LT3187B - Method for determination of glucose in whole blood, single use cuvette and photometer for carrying out said method - Google Patents

Method for determination of glucose in whole blood, single use cuvette and photometer for carrying out said method Download PDF

Info

Publication number: LT3187B
Authority: LT; Lithuania
Prior art keywords: glucose; sample; reagent; blood; chemical reaction
Prior art date: 1989-04-25

Application number

LTIP276A

Other languages

English (en)

Lithuanian (lt)

Inventor

Jan Evert Lilja

Sven-Erik Lennart Nilsson

Original Assignee

Migrata Uk Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-25

Filing date

1992-12-30

Publication date

1995-03-27

1992-12-30 Application filed by Migrata Uk Ltd filed Critical Migrata Uk Ltd

1994-10-25 Publication of LTIP276A publication Critical patent/LTIP276A/xx

1995-03-27 Publication of LT3187B publication Critical patent/LT3187B/lt

Links

WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 84
239000008103 glucose Substances 0.000 title claims abstract description 84
210000004369 blood Anatomy 0.000 title claims abstract description 65
239000008280 blood Substances 0.000 title claims abstract description 65
238000000034 method Methods 0.000 title claims description 41
239000003153 chemical reaction reagent Substances 0.000 claims abstract description 44
238000006243 chemical reaction Methods 0.000 claims abstract description 27
238000010521 absorption reaction Methods 0.000 claims abstract description 23
102000001554 Hemoglobins Human genes 0.000 claims abstract description 20
108010054147 Hemoglobins Proteins 0.000 claims abstract description 20
238000005259 measurement Methods 0.000 claims abstract description 16
230000008859 change Effects 0.000 claims abstract description 6
230000002949 hemolytic effect Effects 0.000 claims abstract description 5
239000000523 sample Substances 0.000 claims description 29
108010050375 Glucose 1-Dehydrogenase Proteins 0.000 claims description 13
238000002835 absorbance Methods 0.000 claims description 5
238000011481 absorbance measurement Methods 0.000 claims description 5
230000008569 process Effects 0.000 claims description 5
102000020006 aldose 1-epimerase Human genes 0.000 claims description 3
108091022872 aldose 1-epimerase Proteins 0.000 claims description 3
239000013026 undiluted sample Substances 0.000 claims description 2
238000005070 sampling Methods 0.000 claims 2
238000002347 injection Methods 0.000 claims 1
239000007924 injection Substances 0.000 claims 1
239000003795 chemical substances by application Substances 0.000 abstract description 4
210000000601 blood cell Anatomy 0.000 abstract 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 67
230000003287 optical effect Effects 0.000 description 10
239000000126 substance Substances 0.000 description 10
238000005375 photometry Methods 0.000 description 6
238000010276 construction Methods 0.000 description 5
210000003743 erythrocyte Anatomy 0.000 description 5
239000004973 liquid crystal related substance Substances 0.000 description 5
239000000243 solution Substances 0.000 description 5
206010018910 Haemolysis Diseases 0.000 description 4
BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 description 4
206010012601 diabetes mellitus Diseases 0.000 description 4
230000008588 hemolysis Effects 0.000 description 4
229950006238 nadide Drugs 0.000 description 4
238000002834 transmittance Methods 0.000 description 4
108010015776 Glucose oxidase Proteins 0.000 description 3
239000004366 Glucose oxidase Substances 0.000 description 3
238000004458 analytical method Methods 0.000 description 3
230000008901 benefit Effects 0.000 description 3
238000010790 dilution Methods 0.000 description 3
239000012895 dilution Substances 0.000 description 3
229940116332 glucose oxidase Drugs 0.000 description 3
235000019420 glucose oxidase Nutrition 0.000 description 3
239000000203 mixture Substances 0.000 description 3
230000032683 aging Effects 0.000 description 2
WQZGKKKJIJFFOK-DVKNGEFBSA-N alpha-D-glucose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-DVKNGEFBSA-N 0.000 description 2
230000005540 biological transmission Effects 0.000 description 2
238000004364 calculation method Methods 0.000 description 2
210000004027 cell Anatomy 0.000 description 2
238000001514 detection method Methods 0.000 description 2
239000003599 detergent Substances 0.000 description 2
238000003745 diagnosis Methods 0.000 description 2
238000009434 installation Methods 0.000 description 2
229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 2
238000006395 oxidase reaction Methods 0.000 description 2
230000002093 peripheral effect Effects 0.000 description 2
210000002966 serum Anatomy 0.000 description 2
238000012360 testing method Methods 0.000 description 2
-1 tetrazole salt Chemical class 0.000 description 2
PFKYCGAUNWCWNO-UHFFFAOYSA-N 1,5-diphenyl-1h-tetrazol-1-ium;bromide Chemical compound [Br-].C1=CC=CC=C1[NH+]1C(C=2C=CC=CC=2)=NN=N1 PFKYCGAUNWCWNO-UHFFFAOYSA-N 0.000 description 1
