LU82517A1 - Synthese de l'isopropylamino-2 pyrimidine - Google Patents

Synthese de l'isopropylamino-2 pyrimidine Download PDF

Info

Publication number: LU82517A1
Authority: LU; Luxembourg
Prior art keywords: pyrimidine; synthesis; isopropylamino; luxembourg; yield
Prior art date: 1979-07-04

Application number

LU82517A

Other languages

English (en)

French (fr)

Inventor

C Aspisi

C Demosthene

Original Assignee

Soc D Etudes Prod Chimique

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-07-04

Filing date

1980-06-11

Publication date

1980-10-24

1980-06-11 Application filed by Soc D Etudes Prod Chimique filed Critical Soc D Etudes Prod Chimique

1980-10-24 Publication of LU82517A1 publication Critical patent/LU82517A1/fr

Links

238000003786 synthesis reaction Methods 0.000 title claims description 11
230000015572 biosynthetic process Effects 0.000 title claims description 10
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
FTCYIGBVOHNHCD-UHFFFAOYSA-N isaxonine Chemical compound CC(C)NC1=NC=CC=N1 FTCYIGBVOHNHCD-UHFFFAOYSA-N 0.000 claims description 7
OIGXNHYFKZCTCH-UHFFFAOYSA-N 2-methylsulfonylpyrimidine Chemical compound CS(=O)(=O)C1=NC=CC=N1 OIGXNHYFKZCTCH-UHFFFAOYSA-N 0.000 claims description 6
JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 claims description 6
238000000034 method Methods 0.000 claims description 6
239000002904 solvent Substances 0.000 claims description 6
238000010992 reflux Methods 0.000 claims description 4
238000007098 aminolysis reaction Methods 0.000 claims description 3
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 5
239000000460 chlorine Substances 0.000 description 5
229910052801 chlorine Inorganic materials 0.000 description 5
FOEMIZSFFWGXHX-UHFFFAOYSA-N 2-methylsulfanylpyrimidine Chemical compound CSC1=NC=CC=N1 FOEMIZSFFWGXHX-UHFFFAOYSA-N 0.000 description 4
238000006243 chemical reaction Methods 0.000 description 4
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
230000005587 bubbling Effects 0.000 description 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
238000000605 extraction Methods 0.000 description 2
239000000203 mixture Substances 0.000 description 2
239000012074 organic phase Substances 0.000 description 2
HBCQSNAFLVXVAY-UHFFFAOYSA-N pyrimidine-2-thiol Chemical compound SC1=NC=CC=N1 HBCQSNAFLVXVAY-UHFFFAOYSA-N 0.000 description 2
238000004809 thin layer chromatography Methods 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
UNCQVRBWJWWJBF-UHFFFAOYSA-N 2-chloropyrimidine Chemical compound ClC1=NC=CC=N1 UNCQVRBWJWWJBF-UHFFFAOYSA-N 0.000 description 1
UZEKTDVGUQCDBI-UHFFFAOYSA-N 2-propan-2-ylguanidine Chemical compound CC(C)NC(N)=N UZEKTDVGUQCDBI-UHFFFAOYSA-N 0.000 description 1
125000002066 L-histidyl group Chemical group [H]N1C([H])=NC(C([H])([H])[C@](C(=O)[*])([H])N([H])[H])=C1[H] 0.000 description 1
239000007832 Na2SO4 Substances 0.000 description 1
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
239000007900 aqueous suspension Substances 0.000 description 1
150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
230000008018 melting Effects 0.000 description 1
238000002844 melting Methods 0.000 description 1
JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
239000001294 propane Substances 0.000 description 1
LJXQPZWIHJMPQQ-UHFFFAOYSA-N pyrimidin-2-amine Chemical compound NC1=NC=CC=N1 LJXQPZWIHJMPQQ-UHFFFAOYSA-N 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
238000007363 ring formation reaction Methods 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
239000000126 substance Substances 0.000 description 1
230000029305 taxis Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

LU82517A 1979-07-04 1980-06-11 Synthese de l'isopropylamino-2 pyrimidine LU82517A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB7923224		1979-07-04
GB7923224		1979-07-04

Publications (1)

Publication Number	Publication Date
LU82517A1 true LU82517A1 (fr)	1980-10-24

Family

ID=10506281

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU82517A LU82517A1 (fr)	1979-07-04	1980-06-11	Synthese de l'isopropylamino-2 pyrimidine

Country Status (30)

