1985-01-16 Dai Ichi Seiyaku Co Ltd リポソーム懸濁液およびその製法
US4753788A (en) * 1985-01-31 1988-06-28 Vestar Research Inc. Method for preparing small vesicles using microemulsification

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101405417B1 (ko) * 2007-07-19 2014-06-12 (주)아모레퍼시픽 라이소인지질 콜로이드의 상거동을 이용하여 경피흡수도가조절된 피부 외용제의 제조방법

Also Published As

Publication number Publication date
GR3022121T3 (en) 1997-03-31
EP0349429B2 (fr) 1996-11-20
JPH02149336A (ja) 1990-06-07
GR3007265T3 (en) 1993-07-30
EP0349429A2 (fr) 1990-01-03
EP0349429B1 (fr) 1993-02-24
FR2634375B3 (fr) 1991-07-05
ATE85888T1 (de) 1993-03-15
EP0349429A3 (en) 1990-08-22
KR960014869B1 (ko) 1996-10-21
ES2054053T3 (es) 1994-08-01
DE68904999D1 (de) 1993-04-01
FR2634375A1 (fr) 1990-01-26
JPH0824840B2 (ja) 1996-03-13
DE68904999T3 (de) 1997-06-12
DE68904999T2 (de) 1993-09-02
ES2054053T5 (es) 1997-01-16

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