VDJKJPMLWJWQIH-UHFFFAOYSA-M 5-ethylphenazin-5-ium;ethyl sulfate Chemical compound CCOS([O-])(=O)=O.C1=CC=C2[N+](CC)=C(C=CC=C3)C3=NC2=C1 VDJKJPMLWJWQIH-UHFFFAOYSA-M 0.000 description 1
RXGJTUSBYWCRBK-UHFFFAOYSA-M 5-methylphenazinium methyl sulfate Chemical compound COS([O-])(=O)=O.C1=CC=C2[N+](C)=C(C=CC=C3)C3=NC2=C1 RXGJTUSBYWCRBK-UHFFFAOYSA-M 0.000 description 1
101710088194 Dehydrogenase Proteins 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
102000005548 Hexokinase Human genes 0.000 description 1
108700040460 Hexokinases Proteins 0.000 description 1
XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
208000003443 Unconsciousness Diseases 0.000 description 1
238000000862 absorption spectrum Methods 0.000 description 1
239000013543 active substance Substances 0.000 description 1
210000001789 adipocyte Anatomy 0.000 description 1
238000000149 argon plasma sintering Methods 0.000 description 1
238000003556 assay Methods 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
239000012752 auxiliary agent Substances 0.000 description 1
238000009534 blood test Methods 0.000 description 1
230000036760 body temperature Effects 0.000 description 1
238000011088 calibration curve Methods 0.000 description 1
230000000711 cancerogenic effect Effects 0.000 description 1
231100000315 carcinogenic Toxicity 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000013078 crystal Substances 0.000 description 1
230000007423 decrease Effects 0.000 description 1
230000002950 deficient Effects 0.000 description 1
238000006356 dehydrogenation reaction Methods 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
238000013461 design Methods 0.000 description 1
238000010586 diagram Methods 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000000428 dust Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
230000002124 endocrine Effects 0.000 description 1
230000002255 enzymatic effect Effects 0.000 description 1
238000006911 enzymatic reaction Methods 0.000 description 1
229940088598 enzyme Drugs 0.000 description 1
230000000925 erythroid effect Effects 0.000 description 1
230000005284 excitation Effects 0.000 description 1
210000003722 extracellular fluid Anatomy 0.000 description 1
238000001125 extrusion Methods 0.000 description 1
239000012634 fragment Substances 0.000 description 1
239000011521 glass Substances 0.000 description 1
230000005802 health problem Effects 0.000 description 1
238000003424 hydrogenase reaction Methods 0.000 description 1
230000002452 interceptive effect Effects 0.000 description 1
210000002977 intracellular fluid Anatomy 0.000 description 1
238000005342 ion exchange Methods 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
230000005226 mechanical processes and functions Effects 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
239000002245 particle Substances 0.000 description 1
230000035699 permeability Effects 0.000 description 1
239000004033 plastic Substances 0.000 description 1
238000012545 processing Methods 0.000 description 1
230000006920 protein precipitation Effects 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
238000011002 quantification Methods 0.000 description 1
239000001397 quillaja saponaria molina bark Substances 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
229930182490 saponin Natural products 0.000 description 1
150000007949 saponins Chemical class 0.000 description 1
238000000926 separation method Methods 0.000 description 1
238000004904 shortening Methods 0.000 description 1
229910052710 silicon Inorganic materials 0.000 description 1
239000010703 silicon Substances 0.000 description 1
238000005476 soldering Methods 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000002798 spectrophotometry method Methods 0.000 description 1
230000002269 spontaneous effect Effects 0.000 description 1
239000000725 suspension Substances 0.000 description 1
125000003831 tetrazolyl group Chemical group 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000007704 transition Effects 0.000 description 1
208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
- G01N2015/011—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells with lysing, e.g. of erythrocytes
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0321—One time use cells, e.g. integrally moulded
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0325—Cells for testing reactions, e.g. containing reagents
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0346—Capillary cells; Microcells
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
- G01N2021/3181—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths using LEDs
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/12—Circuits of general importance; Signal processing
- G01N2201/122—Kinetic analysis; determining reaction rate
- G01N2201/1222—Endpoint determination; reaction time determination
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/12—Circuits of general importance; Signal processing
- G01N2201/126—Microprocessor processing
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/493—Physical analysis of biological material of liquid biological material urine

