LT4545101T - Stabilūs, koncentruoti radionuklidų kompleksų tirpalai - Google Patents

Stabilūs, koncentruoti radionuklidų kompleksų tirpalai

Info

Publication number
LT4545101T
LT4545101T LTEP25162396.3T LT25162396T LT4545101T LT 4545101 T LT4545101 T LT 4545101T LT 25162396 T LT25162396 T LT 25162396T LT 4545101 T LT4545101 T LT 4545101T
Authority
LT
Lithuania
Prior art keywords
stable
complex solutions
radionuclide complex
concentrated
concentrated radionuclide
Prior art date
Application number
LTEP25162396.3T
Other languages
English (en)
Inventor
Daniela Chicco
Donato BARBATO
Francesco DE PALO
Lorenza Fugazza
Maurizio Mariani
Giovanni TESORIERE
Clementina BRAMBATI
Original Assignee
Advanced Accelerator Applications S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=63794577&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT4545101(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/IB2018/055575 external-priority patent/WO2020021310A1/en
Priority claimed from US16/045,484 external-priority patent/US20200030465A1/en
Application filed by Advanced Accelerator Applications S.A. filed Critical Advanced Accelerator Applications S.A.
Publication of LT4545101T publication Critical patent/LT4545101T/lt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/083Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0474Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A61K51/048DTPA (diethylenetriamine tetraacetic acid)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0474Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/121Solutions, i.e. homogeneous liquid formulation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
LTEP25162396.3T 2018-07-25 2018-09-25 Stabilūs, koncentruoti radionuklidų kompleksų tirpalai LT4545101T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/IB2018/055575 WO2020021310A1 (en) 2018-07-25 2018-07-25 Stable, concentrated radionuclide complex solutions
US16/045,484 US20200030465A1 (en) 2018-07-25 2018-07-25 Stable, concentrated radionuclide complex solutions

Publications (1)

Publication Number Publication Date
LT4545101T true LT4545101T (lt) 2026-03-10

Family

ID=63794577

Family Applications (6)

Application Number Title Priority Date Filing Date
LTEPPCT/IB2018/057415T LT3826686T (lt) 2018-07-25 2018-09-25 Stabilūs, koncentruoti radionuklidų kompleksų tirpalai
LTEP25162396.3T LT4545101T (lt) 2018-07-25 2018-09-25 Stabilūs, koncentruoti radionuklidų kompleksų tirpalai
LTEP25162394.8T LT4545100T (lt) 2018-07-25 2018-09-25 Stabilūs, koncentruoti radionuklidų kompleksų tirpalai
LTEP25162391.4T LT4541380T (lt) 2018-07-25 2018-09-25 Stabilūs, koncentruoti radionuklidų kompleksų tirpalai
LTEP25162390.6T LT4541379T (lt) 2018-07-25 2018-09-25 Stabilūs, koncentruoti radionuklidų kompleksų tirpalai
LTEP25162403.7T LT4541381T (lt) 2018-07-25 2018-09-25 Stabilūs, koncentruoti radionuklidų kompleksų tirpalai

Family Applications Before (1)

Application Number Title Priority Date Filing Date
LTEPPCT/IB2018/057415T LT3826686T (lt) 2018-07-25 2018-09-25 Stabilūs, koncentruoti radionuklidų kompleksų tirpalai

Family Applications After (4)

Application Number Title Priority Date Filing Date
LTEP25162394.8T LT4545100T (lt) 2018-07-25 2018-09-25 Stabilūs, koncentruoti radionuklidų kompleksų tirpalai
LTEP25162391.4T LT4541380T (lt) 2018-07-25 2018-09-25 Stabilūs, koncentruoti radionuklidų kompleksų tirpalai
LTEP25162390.6T LT4541379T (lt) 2018-07-25 2018-09-25 Stabilūs, koncentruoti radionuklidų kompleksų tirpalai
LTEP25162403.7T LT4541381T (lt) 2018-07-25 2018-09-25 Stabilūs, koncentruoti radionuklidų kompleksų tirpalai

Country Status (23)