Country	Link
US (1)	US4266058A (de)
JP (1)	JPS6054312B2 (de)
AR (1)	AR222393A1 (de)
AT (1)	AT375072B (de)
AU (1)	AU529586B2 (de)
BE (1)	BE883751A (de)
CA (1)	CA1132563A (de)
CH (1)	CH644109A5 (de)
DE (1)	DE3025419C2 (de)
DK (1)	DK287480A (de)
EG (1)	EG14820A (de)
ES (1)	ES492747A0 (de)
FI (1)	FI66356C (de)
FR (1)	FR2460937A1 (de)
GR (1)	GR69276B (de)
HK (1)	HK32584A (de)
IE (1)	IE49932B1 (de)
IL (1)	IL60234A (de)
IN (1)	IN154499B (de)
LU (1)	LU82517A1 (de)
MA (1)	MA18890A1 (de)
MX (1)	MX6162E (de)
NL (1)	NL8003616A (de)
NO (1)	NO802004L (de)
NZ (1)	NZ194017A (de)
OA (1)	OA06607A (de)
PT (1)	PT71477A (de)
SE (1)	SE435178B (de)
SG (1)	SG50383G (de)
ZA (1)	ZA803340B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4661303A (en) *	1985-06-11	1987-04-28	The Dow Chemical Company	Reactive coextrusion of functionalized polymers
US5264435A (en) *	1988-12-29	1993-11-23	Mitsui Petrochemical Industries, Ltd.	Pyrimidines and their pharmaceutical acceptable salts, and their use as medicines
HU206337B (en) *	1988-12-29	1992-10-28	Mitsui Petrochemical Ind	Process for producing pyrimidine derivatives and pharmaceutical compositions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2586844A (en) *	1947-10-21	1952-02-26	Ayerst Mckenna & Harrison	Preparation of delta2-1, 3-diazacycloalkenes
GB1523274A (en) *	1974-08-05	1978-08-31	Ici Ltd	Herbicidal compositions containing substituted pyrimidine

1980
- 1980-06-04 ZA ZA00803340A patent/ZA803340B/xx unknown
- 1980-06-04 IN IN414/DEL/80A patent/IN154499B/en unknown
- 1980-06-05 FI FI801817A patent/FI66356C/fi not_active IP Right Cessation
- 1980-06-05 IL IL60234A patent/IL60234A/xx unknown
- 1980-06-06 GR GR62136A patent/GR69276B/el unknown
- 1980-06-10 BE BE0/200985A patent/BE883751A/fr not_active IP Right Cessation
- 1980-06-11 NZ NZ194017A patent/NZ194017A/xx unknown
- 1980-06-11 LU LU82517A patent/LU82517A1/fr unknown
- 1980-06-12 AT AT0310580A patent/AT375072B/de not_active IP Right Cessation
- 1980-06-23 US US06/162,114 patent/US4266058A/en not_active Expired - Lifetime
- 1980-06-23 NL NL8003616A patent/NL8003616A/nl not_active Application Discontinuation
- 1980-06-24 SE SE8004659A patent/SE435178B/sv not_active IP Right Cessation
- 1980-06-25 ES ES492747A patent/ES492747A0/es active Granted
- 1980-06-27 CH CH494480A patent/CH644109A5/fr not_active IP Right Cessation
- 1980-06-30 IE IE1355/80A patent/IE49932B1/en unknown
- 1980-06-30 JP JP55088001A patent/JPS6054312B2/ja not_active Expired
- 1980-07-01 MX MX808898U patent/MX6162E/es unknown
- 1980-07-01 PT PT71477A patent/PT71477A/pt unknown
- 1980-07-01 MA MA19087A patent/MA18890A1/fr unknown
- 1980-07-02 AR AR281619D patent/AR222393A1/es active
- 1980-07-03 CA CA355,324A patent/CA1132563A/en not_active Expired
- 1980-07-03 DK DK287480A patent/DK287480A/da unknown
- 1980-07-03 NO NO802004A patent/NO802004L/no unknown
- 1980-07-04 DE DE3025419A patent/DE3025419C2/de not_active Expired
- 1980-07-04 FR FR8014890A patent/FR2460937A1/fr active Granted
- 1980-07-04 AU AU60113/80A patent/AU529586B2/en not_active Ceased
- 1980-07-04 OA OA57154A patent/OA06607A/xx unknown
- 1980-07-05 EG EG398/80A patent/EG14820A/xx active
1983
- 1983-08-13 SG SG50383A patent/SG50383G/en unknown
1984
- 1984-04-12 HK HK325/84A patent/HK32584A/xx unknown

Also Published As

Publication number	Publication date
ES8105717A1 (es)	1981-06-01
NO802004L (no)	1981-01-05
BE883751A (fr)	1980-10-01
MA18890A1 (fr)	1981-04-01
ZA803340B (en)	1981-05-27
IN154499B (de)	1984-11-03
FI801817A7 (fi)	1981-01-05
ES492747A0 (es)	1981-06-01
IL60234A0 (en)	1980-09-16
FR2460937A1 (fr)	1981-01-30
CH644109A5 (fr)	1984-07-13
SE435178B (sv)	1984-09-10
CA1132563A (en)	1982-09-28
FI66356B (fi)	1984-06-29
FR2460937B1 (de)	1983-03-25
JPS5610177A (en)	1981-02-02
ATA310580A (de)	1983-11-15
US4266058A (en)	1981-05-05
IL60234A (en)	1985-09-29
SG50383G (en)	1984-07-20
AU529586B2 (en)	1983-06-09
DK287480A (da)	1981-01-05
EG14820A (en)	1985-12-31
DE3025419C2 (de)	1985-12-12
HK32584A (en)	1984-04-19
IE801355L (en)	1981-01-04
DE3025419A1 (de)	1981-01-15
NZ194017A (en)	1982-03-09
AT375072B (de)	1984-06-25
AU6011380A (en)	1981-01-15
SE8004659L (sv)	1981-01-05
IE49932B1 (en)	1986-01-08
NL8003616A (nl)	1981-01-06
JPS6054312B2 (ja)	1985-11-29
OA06607A (fr)	1981-08-31
GR69276B (de)	1982-05-13
FI66356C (fi)	1984-10-10
MX6162E (es)	1984-11-29
AR222393A1 (es)	1981-05-15
PT71477A (en)	1980-08-01

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