Landscapes

Chemical & Material Sciences (AREA)
Physics & Mathematics (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
General Health & Medical Sciences (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
Spectroscopy & Molecular Physics (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Genetics & Genomics (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
Emergency Medicine (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Investigating Or Analysing Biological Materials (AREA)
Investigating Or Analysing Materials By Optical Means (AREA)
Optical Measuring Cells (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

LTIP276A 1989-04-25 1992-12-30 Method for determination of glucose in whole blood, single use cuvette and photometer for carrying out said method LT3187B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE8901514A SE466157B (sv)	1989-04-25	1989-04-25	Saett att bestaemma glukoshalten hos helblod samt engaangskuvett foer detta

Publications (2)

Publication Number	Publication Date
LTIP276A LTIP276A (en)	1994-10-25
LT3187B true LT3187B (en)	1995-03-27

Family

ID=20375801

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LTIP276A LT3187B (en)	1989-04-25	1992-12-30	Method for determination of glucose in whole blood, single use cuvette and photometer for carrying out said method

Country Status (18)

Country	Link
US (1)	US5866349A (de)
EP (1)	EP0469097B1 (de)
JP (1)	JPH0734758B2 (de)
KR (1)	KR960004040B1 (de)
AT (1)	ATE133453T1 (de)
AU (1)	AU632569B2 (de)
BR (1)	BR9007340A (de)
CA (1)	CA2053284C (de)
DE (1)	DE69025058T2 (de)
DK (1)	DK0469097T3 (de)
ES (1)	ES2081987T3 (de)
FI (1)	FI102192B (de)
LT (1)	LT3187B (de)
LV (1)	LV10121B (de)
NO (1)	NO300854B1 (de)
RU (1)	RU2050545C1 (de)
SE (1)	SE466157B (de)
WO (1)	WO1990012890A1 (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4935346A (en) *	1986-08-13	1990-06-19	Lifescan, Inc.	Minimum procedure system for the determination of analytes
SE520341C2 (sv)	1998-01-14	2003-06-24	Hemocue Ab	Metod och förfarande för blandning i ett tunt vätskeskick
RU2163722C2 (ru) *	1999-05-12	2001-02-27	Рязанский государственный медицинский университет им. акад. И.П. Павлова	Способ определения моносахаридов в сыворотке крови
US6458326B1 (en)	1999-11-24	2002-10-01	Home Diagnostics, Inc.	Protective test strip platform
RU2157994C1 (ru) *	1999-12-30	2000-10-20	Институт молекулярной биологии им. В.А. Энгельгардта РАН	Способ проведения клинического и биохимического анализа биологических жидкостей и устройство для его осуществления (варианты)
US6485923B1 (en) *	2000-02-02	2002-11-26	Lifescan, Inc.	Reagent test strip for analyte determination having hemolyzing agent
SE518539C2 (sv) *	2000-06-28	2002-10-22	Migrata U K Ltd	Sätt och kyvett för kvantitativ hemoglobinbestämning i outspätt helblod
US6562625B2 (en)	2001-02-28	2003-05-13	Home Diagnostics, Inc.	Distinguishing test types through spectral analysis