Country Link
EP (7) EP4640241A3 (lt)
JP (3) JP7402218B2 (lt)
KR (4) KR102865113B1 (lt)
CN (5) CN120860272A (lt)
AU (6) AU2018433575B2 (lt)
BR (1) BR112021001148A2 (lt)
CA (1) CA3153630A1 (lt)
CO (1) CO2021000506A2 (lt)
DE (3) DE202018007007U1 (lt)
DK (6) DK4541379T3 (lt)
ES (2) ES3038413T3 (lt)
FI (6) FI4541380T3 (lt)
HR (6) HRP20260100T1 (lt)
HU (1) HUE072720T2 (lt)
IL (4) IL319541B2 (lt)
LT (6) LT3826686T (lt)
MX (2) MX2021000805A (lt)
PL (5) PL4545100T3 (lt)
PT (6) PT4541380T (lt)
RS (5) RS67729B1 (lt)
SG (1) SG11202100645XA (lt)
SI (3) SI4545100T1 (lt)
WO (1) WO2020021322A1 (lt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11541134B1 (en) 2021-08-02 2023-01-03 Rayzebio, Inc. Stabilized compositions of radionuclides and uses thereof
WO2023100852A1 (ja) * 2021-11-30 2023-06-08 日本メジフィジックス株式会社 安定化放射性医薬組成物
CN118159303A (zh) * 2022-02-04 2024-06-07 先进加速器应用公司 用于大规模合成放射性核素络合物的方法
CN114404618A (zh) * 2022-03-28 2022-04-29 北京先通国际医药科技股份有限公司 放射性药物水溶液及其用途
CN114404619A (zh) * 2022-03-28 2022-04-29 北京先通国际医药科技股份有限公司 放射性药物水溶液及其制备方法和用途
CN116920129A (zh) * 2022-04-02 2023-10-24 北京先通国际医药科技股份有限公司 放射性药物水溶液及其制备方法和用途
US20260102526A1 (en) * 2024-06-27 2026-04-16 Curium Us Llc 177lutetium-dota-tate formulations

Family Cites Families (16)

* Cited by examiner, † Cited by third party
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US2779780A (en) 1955-03-01 1957-01-29 Du Pont 1, 4-diamino-2, 3-dicyano-1, 4-bis (substituted mercapto) butadienes and their preparation
US4261989A (en) 1979-02-19 1981-04-14 Kaken Chemical Co. Ltd. Geldanamycin derivatives and antitumor drug
EP0647450A1 (en) 1993-09-09 1995-04-12 BEHRINGWERKE Aktiengesellschaft Improved prodrugs for enzyme mediated activation
US6066309A (en) * 1996-02-02 2000-05-23 Rhomed Incorporated Post-labeling stabilization of radiolabeled proteins and peptides
AU776788C (en) 1998-12-16 2005-10-27 Warner-Lambert Company Treatment of arthritis with MEK inhibitors
DZ3401A1 (fr) 2000-07-19 2002-01-24 Warner Lambert Co Esters oxygenes d'acides 4-iodophenylamino benzhydroxamiques
US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
JP4547911B2 (ja) 2002-02-01 2010-09-22 アリアド・ファーマシューティカルズ・インコーポレイテッド リン含有化合物およびその用途
AU2003224672B2 (en) 2002-03-08 2010-02-04 Eisai R&D Management Co., Ltd. Macrocyclic compounds useful as pharmaceuticals
SG2013013339A (en) 2002-03-13 2014-12-30 Array Biopharma Inc N3 alkylated benzimidazole derivatives as mek inhibitors
TWI275390B (en) 2002-04-30 2007-03-11 Wyeth Corp Process for the preparation of 7-substituted-3- quinolinecarbonitriles
CA2526556C (en) 2003-07-24 2012-09-25 Bracco Imaging S.P.A. Stable radiopharmaceutical compositions and methods for their preparation
MX2008002114A (es) 2005-07-21 2008-04-17 Ardea Biosciences Inc Inhibidores de n-(arilamino)-sulfonamida de mek.
WO2008009444A1 (en) 2006-07-19 2008-01-24 Van Dulmen, Adrianus, A. Use of ethanol for stabilizing a single-vial liquid formulation of a radiolabeled peptide
AU2017354941B2 (en) * 2016-11-04 2021-02-11 Clarity Pharmaceuticals Ltd Formulations for radiotherapy and diagnostic imaging
US10596276B2 (en) 2018-07-25 2020-03-24 Advanced Accelerator Applications (Italy) S.R.L. Stable, concentrated radionuclide complex solutions

