LU80509A1 - Nouveaux 1,9-dihydroxyoctahydrophenanthrenes et medicamentmedicament les contenant - Google Patents

Nouveaux 1,9-dihydroxyoctahydrophenanthrenes et medicamentmedicament les contenant Download PDF

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Publication number
LU80509A1
LU80509A1 LU80509A LU80509A LU80509A1 LU 80509 A1 LU80509 A1 LU 80509A1 LU 80509 A LU80509 A LU 80509A LU 80509 A LU80509 A LU 80509A LU 80509 A1 LU80509 A1 LU 80509A1
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Luxembourg
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group
carbon atoms
hydrogen atom
phenyl
methyl
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LU80509A
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English (en)
French (fr)
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C Harbert
M Johnson
T Althuis
L Melvin Jr
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Pfizer
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Publication of LU80509A1 publication Critical patent/LU80509A1/fr

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
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    • C07C45/73—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with hydrogenation
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    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
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    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
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    • C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes

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  • Chemical & Material Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
LU80509A 1977-11-14 1978-11-13 Nouveaux 1,9-dihydroxyoctahydrophenanthrenes et medicamentmedicament les contenant LU80509A1 (fr)

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Application Number Priority Date Filing Date Title
US85150377 1977-11-14
US05/851,503 US4188495A (en) 1977-11-14 1977-11-14 1,9-Dihydroxyoctahydrophenanthrenes and intermediates therefor

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LU80509A1 true LU80509A1 (fr) 1980-06-05

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US (1) US4188495A (de)
JP (1) JPS5484562A (de)
AR (1) AR220158A1 (de)
AT (1) AT358024B (de)
AU (1) AU509680B2 (de)
BE (1) BE871907A (de)
CA (1) CA1097668A (de)
CH (1) CH635813A5 (de)
DE (1) DE2849224C2 (de)
DK (3) DK414778A (de)
ES (1) ES475040A1 (de)
FI (1) FI71120C (de)
FR (2) FR2411821A1 (de)
GB (4) GB2078721B (de)
IE (1) IE47505B1 (de)
IL (1) IL55930A (de)
IT (1) IT1100945B (de)
LU (1) LU80509A1 (de)
NL (1) NL180206C (de)
PH (2) PH14713A (de)
PT (1) PT68775A (de)
SE (1) SE430983B (de)
YU (2) YU40834B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4285867A (en) * 1980-09-19 1981-08-25 Pfizer Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
US4473704A (en) * 1982-03-16 1984-09-25 Pfizer Inc. Substituted dodecahydrotriphenylenes, decahydro-1H-cyclopenta[1]phenanthrenes, decahydro-1H-pyrido[1,2-f]phenanthridines and decahydropyrrolo[1,2-f]phenanthridines as CNS agents
US4476131A (en) * 1982-03-16 1984-10-09 Pfizer Inc. Substituted hexahydropyrrolo[1,2-a]-quinolines, hexahydro-1H-pyrido[1,2-a]-q
US4576964A (en) * 1982-03-16 1986-03-18 Pfizer Inc. Substituted hexahydrobenzo[e]indene and octahydrophenanthrene CNS agents and pharmaceutical compositions thereof
US4486428A (en) * 1982-03-16 1984-12-04 Pfizer Inc. Bicyclic benzo fused compounds
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AU4152178A (en) 1979-05-24
US4188495A (en) 1980-02-12
BE871907A (fr) 1979-05-10
FI71120B (fi) 1986-08-14
NL180206B (nl) 1986-08-18
IE47505B1 (en) 1984-04-04
DE2849224A1 (de) 1979-05-17
FI783456A7 (fi) 1979-05-15
GB2007665A (en) 1979-05-23
IT1100945B (it) 1985-09-28
YU40834B (en) 1986-06-30
CH635813A5 (fr) 1983-04-29
FR2411821B1 (de) 1982-02-05
PT68775A (en) 1978-12-01
ATA812078A (de) 1980-01-15
PH15429A (en) 1983-01-18
JPS5484562A (en) 1979-07-05
FR2411821A1 (fr) 1979-07-13
GB2078721A (en) 1982-01-13
IE782238L (en) 1979-05-14
IL55930A (en) 1982-11-30
GB2078721B (en) 1982-08-11
DK463288D0 (da) 1988-08-18
NL7811235A (nl) 1979-05-16
FR2414035B1 (de) 1983-12-09
GB2007665B (en) 1982-08-18
SE7811653L (sv) 1979-05-15
YU261578A (en) 1983-06-30
IL55930A0 (en) 1979-01-31
PH14713A (en) 1981-11-13
AT358024B (de) 1980-08-11
GB2078720B (en) 1982-08-11
DK414778A (da) 1979-05-15
ES475040A1 (es) 1979-12-01
SE430983B (sv) 1983-12-27
DE2849224C2 (de) 1984-04-05
IT7829727A0 (it) 1978-11-13
DK463388D0 (da) 1988-08-18
DK463288A (da) 1988-08-18
GB2079269B (en) 1983-02-16
AR220158A1 (es) 1980-10-15
CA1097668A (en) 1981-03-17
GB2079269A (en) 1982-01-20
JPS5757015B2 (de) 1982-12-02
NL180206C (nl) 1987-01-16
FI71120C (fi) 1986-11-24
GB2078720A (en) 1982-01-13
DK463388A (da) 1988-08-18
FR2414035A1 (fr) 1979-08-03
AU509680B2 (en) 1980-05-22
YU277282A (en) 1986-04-30

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