US6525330B2 (en)	2001-02-28	2003-02-25	Home Diagnostics, Inc.	Method of strip insertion detection
US6541266B2 (en)	2001-02-28	2003-04-01	Home Diagnostics, Inc.	Method for determining concentration of an analyte in a test strip
RU2198402C2 (ru) *	2001-03-11	2003-02-10	ГУ Тверская государственная медицинская академия	Способ диагностики сахарного диабета
US6586195B1 (en)	2001-11-19	2003-07-01	R.E. Davis Chemical Corporation	Method of detecting sugars
SE0104443D0 (sv) *	2001-12-28	2001-12-28	Hemocue Ab	Analysis method and cuvette therefor
CA2446368C (en) *	2002-10-29	2014-10-14	Bayer Healthcare Llc	Diffuse reflectance readhead
EP1936356A1 (de) *	2002-10-29	2008-06-25	Bayer HealthCare LLC	Diffuser Reflexionslesekopf
US6900058B2 (en) *	2003-03-11	2005-05-31	Bionostics, Inc.	Control solution for photometric analysis
ATE509276T1 (de) *	2003-08-13	2011-05-15	Ceapro Inc	Diagnostische zusammensetzung für typ-2-diabetes und beeinträchtigte glucosetoleranz sowie verwendungsverfahren
EP2752662B1 (de) *	2004-02-06	2020-01-29	Ascensia Diabetes Care Holdings AG	Flüssigkeitstestsensor mit Öffnungen zur Steuerung des Flüssigkeitsstroms
JP4128160B2 (ja)	2004-06-30	2008-07-30	三洋電機株式会社	混合比検出装置の制御方法
CN101076728A (zh)	2004-12-13	2007-11-21	拜尔保健有限公司	区分含有共同的分析物的血液和对照溶液的方法
EP1875203B1 (de) *	2004-12-13	2011-05-04	Bayer HealthCare LLC	Transmissionspektroskopiesystem zur verwendung bei der bestimmung von analyten in körperflüssigkeit
US20060281187A1 (en)	2005-06-13	2006-12-14	Rosedale Medical, Inc.	Analyte detection devices and methods with hematocrit/volume correction and feedback control
US8801631B2 (en)	2005-09-30	2014-08-12	Intuity Medical, Inc.	Devices and methods for facilitating fluid transport
JP5232003B2 (ja)	2005-09-30	2013-07-10	インテュイティメディカルインコーポレイテッド	多部分体液試料採取及び分析カートリッジ
SE531041C2 (sv) *	2006-07-17	2008-11-25	Hemocue Ab	Räkning av trombocyter
US7797987B2 (en) *	2006-10-11	2010-09-21	Bayer Healthcare Llc	Test sensor with a side vent and method of making the same
US20080105024A1 (en) *	2006-11-07	2008-05-08	Bayer Healthcare Llc	Method of making an auto-calibrating test sensor
WO2008076212A1 (en) *	2006-12-13	2008-06-26	Bayer Healthcare Llc	Biosensor with coded information and method for manufacturing the same
US20080248581A1 (en) *	2007-04-06	2008-10-09	Bayer Healthcare Llc	Method for performing correction of blood glucose assay bias using blood hemoglobin concentration
MX2010001470A (es) *	2007-08-06	2010-03-01	Bayer Healthcare Llc	Sistema y metodo para la calibracion automatica.
WO2009050177A1 (en) *	2007-10-15	2009-04-23	Ima Life S.R.L.	Inline measurement of moving containers with infrared (ir) spectroscopy
US8241488B2 (en)	2007-11-06	2012-08-14	Bayer Healthcare Llc	Auto-calibrating test sensors
DE102008006245A1 (de) *	2008-01-25	2009-07-30	Nirlus Engineering Ag	Verfahren zur nichtinvasiven, optischen Bestimmung der Temperatur eines Mediums