Also Published As

Publication number Publication date
ES3038413T3 (en) 2025-10-13
CA3153630A1 (en) 2020-01-30
IL319541A (en) 2025-05-01
DE202018007006U1 (de) 2025-11-13
EP4541380B1 (en) 2025-12-10
EP4541381A3 (en) 2025-07-23
CN120860271A (zh) 2025-10-31
AU2025202231A1 (en) 2025-04-17
RS67034B1 (sr) 2025-08-29
KR20210035855A (ko) 2021-04-01
LT4545100T (lt) 2026-02-25
DK4545100T3 (da) 2026-02-23
DK3826686T3 (da) 2025-08-25
FI4541379T3 (fi) 2026-02-17
JP2025111424A (ja) 2025-07-30
HRP20250912T1 (hr) 2025-09-26
EP3826686A1 (en) 2021-06-02
EP4545100A3 (en) 2025-07-23
AU2025220852B2 (en) 2025-10-23
IL313560B2 (en) 2025-11-01
IL319541B2 (en) 2026-01-01
CN112584875A (zh) 2021-03-30
FI3826686T3 (fi) 2025-08-20
RS67729B1 (sr) 2026-03-31
CN120860272A (zh) 2025-10-31
FI4541381T3 (fi) 2026-04-01
PT4541379T (pt) 2026-01-29
AU2018433575A1 (en) 2021-02-11
IL313560A (en) 2024-08-01
AU2018433575B2 (en) 2022-07-07
MX2025012060A (es) 2025-11-03
PL4545100T3 (pl) 2026-03-30
BR112021001148A2 (pt) 2021-04-20
PL4541379T3 (pl) 2026-03-23
DK4541379T3 (da) 2026-02-02
PT4541381T (pt) 2026-03-17
HRP20260237T1 (hr) 2026-04-10
PT3826686T (pt) 2025-08-04
SI4541379T1 (sl) 2026-03-31
AU2022203683A1 (en) 2022-06-16
MX2021000805A (es) 2021-05-12
EP4541379B1 (en) 2025-11-19
SI4545100T1 (sl) 2026-03-31
EP4541381B1 (en) 2026-02-04
EP4541380A3 (en) 2025-07-23
JP7402218B2 (ja) 2023-12-20
EP4541379A2 (en) 2025-04-23
FI4541380T3 (fi) 2026-03-02
JP2022501313A (ja) 2022-01-06
CN121081692A (zh) 2025-12-09
AU2025204901A1 (en) 2025-07-17
EP4545101A3 (en) 2025-07-23
AU2025220852A1 (en) 2025-09-11
PT4545101T (pt) 2026-02-24
PT4545100T (pt) 2026-02-16
RS67667B1 (sr) 2026-02-27
PL4545101T3 (pl) 2026-03-30
KR102865113B1 (ko) 2025-09-26
HRP20260179T1 (hr) 2026-04-10
EP4640241A3 (en) 2025-12-10
PL3826686T3 (pl) 2025-09-22
HRP20260338T1 (hr) 2026-04-10
EP4541381A2 (en) 2025-04-23
AU2024201217B2 (en) 2025-02-27
PT4541380T (pt) 2026-02-24
IL319541B1 (en) 2025-09-01
FI4545101T3 (fi) 2026-02-24
JP7796696B2 (ja) 2026-01-09
LT4541380T (lt) 2026-03-10
EP4545100A2 (en) 2025-04-30
EP4541380A2 (en) 2025-04-23
CN120860270A (zh) 2025-10-31
CO2021000506A2 (es) 2021-04-19
IL319542B1 (en) 2026-04-01
IL313560B1 (en) 2025-07-01
RS67755B1 (sr) 2026-03-31
LT4541381T (lt) 2026-03-25
SG11202100645XA (en) 2021-02-25
ES3063402T3 (en) 2026-04-16
EP4640241A2 (en) 2025-10-29
SI3826686T1 (sl) 2025-09-30
EP4545101A2 (en) 2025-04-30
AU2022203683B2 (en) 2023-12-21
KR102932818B1 (ko) 2026-03-03
RS67754B1 (sr) 2026-03-31
DK4541380T3 (da) 2026-02-23
DK4545101T3 (da) 2026-03-02
IL280314A (en) 2021-03-25
PL4541380T3 (pl) 2026-03-30
LT4541379T (lt) 2026-02-10
IL319542A (en) 2025-05-01
LT3826686T (lt) 2025-08-25
FI4545100T3 (fi) 2026-03-02
DK4541381T3 (da) 2026-04-07
HRP20260100T1 (hr) 2026-04-10
KR20240033296A (ko) 2024-03-12
HRP20260222T1 (hr) 2026-03-27
EP4545100B1 (en) 2025-12-10
AU2024201217A1 (en) 2024-03-14
DE202018006567U1 (de) 2021-04-01
KR20260030955A (ko) 2026-03-06
EP3826686B1 (en) 2025-05-21
DE202018007007U1 (de) 2025-11-13
KR102643582B1 (ko) 2024-03-05
EP4541379A3 (en) 2025-07-23
KR20250017751A (ko) 2025-02-04
HUE072720T2 (hu) 2025-12-28
EP4545101B1 (en) 2025-12-10
AU2025204901B2 (en) 2025-09-18
JP2023117417A (ja) 2023-08-23
WO2020021322A1 (en) 2020-01-30

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