US20090205399A1 (en) *	2008-02-15	2009-08-20	Bayer Healthcare, Llc	Auto-calibrating test sensors
JP2011516118A (ja)	2008-03-25	2011-05-26	ザ・キュレイターズ・オブ・ザ・ユニバーシティ・オブ・ミズーリ	グルコース以外の１つ以上の成分のスペクトルデータを使用して非侵襲で血糖を検出するための方法およびシステム
CN102988061B (zh) *	2008-05-22	2015-04-01	密苏里大学董事会	用光谱数据分析进行无创的光学血糖检测的方法和系统
WO2009145920A1 (en)	2008-05-30	2009-12-03	Intuity Medical, Inc.	Body fluid sampling device -- sampling site interface
US10383556B2 (en)	2008-06-06	2019-08-20	Intuity Medical, Inc.	Medical diagnostic devices and methods
JP5642066B2 (ja)	2008-06-06	2014-12-17	インテュイティメディカルインコーポレイテッド	体液の試料内に含まれている検体の存在または濃度を決定する検定を行う方法および装置
EP2169384B1 (de) *	2008-09-30	2013-04-10	General Electric Company	IR-Gassensor mit einem vereinfachten Strahlenteiler.
US8424763B2 (en) *	2008-10-07	2013-04-23	Bayer Healthcare Llc	Method of forming an auto-calibration circuit or label
WO2010048277A2 (en)	2008-10-21	2010-04-29	Bayer Healthcare Llc	Optical auto-calibration method
CN104297248B (zh)	2008-12-18	2018-09-14	安晟信医疗科技控股公司	用于测定流体样本中的分析物浓度的测试传感器
RU2405148C2 (ru) *	2009-02-25	2010-11-27	Государственное образовательное учреждение высшего профессионального образования "Нижегородская государственная медицинская академия Федерального Агентства по здравоохранению и социальному развитию" (ГОУ ВПО НижГМА Росздрава)	Способ диагностики сахарного диабета
EP3106871B1 (de)	2009-11-30	2021-10-27	Intuity Medical, Inc.	Verfahren zum verifizieren der genauigkeit des betriebs einer analyt-überwachungsvorrichtung
EP2550530A1 (de) *	2010-03-22	2013-01-30	Bayer HealthCare LLC	Restkompensation für einen biosensor
EP3750480B1 (de)	2011-08-03	2022-02-02	Intuity Medical, Inc.	Vorrichtung zur entnahme von körperflüssigkeiten
RU2509297C1 (ru) *	2012-08-31	2014-03-10	Закрытое акционерное общество Научно-производственное предприятие "ТЕХНОМЕДИКА"	Фотометрический анализатор с ячейкой для установки оптической наливной кюветы
DE102012018015B3 (de) *	2012-09-06	2013-12-05	Jenoptik Polymer Systems Gmbh	Messmodul zur remissions-photometrischen Analyse und Verfahren zu dessen Herstellung
FR3038723B1 (fr)	2015-07-07	2019-06-14	Commissariat A L'energie Atomique Et Aux Energies Alternatives	Procede d’estimation d’une quantite d’analyte dans un liquide
JP6757400B2 (ja)	2016-03-08	2020-09-16	テルモ株式会社	成分測定装置、成分測定方法及び成分測定プログラム
FR3049062B1 (fr)	2016-03-17	2023-06-02	Commissariat Energie Atomique	Procede de caracterisation d’un echantillon liquide comportant des particules
MX2019005697A (es) *	2016-11-18	2020-02-07	Siemens Healthcare Diagnostics Inc	Medicion de longitud de onda secuencial multiple de una muestra liquida.
JP7155109B2 (ja)	2017-03-23	2022-10-18	テルモ株式会社	成分測定装置及び成分測定装置セット
CN110609002B (zh) *	2018-12-29	2024-05-31	深圳迈瑞生物医疗电子股份有限公司	一种干扰检测方法及样本分析仪
CN110715923A (zh) *	2019-11-24	2020-01-21	天津市宝坻区人民医院	α-D-葡萄糖检测试剂盒

Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2964974A (en)	1957-12-24	1960-12-20	Cemam Conord Sa	Transmission means for clothes washing machines
US3964974A (en)	1972-09-28	1976-06-22	Merck Patent Gesellschaft Mit Beschrankter Haftung	Enzymatic determination of glucose
US4088448A (en)	1975-09-29	1978-05-09	Lilja Jan Evert	Apparatus for sampling, mixing the sample with a reagent and making particularly optical analyses
US4120755A (en)	1977-04-28	1978-10-17	Beckman Instruments, Inc.	Kinetic method for determination of glucose concentrations with glucose dehydrogenase
US4375105A (en)	1978-01-20	1983-02-22	Siemens Aktiengesellschaft	X-Ray diagnostic generator
EP0140337A2 (de)	1983-10-28	1985-05-08	EASTMAN KODAK COMPANY (a New Jersey corporation)	Element mit mehreren Zonen und Verfahren zur Bestimmung von Ganzblut

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3642444A (en) *	1969-05-02	1972-02-15	Minnesota Mining & Mfg	Analytical reagent and method for carbohydrate analysis in body fluids
US3615228A (en) *	1969-11-20	1971-10-26	Dow Chemical Co	Glucose determination method employing orthotoluidine
SE422115B (sv) *	1976-09-13	1982-02-15	Jan Evert Lilja	Kyvett enligt patenkravet 1 i patentet 7510863-9
DE3303098A1 (de) *	1983-01-31	1984-08-02	Boehringer Mannheim Gmbh, 6800 Mannheim	Verfahren und reagenz zur glucosebestimmung im haemolysierten blut
GB2138936B (en) *	1983-04-26	1986-09-10	Gen Electric Co Plc	Optical sensor systems
US5112490A (en) *	1986-02-19	1992-05-12	Jon Turpen	Sample filtration, separation and dispensing device
US4865813A (en) *	1986-07-07	1989-09-12	Leon Luis P	Disposable analytical device
JPS6371653A (ja) *	1986-09-16	1988-04-01	Fuji Photo Film Co Ltd	全血希釈液
JPH0726960B2 (ja) *	1988-04-05	1995-03-29	富士写真フイルム株式会社	乾式全血分析要素

1989
- 1989-04-25 SE SE8901514A patent/SE466157B/sv not_active IP Right Cessation
1990
- 1990-04-24 EP EP90908120A patent/EP0469097B1/de not_active Expired - Lifetime
- 1990-04-24 JP JP2507032A patent/JPH0734758B2/ja not_active Expired - Fee Related
- 1990-04-24 AT AT90908120T patent/ATE133453T1/de not_active IP Right Cessation
- 1990-04-24 RU SU905010233A patent/RU2050545C1/ru active
- 1990-04-24 DK DK90908120.0T patent/DK0469097T3/da active
- 1990-04-24 CA CA002053284A patent/CA2053284C/en not_active Expired - Lifetime
- 1990-04-24 BR BR909007340A patent/BR9007340A/pt not_active Application Discontinuation
- 1990-04-24 WO PCT/SE1990/000273 patent/WO1990012890A1/en not_active Ceased
- 1990-04-24 ES ES90908120T patent/ES2081987T3/es not_active Expired - Lifetime
- 1990-04-24 AU AU55576/90A patent/AU632569B2/en not_active Ceased
- 1990-04-24 KR KR1019910701446A patent/KR960004040B1/ko not_active Expired - Fee Related
- 1990-04-24 DE DE69025058T patent/DE69025058T2/de not_active Expired - Lifetime
- 1990-04-24 US US07/768,255 patent/US5866349A/en not_active Expired - Lifetime
1991
- 1991-10-24 NO NO914182A patent/NO300854B1/no not_active IP Right Cessation
- 1991-10-24 FI FI915021A patent/FI102192B/fi active
1992
- 1992-12-17 LV LVP-92-307A patent/LV10121B/en unknown
- 1992-12-30 LT LTIP276A patent/LT3187B/lt not_active IP Right Cessation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2964974A (en)	1957-12-24	1960-12-20	Cemam Conord Sa	Transmission means for clothes washing machines
US3964974A (en)	1972-09-28	1976-06-22	Merck Patent Gesellschaft Mit Beschrankter Haftung	Enzymatic determination of glucose
US4088448A (en)	1975-09-29	1978-05-09	Lilja Jan Evert	Apparatus for sampling, mixing the sample with a reagent and making particularly optical analyses
US4120755A (en)	1977-04-28	1978-10-17	Beckman Instruments, Inc.	Kinetic method for determination of glucose concentrations with glucose dehydrogenase
US4375105A (en)	1978-01-20	1983-02-22	Siemens Aktiengesellschaft	X-Ray diagnostic generator
EP0140337A2 (de)	1983-10-28	1985-05-08	EASTMAN KODAK COMPANY (a New Jersey corporation)	Element mit mehreren Zonen und Verfahren zur Bestimmung von Ganzblut

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SKUGO WEST: "Analitinės chemijos pagrindai", pages: 29

Also Published As

Publication number	Publication date
JPH0734758B2 (ja)	1995-04-19
ATE133453T1 (de)	1996-02-15
AU5557690A (en)	1990-11-16
SE8901514L (sv)	1990-10-26
SE466157B (sv)	1992-01-07
EP0469097B1 (de)	1996-01-24
NO300854B1 (no)	1997-08-04
NO914182D0 (no)	1991-10-24
BR9007340A (pt)	1992-04-21
WO1990012890A1 (en)	1990-11-01
CA2053284C (en)	2001-12-11
FI102192B1 (fi)	1998-10-30
LV10121A (lv)	1994-05-10
AU632569B2 (en)	1993-01-07
DE69025058T2 (de)	1996-05-30
KR920701475A (ko)	1992-08-11
DK0469097T3 (da)	1996-02-19
US5866349A (en)	1999-02-02
NO914182L (no)	1991-10-24
JPH04504662A (ja)	1992-08-20
FI102192B (fi)	1998-10-30
LTIP276A (en)	1994-10-25
FI915021A0 (fi)	1991-10-24
ES2081987T3 (es)	1996-03-16
LV10121B (en)	1995-02-20
DE69025058D1 (de)	1996-03-07
SE8901514D0 (sv)	1989-04-25
RU2050545C1 (ru)	1995-12-20
EP0469097A1 (de)	1992-02-05
KR960004040B1 (ko)	1996-03-25
CA2053284A1 (en)	1990-10-26

Legal Events

Date	Code	Title	Description
2010-08-25	MM9A	Lapsed patents	Effective date: 20091230

Publication	Publication Date	Title
RU2050545C1 (ru)	1995-12-20	Способ определения содержания глюкозы в цельной крови, фотометр для его реализации
RU2302638C2 (ru)	2007-07-10	Способ анализа гемоглобина и система для его осуществления
Ettinger et al.	1952	A simplified photometric method for the determination of citric acid in biological fluids
US6750962B2 (en)	2004-06-15	Optics alignment and calibration system
Dawson et al.	1969	Direct determination of zinc in whole blood, plasma and urine by atomic absorption spectroscopy
CA2283154C (en)	2009-03-24	Method and apparatus for measurement of blood substitutes
JP4828168B2 (ja)	2011-11-30	測定中におけるキュベットの安定化
JP3014633B2 (ja)	2000-02-28	尿検査方法
US5989916A (en)	1999-11-23	Direct cholesterol assay reagent
EP1092978B1 (de)	2010-09-08	Verfahren zur Bestimmung der Heparinkonzentration in Flüssigproben
US5252488A (en)	1993-10-12	Circular dichroism and spectrophotometric absorption detection methods and apparatus
Fonseca-Wollheim	1993	Haemoglobin interference in the bichromatic spectrophotometry of NAD (P) H at 340/380 nm
IE910070A1 (en)	1991-07-17	Circular dichroism and spectrophotometric absorption¹detection methods and apparatus
Cimato et al.	1998	A spectrophotometric method for the determination of hydroperoxides in liposomes
He et al.	1993	Non-enzymatic optical sensor for penicillins
SU1589162A1 (ru)	1990-08-30	Способ количественного определени олеиновой кислоты в пробе воды
AU7169291A (en)	1991-08-05	Circular dichroism and spectrophotometric absorption detection methods and apparatus
SU1617333A1 (ru)	1990-12-30	Способ определени производных амида сульфаниловой кислоты
SU1656417A1 (ru)	1991-06-15	Способ определени 2-( @ -аминобензолсульфамидо)-5-этил-1,3,4-тиадиазол-натри
SU1213400A1 (ru)	1986-02-23	Способ определени эрпенала
RU2093831C1 (ru)	1997-10-20	Способ определения концентрации креатинина в биологических жидкостях
ÅBerg	1967	Interference of light on the determination of low glucose concentrations with glucose oxidase
SU1684638A1 (ru)	1991-10-15	Способ количественного определени полиэтиленполиамина
SU1497526A1 (ru)	1989-07-30	Способ контрол степени очистки сахара
Shishkin et al.	2000	A portable reflectometric photometer for quantitative enzyme immunoassay